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| 1 | Dry Heat Treatment Reduces the Occurrence of Cladosporium cucumerinum, Ascochyta citrullina, and Colletotrichum orbiculare on the Surface and Interior of Cucumber Seeds显示文摘Dry heat treatment has been identifie as a method for disinfecting seed-borne pathogens in vegetable seeds. This study demonstrated that three seed-borne pathogens of cucumber(Cladosporium cucumerinum that causes scabs, Ascochyta citrullina that results in gummy stem blight,and Colletotrichum orbiculare that induces anthracnose) could be effectively eradicated from cucumber seeds by dry heat treatment. In vitro growth of these three pathogens was inhibited by dry heat treatment at 70 °C for 40 min. These pathogens were inactivated after exposing infected seeds to 70 °C dry heat for at least 90 min. Seed infection was significant y reduced by exposing the seeds to 70 °C dry heat for at least 40 min. Seed moisture content and germination were slightly reduced after 70 °C heat treatment for 40–120 min. Seed vigor remained at a high level after dry heat treatment at 70 °C for 90 min. In conclusion, 70 °C dry heat treatment for 90 min was determined to be the optimal method for eradication of C. cucumerinum, Didymella bryoniae, and C. orbiculare from cucumber seeds. | SHI Yanxia MENG Shanshan XIE Xuewen CHAI Ali LI Baoju | 2016 | Horticultural Plant Journal2016，2，1： | 5 |
| 2 | Development and Evaluation of a Loop-mediated Isothermal Amplification Assay for the Rapid Detection and Identification of Pectobacterium carotovorum on Celery in the Field显示文摘Pectobacterium carotovorum is the causal agent of bacterial soft rot in a wide range of vegetable host species.Once P.carotovorum infects the plant,the spread of the disease is difficult to control.In this study,a rapid and sensitive method based on loop-mediated isothermal amplification(LAMP)was developed for detecting P.carotovorum in celery with soft rot using a primer set designed from the pmrA conserved sequence of P.carotovorum.The specificity of the LAMP primer set for P.carotovorum was extensively validated on both P.carotovorum strains and nontarget strains.The sensitivity was 1 pg of P.carotovorum genomic DNA,which demonstrated 10 times more sensitive than the conventional PCR assay.LAMP was also used to detect P.carotovorum in bacterial suspension.The lowest detection concentration was 104 CFU·mL^−1.In addition,a LAMP assay,in conjunction with a crude DNA extraction method,was successfully performed on P.carotovorum-infected samples derived from both artificially and naturally infected plants.In summary,the LAMP assay established in this study constitutes a simple,sensitive,and rapid method for the detection of P.carotovorum,and has potential application in the control of celery soft rot disease through early detection. | Yanxia Shi Zhiwen Jin Xianglong Meng Lixue Wang Xuewen Xie Ali Chai Baoju Li | 2020 | Horticultural Plant Journal2020，6，5： | 3 |
| 3 | Accumulation and Elimination Kinetics of 2-Methylisoborneol in Crucian Carp (Carassius carassius)显示文摘2-methylisoborneol(2-MIB) is a common, earthysmelling compound that causes taste and odor issues in aquaculture. To quantify the distribution, absorption, and depuration of 2-MIB in crucian carp(Carassius carassius), we detected and measured 2-MIB it via microwave, headspace solid-phase microextraction(HS-SPME), and gas chromatography before and after exposing fish to two different concentrations of 2-MIB(200 ng/L and 500 ng/L). The results showed that during the exposure time, the fish absorbed 2-MIB rapidly within 4 h. After exposure to 2-MIB for 120 h, the 2-MIB in gill and liver were rapidly removed. The processes of accumulation and elimination of 2-MIB in fish were investigated using the one-compartment kinetic model. The modeling results showed that the range of the uptake rate constant(k1) was 0.49-6.91. The range of the elimination rate constant(k2) was 0.05-0.27 and uptake rates were higher than elimination rates. The bioconcentration factor(BCF) was estimated according to the physicochemical properties of 2-MIB, and the bioaccumulation of 2-MIB in fish had a close correlation with the octanol/water partition coefficient(Kow). | YANG Meng HU Jiaming LIU Liming SHI Xiaotao LIU Guoyong ZUO Yanxia | 2019 | Wuhan University Journal of Natural Sciences2019，24，1： | 3 |
| 4 | Target serum concentration of vancomycin may be reached earlier with a loading dose显示文摘Background:Vancomycin treatment failure against vancomycin-susceptible gram-positive cocci is not rare in the intensive care unit(ICU).One of the reasons for this is the substandard drug trough concentration.We aimed to examine the hypothesis that the target serum concentration could be reached earlier with a loading dose of vancomycin.Methods:This retrospective cohort study was conducted at our ICU between June 2018 and June 2020 and involved patients who were suspected of having,or confirmed to have,gram-positive cocci infection and treated with vancomycin.One group of the patients was administered a loading dose of vancomycin(loading group)and compared with the group that did not receive a loading dose(control group).The baseline characteristics,vancomycin serum concentrations,and clinical outcomes were collected and analyzed.Results:Fifty-five patients were finally included,of which 29 received a loading dose of vancomycin.The serum concentration of vancomycin before the second dose was significantly higher for the loading group than for the control group(10.3±6.1 mg/Lvs.5.7±4.4 mg/L,P=0.002).The results for both groups were similar before the fifth dose(12.4±7.3 mg/Lvs.10.3±6.3 mg/L in the loading and the control groups,respectively;P=0.251).The 28-day mortality was lower for the loading group than for the control group(6.7%vs.34.6%in the loading and control groups,respectively;P=0.026).No significant differences were observed in serum creatinine(Cr)concentrations of the two groups.Conclusion:With the loading dose of vancomycin,the target serum concentration of vancomycin may be reached earlier without increasing the risk of acute kidney injury. | Yanxia Huang Le He Yunxin Deng Renjing Zhang Mei Meng Jiao Liu Dechang Chen | 2022 | Chinese Medical Journal2022，，3： | 2 |
| 5 | Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma显示文摘This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns. | Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 6 | Reprogramming of phytopathogen transcriptome by a non-bactericidal pesticide residue alleviates its virulence in rice显示文摘Bacteria equipped with virulence systems based on highly bioactive small molecules can circumvent their host's defense mechanisms.Pathogens employing this strategy are currently threatening global rice production.In the present study,variations in the virulence of the highly destructive Barkholderiaplantarii were observed in different rice-producing regions.The environment-linked variation was not attributable to any known host-related or external factors.Co-occurrence analyses indicated a connection between reduced virulence and 5-Amino-l,3,4-thiadiazole-2-thiol(ATT),a non-bactericidal organic compound.ATT,which accumulates in rice plants during metabolization of specific agrochemicals,was found to reduce virulence factor secretion by B.plantarii up to 88.8%and inhibit pathogen virulence by hijacking an upstream signaling cascade.Detailed assessment of the newly discovered virulence inhibitor resulted in mechanistic insights into positive effects of ATT accumulation in plant tissues.Mechanisms of virulence alleviation were deciphered by integrating high-throughput data,gene knockout mutants,and molecular interaction assays.TroK,a histidine protein kinase in a two-component system that regulates virulence factor secretion,is likely the molecular target antagonized by ATT.Our findings provide novel insights into virulence modulation in an important plant-pathogen system that relies on the host's metabolic activity and subsequent signaling interference. | Haruna Matsumoto Yuan Qian Xiaoyan Fan Sunlu Chen Yanxia Nie Kun Qiao Dandan Xiang Xinzhong Zhang Meng Li Bo Guo Peilin Shen Qiangwei Wang Yunlong Yu Tomislav Cemava Mengcen Wang | 2022 | Fundamental Research2022，2，2： | 2 |
| 7 | A shedding soluble form of interleukin-17 receptor D exacerbates collagen-induced arthritis through facilitating TNF-α-dependent receptor clustering显示文摘Rheumatoid arthritis(RA)is exacerbated by TNF-alpha signaling.However,it remains unclear whether TNF-α-activated TNFR1 and TNFR2 are regulated by extracellular factors.Here,we showed that soluble glycosylated interleukin-17 receptor D(sIL-17RD),which was produced by proteolytic cleavage,enhanced TNF-α-induced RA.We revealed that IL-17RD shedding was induced by the proteolytic enzyme TACE and enhanced by TNF-αexpression in macrophages.Intriguingly,sIL-17RD was elevated in the sera of arthritic mice and rats.Recombinant sIL-17RD significantly enhanced the TNF-α-induced proinflammatory response by promoting TNF-α-TNFR-sIL-17RD complex formation and receptor clustering,leading to the accelerated development of collagen-induced arthritis.Our observations revealed that ectodomain shedding of IL-17RD occurred in RA to boost the TNF-α-induced inflammatory response.Targeting sIL-17RD may provide a new strategy for the therapy of RA. | Sihan Liu Yanxia Fu Kunrong Mei Yinan Jiang Xiaojun Sun Yinyin Wang Fangli Ren Congshan Jiang Liesu Meng Shemin Lu Zhihai Qin Chen Dong Xinquan Wang Zhijie Chang Shigao Yang | 2021 | Cellular & Molecular Immunology2021，18，8： | 1 |
| 8 | Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation显示文摘 | Yang Zhao Xiaolei Yin Han Qin Fangfang Zhu Haisong Liu Weifeng Yang Qiang Zhang Chengang Xiang Pingping Hou Zhihua Song Yanxia Liu Jun Yong Pengbo Zhang Jun Cai Meng Liu Honggang Li Yanqin Li Xiuxia Qu Kai Cui Weiqi Zhang Tingting Xiang Yetao Wu Yiding Zh | 2008 | Cell Stem Cell2008，，5： | 1 |
| 9 | Effect of oligochitosan on development of Colletotrichum musae in vitro and in situ and its role in protection of banana fruits显示文摘 | MENG Xiangchun TANG Yanxia ZHANG Aiyu | 2012 | Fruits2012，67，3： | 1 |
| 10 | Highly effective visible-photocatalytic hydrogen evolution and simultaneous organic pollutant degradation over an urchin-like oxygen-doped MoS_(2)/ZnIn_(2)S_(4)composite显示文摘Achieving hydrogen production and simultaneous decomposition of organic pollutants through dual-functional photocatalytic reactions has received increasing attention due to the environmentally friendly and cost-effective characteristics of this approach.In this work,an urchin-like oxygen-doped MoS_(2)/ZnIn_(2)S_(4)(OMS/ZIS)composite was fabricated for the first time using a simple solvothermal method.The unique microstructure with abundant active sites and fast charge transfer channels further shortened the charge migration distance and compressed carrier recombination.The obtained composite exhibited an efficient H2 evolution reaction rate of 12.8 mmol/g/h under visible light,which was nearly times higher than pristine ZnIn_(2)S_(4),and the apparent quantum efficiency was 14.9%(420 nm).The results of the simultaneous photocatalytic H2 evolution and organic pollutant decomposition test were satisfactory,resulting in decomposition efficiencies of resorcinol,tetracycline,and bisphenol A that reached 41.5%,63.5%,and 53.0%after 4 h,respectively,and the highest H2 evolution rate was 672.7 umol/g/h for bisphenol A.Furthermore,natural organic matter(NOM)abundantly found in actual water was adopted as an electron donor for H production under simulated sunlight irradiation,indicating the promising practicability of simultaneous hydrogen evolution and NOM decomposition.Moreover,the mechanisms of the dual-purpose photocatalytic reactions,as well as the synergistic effect between the molecular structures of the organic pollutants and the corresponding adsorption behavior on the photocatalyst surface were illustrated in detail.These obtained results may serve as an inspiration for the rational design of highly efficient,dual-functional photocatalysts in the future. | Tao Yan Qianqian Yang Rui Feng Xiang Ren Yanxia Zhao Meng Sun Liangguo Yan Qin Wei | 2022 | Frontiers of Environmental Science & Engineering2022，16，10： | 1 |
| 11 | Effects of crystal structure on the activity of MnO2 nanorods oxidase mimics显示文摘The crystal structures would directly affect the physical and chemical properties of the surface of the material,and would thus influence the catalytic activity of the material.α-MnO2,β-MnO2 andγ-MnO2 nanorods with the same morphology yet different crystal structures were prepared and tested as oxidase mimics using 3,3’,5,5’-tetramethylbenzidine(TMB)as the substrate.β-MnO2 that exhibited the highest activity had a catalytic constant of 83.75μmol·m^−2·s^−1,2.7 and 19.0 times of those ofα-MnO2 andγ-MnO2(30.91 and 4.41μmol·m^−2·s^−1),respectively.The characterization results showed that there were more surface hydroxyls as well as more Mn4+on the surface of theβ-MnO2 nanorods.The surface hydroxyls were conducive to the oxidation reaction,while Mn4+was conducive to the regeneration of surface hydroxyls.The synergistic effect of the two factors significantly improved the activity ofβ-MnO2 oxidase mimic.Usingβ-MnO2,aβ-MnO2-TMB-GSH system was established to detect the content of glutathione(GSH)rapidly and sensitively by colorimetry.This method had a wide detection range(0.11-45μM)and a low detection limit(0.1μM),and had been successfully applied to GSH quantification in human serum samples. | Yanxia Meng Kunfeng Zhao Zhaokun Zhang Peng Gao Jing Yuan Ting Cai Qin Tong Gang Huang Dannong He | 2020 | Nano Research2020，13，3： | 1 |
| 12 | A PRIORI AND A POSTERIORI ERROR ESTIMATES OF A WEAKLY OVER-PENALIZED INTERIOR PENALTY METHOD FOR NON-SELF-ADJOINT AND INDEFINITE PROBLEMS显示文摘在这份报纸,我们为 non-self-adjoint 和不定的问题学习一个弱过去惩罚的内部惩罚方法。一最佳在精力标准的 priori 错误估计被导出。另外,我们介绍一基于剩余一个 posteriori 错误评估者,它被证明在精力标准可靠、有效。一些数字睾丸被介绍验证我们的理论分析。[从作者抽象] | Yuping Zeng Jinru Chen Feng Wang Yanxia Meng | 2014 | Journal of Computational Mathematics2014，32，3： | 1 |
| 13 | 野生型p53通过激活PUMA抑制氧化磷酸化而促进肿瘤代谢显示文摘文章简介在一半的人类癌症中,肿瘤抑制因子p53发生了基因突变。然而令人困惑的是,在某些人类癌症如肝癌(HCC)中常常保留有野生型p53。本研究最新研究发现,野生型p53可通过诱导PUMA来抑制丙酮酸驱动的氧化磷酸化,从而产生致癌作用。IκB激酶介导PUMA在位点Ser96/106磷酸化,与线粒体丙酮酸载体(MPC)发生相互作用,进而破坏MPC寡聚化和功能,以抑制线粒体丙酮酸的摄取。 | Jinchul Kim Lili Yu Wancheng Chen Yanxia Xu Meng Wu Dilyana Todorova Qingshuang Tang Bingbing Feng Lei Jiang Jingjin He Guihua Chen 付雪梅 Yang Xu | 2020 | 科学新闻2020，，2： | 0 |
| 14 | Plastome sequencing of Myripnois dioica and comparison within Asteraceae显示文摘Myripnois is a monotypic shrub genus in the daisy family constricted to northern China.Although wild populations of Myripnois dioica are relatively rare,this plant may potentially be cultured as a fine ornamental.In the present study,we sequenced the complete plastome of M.dioica,generating the first plastome sequences of the subfamily Pertyoideae.The plastome of M.dioica has a typical quadripartite circular structure.A large^20-kb and a small^3-kb inversion were detected in the large single copy(LSC)region and shared by other Asteraceae species.Plastome phylogenomic analyses based on 78 Asteraceae species and three outgroups revealed four groups,corresponding to four Asteraceae subfamilies:Asteroideae,Cichorioideae,Pertyoideae and Carduoideae.Among these four subfamilies,Pertyoideae is sister to Asteroideae+Cichorioideae;Carduoideae is the most basal clade.In addition,we characterized 13 simple sequence repeats(SSRs)that may be useful in future studies on population genetics. | Nan Lin Xu Zhang Tao Deng Jianwen Zhang Aiping Meng Hengchang Wang Hang Sun Yanxia Sun | 2019 | Plant Diversity2019，41，5： | 0 |
| 15 | Histone lactylation driven by mROS-mediated glycolytic shift promotes hypoxic pulmonary hypertension显示文摘Increased mitochondrial reactive oxygen species(mROS)and glycolysis have been established in pulmonary hypertension(PH).However,the effect of elevated mROS on glycolytic shift and how increased glycolysis promotes hypoxic pulmonary artery smooth muscle cell(PASMC)proliferation and vascular remodeling remain elusive.Here,we reported that hypoxia-induced mROS inhibit HIF-1αhydroxylation and further trigger PASMC glycolytic switch through the upregulated HIF-1α/PDK1&PDK2/p-PDH-E1αaxis,which facilitates lactate accumulation and histone lactylation.Through H3K18la and HIF-1αChIP–seq analysis,we found that the enhanced histone lactylation of HIF-1αtargets,such as Bmp5,Trpc5,and Kit,promotes PASMC proliferation.Knockdown of Pdk1&2 blunts lactate production,histone lactylation marks,and PASMC proliferation.Moreover,pharmacological intervention with lactate dehydrogenase inhibitor diminishes histone lactylation and ameliorates PASMC proliferation and vascular remodeling in hypoxic PH rats.Taken together,this study provides proof of concept for anti-remodeling therapy through lactate manipulation. | Jian Chen Meiling Zhang Yanjie Liu Shihong Zhao Yanxia Wang Meng Wang Wen Niu Faguang Jin Zhichao Li | 2022 | Journal of Molecular Cell Biology2022，14，12： | 0 |
| 16 | Space Weather Service for Chinese Space Science Satellites显示文摘Strategic Priority Research Program on Space Science has gained remarkable achievements. Space Environment Prediction Center(SEPC) affiliated with the National Space Science Center(NSSC) has been providing space weather services and helps secure space missions. Presently, SEPC is capable to offer a variety of space weather services covering many phases of space science missions including planning, design, launch,and orbital operation. The service packages consist of space weather forecasts, warnings, and effect analysis that can be utilized to avoid potential space weather hazard or reduce the damage caused by space storms,space radiation exposure for example. Extensive solar storms that occurred over Chinese Ghost Festival(CGF)in September 2017 led to a large enhancement of the solar energetic particle flux at 1 AU, which affected the near Earth radiation environment and brought great threat to orbiting satellites. Based on the space weather service by SEPC, satellite ground support groups collaborating with the space Tracking, Telemetering and Command system(TT&C) team were able to take immediate measures to react to the CGF solar storm event. | LIU Siqing ZHONG Qiuzhen GONG Jiancun SHI Liqin CHEN Dong MIAO Juan CAI Yanxia BAI Meng MA Wenzhen LI Zhitao LIU Fanghua CHEN Yanhong | 2018 | 空间科学学报2018，38，5： | 0 |
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