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| 1 | Hepatic artery infusion chemotherapy using mFOLFOX versus transarterial chemoembolization for massive unresectable hepatocellular carcinoma:a prospective non.randomized study显示文摘Background: Transarterial chemoembolization(TACE) is recommended as the standard care for unresectable hepatocellular carcinoma(HCC) at Barcelona Clinic Liver Cancer(BCLC) stage A-B. However, the efficacy of TACE on large(> 10 cm) stage A-B HCC is far from satisfactory, and it is proposed that hepatic artery infusion chemotherapy(HAIC)might be a better first-line treatment of this disease. Hence, we compared the safety and efficacy of HAIC with the modified FOLFOX(mFOLFOX) regimen and those ofTACE in patients with massive unresectable HCC.Methods: A prospective, non-randomized, phase II study was conducted on patients with massive unresectable HCC. The protocol involved HAIC with the mFOLFOX regimen(oxaliplatin, 85 mg/m^2 intra-arterial infusion; leucovorin,400 mg/m^2 intra-arterial infusion; and fluorouracil, 400 mg/m2 bolus infusion and 2400 mg/m^2 continuous infusion)every 3 weeks and TACE with 50 mg of epirubicin, 50 mg of lobaplatin, 6 mg of mitomycin, and lipiodol and polyvinyl alcohol particles. The tumor responses, time-to-progression(TTP), and safety were assessed.Results: A total of 79 patients were recruited for this study: 38 in the HAIC group and 41 in the TACE group. The HAIC group exhibited higher partial response and disease control rates than did the TACE group(52.6% vs. 9.8%, P < 0.001;83.8% vs. 52.5%, P = 0.004). The median TTPs for the HAIC and TACE groups were 5.87 and 3.6 months(hazard radio[HR] = 2.35,95% confidence interval [CI] = 1.16-4.76, P = 0.015). More patients in the HAIC group than in the TACE group underwent resection(10 vs. 3,P = 0.033). The proportions of grade 3-4 adverse events(AE) and serious adverse events(SAE) were lower in the HAIC group than in the TACE group(grade 3-4 AEs: 13 vs. 27, P = 0.007;SAEs: 6 vs. 15,p = 0.044). More patients in the TACE group than in the HAIC group had the study treatment terminated early due to intolerable treatment-related adverse events or the withdrawal of consent(10 vs. 2,P = 0.026).Conclusions: HAIC with mFOLFOX yielded significantly better treatment responses and less serious toxicity than did TACE. HAIC might represent a feasible and promising first-line treatment for patients with massive unresectable HCC. | Min-Ke He Yong Le Qi-Jiong Li Zi-Shan Yu Shao-Hua Li Wei Wei Rong-Ping Guo Ming Shi | 2017 | Chinese Journal of Cancer2017，36，12： | 95 |
| 2 | A Novel QTL qTGW3 Encodes the GSK3/ SHAGGY-Like Kinase OsGSK5/OsSK41 that Interacts with OsARF4 to Negatively Regulate Grain Size and Weight in Rice显示文摘谷物尺寸和形状在米饭是谷物重量和产量的重要决定因素。这里,我们报导一个新主要量的特点在米饭的地点(QTL ) , qTGW3,那种控制谷物尺寸和重量。这个地点, qTGW3,编码 OsSK41 (也作为 OsGSK5 知道) , GLYCOGEN SYNTHASE KINASE 3/SHAGGY-like 家庭的一个成员。带 OsSK41 的 loss-of-function 等位基因的瑞斯 near-isogenic 线增加了谷物长度和重量。我们证明那 OsSK41 交往与并且 phosphorylates 植物生长素反应因素 4 (OsARF4 ) 。有 OsARF4 的 OsSK41 的合作表示在米饭原物增加 OsARF4 的累积。OsARF4 的功能的损失导致更大的米饭谷物。定序 RNA 分析建议 OsARF4 和 OsSK41 镇压下游的基因的一个普通集合的表示, ? 包括一些植物生长素应答的基因,在米饭谷物开发期间。在 qTGW3 的 OsSK41 的 loss-of-function 形式代表没被指向的基因编辑或 QTL 节节上升广泛地在 OsSK41 功能的米饭 breeding.?Suppression 利用了的稀罕等位基因提高米饭谷物尺寸和重量。因此,我们的学习在米饭谷物开发揭示 OsSK41 的重要角色 ?? 并且在另外的谷物庄稼在米饭并且也许为谷物产量的基因改进提供新候选人基因。 | Zejun Hu Sun-Jie Lu Mei-Jing Wang Haohua He Le Sun Hongru Wang Xue-Huan Liu Ling Jiang Jing-Liang sun Xiaoyun Xin Wei Kong Chengcai Chu Hong-Wei Xue Jinshui Yang Xiaojin Luo Jian-Xiang Liu | 2018 | Molecular Plant2018，11，5： | 47 |
| 3 | An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay显示文摘Objective To investigate oxidative DNA damage in pharmacy technicians preparing antineoplastic drugs at the PIVAS (Pharmacy Intravenous Admixture Service) in two Chinese hospitals.Methods Urinary 8-OHdG served as a biomarker.5-Fluorouracil (5-FU) concentrations in air,masks and gloves were determined.The spill exposure of each PIVAS technician to antineoplastic drugs was investigated.Eighty subjects were divided into exposed group I,II,and control group I,II.Results 5-FU concentration ratios for gloves and masks in exposed group I were significantly higher than those in exposed group II (P<0.05 or P<0.01).The average urinary 8-OHdG concentrations in exposed group I,control group I,exposed group II,and control group II were 14.69±0.93,10.68±1.07,10.57±0.55,and 11.96±0.73 ng/mg Cr,respectively.Urinary 8-OHdG concentration in exposed group I was significantly higher than that in control group I or that in exposed group II (P<0.01).There was a significant correlation between urinary 8-OHdG concentrations and spill frequencies per technician (P<0.01).Conclusion There was detectable oxidative DNA damage in PIVAS technicians exposed to antineoplastic drugs.This oxidative DNA damage may be associated with their spill exposure experience and contamination of their personal protective equipment. | HUANG Yu Wen JIAN Le ZHANG Mei Bian ZHOU Quan YAN Xiao Feng HUA Xu Dong ZHOU Ying HE Ji Liang | 2012 | Biomedical and Environmental Sciences2012，25，1： | 30 |
| 4 | Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a hospital.based,multicenter,cross-sectional survey显示文摘Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective. | Hui-Yao Huang Ju-Fang Shi Lan-Wei Guo Ya-Na Bai Xian-Zhen Liao Guo-iangLiu A-Yan Mao Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Le Wang Bing-Bing Song Ling-Bin Du Lin Zhu Ji-Yong Gong Qi Zhou Yu-Qin Liu Rong Cao Ling Mai Li Lan Xiao-Hua Sun Ying Ren Jin-Yi Zhou Yuan-Zheng Wang Xiao Qi Pei-An Lou Dian Shi Ni Li Kai Zhang Jie He Min Dai | 2017 | Chinese Journal of Cancer2017，36，8： | 25 |
| 5 | Performances evaluation of four typical unmanned aerial vehicles used for pesticide application in China显示文摘In recent years,unmanned aerial vehicles(UAVs)for plant protection have achieved rapid development in China.In order to test and evaluate the performances of pesticides application and development status of UAVs in China,four typical UAV models were selected to test the spraying coverage,penetrability,droplets density and the work efficiency.The results showed that the deposition and spraying liquid coverage were inconsistent both in lateral and longitudinal direction.Under the condition of the similar amount of spray volume and operation parameters,the volume median diameter(VMD)of the droplet was negatively correlated with the coverage density.The failure of the UAVs for plant protection mainly took up on the blockage of nozzle,transfusion tube and the liquid pump.The failure rate of UAVs took up 3.73%-4.36%of the total working time.The operation of UAVs during ground service took up 50%of the total working time,the preparation work took up 10%,and the route planning took up around 10%,while net operation time only took up around 30%.On the whole,the high efficiency of UAV was not fully achieved;the daily operated area was not in a satisfactory level now.The spraying performances of UAVs still need further improvement. | Wang Shilin Song Jianli He Xiongkui Song Le Wang Xiaonan Wang Changling Wang Zhichong Ling Yun | 2017 | International Journal of Agricultural and Biological Engineering2017，10，4： | 25 |
| 6 | Endothelial Nitric Oxide Synthase Gene Intron 4, 27 bp Repeat Polymorphism and Essential Hypertension in the Kazakh Chinese Population显示文摘为了调查在 27 bp 之间的关系,在内含子 4in 重复多型性 endothelial 在 KazakhChinese 人口的氮的氧化物合酶( eNOS4 )基因和必要高血压,有必要高血压和 138 个健康的人的 151 个病人在 Xinjiang uygur 从 Shawan 区域的 Boertonggu 农村被选择中国 in2006 的自治区域。在二个组的 eNOS 的多型性与聚合酶链反应试金被检测,在每个组的遗传型频率是计算的跟随 Hardy-Weinberg 法律。Fourand 27 bp 重复的五辆双人脚踏车是被指明一 and “ b' 分别地。b/b, b/a 和 eNOS4 基因的 a/a 遗传型的频率在控制组是 84.06% , 15.22% 和 0.72% ,这被发现,并且 81.46% , 15.89% 和 2.65% 分别地在高血压组织。基因的频率一 and “ b' 在控制组是 91.67% 和 8.33% , 89.40% 和 10.60% 分别地在高血压组织。血浆 eNOS 活动没与 eNOS 基因的遗传型和等位基因被联系,这被发现。在高血压组的血浆 eNOS 活动显著地与控制组(P<0.01 ) 相比被减少。结果建议 eNOS4 基因多型性是不大可能的是为在 Xinjiang 哈萨克人口的必要高血压的主要基因危险性因素。然而,在血浆 eNOS 活动之间的一个积极协会和必要高血压被揭示了。 | Fengmei DENG Qinghua HU Bin TANG Fang HE Shuxia GUO Jiang CHEN Feng LI Xuehua WU Jun ZHANG Huimin ZHANG Juan ZHAO Hua ZHONG Ling HE Jun LI Le ZHANG Shuren WANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，5： | 18 |
| 7 | Geologic characteristics of the Chang'E-3 exploration region显示文摘We present topographic,geomorphologic and compositional characteristics of a 1°×1°(~660 km2)region centered near the landing site of Chang’E-3 using the highest spatial resolution data available.We analyze the topography and slope using Digital Terrain Model(DTM)generated from Terrain Camera(TC)images.The exploration region is overall relatively flat and the elevation difference is less than 300 m,and the slopes of 80%area are less than 5°.Impact craters in the exploration region are classified into four types based on their degradation states.We investigate the wrinkle ridges visible in the exploration region in detail using TC and Lunar Reconnaissance Orbiter(LRO)Narrow Angle Camera(NAC)images.We calculate FeO and TiO2 abundances using Multispectral Imager(MI)data,and confirm two basaltic units:the northern part belongs to Imbrian low-Ti/very-low-Ti mare basalts,and the southern part is Eratosthenian low-Ti/high-Ti mare basalts.Finally,we produce a geological map and propose the geologic evolution of the exploration region.We also suggest several rover traverses to explore interesting targets and maximize the potential scientific output. | ZHAO JianNan HUANG Jun QIAO Le XIAO ZhiYong HUANG Qian WANG Jiang HE Qi XIAO Long | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，3： | 14 |
| 8 | Multidrug-resistant Tuberculosis Burden among the New Tuberculosis Patients in Zhejiang Province: An Observational Study, 2009-2013显示文摘 | Ying Peng Song-Hua Chen Le Zhang Bin Chen Ming-Wu Zhang Tie-Niu He Fei Wang Cheng-Liang Chai Lin Zhou Yu Zhang Xiao-Meng Wang Zhongwei Jia | 2017 | Chinese Medical Journal2017，，17： | 13 |
| 9 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 10 | In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine显示文摘Berberrubine (BRB ) 是在 vivo 比 BBR 显示出更强壮的葡萄糖阴沉的效果的 berberine (BBR ) 的主要代谢物。在另一方面, BRB 快速并且广泛地被使产生代射变化进 berberrubine-9-O -- 在在口头的管理以后的老鼠的 D-glucuronide (BRBG ) 。在这研究,我们在老鼠比较了 BRB 和 BRBG 的 pharmacokinetic 性质,并且探索了位于他们的葡萄糖阴沉的活动下面的机制。有导致 HFD 的多糖症的 C57BL/6 老鼠被管理 BRB (50 mg 吗?? | Na YANG Run-bin SUN Xing-long CHEN Le ZHEN Chun GE Yu-qing ZHAO Jun HE Jian-liang GENG Jia-hua GUO Xiao-yi YU Fei FEI Si-qi FENG Xuan-xuan ZHU Hong-bo WANG Feng-hua FU Ji-ye AA Guang-ji WANG | 2017 | Acta Pharmacologica Sinica2017，38，3： | 9 |
| 11 | Xa7, a new executor R gene that confers durable and broad-spectrum resistance to bacterial blight disease in rice显示文摘Bacterial blight(BB)is a globally devastating rice disease caused by Xanthomonas oryzae pv.oryzae(Xoo).The use of disease resistance(R)genes in rice breeding is an effective and economical strategy for the control of this disease.Nevertheless,a majority of R genes lack durable resistance for long-term use under global warming conditions.Here,we report the isolation of a novel executor R gene,Xa7,that confers extremely durable,broad-spectrum,and heat-tolerant resistance to Xoo.The expression of Xa7 was induced by incompatible Xoo strains that secreted the transcription activator-like effector(TALE)AvrXa7 or PthXo3,which recognized effector binding elements(EBEs)in the Xa7 promoter.Furthermore,Xa7 induction was faster and stronger under high temperatures.Overexpression of Xa7 or co-transformation of Xa7 with avrXa7 triggered a hypersensitive response in plants.Constitutive expression of Xa7 activated a defense response in the absence of Xoo but inhibited the growth of transgenic rice plants.In addition,analysis of over 3000 rice varieties showed that the Xa7 locuswas found primarily in the indica and aus subgroups.A variation consisting of an 11-bp insertion and a base substitution(G to T)was found in EBEAvrXa7 in the tested varieties,resulting in a loss of Xa7 BB resistance.Through a decade of effort,we have identified an important BB resistance gene and characterized its distinctive interaction with Xoo strains;these findings will greatly facilitate research on the molecular mechanism of Xa7-mediated resistance and promote the use of this valuable gene in breeding. | Xifeng Chen Pengcheng Liu Le Mei Xiaoling He Long Chen Hui Liu Shurong Shen Zhandong Ji Xixi Zheng Yuchen Zhang Zhenyu Gao Dali Zeng Qian Qian Bojun Ma | 2021 | Plant Communications2021，2，3： | 9 |
| 12 | A plasmonic route for the integrated wireless communication of subdiffraction-limited signals显示文摘Perfect lenses,superlenses and time-reversal mirrors can support and spatially separate evanescent waves,which is the basis for detecting subwavelength information in the far field.However,the inherent limitations of these methods have prevented the development of systems to dynamically distinguish subdiffraction-limited signals.Utilizing the physical merits of spoof surface plasmon polaritons(SPPs),we demonstrate that subdiffraction-limited signals can be transmitted on planar integrated SPP channels with low loss,low channel interference,and high gain and can be radiated with a very low environmental sensitivity.Furthermore,we show how deep subdiffraction-limited signals that are spatially coupled can be distinguished after line-of-sight wireless transmission.For a visualized demonstration,we realize the high-quality wireless communication of two movies on subwavelength channels over the line of sight in real time using our plasmonic scheme,showing significant advantages over the conventional methods. | Hao Chi Zhang Le Peng Zhang Pei Hang He Jie Xu Cheng Qian Francisco J.Garcia-Vidal Tie Jun Cui | 2020 | Light(Science & Applications)2020，9，1： | 8 |
| 13 | Design and experimental study of a practical Osculating Inward Cone Waverider Inlet显示文摘A design method based on tip to tail streamline tracing and osculating inward cone methods is discussed for designing the integrated Osculating Inward Cone Waverider Inlet(OICWI). A practical geometrical constrained experimental model of OICWI is designed based on the validated design method. It has a total contraction ratio of 4.61 and inner contraction ratio is 2.0. Wind-tunnel tests have been conducted for the OICWI model at free stream Mach number(Ma_∞) of 4.0, 3.5 and 3.0 respectively. The experimental results show that the OICWI has high flow capture ratio and compression abilities. It can self-start at Ma_∞= 3.5 and 4.0 and its flow capture ratio is 0.73 at Ma_∞= 4.0, and Angle of Attack(AOA) 0°. The research results show that the OICWI has advantages of inward cone waverider and streamline tracing inlet. Present OICWI is a novel approach for waverider inlet integration studies and it will promote the use of waverider inlet integration configuration in the studies of airbreathing hypersonic vehicles. | He Xuzhao Zhou Zheng Qin Si Wei Feng Le Jialing | 2016 | Chinese Journal of Aeronautics2016，29，6： | 8 |
| 14 | A study on pathogenicity of hepatitis G virus显示文摘AIM To study the pathogenicity of hepatitis G virus (HGV) and observe the genesis and pathological process of hepatitis G.METHODS HGV-RNA in serum was detected by RT-PCR assay. The immunohistochemical assays of liver tissue were performed with HGV monocoloned antibody (McAb)expressed from the region of HGV NS5 nucleic acid sequence. The clinical and pathological data of 52 patients with hepatitis G were discussed. In animal experiment,the Chinese Rhesus monkeys were infected with the serum of a patient with HGV infection. And the dynamic changes in serology and liver histology of animals were observed.RESULTS One hundred and fifty-four patients with HGVRNA positive were selected from 1552 patients with various kinds of hepatitis. Of 154 patients with HGV infection, 52 were infected with HGV only, which accounted for 33.8% (52/154) and 102 with positive HGVRNA were super-infected with other hepatitis viruses,which accounted for 66.2% (102/154). The clinical and pathological observation showed that the acute and chronic hepatitis could be induced by HGV. The slight abnormality of transaminases ALT and AST in serum of monkeys lasted nearly 12 months and histological results showed a series of pathological changes.CONCLUSION HGV is a hepatotropic virus and has pathogenicty. | Jia-Zhang Xu Zhi-Guo Yang Mei-Zhao Le Mao-Rong Wang Chang-Lun He Yun-Hua Sui Institute of Hepatology,the 81st Hospital of PLA,Nanjing 210002,Jiangsu Province,ChinaDepartment of Pathology,the 81st Hospital of PLA,Nanjing 210002,Jiangsu Province,China | 2001 | World Journal of Gastroenterology2001，7，4： | 8 |
| 15 | An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma显示文摘No clinically available biomarkers can predict pathological complete response(pCR)for esophageal squamous cell carcinomas(ESCCs)with neoadjuvant chemoradiotherapy(nCRT).Considering that antitumor immunity status is an important determinant for nCRT,we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter analysis.During the discovery phase,14 differentially expressed immune-related genes(DEIGs)with greater than a twofold change between pCRs and less than pCRs( | Chaoqi Zhang Guochao Zhang Nan Sun Zhen Zhang Liyan Xue Zhihui Zhang Haijun Yang Yuejun Luo Xiaoli Zheng Yonglei Zhang Yufen Yuan Ruixue Lei Zhaoyang Yang Bo Zheng Le Wang Yun Che Feng Wang Sihui Wang Shugeng Gao Qi Xue Yi Zhang Jie He | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 16 | Whole-genome sequencing provides insights into the genetic diversity and domestication of bitter gourd(Momordica spp.)显示文摘Bitter gourd(Momordica charantia)is a popular cultivated vegetable in Asian and African countries.To reveal the characteristics of the genomic structure,evolutionary trajectory,and genetic basis underlying the domestication of bitter gourd,we performed whole-genome sequencing of the cultivar Dali-11 and the wild small-fruited line TR and resequencing of 187 bitter gourd germplasms from 16 countries.The major gene clusters(Bi clusters)for the biosynthesis of cucurbitane triterpenoids,which confer a bitter taste,are highly conserved in cucumber,melon,and watermelon.Comparative analysis among cucurbit genomes revealed that the Bi cluster involved in cucurbitane triterpenoid biosynthesis is absent in bitter gourd.Phylogenetic analysis revealed that the TR group,including 21 bitter gourd germplasms,may belong to a new species or subspecies independent from M.charantia.Furthermore,we found that the remaining 166 M.charantia germplasms are geographically differentiated,and we identified 710,412,and 290 candidate domestication genes in the South Asia,Southeast Asia,and China populations,respectively.This study provides new insights into bitter gourd genetic diversity and domestication and will facilitate the future genomics-enabled improvement of bitter gourd. | Junjie Cui Yan Yang Shaobo Luo Le Wang Rukui Huang Qingfang Wen Xiaoxia Han Nansheng Miao Jiaowen Cheng Ziji Liu Changyuan Zhang Chengcheng Feng Haisheng Zhu Jianwen Su Xinjian Wan Fang Hu Yu Niu Xiaoming Zheng Yulan Yang Dai Shan Zhensheng Dong Weiming He Narinder P.S.Dhillon Kailin Hu | 2020 | Horticulture Research2020，7，1： | 7 |
| 17 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 18 | A novel approach for one-step forming ε-caprolactam from cyclohexane nitrozation catalyzed by transition metal salt显示文摘The nitrozation reaction of cyclohexane in one-step reaction to form ε-caprolactam has been studied using transition metal salt as catalysts in this work. The results indicated that the catalysts play an especially important role. This method is expected to be a novel way to synthesize other lactam by similar reaction. The possible mechanism was suggested. | Li Qiu Mao Bo Hua Wu Du Lin Yin Kui Yi You Ping Le Liu He An Luo | 2007 | Chinese Chemical Letters2007，18，3： | 6 |
| 19 | Human movement monitoring and behavior recognition for intelligent sports using customizable and flexible triboelectric nanogenerator显示文摘Effective collection,recognition,and analysis of sports information is the key to intelligent sports,which can help athletes to improve their skills and formulate scientific training plans and competition strategies.At present,wearable electronic devices used for movement monitoring still have some limitations,such as high cost and energy consumption,incompatibility of suitable flexibility and personalized spatial structure,dissatisfactory data analysis methods,etc.In this work,a novel three-dimensionalprinted thermoplastic polyurethane is introduced as the elastic shell and friction layer,and it endows the proposed customizable and flexible triboelectric nanogenerator(CF-TENG)with personalized spatial structure and robust correlation to external pressure.In practical application,it exhibits highly sensitive responses to the joint-bending motion of the finger,wrist,or elbow.Furthermore,a pressure-sensing insole and smart ski pole based on CF-TENG are manufactured to build a comprehensive sports monitoring system to transmit the athletes’motion information from feet and hands through the plantar pressure distribution and ski pole action.To recognize the movement status,the self-developed automatic peak recognition algorithm(P-Find)and machine learning algorithm(subspace K-Nearest Neighbors)were introduced to accurately distinguish the four typical motion behaviors and three primary sub-techniques of cross-country skiing,with accuracy rates of 98.2%and 100%.This work provides a novel strategy to promote the personalized applications of TENGs in intelligent sports. | YANG Yun HOU XiaoJuan GENG WenPing MU JiLiang ZHANG Le WANG XiangDong HE Jian XIONG Ji Jun CHOU XiuJian | 2022 | Science China(Technological Sciences)2022，65，4： | 6 |
| 20 | Active digital spoof plasmonics显示文摘Digital coding and digital modulation are the foundation of modern information science.The combination of digital technology with metamaterials provides a powerful scheme for spatial and temporal controls of electromagnetic waves.Such a technique,however,has thus far been limited to the control of free-space light.Its application to plasmonics to shape subwavelength fields still remains elusive.Here,we report the design and experimental realization of a tunable conformal plasmonic metasurface;which is capable of digitally coding and modulating designer surface plasmons at the deep-subwavelength scale.Based on dynamical switching between two discrete dispersion states in a controlled manner;we achieve digital modulations ofboth amplitude and phase of surface waves with nearly 100%modulation depth on a single device.Our study not only introduces a new approach for active dispersion engineering,but also constitutes an important step towards the realization of subwavelength integrated plasmonic circuits. | Hao Chi Zhang Tie Jun Cui Yu Luo Jingjing Zhang Jie Xu Pei Hang He Le Peng Zhang | 2020 | National Science Review2020，7，2： | 5 |
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