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| 1 | Output feedback control of hypersonic vehicles based on neural network and high gain observer显示文摘In this paper,the output feedback control problem for a genetic hypersonic vehicle is considered under the restriction that only the vehicle's velocity and altitude are measurable. High gain observers (HGO) are utilized to provide estimation signals for unmeasurable derivatives of the vehicle's velocity and altitude. Neural network based feedforward function is designed to compensate for model uncertainties. The proposed control design require less knowledge of the hypersonic vehicle's dynamic model. A comprehensive stability analysis of the closed loop system under the output feedback control is carried to prove that the proposed control law yields semiglobal uniformly ultimately bounded tracking while keeping all the closed loop signals bounded. Numerical simulation results are presented to validate the proposed control design. | LI XinDong KIAN Bin DIAO Chen YU YanPing YANG KaiYan ZHANG Yao | 2011 | Science China(Information Sciences)2011，54，3： | 20 |
| 2 | Identification of a novel mutation in POU3F4 for prenatal diagnosis in a Chinese family with X-linked nonsyndromic hearing loss显示文摘We present the clinical and genetic findings for a Chinese family with X-linked non-syndromic hearing loss in which the affected males showed congenital profound sensorineural hearing impairment. In two affected brothers, the computer tomography of temporal bone showed bilateral dilation of the internal auditory canal with fistulous communication between the lateral canal and the basal cochlear turn, which is consistent with the typical DFNX2 phenotype. A missense mutation (c.647G→A) in the POU3F4 gene caused a substitu- tion from glycine to glutamic acid at position 216 (p.G216E), and this mutation was found to consistently cosegregate with the deafness phenotype in the family. The mutation resulted in the loss of function of the POU3F4 by decreasing the affinity between the protein and DNA, as shown in silico by the structural analysis. Prenatal diagnosis of pregnant proband of this family revealed the c.647G→A muta- tion in DNA extracted from the amniotic fluid surrounding the fetus. The appropriate use of genetic testing and prenatal diagnosis plays a key role in reducing the recurrence of genetic defects in high-risk families. | Jianzhong Li Jing Cheng Yanping Lu Yu Lu Airing Chen YiSun Dongyang Kang Xin Zhang Pu Dai Dongyi Han Huijun Yuan | 2010 | Journal of Genetics and Genomics2010，37，12： | 9 |
| 3 | Effect of nitrogen fertilizer on distribution of starch granules in different regions of wheat endosperm显示文摘This study provided visual evidence of a nitrogen effect on starch granules(SGs) in wheat endosperm. Winter wheat(Titicum aestivum L.) cultivar Xumai 30 was cultured under no nitrogen(control) and 240 kg ha-1of nitrogen applied at the booting stage. The number, morphology, and size of Aand B-type SGs in subaleurone of dorsal endosperm(SDE), center of dorsal endosperm(CDE), modified aleurone(MA), subaleurone of ventral endosperm(SVE), and center of ventral endosperm(CVE) were observed under light and electron microscopes.(1) The distribution of SGs in SDE was similar to that in SVE, the distributions of SGs in CDE and CVE were similar, but the distribution of SGs in MA was different from those in the other four endosperm regions. The number of SGs in the five endosperm regions was in the order SDE > CDE > SVE > CVE > MA.(2) Nitrogen increased the number of Aand B-type SGs in SDE and SVE. Nitrogen also increased the number of B-type SGs but decreased the number of A-type SGs in CDE and CVE. Nitrogen decreased the numbers of A-type and B-type SGs in MA. The results suggest that increased N fertilizer application mainly increased the numbers of small SGs and decreased the numbers of large SGs, but that the results varied in different regions of the wheat endosperm. | Fei Xiong Xurun Yu Liang Zhou Jing Zhang Yanping Jin Dongliang Li Zhong Wang | 2014 | The Crop Journal2014，2，1： | 8 |
| 4 | Valleytronics in transition metal dichalcogenides materials显示文摘Valley degree of freedom in the first Brillouin zone of Bloch electrons offers an innovative approach to information storage and quantum computation.Broken inversion symmetry together with the presence of time-reversal symmetry endows Bloch electrons non-zero Berry curvature and orbital magnetic moment,which contribute to the valley Hall effect and optical selection rules in valleytronics.Furthermore,the emerging transition metal dichalcogenides(TMDs)materials naturally become the ideal candidates for valleytronics research attributable to their novel structural,photonic and electronic properties,especially the direct bandgap and broken inversion symmetry in the monolayer.However,the mechanism of inter-valley relaxation remains ambiguous and the complicated manipulation of valley predominantly incumbers the realization of valleytronic devices.In this review,we systematically demonstrate the fundamental properties and tuning strategies(optical,electrical,magnetic and mechanical tuning)of valley degree of freedom,summarize the recent progress of TMD-based valleytronic devices.We also highlight the conclusion of present challenges as well as the perspective on the further investigations in valleytronics. | Yanping Liu Yuanji Gao Siyu Zhang Jun He Juan Yu Zongwen Liu | 2019 | Nano Research2019，12，11： | 6 |
| 5 | Notch signaling in the differentiation of MEE cells from the developing mouse palate显示文摘 | Yanping Zhang Jixia Chai Yi Qiu Meihua Zhang Lihong Zhang Jianchun Yu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 5 |
| 6 | Effects of Feiwei granules in the treatment of idiopathic pulmonary fibrosis:a randomized and placebo-controlled trial显示文摘OBJECTIVE:To document the therapeutic effect of Feiwei granules(FGs) for idiopathic pulmonary fi brosis(IPF).METHODS:One hundred cases with IPF were randomized into the treatment group(80) and control group(20).Both groups were given basic treatment with prednisone.The treatment group was given FGs,and the control group was given Jinshuibao capsules(JCs).Treatment lasted for 6 months.The Medical Research Council Dyspnea Scale(MRCDS),the Saint George's Hospital Respiratory Questionnaire(SGHRQ),pulmonary function,the Traditional Chinese Medicine Syndrome Score(TCMSS),6-min walking test(6MWT) and blood gas analyses were recorded before the study as well as3 months and 6 months after treatment.RESULTS:FGs showed greater efficacy than the control in certain parameters between before the study and 6 months,and between 3 months and 6months,in the MRCDS,some indicators in the SGHRQ,and the TCMSS.There were no significant differences between the treatment group and control group in the remainder of the indices evaluated.In the treatment group,there were significant differences in before and after treatment in the MRCDS,SGHRQ,TCMSS and 6MWT.CONCLUSION:FGs were similar to JCs for IPF treatment. | Yu Yang Sun Zengtao Shi Liqing Zhang Yanping Zhou Zhaoshan Zhang Shunan Chao Enxiang | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 5 |
| 7 | Single Nucleotide Polymorphism of FSHβ Gene Associated with Reproductive Traits in Japanese Flounder (Paralichthys olivaceus)显示文摘Follicle stimulating hormone β (FSHβ) of Japanese flounder (Paralichthys olivaceus) plays a key role in the regulation of gonadal development.This study aimed to investigate molecular genetic characteristics of the FSHβ gene and elucidate the effects of single nucleotide polymorphisms (SNPs) of FSHβ on reproductive traits in Japanese flounder.We used polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) and sequencing of the FSHβ gene in 60 individuals.We identified only an SNP (T/C) in the coding region of exon3 of FSHβ.The SNP (T/C) did not lead to amino acid changes at the position 340 bp of FSHβ gene.Statistical analysis showed that the SNP was significantly associated with testosterone (T) level and gonadosomatic index (GSI) (P<0.05).Individuals with genotype TC of the SNP had significantly higher serum T levels and GSI (P<0.05) than that of genotype CC.Therefore, FSHβ gene could be a useful molecular marker in selection for prominent reproductive trait in Japanese Flounder. | HE Feng WEN Haishen YU Dahui LI Jifang SHI Bao CHEN Caifang ZHANG Jiaren JIN Guoxiong CHEN Xiaoyan Shi Dan Yang Yanping | 2010 | Journal of Ocean University of China2010，9，4： | 4 |
| 8 | Influence of filler morphology on percolation threshold of isotropical conductive adhesives (ICA)显示文摘Different aspect ratio silver nano-structured materials including nanocubes,nanorods and nanowires were prepared by micro-waved assisted glycol reduction method.Different characterization methods including SEM and XRD were processed on these nanomaterials.Isotropical conductive adhesives(ICA) were developed by using these Ag nanomaterials as conductive fillers.It was found that the conductivity and thermal conductivity percolation threshold of the ICA depended on the morphologies of the fillers,lower percolation threshold could be obtained by using higher aspect ratio filler.A modified percolation threshold theory was put forward to explain and simulate the experiment results,the simulated results could match the experiment results very well. | TAO Yu YANG ZhenGuo LU XiaoLu TAO GuoLiang XIA YanPing WU HaiPing | 2012 | Science China(Technological Sciences)2012，55，1： | 4 |
| 9 | Optically stimulated luminescence dosimeter based on CaS:Eu,Sm显示文摘Alkaline earth sulfides (MgS,CaS and BaS) crystal doped with rare-earth ions is an optically stimulated luminescence dosimeter with very high sensitivity,short time constant of the optically stimulated luminescence (OSL) separated perfectly from the stimulation.In this paper,an OSL dosimeter is described.It has linear dose response from 0.01 to 1000 Gy.The equipment,relatively simple and small in size is promising for applications in space exploration and for high dose irradiation and dangerous irradiation conditions. | LIU Yanping CHEN Zhaoyang BA Weizhen FAN Yanwei GUO Qi YU Xuefeng CHANG Aiming LU Wu DU Yanzhao | 2008 | Nuclear Science and Techniques2008，19，2： | 4 |
| 10 | PhaseⅡstudy of induction chemotherapy followed by concurrent chemoradiotherapy with raltitrexed and cisplatin in locally advanced nasopharyngeal carcinoma显示文摘Objective:For locally advanced nasopharyngeal carcinoma(LA-NPC)patients,high incidences of distant metastases and severe treatment related toxicities are the main obstacles needed to be overcome.Raltitrexed,a specific thymidylate synthase inhibitor with a convenient administration schedule,has an acceptable and manageable toxicity,and possesses radio-sensitizing properties.To investigate the efficacy and safety of raltitrexed and cisplatin induction chemotherapy and concurrent chemoradiotherapy(IC+CCRT)in patients with LA-NPC,a phaseⅡclinical study was conducted.Methods:Sixty eligible patients with LA-NPC were enrolled into this study.A raltitrexed-cisplatin combination was used as part of an IC+CCRT regimen.Raltitrexed-cisplatin IC was given once every 3 weeks(q3 w)for two cycles,followed by raltitrexed-cisplatin based CCRT q3 w for two cycles.Intensity-modulated radiotherapy(IMRT)was given for all enrolled patients.Results:All patients were included in survival analysis according to the intent-to-treat principle.The objective response rate(ORR)3 months after treatment was 98%.The 2-year overall survival(OS)rate was 92%.The median relapse-free survival(RFS)time was 30.5[95%confidence interval(95%CI),28.4-32.3]months.The 2-year RFS rate was 85%.The 2-year local failure-free survival(LFFS)rate was 97%and the 2-year distant metastasis-free survival(DMFS)rate was 88%.Acute toxicities were mostly grade 2 and 3 reactions in bone marrow suppression,gastrointestinal side effect and oropharyngeal mucositis.Only two patients occurred grade 4 acute toxicities,one was bone marrow suppression and the other was dermatitis radiation.Conclusions:The combination of raltitrexed and cisplatin has a comparable efficacy to those in standard firstline therapy. | Yuan Wu Xueyan Wei Zilong Yuan Hongbin Xu Yanping Li Ying Li Liu Hu Guang Han Yu Qian Desheng Hu | 2020 | Chinese Journal of Cancer Research2020，32，5： | 4 |
| 11 | High-performance polarization-sensitive photodetector based on a few-layered PdSe2 nanosheet显示文摘The extraordinary optical and electronic properties of anisotropic two-dimensional materials,such as black phosphorus,ReS2,and GeSe,enable them a promising component of polarization-sensitive photodetectors.However,these applications are significantly limited by the challenges of air-stability,response time,and linearly dichroic ratio.Interestingly,palladium diselenide(PdSe2)with high air stability is an emerging material that has robust in-plane anisotropy induced by its asymmetric pentagonal lattice structure.We have successfully prepared a few-layer PdSe2 using micromechanical exfoliation,and here we demonstrate the strong linear dichroism behavior of PdSe2 by polarization-resolved absorption spectra measurements.Such unique linear dichroism,endows the PdSe2 photodetector powerful ability to detect polarized light.The photodetector based on 5L PdSe2,as tested with polarization-dependent photocurrent mapping,exhibited competitive capability to detect polarized light,achieving a significant photocurrent on/off ratio(>10^2),the quite fast response time(<11 ms)and robust linearly dichroic ratios(/max//min≈1.9 at 532 nm).These results are essential advance in the development of polarization-sensitive photodetector,a crucial step towards opening up a new avenue for the application of 2D optoelectronic devices. | Jiahong Zhong Juan Yu Lingkai Cao Cheng Zeng Junnan Ding Chunxiao Cong Zongwen Liu Yanping Liu | 2020 | Nano Research2020，13，6： | 4 |
| 12 | Intelligent Immunity Based Security Defense System for Multi-Access Edge Computing Network显示文摘In this paper,the security problem for the multi-access edge computing(MEC)network is researched,and an intelligent immunity-based security defense system is proposed to identify the unauthorized mobile users and to protect the security of whole system.In the proposed security defense system,the security is protected by the intelligent immunity through three functions,identification function,learning function,and regulation function,respectively.Meanwhile,a three process-based intelligent algorithm is proposed for the intelligent immunity system.Numerical simulations are given to prove the effeteness of the proposed approach. | Chengcheng Zhou Yanping Yu Shengsong Yang Haitao Xu | 2021 | China Communications2021，18，1： | 3 |
| 13 | Epidemic Characteristics,High-Risk Areas and Space-Time Clusters of Human Brucellosis—China,2020-2021显示文摘Introduction:Analyze the recent epidemiological and temporal-spatial characteristics of human brucellosis in China and provide information for adjusting strategies for brucellosis control.Methods:Human brucellosis data were obtained from the National Notifiable Disease Reporting System(NNDRS).A geographical information system(GIS)was used to visualize high-risk areas with annual incidence based on county(district)polygons.The space-time scan statistic(STSS)was applied to detect the space-time clusters of human brucellosis.Results:A total of 69,767 cases were reported from 2,083 counties in the mainland of China in 2021,a 47.7%increase from 2020(47,425).About 95.5%of the total cases were centralized in northern China and 31.8%in Inner Mongolia(IM).The number of counties with an incidence exceeding 100 per 100,000 was 34 in 2020 and 65 in 2021.From 2020 to 2021,24 space-time clusters were detected.The two primary clusters were located northeast of IM,including 109 counties.The secondary clusters affected 208 counties in 2020 and spread to 297 counties in 2021,the majority of which were located in the middle of IM,exhibiting a trend spreading west from IM to neighboring provincial-level administrative divisions(PLADs).Conclusions:From 2020 to 2021,the incidence of human brucellosis nationwide was exponential,demonstrating distinct spatiotemporal characteristics.Space-time clusters were located in IM and neighboring areas.Therefore,considerable efforts are required to curb this momentum. | Huimin Yang Quilan Chen Yu Li Di Mu Yanping Zhang Wenwu Yin | 2023 | China CDC weekly2023，5，1： | 3 |
| 14 | Plant multiscale networks:charting plant connectivity by multi-level analysis and imaging techniques显示文摘In multicellular and even single-celled organisms,individual components are interconnected at multiscale levels to produce enormously complex biological networks that help these systems maintain homeostasis for development and environmental adaptation.Systems biology studies initially adopted network analysis to explore how relationships between individual components give rise to complex biological processes.Network analysis has been applied to dissect the complex connectivity of mammalian brains across different scales in time and space in The Human Brain Project.In plant science,network analysis has similarly been applied to study the connectivity of plant components at the molecular,subcellular,cellular,organic,and organism levels.Analysis of these multiscale networks contributes to our understanding of how genotype determines phenotype.In this review,we summarized the theoretical framework of plant multiscale networks and introduced studies investigating plant networks by various experimental and computational modalities.We next discussed the currently available analytic methodologies and multi-level imaging techniques used to map multiscale networks in plants.Finally,we highlighted some of the technical challenges and key questions remaining to be addressed in this emerging field. | Xi Zhang Yi Man Xiaohong Zhuang Jinbo Shen Yi Zhang Yaning Cui Meng Yu Jingjing Xing Guangchao Wang Na Lian Zijian Hu Lingyu Ma Weiwei Shen Shunyao Yang Huimin Xu Jiahui Bian Yanping Jing Xiaojuan Li Ruili Li Tonglin Mao Yuling Jiao Sodmergen Haiyun Ren Jinxing Lin | 2021 | Science China(Life Sciences)2021，64，9： | 3 |
| 15 | Structural basis of ALMT1-mediated aluminum resistance in Arabidopsis显示文摘The plant aluminum(Al)-activated malate transporter ALMT1 mediates the efflux of malate to chelate the Al in acidic soils and underlies the plant Al resistance.Here we present cryo-electron microscopy(cryo-EM)structures of Arabidopsis thaliana ALMT1(AtALMT1)in the apo,malate-bound,and Al-bound states at neutral and/or acidic pH at up to 3.0Åresolution.The AtALMT1 dimer assembles an anion channel and each subunit contains six transmembrane helices(TMs)and six cytosolicα-helices.Two pairs of Arg residues are located in the center of the channel pore and contribute to malate recognition.Al binds at the extracellular side of AtALMT1 and induces conformational changes of the TM1-2 loop and the TM5-6 loop,resulting in the opening of the extracellular gate.These structures,along with electrophysiological measurements,molecular dynamic simulations,and mutagenesis study in Arabidopsis,elucidate the structural basis for Al-activated malate transport by ALMT1. | Jiangqin Wang Xiafei Yu Zhong Jie Ding Xiaokang Zhang Yanping Luo Ximing Xu Yuan Xie Xiaoxiao Li Tian Yuan Shao Jian Zheng Wei Yang Jiangtao Guo | 2022 | Cell Research2022，32，1： | 3 |
| 16 | Correction: The NAC transcription factor ClNAC68 positively regulates sugar content and seed development in watermelon by repressing ClINV and ClGH3.6显示文摘In this article 1,author name Yanping Wang was incorrectly tagged as corresponding author.Prof.Wang should be the co-first author,instead of the corresponding author.The original article has been corrected. | Jinfang Wang Yanping Wang Jie Zhang Yi Ren Maoying Li Shaowei Tian Yongtao Yu Yi Zuo Guoyi Gong Haiying Zhang Shaogui Guo Yong Xu | 2021 | Horticulture Research2021，8，1： | 2 |
| 17 | High-temperature superconductivity in sulfur hydride evidenced by alternating-current magnetic susceptibility显示文摘The search for high-temperature superconductivity is one of the research frontiers in physics. In the sulfur hydride system, an extremely high T_c(~200 K) has been recently developed at pressure. However, the Meissner effect measurement above megabar pressures is still a great challenge. Here, we report the superconductivity identification of sulfur hydride at pressure, employing an in situ alternating-current magnetic susceptibility technique. We determine the superconducting phase diagram, finding that superconductivity suddenly appears at 117 GPa and Tcreaches 183 K at 149 GPa before decreasing monotonically with increasing pressure. By means of theoretical calculations, we elucidate the variation of T_c in the low-pressure region in terms of the changing stoichiometry of sulfur hydride and the further decrease in Tcowing to a drop in the electron–phonon interaction parameter λ. This work provides a new insight into clarifying superconducting phenomena and anchoring the superconducting phase diagram in the hydrides. | Xiaoli Huang Xin Wang Defang Duan Bertil Sundqvist Xin Li Yanping Huang Hongyu Yu Fangfei Li Qiang Zhou Bingbing Liu Tian Cui | 2019 | National Science Review2019，6，4： | 2 |
| 18 | Cloning, identification, and expression analysis at the stage of gonadal sex differentiation of chicken miR-363 and 363显示文摘miRNAs (microRNAs ) 是小的,功能的、非编码的 RNA 并且被证明了在从房间区别到有机体开发的多样的生物过程的规定含有。以达到在鸡胚胎上探索 miRNAs 的角色性决心和 gonadal 区别,我们克隆并且识别茎环先锋结构( GenBank 同意没有 GU597370 )鸡肉, miR-363 和363*由在 E3.56.5 d 的阶段在鸡胚胎学习他们的时间、空间的表示模式列在后面(胚胎的天 3.56.5 )由半量的 RT-PCR 和愿望(在 situ 杂交整个山)在这研究。结果显示出那 miR-363 * 根据 miRNAs 的结构的特征在 miR-363 和 363* 的鸡染色体,和 flanking 顺序在未知片断的克隆的顺序定位了先锋。显著地微分的表示(P < 0.05 ) 在雌、雄的鸡肉之间的 gga-miR-363,胚胎的性腺被发现在 E4.5 和 6.5 d,而是 gga-miR-363 的微分表示 * 从 E3.5,到 6.5,在两性之间的 d 达不到重要水平。那个表达式 gga-miR-363 表明的显示的愿望的结果主要在 E6.5 出现在手足芽,脊索,外胚层,在 E4.5 d 鸡胚胎的大脑,和尿生殖的系统(UGS ) d,和 E6.5 d 的表达式水平在男性比那在女性是更高的。gga-miR-363 将在 gonadal 发展和 gga-miR-363 包含,这能被推测 * 可能在鸡胚胎开发的早阶段期间有短暂规章的功能。 | Pan Huang Yanzhang Gong Xiuli Peng ShijunLi Yu Yang Yanping Feng | 2010 | Acta Biochimica et Biophysica Sinica2010，42，8： | 2 |
| 19 | Prognostic Nomogram for Patients with Hepatitis E Virus-related Acute Liver Failure:A Multicenter Study in China显示文摘Background and Aims:Timely and effective assessment scoring systems for predicting the mortality of patients with hepatitis E virus-related acute liver failure(HEV-ALF)are urgently needed.The present study aimed to establish an effective nomogram for predicting the mortality of HEV-ALF patients.Methods:The nomogram was based on a cross-sectional set of 404 HEV-ALF patients who were identified and enrolled from a cohort of 650 patients with liver failure.To compare the performance with that of the model for end-stage liver disease(MELD)scoring and CLIF-Consortiumacute-on-chronic liver failure score(CLIF-C-ACLFs)models,we assessed the predictive accuracy of the nomogram using the concordance index(C-index),and its discriminative ability using time-dependent receiver operating characteristics(td-ROC)analysis,respectively.Results:Multivariate logistic regression analysis of the development set carried out to predict mortality revealed that γ-glutamyl transpeptidase,albumin,total bilirubin,urea nitrogen,creatinine,international normalized ratio,and neutrophil-to-lymphocyte ratio were independent factors,all of which were incorporated into the new nomogram to predict the mortality of HEV-ALF patients.The area under the curve of this nomogram for mortality prediction was 0.671(95%confidence interval:0.602-0.740),which was higher than that of the MELD and CLIF-C-ACLFs models.Moreover,the td-ROC and decision curves analysis showed that both discriminative ability and threshold probabilities of the nomogram were superior to those of the MELD and CLIF-C-ACLFs models.A similar trend was observed in the validation set.Conclusions:The novel nomogram is an accurate and efficient mortality prediction method for HEV-ALF patients. | Jian Wu Cuifen Shi Xinyu Sheng Yanping Xu Jinrong Zhang Xinguo Zhao Jiong Yu Xinhui Shi Gongqi Li Hongcui Cao Lanjuan Li | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 2 |
| 20 | Mechanisms of biochar decreasing methane emission from Chinese paddy soils显示文摘 | Youzhi Feng Yanping Xu Yongchang Yu Zubin Xie Xiangui Lin | 2011 | Soil Biology and Biochemistry2011，，： | 2 |
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