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| 1 | Curative effect of warming kidney and fortifying spleen recipe on diarrhea-predominant irritable bowel syndrome显示文摘OBJECTIVE:To observe the curative effect of a recipe for warming the kidney and fortifying the spleen on diarrhea-predominant irritable bowel syndrome(IBS-D).METHODS:This multi-center,double-blind,randomized,and controlled trial included 240 patients that met the inclusion criterion and were then divided into two groups of 120.Patients in the treatment group(group A)took modified Sishen Wan orally for warming the kidney and fortifying the spleen and patients in the control group(group B)took a placebo,Chao Maiya,for 4 weeks.28 days after withdrawal,there was a 6-month follow-up to observe patient recurrence condition.The total effective rate,curative effect,and recurrence rate were evaluated after treatment.RESULTS:There was statistical difference(P<0.01)between the two groups in total effective rate(92.24%in the treatment group and 49.07%in the control group),in curative effect of TCM syndrome(90.52%and 47.22%,respectively),and in the recurrence rate(15.79%and 56.86%,respectively)within6 months after treatment.CONCLUSION:Modified Sishen Wan,for warming the kidney and fortifying the spleen,can effectively treat IBS-D and better control its recurrence. | Xiaolan Su Yanping Tang Jing Zhang Yuebin Dong Wei Wei Yibing Bai Yong Liu | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 22 |
| 2 | Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment显示文摘A couple with a proband child of GJB2(encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis(PGD), noninvasive prenatal testing(NIPT), and noninvasive prenatal diagnosis(NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2 c.235del C heterozygous embryo resulted in a singleton pregnancy. At the 13 th week of gestation, genomic DNA(g DNA) from the trio family and cell-free DNA(cf DNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by invasive procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing impairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders. | XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE LinYi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu | 2015 | Science China(Life Sciences)2015，58，9： | 12 |
| 3 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 4 | Identification of a novel mutation in POU3F4 for prenatal diagnosis in a Chinese family with X-linked nonsyndromic hearing loss显示文摘We present the clinical and genetic findings for a Chinese family with X-linked non-syndromic hearing loss in which the affected males showed congenital profound sensorineural hearing impairment. In two affected brothers, the computer tomography of temporal bone showed bilateral dilation of the internal auditory canal with fistulous communication between the lateral canal and the basal cochlear turn, which is consistent with the typical DFNX2 phenotype. A missense mutation (c.647G→A) in the POU3F4 gene caused a substitu- tion from glycine to glutamic acid at position 216 (p.G216E), and this mutation was found to consistently cosegregate with the deafness phenotype in the family. The mutation resulted in the loss of function of the POU3F4 by decreasing the affinity between the protein and DNA, as shown in silico by the structural analysis. Prenatal diagnosis of pregnant proband of this family revealed the c.647G→A muta- tion in DNA extracted from the amniotic fluid surrounding the fetus. The appropriate use of genetic testing and prenatal diagnosis plays a key role in reducing the recurrence of genetic defects in high-risk families. | Jianzhong Li Jing Cheng Yanping Lu Yu Lu Airing Chen YiSun Dongyang Kang Xin Zhang Pu Dai Dongyi Han Huijun Yuan | 2010 | Journal of Genetics and Genomics2010，37，12： | 9 |
| 5 | Effects of electroacupuncture at Guanyuan(CV 4)or Sanyinjiao(SP 6)on hypothalamus-pituitary-ovary axis and spatial learning and memory in female SAMP8 mice显示文摘OBJECTIVE: To investigate the effects of electroacupuncture(EA) at the Guanyuan(CV 4) or Sanyinjiao(SP 6) acupoints on the hypothalamus-pituitary-ovary(HPO) axis and spatial learning and memory in female mice.METHODS: Nine-month-old female mice with senescence-accelerated mouse prone 8(SAMP8)were divided into three groups: the disease model,EA-Guanyuan and EA-Sanyinjiao groups. Concurrently, 9-month old female mice with senescence-accelerated mouse resistance 1(SAMR1)were set as the control model group. The two treatment groups were given the same pattern of EA stimulation. Gonadotropin-releasing hormone, luteinizing hormone, follicle-stimulating hormone(FSH) and Serum estradiol levels in the Hypothalamus-pituitary-ovary axis were assessed by enzyme-linked immunosorbent assay to determinethe HPO axis function level. Spatial learning and memory were assessed by the Morris Water Maze(MWM) test.RESULTS:(a) HPO axis: compared with the control model group, the disease model group displayed a decrease in E2 levels(P < 0.01), and an increase in Gn RH, LH and FSH levels(P < 0.01). E2 levels were increased in EA treatment groups compared with the disease model group(P < 0.05). In contrast,Gn RH and LH and FSH levels were reduced(P <0.05). EA-Sanyinjiao group was superior than EA-Guanyuan group on increasing E2 and declining Gn RH levels(P < 0.01).(b) The MWM test demonstrated that the response latency in the EA-Sanyinjiao treatment group declined from day 2 to day5 compared with the disease model group(P <0.05), whereas the EA-Guanyuan treatment group showed no significant difference.CONCLUSION: EA can regulate hormone(E2, FSH,LH, Gn RH) levels in the HPO axis and the spatial learning and memory ability in female SAMP8 mice. Moreover, this effect may have been more pronounced in the EA-Sanyinjiao group than the EA-Guanyuan group. The underlying mechanism of the EA-induced changes may be related to gonadal hormone shifts in the HPO axis, followed by an improvement in spatial learning and memory. | Wang Jing Cheng Kai Qin Zhuo Wang Yanping Zhai Lijing You Min Wu Juanjiao | 2017 | Journal of Traditional Chinese Medicine2017，37，1： | 8 |
| 6 | Effect of nitrogen fertilizer on distribution of starch granules in different regions of wheat endosperm显示文摘This study provided visual evidence of a nitrogen effect on starch granules(SGs) in wheat endosperm. Winter wheat(Titicum aestivum L.) cultivar Xumai 30 was cultured under no nitrogen(control) and 240 kg ha-1of nitrogen applied at the booting stage. The number, morphology, and size of Aand B-type SGs in subaleurone of dorsal endosperm(SDE), center of dorsal endosperm(CDE), modified aleurone(MA), subaleurone of ventral endosperm(SVE), and center of ventral endosperm(CVE) were observed under light and electron microscopes.(1) The distribution of SGs in SDE was similar to that in SVE, the distributions of SGs in CDE and CVE were similar, but the distribution of SGs in MA was different from those in the other four endosperm regions. The number of SGs in the five endosperm regions was in the order SDE > CDE > SVE > CVE > MA.(2) Nitrogen increased the number of Aand B-type SGs in SDE and SVE. Nitrogen also increased the number of B-type SGs but decreased the number of A-type SGs in CDE and CVE. Nitrogen decreased the numbers of A-type and B-type SGs in MA. The results suggest that increased N fertilizer application mainly increased the numbers of small SGs and decreased the numbers of large SGs, but that the results varied in different regions of the wheat endosperm. | Fei Xiong Xurun Yu Liang Zhou Jing Zhang Yanping Jin Dongliang Li Zhong Wang | 2014 | The Crop Journal2014，2，1： | 8 |
| 7 | Preliminary assessment of heavy metal contamination in surface water and sediments from Honghu Lake, East Central China显示文摘表面水和沉积里的重金属集中在湖北省从洪胡·莱克收集了,中国被分析,并且生态的风险根据沉积质量指南被评估。结果证明表面水里的重金属的平均集中是被评价:作为 > Zn > Cu > Cr > Pb > Ni > Cd > Hg。与在另外的河和背景价值里报导的结果比较,洪胡·莱克被弄脏由作为, Cr, Pb, Cu 和 Ni。大多数金属可能主要从在湖附近的化肥,工业自河和国内废水。重金属集中比在另外的区域在入口区域是相对更高的。当重要积极关联在 Zn, Cd 和 Pb 之间是在场的时,否定关联在很重的金属和 pH 之间被观察。在沉积核心,当时, Cu, Zn, Cr 和 Ni 显示出一个减少的趋势在场的 Cd 一个增加的趋势。减少作为,在由于在 1998 的洪水事件的 1990 年代力量的 Cu, Zn, Cr 和 Ni。生态的风险评价的分析基于沉积质量指南建议在从洪胡·莱克的大多数沉积的重金属有中等毒性,与 Cr being 最高的优先级污染物质[出版摘要] | Ying HU Shihua QI Chenxi WU Yanping KE Jing CHEN Wei CHEN Xiangyi GONG | 2012 | Frontiers of Earth Science2012，6，1： | 7 |
| 8 | Inner Envelope CHLOROPLAST MANGANESE TRANSPORTER 1 Supports Manganese Homeostasis and Phototrophic Growth in Arabidopsis显示文摘 | Bin Zhang Chi Zhang Congge Liu Yanping Jing Yuan Wang Ling Jin Lei Yang Aigen Fu Jisen Shi Fugeng Zhao Wenzhi Lan Sheng Luan | 2018 | Molecular Plant2018，11，7： | 6 |
| 9 | Effects of nitrogen ion implantation on Ca^(2+) concentration and membrane potential of pollen cell显示文摘The effects of low energy nitrogen ion implantation on Ca2+ concentration and membrane potential of illy (Mum davidii Duch) pollen cell have been studied. The results showed that the Ca2+ concentration was increased when pollen grain was implanted by nitrogen ion with energy 100 keV and dose 1013 ions/cm2. However, the increase of Ca2+ concentration was partly inhibited by the addition of Ca2+ channel inhibitor depending on dose. And nitrogen ion implantation caused depolarization of pollen cell membrane potential. In other words, membrane potential was increased, but the effect decreased by adding Ca2+ channel inhibitor. However, it was still significantly higher than the membrane potential of control cells. It was indicated that the depolarization of cell membrane potential opened the calcium channel on the membrane that caused the increasing of intracel-lular calcium concentration. This might be an earlier step of the effect of low energy nitrogen ion implantation on pollen germination. | HUANG Zhonglian, JING Yanping, ZHU Guoli, LU Ting, ZHOU Hongyu & REN Haiyun1. Key Laboratory of Cell Proliferation and Regulation Biology of the Ministry of Education, Beijing Normal University, Beijing 100875, China 2. Key Laboratory of Plant Physiology and Biochemistry of the Ministry of Agriculture, China Agriculture University, Beijing 100094, China 3. Institution of Low Energy Nuclear Physics, Beijing Normal University, Beijing 100875, China | 2001 | Chinese Science Bulletin2001，46，20： | 5 |
| 10 | Interaction of polyhydroxy fullerenes with ferrihydrite:adsorption and aggregation显示文摘The rapid development of nanoscience and nanotechnology, with thousands types of nanomaterials being produced, will lead to various environmental impacts. Thus,understanding the behaviors and fate of these nanomaterials is essential. This study focused on the interaction between polyhydroxy fullerenes(PHF) and ferrihydrite(Fh), a widespread iron(oxyhydr)oxide nanomineral and geosorbent. Our results showed that PHF were effectively adsorbed by Fh. The adsorption isotherm fitted the D-R model well, with an adsorption capacity of 67.1 mg/g. The adsorption mean free energy of 10.72 k J/mol suggested that PHF were chemisorbed on Fh. An increase in the solution p H and a decrease of the Fh surface zeta potential were observed after the adsorption of PHF on Fh; moreover, increasing initial solution p H led to a reduction of adsorption. The Fourier transform infrared spectra detected a red shift of C–O stretching from 1075 to 1062 cm-1 and a decrease of Fe–O bending, implying the interaction between PHF oxygenic functional groups and Fh surface hydroxyls. On the other hand, PHF affected the aggregation and reactivity of Fh by changing its surface physicochemical properties. Aggregation of PHF and Fh with individual particle sizes increasing from 2 nm to larger than 5 nm was measured by atomic force microscopy. The uniform distribution of C and Fe suggested that the aggregates of Fh were possibly bridged by PHF. Our results indicated that the interaction between PHF and Fh could evidently influence the migration of PHF, as well as the aggregation and reactivity of Fh. | Jing Liu Runliang Zhu Tianyuan Xu Mingwang Laipan Yanping Zhu Qing Zhou Jianxi Zhu Hongping He | 2018 | Journal of Environmental Sciences2018，30，2： | 5 |
| 11 | MR-IDPSO: A Novel Algorithm for Large-Scale Dynamic Service Composition显示文摘In the era of big data, data intensive applications have posed new challenges to the field of service composition. How to select the optimal composited service from thousands of functionally equivalent services but different Quality of Service(Qo S) attributes has become a hot research in service computing. As a consequence,in this paper, we propose a novel algorithm MR-IDPSO(Map Reduce based on Improved Discrete Particle Swarm Optimization), which makes use of the improved discrete Particle Swarm Optimization(PSO) with the Map Reduce to solve large-scale dynamic service composition. Experiments show that our algorithm outperforms the parallel genetic algorithm in terms of solution quality and is efficient for large-scale dynamic service composition. In addition,the experimental results also demonstrate that the performance of MR-IDPSO becomes more better with increasing number of candidate services. | Yanping Zhang Zihui Jing Yiwen Zhang | 2015 | Tsinghua Science and Technology2015，20，6： | 5 |
| 12 | Three-dimensional reconstruction of Picea wilsonii Mast. pollen grains using automated electron microscopy显示文摘Three-dimensional electron microscopy(3 D-EM) has attracted considerable attention because of its ability to provide detailed information with respect to developmental analysis. However, large-scale high-resolution 3 D reconstruction of biological samples remains challenging. Herein, we present a 3 D view of a Picea wilsonii Mast. pollen grain with 100 nm axial and38.57 nm lateral resolution using AutoCUTS-SEM(automatic collector of ultrathin sections-scanning electron microscopy). We established a library of 3,127 100 nm thick serial sections of pollen grains for preservation and observation, demonstrating that the protocol can be used to analyze large-volume samples. After obtaining the SEM images, we reconstructed an entire pollen grain comprising 734 serial sections. The images produced by 3D reconstruction clearly revealed the main components of the P.wilsonii pollen grain, i.e., two sacci and pollen corpus, tube cell, generative cell, and two degenerated prothallial cells, and their internal organization. In addition, we performed a quantitative analysis of the different pollen grain cells, including sacci, and found that there were 202 connections within a saccus SEM image. Thus, for the first time, this study provided a global 3D view of the entire pollen grain, which will be useful for analyzing pollen development and growth. | Weiwei Shen Lingyu Ma Xi Zhang Xixia Li Yuanyuan Zhao Yanping Jing Yun Feng Xueke Tan Fei Sun Jinxing Lin | 2020 | Science China(Life Sciences)2020，63，2： | 3 |
| 13 | Plant multiscale networks:charting plant connectivity by multi-level analysis and imaging techniques显示文摘In multicellular and even single-celled organisms,individual components are interconnected at multiscale levels to produce enormously complex biological networks that help these systems maintain homeostasis for development and environmental adaptation.Systems biology studies initially adopted network analysis to explore how relationships between individual components give rise to complex biological processes.Network analysis has been applied to dissect the complex connectivity of mammalian brains across different scales in time and space in The Human Brain Project.In plant science,network analysis has similarly been applied to study the connectivity of plant components at the molecular,subcellular,cellular,organic,and organism levels.Analysis of these multiscale networks contributes to our understanding of how genotype determines phenotype.In this review,we summarized the theoretical framework of plant multiscale networks and introduced studies investigating plant networks by various experimental and computational modalities.We next discussed the currently available analytic methodologies and multi-level imaging techniques used to map multiscale networks in plants.Finally,we highlighted some of the technical challenges and key questions remaining to be addressed in this emerging field. | Xi Zhang Yi Man Xiaohong Zhuang Jinbo Shen Yi Zhang Yaning Cui Meng Yu Jingjing Xing Guangchao Wang Na Lian Zijian Hu Lingyu Ma Weiwei Shen Shunyao Yang Huimin Xu Jiahui Bian Yanping Jing Xiaojuan Li Ruili Li Tonglin Mao Yuling Jiao Sodmergen Haiyun Ren Jinxing Lin | 2021 | Science China(Life Sciences)2021，64，9： | 3 |
| 14 | Regulation of cytoskeleton-associated protein activities: Linking cellular signals to plant cytoskeletal function显示文摘The plant cytoskeleton undergoes dynamic remodeling in response to diverse developmental and environmental cues. Remodeling of the cytoskeleton coordinates growth in plant cells, including trafficking and exocytosis of membrane and wall components during cell expansion, and regulation of hypocotyl elongation in response to light. Cytoskeletal remodeling also has key functions in disease resistance and abiotic stress responses. Many stimuli result in altered activity of cytoskeleton-associatedproteins,microtubuleassociated proteins(MAPs) and actin-binding proteins(ABPs). MAPs and ABPs are the main players determining the spatiotemporally dynamic nature of the cytoskeleton, functioning in a sensory hub that decodes signals to modulate plant cytoskeletal behavior. Moreover, MAP and ABP activities and levels are precisely regulated during development and environmental responses, but our understanding of this process remains limited. In this review, we summarize the evidence linking multiple signaling pathways, MAP and ABP activities and levels, and cytoskeletal rearrangements in plant cells. We highlight advances in elucidating the multiple mechanisms that regulate MAP and ABP activities and levels, including calcium and calmodulin signaling, ROP GTPase activity, phospholipid signaling, and post-translational modifications. | Na Lian Xinwei Wang Yanping Jing Jinxing Lin | 2021 | Journal of Integrative Plant Biology2021，63，1： | 3 |
| 15 | Optimisation of ultrasound-assisted extraction of phenolic compounds from wheat bran显示文摘 | Jing Wang Baoguo Sun Yanping Cao Yuan Tian Xuehong Li | 2007 | Food Chemistry2007，，2： | 3 |
| 16 | Nanoimprint Lithography:A Processing Technique for Nanofabrication Advancement显示文摘Nanoimprint lithography(NIL) is an emerging micro/nano-patterning technique,which is a high-resolution,high-throughput and yet simple fabrication process.According to International Technology Roadmap for Semiconductor(ITRS),NIL has emerged as the next generation lithography candidate for the22 nm and 16 nm technological nodes.In this paper,we present an overview of nanoimprint lithography.The classfication,research focus,critical issues,and the future of nanoimprint lithography are intensively elaborated.A pattern as small as 2.4 nm has been demonstrated.Full-wafer nanoimprint lithography has been completed on a 12-inch wafer.Recently,12.5 nm pattern resolution through soft molecular scale nanoimprint lithography has been achieved by EV Group,a leading nanoimprint lithography technology supplier. | Weimin Zhou Guoquan Min Jing Zhang Yanbo Liu Jinhe Wang Yanping Zhang Feng Sun | 2011 | Nano-Micro Letters2011，3，2： | 3 |
| 17 | Finite Control Set Model Predictive Torque Control Using Sliding Model Control for Induction Motors显示文摘Finite control set model predictive torque control(FCS-MPTC)has become increasingly prevalent for induction motors(IM)owing to its simple concept,easy incorporation of constraints and strong flexibility.In traditional FCS-MPTC speed controller design,a classical proportional integral(PI)controller is typically chosen to generate the torque reference.However,the PI controller is dependent on system parameters and sensitive to the load torque variation,which seriously affects control performance.In this paper,a model predictive torque control using sliding mode control(MPTC+SMC)for IM is proposed to enhance the robust performance of the drive system.First,the influence of the parameter mismatches for FCS-MPTC is analyzed.Second,the shortcomings of traditional PI controller are derived.Then,the proposed MPTC+SMC method is designed,and the MPTC+PI and MPTC+SMC are compared theoretically.Finally,experimental results demonstrate the correctness and effectiveness of the proposed MPTC+SMC.In comparison with MPTC+PI,MPTC+SMC has the better dynamic performance and stronger robust performance against parameter variations and load disturbance. | Yanqing Zhang Zhonggang Yin Wei Li Jing Liu Yanping Xu | 2021 | CES Transactions on Electrical Machines and Systems2021，5，3： | 2 |
| 18 | Traditional Chinese Medicine guidelines for coronavirus disease 2019显示文摘OBJECTIVE:To summarize the evidence from Traditional Chinese Medicine(TCM)practice in the treatment of coronavirus disease 2019(COVID-19)and provide timely clinical practice guidance.METHODS:The guidelines were developed in accordance with the World Health Organization rapid guideline process.The evidence on TCM for COVID-19 from published guidelines,direct and indirect published clinical evidence,first hand clinical data,and expert experience and consensus were collected.The grading of recommendations assessment,development and evaluation(GRADE)method was used to grade the evidence and make the recommendations.RESULTS:Based on the available evidence,the guidelines recommended 17 Chinese medicines for COVID-19:2 Chinese herbal granules,7 Chinese patent medicines,and 8 Chinese herbal injections.CONCLUSION:As the literature search was conducted on March,any subsequent versions of these guidelines require an up-to-date literature review.We hope that the evidence summary in these guidelines will be helpful in global efforts to address COVID-19. | Liang Ning Ma Yanfang Wang Jingya Li Huizhen Wang Xiaohui Jiao Liwen Liu Bin Ma Yan Zhao Chen Luo Xufei Zhao Siya Lu Meng Cao Jin Hu Wenpin Zhang Hairong Liu Guoxiu Lu Cheng Liu Mengyu Li Li Han Xuejie Liu Yuqi Wang Liying Zhao Xueyao Wei Dongfeng Bai Jing Sun Mingyu Yang Yong Wu Xiaodan Chen Yaolong Shi Nannan Wang Yanping Wang Yongyan | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 2 |
| 19 | Identification of two novel missense WFS1 mutations,H696Y and R703H,in patients with non-syndromic low-frequency sensorineural hearing loss显示文摘Non-syndromic 低频率的 sensorineural 听觉损失(LFSNHL ) 是听见在频率, 2000 Hz 主要被影响的损失的一种不平常的类型。迄今为止,在二基因, DIAPH1 和 WFS1 的不同变化,被发现了与 LFSNHL 被联系。这里,我们与 postlingual 和进步 LFSNHL 报导一个五产生的中国家庭。我们在在标记 SNP_A-2167174 和 D4S431 之间的染色体 4p16 上印射疾病地点到 2.5 Mb 区域,与 DFNA6/14/38 地点重叠。候选人基因定序揭示了异质接合的 c.2086C > 在 exon 的 T 替换 8 WFS1,在 Wolframin (WFS1 ) 的 C 终点导致 p.H696Y 替换。另外,我们执行了在 37 个分散的病人, WFS1 屏蔽的 mutational 750 岁,与 LFSNHL。我们检测了异质接合的 c.2108G > 在 exon 的替换 8 WFS1,在一个病人导致 p.R703H 替换。在 WFS1 的 H696 和 R703 高度越过种类被保存,包括人,猩猩,老鼠,老鼠,和青蛙(Xenopus ) 。顺序分析表明了 c.2086C 的缺席 > T 或 c.2108G > 在在中国背景的 200 个无关的控制题目之中的 WFS1 基因的 A 替换,支持他们代表的假设原因的变化,和不稀罕的多型性。我们的数据为为 LFSNHL 建立更好的 genotypephenotype 关联提供另外的分子、临床的信息。 | Yi Sun Jing Cheng Yanping Lu Jianzhong Li Yu Lu Zhanguo Jin Pu Dai Rongguang Wang Huijun Yuan | 2011 | Journal of Genetics and Genomics2011，38，2： | 2 |
| 20 | Synthesis and Biological Evaluation of Amino Alcohol Containing 1,3,4-Oxadiazole显示文摘 | WU Yi ZHAO Yanping GUO Jing LV Haoze ZHENG Nan WANG Ensi | 2016 | Chemical Research in Chinese Universities2016，32，5： | 2 |
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