|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types显示文摘The Genome Sequence Archive(GSA)is a data repository for archiving raw sequence data,which provides data storage and sharing services for worldwide scientific communities.Considering explosive data growth with diverse data types,here we present the GSA family by expanding into a set of resources for raw data archive with different purposes,namely,GSA(http://gffzz77e3413bc06540eds95f5pubfxqp966xn.ffgz.tsg.suse.edu.cn/gsa/),GSA for Human(GSA-Human,http://gffzz77e3413bc06540eds95f5pubfxqp966xn.ffgz.tsg.suse.edu.cn/gsa-human/),and Open Archive for Miscellaneous Data(OMIX,http://gffzz77e3413bc06540eds95f5pubfxqp966xn.ffgz.tsg.suse.edu.cn/omix/).Compared with the 2017 version,GSA has been significantly updated in data model,online functionalities,and web interfaces.GSA-Human,as a new partner of GSA,is a data repository specialized in human genetics-related data with controlled access and security.OMIX,as a critical complement to the two resources mentioned above,is an open archive for miscellaneous data.Together,all these resources form a family of resources dedicated to archiving explosive data with diverse types,accepting data submissions from all over the world,and providing free open access to all publicly available data in support of worldwide research activities. | Tingting Chen Xu Chen Sisi Zhang Junwei Zhu Bixia Tang Anke Wang Lili Dong Zhewen Zhang Caixia Yu Yanling Sun Lianjiang Chi Huanxin Chen Shuang Zhai Yubin Sun Li Lan Xin Zhang Jingfa Xiao Yiming Bao Yanqing Wang Zhang Zhang Wenming Zhao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 38 |
| 2 | Study of atmospheric CO2 and CH4 at Longfengshan WMO/GAW regional station: The variations, trends, influence of local sources/sinks, and transport显示文摘Atmospheric CO_2 and CH_4 have been continuously measured since 2009 at Longfengshan WMO/GAW station(LFS) in China. Variations of the mole fractions, influence of long-distance transport, effects of local sources/sinks and the characteristics of synoptic scale variations have been studied based on the records from 2009 to 2013. Both the CO_2 and CH_4 mole fractions display increasing trends in the last five years, with growth rates of 3.1±0.02 ppm yr.1 for CO_2 and 8±0.04 ppb yr.1(standard error, 1-σ)for CH_4. In summer, the regional CO_2 mole fractions are apparently lower than the Marine Boundary Layer reference, with the lowest value of.13.6±0.7 ppm in July, while the CH_4 values are higher than the MBL reference, with the maximum of 139±6 ppb.From 9 to 17(Local time, LT) in summer, the atmospheric CO_2 mole fractions at 10 m a.g.l. are always lower than at 80 m, with a mean difference of.1.1±0.2 ppm, indicating that the flask sampling approach deployed may underestimate the background mole fractions in summer. In winter, anthropogenic emissions dominate the regional CO_2 and CH_4 mole fractions. Cluster analysis of backward trajectories shows that atmospheric CO_2 and CH_4 at LFS are influenced by anthropogenic emissions from the southwest(Changchun and Jilin city) all year. The synoptic scale variations indicate that the northeastern China plain acts as an important source of atmospheric CO_2 and CH_4 in winter. | FANG ShuangXi Pieter P.TANS YAO Bo LUAN Tian WU YanLing YU DaJiang | 2017 | Science China Earth Sciences2017，60，10： | 16 |
| 3 | Antisense MMP-9 RNA inhibits malignant glioma cell growth in vitro and in vivo显示文摘The matrix-degrading metalloproteinases (MMPs), particularly MMP-9, play important roles in the pathogenesis and development of malignant gliomas. In the present study, the oncogenic role of MMP-9 in malignant glioma cells was investigated via antisense RNA blockade in vitro and in vivo. TJ905 malignant glioma cells were transfected with pcDNA3.0 vector expressing antisense MMP-9 RNA (pcDNA-AS-MMP9), which significantly decreased MMP-9 expression, and cell proliferation was assessed. For in vivo studies, U251 cells, a human malignant glioma cell line, were implanted subcutaneously into 4-to 6-week-old BALB/c nude mice. The mice bearing well-established U251 gliomas were treated with intratumoral pcDNA-AS-MMP9-Lipofectamine complex (AS-MMP-9-treated group), subcutaneous injection of endostatin (endostatin-treated group), or both (combined therapy group). Mice treated with pcDNA (empty vector)-Lipofectamine served as the control group. Four or eight weeks later, the volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity were assayed. We demonstrate that pcDNA-AS-MMP9 significantly decreased MMP-9 expression and inhibited glioma cell proliferation. Volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity in the antisense-MMP-9-treated and therapeutic alliance groups were significantly lower than those in the control group. The results suggest that MMP-9 not only promotes malignant glioma cell invasiveness, but also affects tumor cell proliferation. Blocking the expression of MMP-9 with antisense RNA substantially suppresses the malignant phenotype of glioma cells, and thus can be used as an effective therapeutic strategy for malignant gliomas. | Cuiyun Sun Qian Wang Hongxu Zhou Shizhu Yu Alain R. Simard Chunsheng Kang Yanyan Li Yanling Kong Tongling An Yanjun Wen Fudong Shi Junwei Hao | 2013 | Neuroscience Bulletin2013，29，1： | 14 |
| 4 | Gene expression signatures for phlegm-dampness constitution of Chinese Medicine显示文摘Dear Editor,The term'individualized medicine'was first used in Biochemistry Individuality in 1956 by Williams(Williams et al.,1956).With the emergence of the post-genome era in the21st century,individualized precision medicine has attracted increasing attention.In traditional Chinese medicine(TCM),there is also concept of individualized medicine,which is known as the Chinese constitutional theory,proposed in the1970s(Wang,2012).According to this theory,the | Lingru Li Juan Feng Haiqiang Yao Lan Xie Yu Chen Lingling Yang Shujuan Hou Shipeng Zhao Ranran Sun Yanling Wu Tongtong Bai Yingshuai Li Ruoxi Yu Ji Wang Qi Wang | 2017 | Science China(Life Sciences)2017，60，1： | 13 |
| 5 | Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing显示文摘Many human genetic diseases,including Hutchinson-Gilford progeria syndrome(HGPS),are caused by single point mutations.HGPS is a rare disorder that causes premature aging and is usually caused by a de novo point mutation in the LMNA gene.Base editors(BEs)composed of a cytidine deaminase fused to CRISPR/Cas9 nickase are highly efficient at inducing C to T base conversions in a programmable manner and can be used to generate animal disease models with single amino-acid substitutions.Here,we generated the first HGPS monkey model by delivering a BE mRNA and guide RNA(gRNA)targeting the LMNA gene via microinjection into monkey zygotes.Five out of six newborn monkeys carried the mutation specifically at the target site.HGPS monkeys expressed the toxic form of lamin A,progerin,and recapitulated the typical HGPS phenotypes including growth retardation,bone alterations,and vascular abnormalities.Thus,this monkey model genetically and clinically mimics HGPS in humans,demonstrating that the BE system can efficiently and accurately generate patient-specific disease models in non-human primates. | Fang Wang Weiqi Zhang Qiaoyan Yang Yu Kang Yanling Fan Jingkuan Wei Zunpeng Liu Shaoxing Dai Hao Li Zifan Li Lizhu Xu Chu Chu Jing Qu Chenyang Si Weizhi Ji Guang-Hui Liu Chengzu Long Yuyu Niu | 2020 | Protein & Cell2020，11，11： | 11 |
| 6 | Efficacy and safety of Yinchenwuling powder for hyperlipidemia: a systematic review and Meta-analysis显示文摘OBJECTIVE:To assess the clinical effectiveness and adverse effects of Yinchenwuling powder(YCWLP)in the treatment of hyperlipidemia using Meta-analysis.METHODS:Seven electronic databases were searched for randomized controlled trials designed to evaluate the clinical effectiveness of YCWLP for hyperlipidemia published in any language prior to February 2015.Two reviewers independently identified articles,extracted data,assessed quality,and cross-checked the results.Revman 5.3 was used to analyze the data.RESULTS:Only five randomized controlled trials with poor methodology were included in the analy-sis.The five trials compared YCWLP with conventional lipid-lowering drugs.Meta-analysis indicated that YCWLP was more effective at the levels of total cholesterol and triglycerides,while increasing the level of high-density lipoprotein cholesterol without serious adverse effects.However,it was not more effective than lipid-lowering drugs in reducing low-density lipoprotein cholesterol and improving hemorheology.CONCLUSION:YCWLP appeared to improve lipid levels.However,given the high risk of bias among the trials,we could not conclude that YCWLP was beneficial to patients with hyperlipidemia.More rigorous trials are required to provide stronger evidence for the conclusion. | Yao Haiqiang Zhang Zengliang Wang Ji Zuo Jiacheng Chen Yu Zhu Libing Li Xiaoke Yang Zheng Wang Zisong Sun Ranran Xu Xuanxuan Li Changming Wu Yanling Li Lingru Wang Qi | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 11 |
| 7 | Single-cell transcriptomic atlas of primate cardiopulmonary aging显示文摘Aging is a major risk factor for many diseases,especially in highly prevalent cardiopulmonary comorbidities and infectious diseases including Coronavirus Disease 2019(COVID-19).Resolving cellular and molecular mechanisms associated with aging in higher mammals is therefore urgently needed.Here,we created young and old non-human primate single-nucleus/cell transcriptomic atlases of lung,heart and artery,the top tissues targeted by SARS-CoV-2.Analysis of cell type-specific aging-associated transcriptional changes revealed increased systemic inflammation and compromised virus defense as a hallmark of cardiopulmonary aging.With age,expression of the SARS-CoV-2 receptor angiotensin-converting enzyme 2(ACE2)was increased in the pulmonary alveolar epithelial barrier,cardiomyocytes,and vascular endothelial cells.We found that interleukin 7(IL7)accumulated in aged cardiopulmonary tissues and induced ACE2 expression in human vascular endothelial cells in an NF-κB-dependent manner.Furthermore,treatment with vitamin C blocked IL7-induced ACE2 expression.Altogether,our findings depict the first transcriptomic atlas of the aged primate cardiopulmonary system and provide vital insights into age-linked susceptibility to SARS-CoV-2,suggesting that geroprotective strategies may reduce COVID-19 severity in the elderly. | Shuai Ma Shuhui Sun Jiaming Li Yanling Fan Jing Qu Liang Sun Si Wang Yiyuan Zhang Shanshan Yang Zunpeng Liu Zeming Wu Sheng Zhang Qiaoran Wang Aihua Zheng Shuguang Duo Yang Yu Juan Carlos Izpisua Belmonte Piu Chan Qi Zhou Moshi Song Weiqi Zhang Guang-Hui Liu | 2021 | Cell Research2021，31，4： | 10 |
| 8 | Habitat Utilization of the Golden Takin During Later Autumn and Winter in Foping National Nature Reserve显示文摘 | SONG YANLING YU YUQUN GONG HUISHENG ZHANG SHANNING | 1995 | 生物多样性1995，3，B06： | 5 |
| 9 | A Utility-Based Buffer Management Policy for Improving Data Dissemination in Opportunistic Networks显示文摘In opportunistic networks, most existing buffer management policies including scheduling and passive dropping policies are mainly for routing protocols. In this paper, we proposed a Utility-based Buffer Management strategy(UBM) for data dissemination in opportunistic networks. In UBM, we first design a method of computing the utility values of caching messages according to the interest of nodes and the delivery probability of messages, and then propose an overall buffer management policy based on the utility. UBM driven by receivers completely implements not only caching policies, passive and proactive dropping policies, but also scheduling policies of senders. Simulation results show that, compared with some classical dropping strategies, UBM can obtain higher delivery ratio and lower delay latency by using smaller network cost. | Jiansheng Yao Chunguang Ma Haitao Yu Yanling Liu Qi Yuan | 2017 | China Communications2017，14，7： | 5 |
| 10 | Correlation between the different chain lengths of free fatty acid oxidation and abili .ty of trophoblastic invasion显示文摘 | Yu Huan Yang Zi Ding Xiaoyan Wang Yanling Han Yiwei | 2014 | Chinese Medical Journal2014，，19： | 5 |
| 11 | Prospects of Carboniferous Shale Gas Exploitation in the Eastern Qaidam Basin显示文摘Shale gas is a resource of emerging importance in the energy field. Many countries in the world have been making big financial investments in this area. Carboniferous shale in the eastern Qaidam Basin shows good exploration prospects, but limited research and exploration work for shale oil and gas resources has been undertaken. Geochemical analyses were performed on shale derived from the Upper Carboniferous Hurleg Formation in the eastern Qaidam Basin, Qinghai Province, and secondary electron imaging capability of a Field Emission scanning electron microscope(FE-SEM) was used to characterize the microstructure of the shale. The reservoir and exploitation potential of the studied shale was assessed by comparison with research results obtained from the Barnett Formation shale in Fort Worth Basin, North America and the Basin shale of Sichuan province. The results indicate that the eastern Qaidam Basin Carboniferous shale is high-quality source rock. There are four major microstructural types in the study area: matrix intergranular pores, dissolution pores, intergranular pores, and micro-fractures. The size of the micropores varies from 6–633 nm, the majority of which is between 39–200 nm, with a relatively small number of micro-scale pores ranging from 0.13–1 μm. The pore characteristics of the studied shales are similar to the North American and Sichuanese shales, indicating that they have good reservoir potential. No micropores are present in the organic matter, which is induced by its composition; instead we found an important lamellar structure in the organic matter. These micropores and microfractures are abundant, and are connected to natural visible cracks that form the network pore system, which controls the storage and migration of shale gas. This connectivity is favorable for shale gas exploitation, providing great scientific potential and practical value. | LI Yingjie SUN Yanling ZHAO Yan CHANG Chun YU Qingchun MA Yinsheng | 2014 | Acta Geologica Sinica(English Edition)2014，88，2： | 4 |
| 12 | Gastrodin blocks neural stem cell differentiation into glial cells mediated by kainic acid显示文摘Kainic acid can simulate excitatory amino acids in vitro.Neural stem cells,isolated from newborn Wistar rats,were cultured in vitro and exposed to 100-4 000 μM kainic acid for 7 days to induce neuronal cell differentiation,causing the number of astrocytes to be significantly increased.Treatment with a combination of 0.5 mg/L gastrodin and kainic acid also caused the number of differentiated neurons to be significantly increased compared with treatment with kainic acid alone.Experimental findings suggest that gastrodin reduces the excitability of kainic acid and induces neural stem cell differentiation into neurons. | Guifang Sun Zhihao Yuan Boai Zhang Yanjie Jia Yangfei Ji Xingrong Ma Yu Liu Yanru Liu Quanqing Wen Yanling Zhao | 2012 | Neural Regeneration Research2012，7，12： | 4 |
| 13 | Gut microbiota from end-stage renal disease patients disrupt gut barrier function by excessive production of phenol显示文摘End stage renal disease (ESRD), an advanced stage of chronic kidney disease, has received increasing attention as a leading public health problem (Webster et al., 2017). Chronic kidney disease (CKD) and ESRD are invariably accompanied by chronic systemic inflammation which plays central roles in CKD progression (Cachofeiro et al., 2008) and the increased mortality due to cardiovascular disease (Landray et al., 2004). | Xifan Wang Yanling Hao Xiaoxue Liu Shoujuan Yu Weibo Zhang Songtao Yang Zhengquan Yu Fazheng Ren | 2019 | Journal of Genetics and Genomics2019，46，8： | 3 |
| 14 | A bifunctional, colorimetric and fluorescent probe for recognition of Cu^(2+) and Hg^(2+) and its application in molecular logic gate显示文摘A bifunctional probe 1 with iminocoumarin scaffold demonstrated different responses for Cu2+and Hg2+.In fluorescence mode of probe 1,the intensity at 528 nm was quenched severely upon the addition of Cu2+or Hg2+.Meanwhile,a new fluorescence band at 574 nm appeared in the case of Hg2+.In its UV-Vis absorption mode,significant hypochromic shift for Cu2+and bathochromic shift for Hg2+occurred,which are in agreement with the observation of distinct color changes.In addition,probe 1can be used for the construction of a molecular logic gate with NOR and INHIBIT logic functions. | YANG YanLing WANG YaWen PENG Yu | 2014 | Science China Chemistry2014，57，2： | 2 |
| 15 | Thrombin is a therapeutic target for non-small-cell lung cancer to inhibit vasculogenic mimicry formation显示文摘Tumor cells transform into endothelial cells by epithelial-to-mesenchymal transition,which is characterized by vasculogenic mimicry(VM).VM not only accelerates tumor progression but also increases drug-induced resistance.However,very little is currently known about the molecular determinants that enable VM.Targeting VM might bring a new breakthrough in cancer treatment.Thrombin is the key enzyme of the blood coagulation system and could contribute to tumor progression.Nevertheless,the association between thrombin and VM formation remains largely unknown.We found that VM was associated with the overall survival of non-small-cell lung cancer(NSCLC)patients,and that thrombin expression was closely related to VM formation.This research revealed that thrombin induced VM formation via PAR-1-mediated NF-κB signaling cascades.The novel thrombin inhibitors r-hirudin and DTIP inhibited VM formation and spontaneous metastases in subcutaneous tumors.Clinical pathological analysis confirmed that NSCLC patients with thrombin-positive/PAR-1-high expression had the poorest prognosis and were the most likely to form VM.The promotional activity of thrombin in VM formation and tumor metastasis was abolished in PAR-1-deficient NSCLC cells.The EGFR inhibitor gefitinib had no effect on VM and increased VEGF expression in tumors.The combination therapy of DTIP and gefitinib achieved a better therapeutic effect than either agent alone.This study is the first to illustrate that thrombin substantially contributes,together with PAR-1,to VM formation and to illustrate that VM might be a target of r-hirudin and DTIP to suppress tumor progression.The anticoagulants r-hirudin and DTIP could be employed for antitumor therapy.Combination therapy with DTIP with an EGFR inhibitor might achieve superior therapeutic effects. | Bing Zhao Mengfang Wu Zhihuang Hu Yixin Ma Wang Qi Yanling Zhang Yaran Li Min Yu Huijie Wang Wei Mo | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 16 | Prevalence and risk factors of enteral nutrition intolerance in intensive care unit patients: a retrospective study显示文摘Background: Feeding intolerance (FI) among intensive care unit (ICU) patients undergoing early continuous enteral nutrition (EN) is related to poor outcomes. This study aimed to explore the prevalence and risk factors of FI in ICU patients.Methods: We retrospectively enrolled 1057 patients who received early continuous EN via a nasogastric tube between January 2014 and August 2019. The prevalence of FI during the first 7 days of ICU stay was calculated, and the risk factors were investigated using multivariate logistic regression analysis.Results: The prevalence of FI during the first 7 days of ICU stay was 10.95%. FI occurred in 159 of 1057 (15.04%) patients on ICU day 2, 114 of 977 (11.67%) patients on ICU day 3, and 86 of 715 (12.03%) patients on ICU day 7. Mechanical ventilation (MV) (odds ratio [OR]: 1.928, 95% confidence interval [CI]: 1.064–3.493,P = 0.03) was an independent risk factor for FI defined by a gastric residual volume (GRV) of 200 mL and/or vomiting, and acute renal failure (OR: 3.445, 95% CI: 1.115–10.707,P = 0.032) was an independent risk factor of FI defined by a GRV of 500 mL and/or vomiting. Continuous renal replacement therapy (CRRT) was an independent predictor regardless of the FI defined by a GRV of 200 mL (OR: 2.064, 95% CI: 1.233–3.456,P = 0.006) or 500 mL (OR: 6.199, 95% CI: 2.108–18.228,P = 0.001) in the ICU patients.Conclusions: FI occurs frequently in early ICU days, especially in patients receiving MV and CRRT. However, further investigation of a consensus definition of FI and risk factors is still warranted in future studies. | Kunrong Yu Na Guo Dingding Zhang Ying Xia Yanling Meng Li Weng Bin Du | 2022 | Chinese Medical Journal2022，，15： | 2 |
| 17 | A Weighted Threshold Secret Sharing Scheme for Remote Sensing Images Based on Chinese Remainder Theorem显示文摘The recent advances in remote sensing and computer techniques give birth to the explosive growth of remote sensing images.The emergence of cloud storage has brought new opportunities for storage and management of massive remote sensing images with its large storage space,cost savings.However,the openness of cloud brings challenges for image data security.In this paper,we propose a weighted image sharing scheme to ensure the security of remote sensing in cloud environment,which takes the weights of participants(i.e.,cloud service providers)into consideration.An extended Mignotte sequence is constructed according to the weights of participants,and we can generate image shadow shares based on the hash value which can be obtained from gray value of remote sensing images.Then we store the shadows in every cloud service provider,respectively.At last,we restore the remote sensing image based on the Chinese Remainder Theorem.Experimental results show the proposed scheme can effectively realize the secure storage of remote sensing images in the cloud.The experiment also shows that no matter weight values,each service providers only needs to save one share,which simplifies the management and usage,it also reduces the transmission of secret information,strengthens the security and practicality of this scheme. | Qi He Shui Yu Huifang Xu Jia Liu Dongmei Huang Guohua Liu Fangqin Xu Yanling Du | 2019 | Computers, Materials & Continua2019，，2： | 2 |
| 18 | Degradation of raw corn stover powder (RCSP) by an enriched microbial consortium and its community structure显示文摘 | Yujie Feng Yanling Yu Xin Wang Youpeng Qu Dongmei Li Weihua He Byung Hong Kim | 2010 | Bioresource Technology2010，，2： | 1 |
| 19 | Prediction and Analysis of Post-Treatment of Sustainable Walnut Shell/Co-PES Parts by Laser Sintering显示文摘In order to enhance the strength of sustainable walnut shell/Co-PES(WSPC)sintered parts,wax-filtrated posttreatment was carried out.The effects of treating fluid temperature,preheating time and immersion time on the bending strength of WSPC wax-filtrated parts were analyzed by single factor analysis method.To obtain an accurate model for predicting the bending strength of the WSPC wax-filtrated part,the experiments were involved by using Box-Behnken design(BBD).Main parameters,such as treating fluid temperature,preheating time and immersion time,and their interactive effects were analyzed through analysis of variance(ANOVA)and graphical contours.The results demonstrated that all parameters’direct effects were significant to bending strength of the WSPC wax-filtrated part.Its optimum value was 5.0 MPa when the treating fluid temperature of 70°C,preheating time of 50 min,and immersion time of 20 s.The predicted models effectively validated had good predicting accuracy.The WSPC wax-filtrated part using optimal processing parameters was processed by investment casting,and then the metal casting of dimensional stability and smooth surface was obtained.Investment casting was done using WSPC wax-filtrated parts under optimal process parameters and then metal parts with stable structure size and smooth surface can be obtained,which indicates that WSPC material can be used for investment casting. | Yueqiang Yu Suling Wang Minzheng Jiang Yanling Guo Ting Jiang | 2021 | Journal of Renewable Materials2021，9，2： | 1 |
| 20 | Construction of SnS2/SnO2 heterostructures with enhanced potassium storage performance显示文摘Increasing attention has been focused on potassium ion batteries(KIBs) as promising energy-sto rage system(ESS) owing to the abundance and low-cost of potassium resources.Here,SnS2/SnO2 hete rostructures were successfully fixed onto stainless steel mesh(SnS2/SnO2/SSM) through a facile two-step hydrothermal method and used as anodes for KIBs.Due to the advantages of SnS2/SnO2 heterostructures and good conductivity of SSM substrate,the SnS2/SnO2/SSM anodes display enhanced electrochemical performance.The SnS2/SnO2/SSM anodes deliver specific capacity of 394 mA h g^-1 at 50 mA g^-1 over 100 cycles,better than SnO2/SSM.Even at 500 mA g^-1 after 250 cycles,high capacity of 155 mA h g^-1 can still be obtained. | Guoquan Suo Dan Li Lei Feng Xiaojiang Hou Xiaohui Ye Li Zhang Qiyao Yu Yanling Yang Wei(Alex)Wang | 2020 | Journal of Materials Science & Technology2020，52，20： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员