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| 1 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 2 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 3 | Panax notogiseng saponin inhibits ischemia-induced apoptosis by activating PI3K/Akt signal pathway in cardiomyocytes显示文摘The panax notoginseng saponin(PNS) had been clinically used for the treatment of cardiovascular diseases and stroke in China.It had been demonstrated that PNS could protect cardiomyocytes from injury induced by ischemi- a,but the underlying molecular mechanisms of this protective effect were still unclear.This study was aimed to investigate the protective effect and molecular mechanisms of PNS on apoptosis in H9c2 cells in vitro and rat myocardial ischemia injury model in vivo.Annexin-V/PI assay shew that PNS could protect H9c2 cells from apoptosis induced by serum, glucose and oxygen deprivation(SGOD) in a dose-dependent manner.However,the anti-apoptotic effect of PNS was reversed by LY294002,a specific PI3K inhibitor.This antiapoptotic effect of PNS was confirmed by JC-1,a specific probe of mitochondrial membrane potential staining.PNS could significantly increase phos-Akt in H9c2 cells by Western blot assays and its effect could be inhibited by LY294002.Furthermore,PNS could improve ischemic-induced left ventricular function as reflected by EF,LVDd and LVDs.PNS could also inhibited cellular apoptosis in myocardial tissues in ischemic rats by TUNEL assay.PNS administration also increased the expression of phos-Akt in rat ischemic myocardial tissues.These results suggested that PNS could protect myocardial cells from apoptosis induced by ischemia in vitro model and in vivo model through activating-PI3K/Akt signal pathway which may be meaningful for further understanding the molecular mechanisms of cardiac protection of PNS.And the results might be useful in treatment of myocardial ischemia in future. | YANG Min,CHEN Shao-Xian,LIU Ju-Li,LIU Xiao-Ying,FU Yong-Heng,ZHANGMeng-zhen,LIN Qiu-Xiong,ZHU Jie-Ning, SHAN Zhi-Xin,YU Xi-yong (Medical Research Center,Guangdong General Hospital, Guangdong Academy of Medical Sciences,Guangzhou 510100,China) | 2011 | 岭南心血管病杂志2011，17，S1： | 47 |
| 4 | Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-KB signaling pathway and activating the PI3K/Akt/Nrf2 pathway显示文摘 | Si-tong LI Qi DAI Shu-xian ZHANG Ya-jun LIU Qiu-qiong YU Fei TAN Shu-hong LU Quan WANG Jian-wen CHEN He-qing HUANG Pei-qing LIU Min LI | 2018 | Acta Pharmacologica Sinica2018，39，8： | 43 |
| 5 | Massive individual orbital angular momentum channels for multiplexing enabled by Dammann gratings显示文摘Data transmission rates in optical communication systems are approaching the limits of conventional multiplexing methods.Orbital angular momentum(OAM)in optical vortex beams offers a new degree of freedom and the potential to increase the capacity of free-space optical communication systems,with OAM beams acting as information carriers for OAM division multiplexing(OAM-DM).We demonstrate independent collinear OAM channel generation,transmission and simultaneous detection using Dammann optical vortex gratings(DOVGs).We achieve 80/160 Tbit s^(-1) capacity with uniform power distributions along all channels,with 1600 individually modulated quadrature phase-shift keying(QPSK)/16-QAM data channels multiplexed by 10 OAM states,80 wavelengths and two polarizations.DOVG-enabled OAM multiplexing technology removes the bottleneck of massive OAM state parallel detection and offers an opportunity to raise optical communication systems capacity to Pbit s^(-1) level. | Ting Lei Meng Zhang Yuru Li Ping Jia Gordon Ning Liu Xiaogeng Xu Zhaohui Li Changjun Min Jiao Lin Changyuan Yu Hanben Niu Xiaocong Yuan | 2015 | Light(Science & Applications)2015，4，1： | 47 |
| 6 | Analysis of bacterial community structures in two sewage treatment plants with different sludge properties and treatment performance by nested PCR-DGGE method显示文摘在二污水处理植物 withdifferent 进程和表演的细菌的社区结构是放大的嵌套的聚合酶链反应(嵌套的 PCR )的调查 bydenaturing 坡度胶化电气泳动( DGGE ) 16S rRNA 基因未加工的污水和对待的自河的fragmentswithgroup特定的 primers.Samples 用thewhole房间 PCR 被放大方法,并且 theactivated 污泥样品用提取 genomic DNAbefore 被放大 PCR 产品为 ba 在一样的 DGGEgel | LIU Xin-chun ZHANG Yu YANG Min WANG Zhen-yu LV Wen-zhou | 2007 | Journal of Environmental Sciences2007，19，1： | 39 |
| 7 | Sevoflurane postconditioning reduces myocardial reperfusion injury in rat isolated hearts via activation of PI3K/Akt signaling and modulation of Bcl-2 family proteins显示文摘Sevoflurane postconditioning reduces myocardial infarct size.The objective of this study was to examine the role of the phosphatidylinositol-3-kinase(PI3K)/Akt pathway in anesthetic postconditioning and to determine whether PI3K/Akt signaling modulates the expression of pro-and antiapoptotic proteins in sevoflurane postconditioning.Isolated and perfused rat hearts were prepared first,and then randomly assigned to the following groups:Sham-operation(Sham),ischemia/reperfusion(Con),sevoflurane postconditioning(SPC),Sham plus 100 nmol/L wortmannin(Sham+Wort),Con+Wort,SPC+Wort,and Con+dimethylsulphoxide(DMSO).Sevoflurane postconditioning was induced by administration of sevoflurane(2.5%,v/v) for 10 min from the onset of reperfusion.Left ventricular developed pressure(LVDP),left ventricular end-diastolic pressure(LVEDP),maximum increase in rate of LVDP(+dP/dt),maximum decrease in rate of LVDP(?dP/dt),heart rate(HR),and coronary flow(CF) were measured at baseline,R30 min(30 min of reperfusion),R60 min,R90 min,and R120 min.Creatine kinase(CK) and lactate dehydrogenase(LDH) were measured after 5 min and 10 min reperfusion.Infarct size was determined by triphenyltetrazolium chloride staining at the end of reperfusion.Total Akt and phosphorylated Akt(phospho-Akt),Bax,Bcl-2,Bad,and phospho-Bad were determined by Western blot analysis.Analysis of variance(ANOVA) and Student-Newman-Keuls' test were used to investigate the significance of differences between groups.The LVDP,±dP/dt,and CF were higher and LVEDP was lower in the SPC group than in the Con group at all points of reperfusion(P<0.05).The SPC group had significantly reduced CK and LDH release and decreased infarct size compared with the Con group [(22.9±8)% vs.(42.4±9.4)%,respectively;P<0.05].The SPC group also had increased the expression of phospho-Akt,Bcl-2,and phospho-Bad,and decreased the expression of Bax.Wortmannin abolished the cardioprotection of sevoflurane postconditioning.Sevoflurane postconditioning may protect the isolated rat heart.Activation of PI3K and modulation of the expression of pro-and antiapoptotic proteins may play an important role in sevoflurane-induced myocardial protection. | Li-na YU Jing YU Feng-jiang ZHANG Mei-juan YANG Ting-ting DING Jun-kuan WANG Wei HE Tao FANG Gang CHEN Min YAN | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，9： | 36 |
| 8 | Associations of CYP3A4, NR1I2, CYP2C19 and P2RY12 polymorphisms with clopidogrel resistance in Chinese patients with ischemic stroke显示文摘瞄准:在亚洲人口有 antiplatelet 药 clopidogrel 抵抗(CR ) 的高发生。因为 clopidogrel 是 prodrug,编码涉及它的 biotransformation 的酶的基因的多型性可以是主要有影响的因素。这研究的目标是与 ischemic stroke.Methods 在中国病人与 CR 调查 CYP3A4, NR1I2, CYP2C19 和 P2RY12 基因的多型性的协会:有 ischemic 击的 191 个病人的一个总数被注册。病人与 clopidogrel 被对待至少 5 天。血小板功能被轻传播 aggregometry 测量。SNP NR1I2 (rs13059232 ) , CYP3A4 *1G (rs2242480 ) , CYP2C19 *2 (rs4244285 ) 和 P2RY12 (rs2046934 ) 是 genotyped.Results:在这张人口的 CR 率是 36% 。CYP2C19 *2 变体是为 CR 的一个风险因素(*2/*2+wt/*2 对 wt/wt,或:2.366, 95% CI:1.180-4.741, P=0.014 ) ,而 CYP3A4 *1G 变体在 CR 上有保护的效果(*1/*1 对 *1G/*1G+*1/*1G, 或:2.360, 95% CI:1.247-4.468, P=0.008 ) 。NR1I2 (rs13059232 ) 多型性中等与 CR 被联系(CC 对 TT+TC,或:0.533, 95% CI:0.286-0.991, P=0.046 ) 。在 P2RY12 (rs2046934 ) 的 C 等位基因被预言是为 CR 的一个保护的因素(CC+TC 对 TT,或:0.407, 95% CI:0.191-0.867, P=0.018 ) 。另外,一个协会在高血压和 CR (P=0.022 ) 之间被发现 .Conclusion:有 CYP2C19 *2 等位基因和高血压的个人在反血栓治疗期间在 CR 的高风险。CYP3A4 *1G 等位基因, P2RY12 (rs2046934 ) C 等位基因和 NR1I2 (rs13059232 ) CC 遗传型可以是为 CR 的保护的因素。学习的联系 SNP 可能是有用的与 ischemic 击在中国病人预言 clopidogrel 抵抗。 | Rui LIU Zi-yi ZHOU Yi-bei CHEN Jia-li LI Wei-bang YU Xin-meng CHEN Min ZHAO Yuan-qi ZHAO Ye-feng CAI Jing JIN Min HUANG | 2016 | Acta Pharmacologica Sinica2016，37，7： | 39 |
| 9 | Delayed hepatocarcinogenesis through antiangiogenic intervention in the nuclear factor-kappa B activation pathway in rats显示文摘BACKGROUND:The active form of nuclear factor-kappa B(NF- κB)is involved in the initiation,generation,and development of hepatocellular carcinoma(HCC),and is up-regulated in inflammation-associated malignancies.We investigated the dynamic expression of NF-κB and its influences on the occurrence of HCC through antiangiogenic(thalidomide) intervention in NF-κB activation. METHODS:Hepatoma models were induced with 2-fluorenyl- acetamide(2-FAA,0.05%)in male Sprague-Dawley rats,and thalidomide(100 mg/kg body weight)was administered intragastrically to intervene in NF-κB activation.The pathological changes in the liver of sacrificed rats were assessed after hematoxylin and eosin staining.NF-κB mRNA was amplified by RT-nested PCR.The alterations of NF-κB and vascular endothelial growth factor(VEGF)expression were analyzed by enzyme-linked immunosorbent assay,immunohistochemistry,and Western blotting. RESULTS:Rat hepatocytes showed denatured,precancerous,and cancerous stages in hepatocarcinogenesis,with an increasing tendency of hepatic NF-κB,NF-κB mRNA,and VEGF expression,and their values in the HCC group were higher than those in controls(P<0.001).In the thalidomide- treated group,the morphologic changes generated only punctiform denaturation and necrosis at the early or middle stages,and nodular hyperplasia or a little atypical hyperplasia at the final stages,with the expression of NF-κB (χ2=9.93,P<0.001)and VEGF(χ2=8.024,P<0.001)lower than that in the 2-FAA group. CONCLUSION:NF-κB is overexpressed in hepatocarcinogenesis and antiangiogenic treatment down-regulates the expression of NF-κB and VEGF,and delays the occurrence of HCC. | Dong, Zhi-Zhen Yao, Deng-Fu Wu, Wei Yao, Min Yu, Hong-Bo Shen, Jun-Jun Qiu, Li-Wei Yao, Ning-Hua Sai, Wen-Li Yang, Jun-Ling | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，2： | 31 |
| 10 | Microinflammation is involved in the dysfunction of arteriovenous fistula in patients with maintenance hemodialysis显示文摘背景脉管的存取( VA )机能障碍是在 hemodialysis 人口的主要临床的复杂并发症,分离 outcome.This 学习上的直接效果被进行了在维护 hemodialysis patients.Methods 在 VA 机能障碍探索 microinflammation 的角色收到维护 hemodialysis 的 47 个病人(男性 35 和女性 12 )被包括为这 study.They 被划分成三 groups:group 1 ( n=15 ),有起始的 hemodialysis 的病人和新动静脉的管( | LIU Bi-cheng LI Li GAO Min WANG Yan-li YU Ji-rong | 2008 | Chinese Medical Journal2008，，21： | 32 |
| 11 | Epidemiologic features of Kawasaki disease in Shanghai from 2003 through 2007显示文摘背景当下列五年里的 KD 的当前的地位仍然是为 KD 的一种问询表形式和诊断指南被送到在上海提供小儿科的医疗保健的 50 所医院的 unknown.Methods 时,在通过 2002 的从 1998 的上海的 Kawasaki 疾病(KD ) 的流行病的图画被报导,中国。有通过 2007 年 12 月在 2003 年 1 月期间诊断的 KD 的所有病人是总共的 recruited.Results, KD 的 1187 个案例被注册。KD 的发生是 36.78 ~ 53.28 (平均数 46.32 ???? 吗?? | MA Xiao-jing YU Cen-yan HUANG Min CHEN Shu-bao HUANG Mei-rong HUANG Guo-ying | 2010 | Chinese Medical Journal2010，，19： | 33 |
| 12 | Generation of neural progenitor cells by chemical cocktails and hypoxia显示文摘神经祖先房间(NPC ) 能被定义因素从体的房间导致。这里,我们报导 NPC 能从老鼠被产生由化学鸡尾酒的胚胎的成纤维细胞,也就是 VCR (V, VPA, HDAC 的一个禁止者;C, CHIR99021, GSK-3 kinases 和 R 的一个禁止者, Repsox, TGF-β 的一个禁止者;小径) ,在一个生理的 hypoxic 条件下面。这些导致化学药品的 NPC (ciNPCs ) 类似于鼠标关于他们为在 vitro 并且在 vivo 的不同 neuroectodermal 系的 proliferative 和自我更新的能力,基因表达式侧面,和 multipotency 的导出大脑的 NPC。进一步的实验揭示那种选择有 histone deacetylation,肝糖 synthase kinase,和 TGF-β 的禁止者的鸡尾酒;小径为 ciNPC 正式就职显示出类似的功效。而且, ciNPCs 能也与一样的化学鸡尾酒 VCR 从老鼠尾巴尖端成纤维细胞和人的尿房间被导致。因此,我们的学习证明没有介绍外长的因素,到 NPC 的体的房间的那系特定的变换能被化学鸡尾酒完成。 | Lin Cheng Wenxlang Hu Binlong Qiu Jian Zhao Yongchun Yu Wuqiang Guan Min Wang Wuzhou Yang Gang Pei | 2014 | Cell Research2014，24，6： | 32 |
| 13 | Dopant-Controlled Synthesis of Water-Soluble Hexagonal NaYF_(4) Nanorods with Efficient Upconversion Fluorescence for Multicolor Bioimaging显示文摘A novel strategy is proposed to directly synthesize water-soluble hexagonal NaYF4 nanorods by doping rare-earth ions with large ionic radius (such as La^(3+), Ce^(3+), Pr^(3+), Nd^(3+), Sm^(3+), Eu^(3+), and Gd^(3+)), and the dopant- controlled growth mechanism is studied. Based on the doping effect, we fabricated water-soluble hexagonal NaYF4:(Yb,Er)/La and NaYF4:(Yb,Er)/Ce nanorods, which exhibited much brighter upconversion fluorescence than the corresponding cubic forms. The sizes of the nanorods can be adjusted over a broad range by changing the dopant concentration and reaction time. Furthermore, we successfully demonstrated a novel depth-sensitive multicolor bioimaging for in vivo use by employing the as-synthesized NaYF4:(Yb,Er)/La nanorods as probes. | Xuefeng Yu Min Li Mengyin Xie Liangdong Chen Yan Li Ququan Wang | 2010 | Nano Research2010，3，1： | 27 |
| 14 | Expression and significance of HBV genes and their antigens in human primary intrahepatic cholangiocarcinoma显示文摘INTRODUCTIONAlargenumberofstudiesindicateacloserelationshipbetweenhumanprimaryhepatocelularcarcinomaandhepatitisBvirus(HBV)in... | WANG Wen Liang, GU Guang Yu and HU Min | 1998 | World Journal of Gastroenterology1998，4，5： | 25 |
| 15 | Expression of fibroblast activation protein in human pancreatic adenocarcinoma and its clinicopathological significance显示文摘AIM: To examine fibroblast activation protein (FAP) expression in pancreatic ductal adenocarcinoma (PDAC) and to analyze its relationship with the clinicopathology of PDAC. METHODS: FAP expression was examined in 134 PDAC specimens by immunohistochemistry, and in four pancreatic cancer cell lines (SW1990, Miapaca-2, AsPC-1 and BxPC-3) by Western blotting assay. We also analyzed the association between FAP expression in PDAC cells and the clinicopathology of PDAC patients. RESULTS: The results showed that the FAP was expressed in both stromal fibroblast cells (98/134, 73.1%) and carcinoma cells (102/134, 76.1%). All 4 pancreatic cancer cell lines expressed FAP protein at different levels. Protein bands corresponding to the proteolytically active 170-kDa seprase dimer and its88-kDa seprase subunit were identif ied. Higher FAP expression in carcinoma cells was associated with tumor size (P < 0.001), fi brotic focus (P = 0.003), perineural invasion (P = 0.009) and worse clinical outcome (P = 0.0085). CONCLUSION: FAP is highly expressed in carcinoma cells and f ibroblasts in PDAC tissues, and its expression is associated with desmoplasia and worse prognosis. | Min Shi Dang-Hui Yu Ying Chen Chen-Yan Zhao Jing Zhang Qing-Hua Liu Can-Rong Ni Ming-Hua Zhu | 2012 | World Journal of Gastroenterology2012，18，8： | 25 |
| 16 | Effects of Momentum Ratio and Weber Number on Spray Half Angles of Liquid Controlled Pintle Injector显示文摘一个舵栓注射者为扼杀一台液体火箭引擎并且减少引擎重量是有益的。这研究为液体气体燃料在舵栓注射者的水花特征上以各种各样的注射条件探索动量比率和威伯数字的效果。一张液体表从一张中心舵栓嘴被注射,它被一口煤气的喷气从环形的差距打破。燃料的压力落下,和舵栓洞距离被看作控制变量;使用 0.1 1.0 液体注射作为为压力的一个酒吧落下,为为舵栓洞距离的煤气的喷气和 0.2 1.0 公里的压力落下的 0.010.2 酒吧。分泌物系数在 0.75 公里的舵栓洞距离前线性地被减少然后,系数稍微被增加。水花图象被一个互补金属氧化物半导体照相机与高分辨率捕获。然后,阴影和反映的图象被分析。水花分布被 patternator 从一个舵栓尖端与 50 公里的轴的距离测量。最后,角度有指数地减少的水花一半动量比率由威伯数字划分了的关联。另外,水花一半从水花分发的角度与从捕获的图象测量的那些相比被低估。 | Min Son Kijeong Yu Jaye Koo Oh Chae Kwon Jeong Soo Kim | 2015 | Journal of Thermal Science2015，24，1： | 26 |
| 17 | Effect of probiotic treatment on cirrhotic patients with minimal hepatic encephalopathy: A meta-analysis显示文摘Background: Minimal hepatic encephalopathy(MHE) is an early and reversible form of hepatic encephalopathy. The documentations on the treatment with probiotics are inconsistent. The present meta-analysis was to verify the role of probiotics in the treatment of cirrhotic patients with MHE.Data sources: Seven electronic databases were searched for relevant randomized controlled trials(RCTs)published until July 2015. The effects of probiotics on serum ammonia, endotoxin, and MHE were evaluated.Results: A total of 14 RCTs(combined n = 1132) were included in the meta-analysis. When probiotics were compared to placebo or no treatment, probiotics were more likely to reduce values in the number connection test(NCT; week 4: MD =-30.25, 95% CI:-49.85 to-10.66), improve MHE(week 4: OR = 0.18,95% CI: 0.07 to 0.47; week 12: OR = 0.15, 95% CI: 0.07 to 0.32), and prevent overt HE progression(week4: OR = 0.22, 95% CI: 0.07 to 0.67) in patients with liver cirrhosis. When probiotics was compared to lactulose, probiotics tended to reduce serum ammonia levels(week 4: MD =-0.33 μmol/L, 95% CI:-5.39 to 4.74; week 8: MD = 6.22 μmol/L, 95% CI:-24.04 to 36.48), decrease NCT(week 8: MD = 3.93, 95% CI:-0.72 to 8.58), improve MHE(week 4: OR = 0.93, 95% CI: 0.45 to 1.91; week 12: OR = 0.73, 95% CI: 0.35 to 1.51) and prevent the development of overt HE(week 4: OR = 0.96, 95% CI: 0.17 to 5.44; week 12:OR = 2.7, 95% CI: 0.50 to 14.64) in patients with liver cirrhosis. However, lactulose appears to be more effective in reducing NCT values as compared to probiotics(week 4: MD = 6.7, 95% CI: 0.58 to 12.82).Conclusion: Probiotics can decrease serum ammonia and endotoxin levels, improve MHE, and prevent overt HE development in patients with liver cirrhosis. | Qing Cao Cheng-Bo Yu Shi-Gui Yang Hong-Cui Cao Ping Chen Min Deng Lan-Juan Li | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，1： | 25 |
| 18 | Schisandrol B protects against acetaminophen- induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway显示文摘目的: 原子因素 erythroid 2-related 因素(NRF2 ) 2 通过抗氧化剂反应元素行动() 处理调整许多除去和为 cytoprotective 负责的抗氧化剂基因的表示。我们以前报导从五味子 sphenanthera 孤立的 Schisandrol B (SolB ) 对导致的 acetaminophen (APAP ) 生产了保护的效果肝损害。在这研究,我们调查了表明小径的 NRF2/ARE 是否涉及这 hepato 保护的 effect.Methods : 男 C57BL/6 老鼠与 SolB 被对待(200 mg· kg −1·d−1, ig ) 为在 APAP 的注射前的 3 d (400 mg/kg, ip ) 。浆液和肝织物样品被收集 6 h 以后。mRNA 和蛋白质表示分别地用 qRT-PCR 和西方的污点试金被测量。 NRF2 的激活用酶记者基因 assay.Results 在 HepG2 房间被检验:显著地减轻的 SolB 预告的处理肝的损害(肝的湾穴的大补缀的坏死和 hyperemia ),浆液著名计算机生产厂商的增加,中高音层次和肝的 MDA 满足,并且肝和 mitochondrial 谷胱甘肽的减少在 对待APAP 的老鼠铺平。而且, SolB 预告的处理显著地增加了 NRF2 的原子累积并且增加了 NRF2 下游的蛋白质的肝的表示,包括在对待 APAP 的鼠标的 GCLC, GSR, NQO1, GST, MRP2, MRP3 和 MRP4。而且,有 SolB 的处理(2.5-20 μ mol/L ) dose-dependently 在 HepG2 cells.Conclusion 增加了 NRF2 记者基因的活动: SolB 对导致 APAP 的 hepatotoxicity 展出显著保护的效果,部分,经由 NRF2/ARE 的激活, NRF2 的小径和规定指向基因,它导致 detoxification 和增加抗氧化剂能力。 | Yi-ming JIANG Ying WANG Hua-sen TAN Tao YU Xiao-mei FAN Pan CHEN Hang ZENG Min HUANG Hui-chang BI | 2016 | Acta Pharmacologica Sinica2016，37，3： | 24 |
| 19 | Glutamine:aprecursor of glutathione and its effect on liver显示文摘METHODSTwentymaleWistarratswererandomlydividedintotwogroups:onereceivingstandardparenteralnutrition(STD)andtheothersuppleme... | YU Jian Chun, JIANG Zhu Ming and LI De Min | 1999 | World Journal of Gastroenterology1999，5，2： | 23 |
| 20 | Relationship between expression of CD44v6 and nm23-H1 and tumor invasion and metastasis in hepatocellular carcinoma显示文摘INTRODUCTIONCD44isacelsurfacetransmembraneglycoprotein.Asakindofadhesivemolecule,itparticipatesincelcelandcelmatrixadhesion... | XIAO Cheng Zhi, DAI Yi Min, YU Hong Yu, WANG Jian Jun and NI Can Rong | 1998 | World Journal of Gastroenterology1998，4，5： | 23 |
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