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| 1 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 2 | Effect of SiC particle addition on microstructure of Mg_2Si/Al composite显示文摘In the present study, by adding SiC particles into Al-Si-Mg melt, Mg2Si and SiC particles hybrid reinforced Al matrix composites were fabricated through the Mg2Si in situ synthesis in melt combined with the SiC ex situ stir casting. The as-cast microstructure containing primary Mg2Si and SiC particles that distribute homogenously in Al matrix was successfully achieved. The effects of SiC particle addition on the microstructure of Mg2Si/Al composites were investigated by using scanning electron microscopy(SEM) and XRD. The results show that, with increasing the fraction of the SiC particles from 5wt.% to 10wt.%, the morphologies of the primary Mg2Si particulates in the prepared samples remain polygonal, but the size of the primary phase decreases slightly. However, when the SiC particle addition reaches 15wt.%, the morphologies of the primary Mg2Si particulates change partially from polygonal to quadrangular with a decrease in size from 50 μm to 30 μm. The size of primary Al dendrites decreases with increasing fraction of the SiC particles from 0wt.% to 15wt.%. The morphology of the eutectic Mg2Si phase changes from a fi ber-form to a short fi ber-form and/or a dot-like shape with increasing fraction of the SiC particles. Furthermore, no signifi cant change in dendrite arm spacing(DAS) was observed in the presence of SiC particles. | Zhao Yuguang Liu Xiaobo Yang Yuanyuan Bian Tianjun | 2014 | China Foundry2014，11，2： | 8 |
| 3 | Designing for Long Campaign Life Blast Furnace (1)──The Mathematical Model of Temperature Field for Blast Furnace Lining and Cooling Apparatus and New Concept of Long Campaignship Blast Furnace Cooler Design显示文摘The physical and mathematical model of temperature field for blast furnace stave coolers was established. The computation results show that the heat resistance of 2-6 mm water scale within the cooling pipe is about 7%-20% of the total heat resistance of cooling stave body, as for drilling duct type, the heat resistance of 2-6 mm water scale is about 88%-98% of the total heat resistance. Using drilling duct or full cast pipe can eliminate gas clearance and coating layer between pipes and cast iron body and reduce the heat resistance of the cooler sharply and improve the coefficient of heat transfer to a great extent. The water velocity within coolers can be kept at the 1evel of 0.5- 1 .5 m/s, the higher water velocity can not decrease the hot surface temperature, but can increase energy consumption for cooling water. | Susen Cheng Qingguo Xue Weiguo Yang kaolin Wu Tianjun Yang(Metallurgy School, University of Science and Technology Beijing, Beijing 100083, China)(Ironmaking Department, Bejing Central Engineering and Incoporation of Iron and Steel Industry, Bejing, 1000 | 1999 | International Journal of Minerals,Metallurgy and Materials1999，13，3： | 5 |
| 4 | Designing for Long Campaign Life Blast Furnace (2)-The Simulation of Temperature Field of Lining and Cooling Apparatus显示文摘Through the numerical modeling of temperature field for Blast Furnace (BF) lining and stave coolers, it can tell designers how to design a cooler which the hot surface temperature is less than its critical temperature under very high heat flux. Applying low heat re- sistance lining and staves cooler to BF is good for a layer of slag skull frozen on the hot surface of cooling stave. As long as the slag skull can stand, the furnace wall is stable and the heat loss of furnace does not increase. This is the basic principle for designing long campa- ignship BF. | Qingguo Xue Weiguo Yang Susen Cheng Maolin Wu Tianjun Yang Metallurgy School, University of Science and Technology Beijing, Beijing 100083, China The Center of Engineering and Research for Iron and Steel, 100053, China | 2000 | International Journal of Minerals,Metallurgy and Materials2000，14，1： | 3 |
| 5 | Advances and challenges on springback control for creep age forming of aluminum alloy显示文摘Creep age forming(CAF)is an advanced forming technology that combines creep deformation and age hardening processes.When compared with the conventional forming technologies including roll bending and shot-peen forming,CAF has many advantages of low residual stress,excellent dimensional stability,good service performance and short production cycle.It is an optimal technique for precise manufacturing for shape and properties of large-scale complicated thinwalled components of light-weight and high strength aluminum alloys in the aviation and aerospace industries.Nevertheless,CAF has an inevitable disadvantage that a large amount of springback occurs after unloading,which brings a challenge on the accurate shape forming and property tailoring of components.Therefore,how to achieve accurate prediction and control of springback has always been a bottleneck hindering the development of CAF to more industrial applications.After the factors of affecting springback and measures of reducing springback are summarized from the internal and external aspects,constitutive models for predicting springback and springback compensation methods for CAF of aluminum alloy panel components are reviewed.Then,a review of research progresses on tool design for CAF is presented.Finally,in view of the key issue that it is difficult to predict and control the shape and properties of components during CAF,the technical challenges are discussed and future development trends of CAF are prospected. | Liwen ZHANG Heng LI Tianjun BIAN Changhui WU Yang GAO Chao LEI | 2022 | Chinese Journal of Aeronautics2022，35，10： | 3 |
| 6 | Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial显示文摘Tocilizumab has been reported to attenuate the“cytokine storm”in COVID-19 patients.We attempted to verify the effectiveness and safety of tocilizumab therapy in COVID-19 and identify patients most likely to benefit from this treatment.We conducted a randomized,controlled,open-label multicenter trial among COVID-19 patients.The patients were randomly assigned in a 1:1 ratio to receive either tocilizumab in addition to standard care or standard care alone.The cure rate,changes of oxygen saturation and interference,and inflammation biomarkers were observed.Thirty-three patients were randomized to the tocilizumab group,and 32 patients to the control group.The cure rate in the tocilizumab group was higher than that in the control group,but the difference was not statistically significant(94.12%vs.87.10%,rate difference 95%CI−7.19%–21.23%,P=0.4133).The improvement in hypoxia for the tocilizumab group was higher from day 4 onward and statistically significant from day 12(P=0.0359).In moderate disease patients with bilateral pulmonary lesions,the hypoxia ameliorated earlier after tocilizumab treatment,and less patients(1/12,8.33%)needed an increase of inhaled oxygen concentration compared with the controls(4/6,66.67%;rate difference 95%CI−99.17%to−17.50%,P=0.0217).No severe adverse events occurred.More mild temporary adverse events were recorded in tocilizumab recipients(20/34,58.82%)than the controls(4/31,12.90%).Tocilizumab can improve hypoxia without unacceptable side effect profile and significant influences on the time virus load becomes negative.For patients with bilateral pulmonary lesions and elevated IL-6 levels,tocilizumab could be recommended to improve outcome. | Dongsheng Wang Binqing Fu Zhen Peng Dongliang Yang Mingfeng Han Min Li Yun Yang Tianjun Yang Liangye Sun Wei Li Wei Shi Xin Yao Yan Ma Fei Xu Xiaojing Wang Jun Chen Daqing Xia Yubei Sun Lin Dong Jumei Wang Xiaoyu Zhu Min Zhang Yonggang Zhou Aijun Pan Xiaowen Hu Xiaodong Mei Haiming Wei Xiaoling Xu | 2021 | Frontiers of Medicine2021，15，3： | 2 |
| 7 | Mesomechanics Finite-element Method for Determining the Shear Strength of Mudded Intercalation Materials显示文摘A new method regarding mesomechanics finite-element research is proposed to predict the peak shear strength of mudded intercalation materials on a mesoscopic scale. Based on geometric and mechanical parameters, along with the strain failure criteria obtained by sample's deformation characteristics, uniaxial compression tests on the sample were simulated through a finite-element model, which yielded values consistent with the data from the laboratory uniaxial compression tests, implying that the method is reasonable. Based on this model, a shear test was performed to calculate the peak shear strength of the mudded intercalation, consistent with values reported in the literature, thereby providing a new approach for investigating the mechanical properties of mudded intercalation materials. | 胡启军 SHI Rendan YANG Xiaoqiang CAI Qijie HE Tianjun HE Leping | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，2： | 2 |
| 8 | An Improved Artificial Neural Network Model for Predicting Silicon Content of Blast Furnace Hot Metal显示文摘Based on the skills of initializing weight distribution, adding an impulse in a neural network and expanding the ideal of plural weights, an artificial neural network model with three connection weights between one and another neural unit was established to predict silicon content of blast furnace hot metal. After the neural network was trained in the off-line state on the basis of a large number of practical data of a commercial blast furnace and making many learning patterns, satisfactory testing and simulating results of the model were obtained. | Bin Yao, Tianjun Yang, Xiaojun Ning (Metallurgy School, University of Science and Technology Beijing, Beijing 100083, China) | 2000 | International Journal of Minerals,Metallurgy and Materials2000，14，4： | 2 |
| 9 | Parameter Tuning and Calibration of RegCM3 with MIT-Emanuel Cumulus Parameterization Scheme over CORDEX East Asia Domain显示文摘 | Zou Liwei Qian Yun Zhou Tianjun Yang Ben | 2014 | Journal of Climate2014，，20： | 1 |
| 10 | Compound behaviors in pheromone robotics 显示文摘 | YANG Tianjun ZUO Haibing | 2008 | Iron & Steel2008，43，1： | 1 |
| 11 | Summer Precipitation Frequency, Intensity, and Diurnal Cycle over China: A Comparison of Satellite Data with Rain Gauge Observations显示文摘 | Zhou Tianjun Yu Rucong Chen Haoming Dai Aiguo Pan Yang | 2008 | Journal of Climate2008，，16： | 1 |
| 12 | Constrained future brightening of solar radiation and its implication for China's solar power显示文摘As Earth's primary energy source,surface downward solar radiation(R_(s))determines the solar power potential and usage for climate change mitigation.Future projections of R_(s)based on climate models have large uncertainties that interfere with the efficient deployment of solar energy to achieve China's carbon-neutrality goal.Here we assess 24 models in the latest Coupled Model Inter comparison Project Phase 6 with historical observations in China and find systematic biases in simulating historical R_(s)values likely due to model biases in cloud cover and clear-sky radiation,resulting in largely uncertain projections for future changes in Based on emergent constraints,we obtain credible R_(s)with narrowed uncertainties by~56%in the mid-twenty-first century and show that the mean R_(s)change during 2050-2069 relative to 1995-2014 is 30%more brightening than the raw projections.Particularly in North China and Southeast China with higher power demand,the constrained projections present more significant brightening,highlighting the importance of considering the spatial changes in future R_(s)when locating new solar energy infrastructures. | Yanyi He Kun Yang Martin Wild Kaicun Wang Dan Tong Changkun Shao Tianjun Zhou | 2023 | National Science Review2023，10，1： | 1 |
| 13 | Distinct Principal Modes of Early and Late Summer Rainfall Anomalies in East Asia*显示文摘 | Wang Bin Liu Jian Yang Jing Zhou Tianjun Wu Zhiwei | 2009 | Journal of Climate2009，，13： | 1 |
| 14 | KINETICS OF CARBON OXIDATION IN CARBON-BEARING REFRACTORIES显示文摘KINETICSOFCARBONOXIDATIONINCARBONBEARINGREFRACTORIES①LuoXingyuan,QiaoZhiyu,YangTianjunDepartmentofPhysicalChemistry,Universi... | Luo, Xingyuan Qiao, Zhiyu Yang, Tianjun | 1997 | 中国有色金属学会会刊:英文版1997，7，2： | 1 |
| 15 | MicroRNA-26a regulates tumorigenic properties of EZH2 in human lung carcinoma cells显示文摘 | Xiaomin Dang Aiqun Ma Lan Yang Hao Hu Bo Zhu Dong Shang Tianjun Chen Yu Luo | 2012 | Cancer Genetics2012，，3： | 1 |
| 16 | Interdecadal Changes in the Major Modes of Asian-Australian Monsoon Variability: Strengthening Relationship with ENSO since the Late 1970s 显示文摘 | Wang Bin Yang Jing Zhou Tianjun | 2008 | Journal of Climate2008，21，8： | 1 |
| 17 | Tempera- ture Field of Lining and Cooling Apparatus显示文摘 | Cheng Shusen Xue Qingguo Yang Tianjun et ai | 2000 | Journal of U- niversity of Science and Technology Beijing2000，7，1： | 1 |
| 18 | G-quadruplex DNA aptamers generated for systemin显示文摘 | Tao Bing Tianjun Chang Xiaojuan Yang Hongcheng Mei Xiangjun Liu Dihua Shangguan | 2011 | Bioorganic & Medicinal Chemistry2011，，14： | 1 |
| 19 | Summer Precipitation Frequency, Intensity, and Diurnal Cycle over China: A Comparison of Satellite Data with Rain Gauge Observations显示文摘 | Zhou Tianjun Yu Rucong Chen Haoming Dai Aiguo Pan Yang | 2008 | Journal of Climate2008，，16： | 1 |
| 20 | Application of artificial neural network model to predict silicon content of blast furnace hot metal显示文摘 | ]Yao Bin Yang Tianjun | 2000 | Asia steel international conference2000，，： | 1 |
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