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| 1 | Mapping the hotspots and coldspots of ecosystem services in conservation priority setting显示文摘空间明确地热点和 coldspots 印射是在将保存放为生态系统服务(ES ) 的优先级的一个重要连接。然而,很少研究都没识别并且测试了他们的 ES 热点和 coldspots 的紧密和效率,它可以削弱生态的保存的有效性。在这学习,基于 RUSLE 模型和 Getis-Ord 官方补给 * 统计,我们确定了年度土壤保存服务(SC ) 的变化并且从 2000 ~ 2013 在中国的 Shaanxi 省识别了统计上重要的热点和 coldspots。结果显示那, 1 ) 有高 SC 的区域也介绍了一个显著地增加的趋势,当有低 SC 的区域仅仅稍微变化了时;2 ) SC 热点和 coldspots 证明热点主要是的明显的空间 differentiationthe 空间地在南部的 Shaanxi 聚集了,当 coldspots 主要在 Guanzhong 盆和沙多风的高原被散布时;并且 3 ) 识别热点有提供 SC 的最高的能力,与提供的 29.6% 全部的区域, 59.7% 总数满足。相反, coldspots 占据了 46.3% 全部的区域,但是仅仅提供了 17.2% 全部的 SC。除了保存单个 ES, Getis-Ord 官方补给 * 统计方法能也帮助为保存多重 ES 和生物多样性识别多功能的优先级区域。 | LI Yingjie ZHANG Liwei YAN Junping WANG Pengtao HU Ningke CHENG Wei FU Bojie | 2017 | Journal of Geographical Sciences2017，27，6： | 19 |
| 2 | Symmetry and tendency judgment of Ms≥8. 0 strong earthquakes in Chile显示文摘The Ms≥8. 0 strong earthquakes occurring in Chile since 1800 were analyzed using the ternary,quaternary,and quinary commensurability methods and the butterfly structure diagram,and it was believed that the earthquake signal in Chile in 2014 is relatively strong,a large earthquake is likely to occur in Chile in2014. An analysis of spatial epicenter migrations showed that the longitudinal and latitudinal epicenter migrations have symmetry and synchronism,and there were five obvious northward migrations and four southward migrations. The symmetry axis of the longitudinal migrations is at about 71. 7°W and that of the latitudinal migrations is at about 30°S; these spatial symmetry axes are located at the subduction zone on the western margin of South America,where two major plates( the Nazca Plate and the South American Plate) converge. | Jin Junfang Yin Shuyan Yan Junping | 2014 | Geodesy and Geodynamics2014，5，1： | 12 |
| 3 | Developing a bacteriophage cocktail for biocontrol of potato bacterial wilt显示文摘Bacterial wilt is a devastating disease of potato and can cause an 80% production loss. To control wilt using bacteriophage therapy, we isolated and characterized twelve lytic bacteriophages from different water sources in Kenya and China. Based on the lytic curves of the phages with the pathogen Ralstonia solanacearum, one optimal bacteriophage cocktail, P1, containing six phage isolations was formulated and used for studying wilt prevention and treatment efficiency in potato plants growing in pots. The preliminary tests showed that the phage cocktail was very effective in preventing potato bacterial wilt by injection of the phages into the plants or decontamination of sterilized soil spiked with R. solanacearum. Eighty percent of potato plants could be protected from the bacterial wilt(caused by R. solanacearum reference strain GIM1.74 and field isolates), and the P1 cocktail could kill 98% of live bacteria spiked in the sterilized soil at one week after spraying.However, the treatment efficiencies of P1 depended on the timing of application of the phages, the susceptibility of the plants to the bacterial wilt, as well as the virulence of the bacteria infected,suggesting that it is important to apply the phage therapy as soon as possible once there are early signs of the bacterial wilt. These results provide the basis for the development of bacteriophagebased biocontrol of potato bacterial wilt as an alternative to the use of antibiotics. | Cuihua Wei Junli Liu Alice Nyarnbura Maina Francis B Mwaura Junping Yu Chenghui Yan Ruofang Zhang Hongping Wei | 2017 | Virologica Sinica2017，32，6： | 8 |
| 4 | Overview of advances in improving uniformity and water use efficiency of sprinkler irrigation显示文摘Water is the scarcest resource and the importance of the judicious use of water in the agricultural sector for sustaining agricultural growth and the retardation of environmental degradation needs no further elaboration.The successes of using sprinkler irrigation to develop new lands,point the way forward to a much greater role for the development of future land reclamation projects.Water use efficiency through a proper improvement of water management techniques and other production factors are essential to boost on-farm productivity.Various factors affecting uniformity and water use efficiency in sprinkler irrigation have been outlined in this research,highlighting possible ways to improve such essential parameters in crop production.The study emphasizes on an irrigation system that works adequately in applying water to stay within the root zone,making the water always available in sufficient quantities to meet the crop water needs.It suggests practical ways of managing irrigation systems within tolerable limits not neglecting the effects of wind which is a major contributing factor to non uniformity in sprinkler irrigation. | Ransford Opoku Darko Yuan Shouqi Liu Junping Yan Haofang Zhu Xingye | 2017 | International Journal of Agricultural and Biological Engineering2017，10，2： | 8 |
| 5 | Surface free energy of copper-zinc alloy for energy-saving of boiler显示文摘Cu-Zn, Cu-Zn-Sn, Cu-Zn-Ni alloys were melted by vacuum smelter. The effect factors to the surface free energy of the alloys such as chemical composition, crystal structure and surface crystal lattice distortion etc. were investigated by OCA30 automatic contact angle test instrument, metallography microscope and XRD instrument etc. Results suggests: adding alloy element to Cu may increase its surface free energy, and the more kinds of alloy elements are added, the more surface free energy increases; the alloy element Sn an increase the surface free energy of Cu-Zn alloy; Cu-Zn alloy with fir-tree crystal structure, great phase discrepancy and obvious composition aliquation has greater surface free energy; Cu-Zn alloy with compounds and serious surface crystal lattice distortion has greater surface free energy. | WANG Man LIANG Jinsheng TANG Qingguo MING Xing MENG Junping DING Yan | 2006 | Rare Metals2006，25，z1： | 6 |
| 6 | Complete genome analysis of Ketogulonigenium sp. WB0104显示文摘Ketogulonigenium sp. may convert L-sorbose into 2-keto-L-gulonic acid, the vitamin C precursor. The genome of Ketogulonigenium sp. WB0104 consists of a circular 2765030 bp chromo- some with 61.69% G+C content and two circular plasmids of 267968 and 242707 bp. The genome contains 2727 open reading frames (ORFs). The systems of replication, transcription, translation, carbohydrate and energy metabolism are intact, but the repair system is incomplete. About 640 predicted ORFs have been found to encode transporter pro- teins, which account for about one fourth of total predicted ORFs, noticeably higher than other docu- mented bacteria. This may be due to the fact that WB0104 adapts to soil circumstance. | YANG Fan JIA Qian XIONG Zhaohui ZHANG Xiaobing WU Hongtao ZHAO Ying YANG Jian ZHU Junping DONG Jie XUE Ying SUN Lilian SHEN Yan JIN Qi | 2006 | Chinese Science Bulletin2006，51，8： | 6 |
| 7 | DC-CIK联合化疗治疗非小细胞肺癌的临床疗效评价(英文)显示文摘Objective: The aim of the study was to evaluate the safety and therapeutic effects of autologous dendritic cells co-cultured with cytokine-induced killer cells (DC-CIK) combined with chemotherapy in advanced non-small cell lung cancer (NSCLC) patients. Methods: Fifty patients with advanced NSCLC (stages III to IV), who had received therapies in our Center (Department of Biotherapy, Affiliated to Cancer Hospital of Shanxi Medical University, Taiyuan, China) from August 2008 to January 2010, were treated by DC-CIK + chemotherapy as the combined treatment group; fifty advanced NSCLC patients treated with chemotherapy at the same time served as controls. The immunologic function, short-term therapeutic effects, the 1-year survival rate, the life quality, the chemotherapy side effects were compared between the two groups, the safety and therapeutic effects of DC-CIK cells therapy were observed too. Results: There was no obvious change of subsets of T cells in peripheral blood before and after therapy in DC-CIK + chemotherapy group, and IFN-γ was improved after therapy in this group (P < 0.05); in chemotherapy alone group, the ratios of CD3+CD4+, CD3+CD8+, CD3-CD56+ cells and the secretion of IL-2, TNF-α decreased significantly after therapy (P < 0.05); the ratios of CD3+CD8+, CD3+CD56+ were improved after cell culture (P < 0.05). The disease control rate (DCR) of DC-CIK + chemotherapy group was higher than that in the chemotherapy alone group (78.0% vs 56.0%, P < 0.05); the 1-year survival rates of DC-CIK + chemotherapy group and chemotherapy alone group were 50% and 44% respectively, had no significant difference. Compared with chemotherapy alone group, the occurrence of chemotherapy side effects (including bone marrow suppression, nausea and vomiting, peripheral nerve toxicity) was less in the DC-CIK + chemotherapy group (P < 0.05). The physical and appetite were better in DC-CIK + chemotherapy group after therapy. Conclusion: To compare with simple chemotherapy, DC-CIK + chemotherapy for advanced NSCLC is safe and effective, and it can improve patients' life quality and remission rate, and prolong their survival time. | Junping Zhang Guanghua Mao Yaping Han Xiaoling Yang Huijing Feng Linzi Jia Ting Zhi Yan Xiao Libin Zhang Jiangtao Wang Tianliang Shi | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，2： | 3 |
| 8 | Substrate-bound structure of the E. coil multidrug resistance transporter MdfA显示文摘 | Jie Heng Yan Zhao Ming Liu Yue Liu Junping Fan Xianping Wang Yongfang Zhao Xuejun C Zhang | 2015 | Cell Research2015，25，9： | 2 |
| 9 | Comprehensive two-dimensional HepG2/cell membrane chromatography/monolithic column/time-of-flight mass spectrometry system for screening anti-tumor components from herbal medicines显示文摘 | Xiaofei Chen Yan Cao Diya Lv Zhenyu Zhu Junping Zhang Yifeng Chai | 2012 | Journal of Chromatography A2012，，： | 1 |
| 10 | The development of the model and arithmetic for the fully distributed fiber optic sensor based on Raman optical-fiber frequency-domain reflectometry显示文摘 | GENG Junping XU Jiadong LI Yan | 2002 | Sensors and Actuaors2002，101，： | 1 |
| 11 | The development of model and arithmetic for the full distributed fiber optical sensor based on Raman optical-fiber frequency-domain reflectometry显示文摘 | Geng Junping Xu Jiadong Li Yan | 2002 | Sensors and Actuators A2002，101，： | 1 |
| 12 | The regulation of hematopoietic stem cell fate in the context of radiation显示文摘Hematopoietic system is one of the main target organs of irradiation injury.Exposure to radiation can cause acute myelosuppression and long-term hematopoietic injury due to the direct and indirect damage of hematopoietic stem cells(HSCs)that can self-renew and differentiate into all types of blood cells.So far,many factors in the modulation of HSC biology at steady status have been revealed,while how to orchestrate HSCs in the context of radiation has not been well established.Recently,an increasing number of studies focus on the underlying mechanisms involved in regulating HSC fate after radiation exposure by affecting DNA damage response(DDR),including DNA-damage repair,cell-cycle arrest,apoptosis and senescence,or bone marrow(BM)microenvironment.In this review,we summarize recent findings on intrinsic and extrinsic factors in the regulation of HSC fate after radiation exposure,which may further deepen our understanding of the radioprotection of HSCs. | Yukai Lu Mengjia Hu Zihao Zhang Yan Qi Junping Wang | 2020 | Radiation Medicine and Protection2020，1，1： | 1 |
| 13 | A novel radiomics signature based on T2-weighted imaging accurately predicts hepatic inflammation in individuals with biopsy-proven nonalcoholic fatty liver disease:a derivation and independent validation study显示文摘Background:Currently,there are no effective methods for assessing hepatic inflammation without resorting to histological examination of liver tissue obtained by biopsy.T2-weighted images(T2WI)are routinely obtained from liver magnetic resonance imaging(MRI)scan sequences.We aimed to establish a radiomics signature based on T2WI(T2-RS)for assessment of hepatic inflammation in people with nonalcoholic fatty liver disease(NAFLD).Methods:A total of 203 individuals with biopsy-confirmed NAFLD from two independent Chinese cohorts with liver MRI examination were enrolled in this study.The hepatic inflammatory activity score(IAS)was calculated by the unweighted sum of the histologic scores for lobular inflammation and ballooning.One thousand and thirty-two radiomics features were extracted from the localized region of interest(ROI)in the right liver lobe of T2WI and,subsequently,selected by minimum redundancy maximum relevance and least absolute shrinkage and selection operator(LASSO)methods.The T2-RS was calculated by adding the selected features weighted by their coefficients.Results:Eighteen radiomics features from Laplacian of Gaussian,wavelet,and original images were selected for establishing T2-RS.The T2-RS value differed significantly between groups with increasing grades of hepatic inflammation(P<0.01).The T2-RS yielded an area under the receiver operating characteristic(ROC)curve(AUROC)of 0.80[95%confidence interval(CI):0.71-0.89]for predicting hepatic inflammation in the training cohort with excellent calibration.The AUROCs of T2-RS in the internal cohort and external validation cohorts were 0.77(0.61-0.93)and 0.75(0.63-0.84),respectively.Conclusions:The T2-RS derived from radiomics analysis of T2WI shows promising utility for predicting hepatic inflammation in individuals with NAFLD. | Zhong-Wei Chen Huan-Ming Xiao Xinjian Ye Kun Liu Rafael S.Rios Kenneth I.Zheng Yi Jin Giovanni Targher Christopher D.Byrne Junping Shi Zhihan Yan Xiao-Ling Chi Ming-Hua Zheng | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 1 |
| 14 | Type2d Iabetesandsyndromecharacter Ist Icsof显示文摘 | Wei Junp Ing Zhou LIbo LIu Fang Zhong Zhen LIu Ya jun Cao A Im ei Wang XIu zhi Zhu Yan Yu Bo LIu XIa Zhang Yanni To ng XIaol In | | 0，，12： | 1 |
| 15 | Calibration and validation of AquaCrop for deficit and full irrigation of tomato显示文摘The objective of this study was to calibrate and test AquaCrop for tomato(Lycopersicon esculentum)grown under deficit and full irrigation.Two field experiments were carried out in the tropical humid coastal savanna zone in Mfantseman district of the Central Region of Ghana.Data from the first experiment were used to calibrate the model while data obtained from the second experiment were used to validate the model.The calibrated AquaCrop model concentrated on its performance to predict crop yield and seasonal crop water requirement(ETc).Four treatments were investigated:T1(no irrigation after plant establishment),T2(50%ETc restoration),T3(100%ETc restoration up to beginning of flowering,then 50%ETc restoration)and T4(100%ETc restoration).The results revealed that AquaCrop was able to simulate the yield of tomato for T2-T4 with the exception of Treatment T1 which was simulated with the highest deviation of 45.1%.On the other hand,the model was able to simulate the seasonal water requirements to an appreciable degree in both experiments.It must be pointed out that the calibration of AquaCrop suffered from a lack of data on the progress of crop canopy cover which is a very important parameter used in developing the model. | Ransford Opoku Darko Yuan Shouqi Yan Haofang Liu Junping Agnes Abbey | 2016 | International Journal of Agricultural and Biological Engineering2016，9，3： | 1 |
| 16 | Modified graphite filled natural rubber composites with good thermal conductivity显示文摘The rubber composites with good thermal conductivity contribute to heat dissipation of tires. Graphite filled natural rubber composites were developed in this study to provide good thermal conductivity. Graphite was coated with polyacrylate polymerized by monomers including methyl methacrylate, n-butyl acrylate and acrylic acid. The ratios between a filler and acrylate polymerization emulsion and those between monomers were varied. Eight types of surface modification formulas were experimentally investigated. Modification formula can affect coating results and composite properties greatly. The best coating type was achieved by a ratio of1:1 between methyl methacrylate and n-butyl acrylate. The coating of graphite was thermally stable in a running tire. Filled with modified graphite, the tire thermal conductivity reached up to 0.517–0.569 W·m-1·K-1. In addition, the mechanical performance was improved with increased crosslink density, extended scorch time and short vulcanization time. | Junping Song Lianxiang Ma Yan He Haiquan Yan Zan Wu Wei Li | 2015 | Chinese Journal of Chemical Engineering2015，23，5： | 1 |
| 17 | Effects of mineral tourmaline particles on photocatalytic activities of RE/TiO2 composite thin films 显示文摘 | MENG Junping LIANG Jinsheng DING Yan | 2004 | J Rare Earth2004，22，2： | 1 |
| 18 | Immune‑Ageing Evaluation of Peripheral T and NK Lymphocyte Subsets in Chinese Healthy Adults显示文摘Ageing is often accompanied with a decline in immune system function,resulting in immune ageing.Numerous studies have focussed on the changes in different lymphocyte subsets in diseases and immunosenescence.The change in immune phenotype is a key indication of the diseased or healthy status.However,the changes in lymphocyte number and phenotype brought about by ageing have not been comprehensively analysed.Here,we analysed T and natural killer(NK)cell subsets,the phenotype and cell differentiation states in 43,096 healthy individuals,aged 20–88 years,without known diseases.Thirty-six immune parameters were analysed and the reference ranges of these subsets were established in different age groups divided into 5-year intervals.The data were subjected to random forest machine learning for immune-ageing modelling and confirmed using the neural network analysis.Our initial analysis and machine modelling prediction showed that na.ve T cells decreased with ageing,whereas central memory T cells(Tcm)and effector memory T cells(Tem)increased cluster of differentiation(CD)28-associated T cells.This is the largest study to investigate the correlation between age and immune cell function in a Chinese population,and provides insightful differences,suggesting that healthy adults might be considerably influenced by age and sex.The age of a person's immune system might be different from their chronological age.Our immune-ageing modelling study is one of the largest studies to provide insights into‘immune-age’rather than‘biological-age’.Through machine learning,we identified immune factors influencing the most through ageing and built a model for immune-ageing prediction.Our research not only reveals the impact of age on immune parameter differences within the Chinese population,but also provides new insights for monitoring and preventing some diseases in clinical practice. | Zhenghu Jia Zhiyao Ren Dongmei Ye Jiawei Li Yan Xu Hui Liu Ziyu Meng Chengmao Yang Xiaqi Chen Xinru Mao Xueli Luo Zhe Yang Lina Ma Anyi Deng Yafang Li Bingyu Han Junping Wei Chongcheng Huang Zheng Xiang Guobing Chen Peiling Li Juan Ouyang Peisong Chen Oscar Junhong Luo Yifang Gao Zhinan Yin | 2023 | Phenomics2023，3，4： | 1 |
| 19 | Effects of mineral tourmaline particles on photocatalytic activities of RE/TiO2 composite thin films显示文摘 | MENG Junping LIANG Jinsheng DING Yan | 2004 | J Rare Earth2004，22，2： | 1 |
| 20 | Engineered macrophage-biomimetic versatile nanoantidotes for inflammation-targeted therapy against Alzheimer’s disease by neurotoxin neutralization and immune recognition suppression显示文摘Immune recognition of excessive neurotoxins by microglia is a trigger for the onset of neuroinflammation in the brain,leading to neurodegeneration in Alzheimer’s disease(AD).Blocking active recognition of microglia while removing neurotoxins holds promise for fundamentally alleviating neurotoxin-induced immune responses,but is very challenging.Herein,an engineered macrophage-biomimetic versatile nanoantidote(OT-Lipo@M)is developed for inflammation-targeted therapy against AD by neurotoxin neutralization and immune recognition suppression.Coating macrophage membranes can not only endow OT-Lipo@M with anti-phagocytic and inflammation-tropism capabilities to target inflammatory lesions in AD brain,but also efficiently reduce neurotoxin levels to prevent them from activating microglia.The loaded oxytocin(OT)can be slowly released to downregulate the expression of immune recognition site Toll-like receptor 4(TLR4)on microglia,inhibiting TLR4-mediated pro-inflammatory signalling cascade.Benefiting from this two-pronged immunosuppressive strategy,OT-Lipo@M exhibits outstanding therapeutic effects on ameliorating cognitive deficits,inhibiting neuronal apoptosis,and enhancing synaptic plasticity in AD mice,accompanied by the delayed hippocampal atrophy and brain microstructural disruption by in vivo 9.4T MR imaging.This work provides new insights into potential AD therapeutics targeting microglia-mediated neuroinflammation at the source. | Meng Cheng Caihua Ye Chunxiao Tian Dongju Zhao Haonan Li Zuhao Sun Yuyang Miao Qiang Zhang Junping Wang Yan Dou | 2023 | Bioactive Materials2023，，8： | 1 |
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