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| 1 | Galectin-3-centered paracrine network mediates cardiac inflammation and fibrosis upon β-adrenergic insult显示文摘Rapid over-activation of β-adrenergic receptors (β-AR) following acute stress initiates cardiac inflammation and injury by activating interleukin-18 (IL-18),however,the process of inflammation cascades has not been fully illustrated.The present study aimed to determine the mechanisms of cardiac inflammatory amplification following acute sympathetic activation.With bioinformatics analysis,galectin-3 was identified as a potential key downstream effector of β-AR and IL-18 activation.The serum level of galectin-3 was positively correlated with norepinephrine or IL-18 in patients with chest pain.In the heart of mice treated with β-AR agonist isoproterenol (ISO,5 mg kg^(-1)),galectin-3 expression was upregulated markedly later than IL-18 activation,and Nlrp3^(-/-)and Il18^(-/-)mice did not show ISO-induced galectin-3 upregulation.It was further revealed that cardiomyocyte-derived IL-18 induced galectin-3 expression in macrophages following ISO treatment.Moreover,galectin-3deficiency suppressed ISO-induced cardiac inflammation and fibrosis without blocking ISO-induced IL-18 increase.Treatment with a galectin-3 inhibitor,but not a β-blocker,one day after ISO treatment effectively attenuated cardiac inflammation and injury.In conclusion,galectin-3 is upregulated to exaggerate cardiac inflammation and injury following acute β-AR activation,a galectin-3 inhibitor effectively blocks cardiac injury one day after β-AR insult. | Guomin Hu Jimin Wu Huijun Gu Xiangning Deng Wenli Xu Shan Feng Shuaixing Wang Yao Song Zhengda Pang Xiuling Deng Aleksandr E.Vendrov Nageswara R.Madamanchi Marschall S.Runge Xinyu Wang Youyi Zhang Han Xiao Erdan Dong | 2023 | Science China(Life Sciences)2023，66，5： | 3 |
| 2 | Target-triggered inhibiting oxidase-mimicking activity of platinum nanoparticles for ultrasensitive colorimetric detection of silver ion显示文摘The development of efficient methods for the detection of hazardous and toxic elements is extremely important for environmental security and public health. In this work, we developed a facile colorimetric assaying system for Ag+ detection in aqueous solution. Chitosan-stabilized platinum nanoparticles(ChPtNPs) were synthesized and severed as an artificial oxidase to catalyze the oxidation of the substrate3,30,5,50-tetramethylbenzidine(TMB) and generate color signal. In the presence of Ag+, due to the strong metallophilic interactions between Ag+ and Pt2+ on the surface of Ch-PtNPs, Ag+ can weaken the affinity to the substrates and inactivate the catalytic activity of Ch-PtNPs, leading to decreased absorbance signal to varying degrees depending on Ag+ amount. Combing the specific binding between Ch-PtNPs and Ag+ with signal amplification procedure based on the Ch-PtNPs-catalyzed TMB oxidation, a sensitive,selective, simple, cost-effective, and rapid detection method for Ag+ can be realized. Ag+ ions in tap and lake waters have been successfully detected. We ensured that the proposed method can be a potential alternative for Ag+ determination in environmental samples. | Haohua Deng Shaobin He Xiuling Lin Lu Yang Zhen Lin Ruiting Chen Huaping Peng Wei Chen | 2019 | Chinese Chemical Letters2019，30，9： | 3 |
| 3 | Study on the hydrogenation coupling of methane显示文摘 | Bin Dai Xiuling Zhang Lin Zhang Weimin Gong Ren He Wenqi Lu Xinlu Deng | 2001 | Science in China Series B: Chemistry2001，，2： | 1 |
| 4 | The epidemic status and genetic diversity of 14 highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) isolates from China in 2009显示文摘 | Zhi Zhou Jianqiang Ni Zhen Cao Xue Han Yingju Xia Zhanchao Zi Kun Ning Qi Liu Lin Cai Peng Qiu Xiaoyu Deng Dongmei Hu Qian Zhang Yunfeng Fan Jiajun Wu Lilin Wang Miaojie Zhang Xiuling Yu Xinyan Zhai Kegong Tian | 2011 | Veterinary Microbiology2011，，3： | 1 |
| 5 | Comparison of alpha1-adrenergic receptor cell-membrane stationary phases prepared from expressed cell line and from rabbit hepatocytes显示文摘 | Yu Wang Bingxiang Yuan Xiuling Deng Langchong He Sicen Wang Youyi Zhang Qide Han | 2006 | Analytical and Bioanalytical Chemistry (-)2006，，7： | 1 |
| 6 | Comparison of alpha1-adrenergic receptor cell-membrane stationary phases prepared from expressed cell line and from rabbit hepatocytes显示文摘 | Yu Wang Bingxiang Yuan Xiuling Deng Langchong He Sicen Wang Youyi Zhang Qide Han | 2006 | Analytical and Bioanalytical Chemistry (-)2006，，7： | 1 |
| 7 | Role of exercise training on insulin resistance and TNF-α in high-fat diet rats显示文摘This study investigated the effect of exercise training on insulin resistance and serum and adipose TNF-αin high-fat diet-induced insulin-resistant rats.Thirty male Wistar rats were randomly divided into two groups:normal control group(NC;n=8)that accepted normal chow and high-fat diet group(HF;n=22)that fed on high-fat diet to induce insulin resistance model.The HF group was randomly assigned to two subgroups after 18 weeks:sedentary group(SE;n=10)and exercise training group(ET;n=12)that performed swimming exercise training for 6 weeks,while both groups continued high-fat diet.Changes of body weight,lipid profile,and fasting plasma glucose and insulin were measured.The insulin sensitivity index(ISI)was calculated.Serum concentration of TNF-αwas detected by ELISA.The expression of TNF-αmRNA and protein in adipose tissue was examined by using real-timefluorescence quantitative polymerase chain reaction(PCR)and Western blot,respectively.After 18 weeks,compared with the NC group,body weight,blood lipid,glucose,and insulin in the HF group were significantly elevated,while the ISI decreased obviously,which suggested that insulin resistance appeared in the HF group.After exercise training for 6 weeks,compared with the SE group,both ISI and serum TNF-αconcentration in the ET group were decreased significantly;however,the expression levels of TNF-αmRNA and protein in adipose tissue increased by 27.5%and 20.5%,respectively.In conclusion,exercise training ameliorates insulin resis-tance.The reduction of the level of serum TNF-αand the increased expression of TNF-αin adipose tissue by exercise training may be involved in this mechanism. | Hui SUN Xiuling DENG Fangxi XIAO Lulu CHEN Huiqing LI | 2009 | Frontiers of Medicine2009，3，4： | 0 |
| 8 | 血压变化和空气污染微粒的化学成分显示文摘[背景]血压升高与颗粒物(PM)空气污染相关,但是与PM化学成分的关联尚不明确。[目的]通过对一组39名大学生进行460次反复访查,探讨血压与不同化学成分的细颗粒物(PM2.5)之间的关联。 | Shaowei Wu Furong Deng Jing Huang Hongyi Wang Masayuki Shima Xin Wang Yu Qin Chanjuan Zheng Hongying Wei Yu Hao Haibo Lv Xiuling Lu Xinbiao Guo | 2013 | 环境与职业医学2013，30，4： | 0 |
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