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| 1 | Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty显示文摘在维生素 D 缺乏和自发的中央早熟的发身(ICPP ) 之间的关系最近被记录了。在这研究, 280 个女孩与 ICPP 诊断了,类似的年龄的 188 个正常发身控制女孩被注册并且回顾地学习了。有的 ICPP 组显著地降低浆液 25-hydroxyvitamin D (25 [哦] D ) 层次比控制组。而且,一种非线性的关系在浆液 25 之间被发现[哦] D 和 ICPP,和为浆液 25 的一个截止的点[哦] D 有或没有调整不同惊讶因素为 ICPP 在 31.8 ng/ml 被发现。有浆液 25 的女孩[哦] D31.8 ng/ml 有更低的机会比率(unadjusted:或 0.36, 95% CI 0.15 到 0.83, P < 0.05;调整的高度和重量:或 0.44, 95% CI 0.18 到 1.08, P = 0.072;BMI 调整了:或 0.36, 95% CI 0.16 到 0.84, P < 0.05 ) 。有 25 的 ICPP 题目[哦] D 缺乏从二另外的亚群比这些题目有一个更高的身体团索引(BMI ) 。关联分析证明那维生素 D 水平在 ICPP 组与 BMI 和一些新陈代谢的参数被相关。我们的学习建议那维生素 D 地位可以与 ICPP 风险被联系并且可以在 ICPP 上有阀值效果。 | Yue Zhao Wenjun Long Caiqi Du Huanhuan Yang Shimin Wu Qin Ning Xiaoping Luo | 2018 | Frontiers of Medicine2018，12，2： | 16 |
| 2 | Super stable CsPbBr3@SiO2 tumor imaging reagent by stress-response encapsulation显示文摘Great photoelectric properties can herald the high potentials of CsPbBr3 nanocrystals(NCs)to function as the fluorescent probes for early tumor diagnosis.However,the intrinsic water vulnerability of CsPbBr3 NCs highly restricts their biomedical applications.To conquer this challenge,we herein introduce a nature inspired'stress-response'method to tightly encapsulate CsPbBr3 into SiO2 nano-shells that can dramatically improve the water stability of CsPbBr3@SiO2 nanoparticles for over 48 h.We further highlighted the advantageous features of CsPbBr3@SiO2 by using them as the fluorescent probes for CT26 tumor cell imaging with their high water stability,biocompatibility,and low cytotoxicity.Our work for the first time exhibited the potential of lead halide perovskite NCs for tumor diagnosis,and can highly anticipate the further in vivo biomedical applications that light up live cells. | Wentao Song Yiming Wang Bing Wang Yingfang Yao Wenguang Wang Jinhui Wu Qing Shen Wenjun Luo Zhigang Zou | 2020 | Nano Research2020，13，3： | 7 |
| 3 | Estimation of the Type of Low Energy Discharge in GIS Adopting Characteristic Gas显示文摘In order to guarantee safe operations, low energy discharge within gas insulated switchgear (GIS) should be detected as soon as possible before they develop severely and cause final breakdown failures. This paper aims to present a GIS discharge diagnosis technique adopting gaseous decompositions. To reach this aim, needle-plate electrode and the sphere-plate electrode with metallic particles on the plate are designed to simulate two kinds of low energy discharge, namely, corona discharge and spark discharge, respectively. After sampling and analyzing the gases, different yields of gaseous by-products under different types of low energy discharge are obtained. Based on the decomposition mechanisms reported by previous researches and the experiment results, it can be concluded that S2OF10, SO2F2 , and SO2 can be used as the characteristic gas to identify low energy discharge; the increment of S2OF10 can indicate the occurrence of low energy discharges while the volume ratio between SO2F2 and SO2 can define the type of low energy discharge. | CHEN Jun LI Li YAO Weijian TANG Yang ZHENG Xiaoguang YU Jianhui LUO Yunbai ZHOU Wenjun | 2011 | Wuhan University Journal of Natural Sciences2011，16，4： | 7 |
| 4 | Three Cases of COVID-19 Variant Delta With and Without Vaccination——Chengdu City,Sichuan Province,April-May,2021显示文摘On April 26,2021,a 33-year-old male Chinese sailor returning from India via Kathmandu,Nepal,tested positive for the coronavirus disease 2019(COVID-19)by Chengdu Customs and was confirmed positive by Chengdu CDC(Case A).On May 2,2021,a housewife in the same flight tested positive for COVID-19 by Pengzhou CDC in Sichuan Province during her quarantine period and was confirmed positive by Chengdu CDC the next day(Case B). | Heng Chen Yi Mao Zhenhua Duan Liang Wang Yue Cheng Yingxue Dai Haixia Luo Wenjun Xie Shuangfeng Fan Yuzhen Zhou Jingpei Xu Lan Feng Liwen Hu Zhu Liu Xian Liang Liangshuang Jiang Xiaoli Tuo | 2021 | China CDC weekly2021，3，25： | 5 |
| 5 | Transcriptome-wide reprogramming of N^6-methyladenosine modification by the mouse microbiome显示文摘Dear Editor, Microbiome affects many aspects of human health and disease and elicits a wide range of host responses including remarkable epigenetic changes such as DNA methylation,histone modification and non-coding RNA expression.A still poorly explored area of microbiome-host interaction is the response of host RNA modification.N^6-methyladenosine (m^6A)is the most abundant mRNA modification in mammalian cells,occurring at -3 modified adenosine residues per transcript. | Xiaoyun Wang Yan Li Wenjun Chen Hailing Shi A.Murat Eren Aleksey Morozov Chuan He Guan-Zheng Luo Tao Pan | 2019 | Cell Research2019，29，2： | 4 |
| 6 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 7 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 8 | Substantial transition to clean household energy mix in rural China显示文摘The household energy mix has significant impacts on human health and climate,as it contributes greatly to many health-and climate-relevant air pollutants.Compared to the well-established urban energy statistical system,the rural household energy statistical system is incomplete and is often associated with high biases.Via a nationwide investigation,this study revealed high contributions to energy supply from coal and biomass fuels in the rural household energy sector,while electricity comprised∼20%.Stacking(the use of multiple sources of energy)is significant,and the average number of energy types was 2.8 per household.Compared to 2012,the consumption of biomass and coals in 2017 decreased by 45%and 12%,respectively,while the gas consumption amount increased by 204%.Increased gas and decreased coal consumptions were mainly in cooking,while decreased biomass was in both cooking(41%)and heating(59%).The time-sharing fraction of electricity and gases(E&G)for daily cooking grew,reaching 69%in 2017,but for space heating,traditional solid fuels were still dominant,with the national average shared fraction of E&G being only 20%.The non-uniform spatial distribution and the non-linear increase in the fraction of E&G indicated challenges to achieving universal access to modern cooking energy by 2030,particularly in less-developed rural and mountainous areas.In some non-typical heating zones,the increased share of E&G for heating was significant and largely driven by income growth,but in typical heating zones,the time-sharing fraction was<5%and was not significantly increased,except in areas with policy intervention.The intervention policy not only led to dramatic increases in the clean energy fraction for heating but also accelerated the clean cooking transition.Higher income,higher education,younger age,less energy/stove stacking and smaller family size positively impacted the clean energy transition. | Guofeng Shen Rui Xiong Yanlin Tian Zhihan Luo Bahabaike Jiangtulu Wenjun Meng Wei Du Jing Meng Yuanchen Chen Bing Xue Bin Wang Yonghong Duan Jia Duo Fenggui Fan Lei Huang Tianzhen Ju Fenggui Liu Shunxin Li Xianli Liu Yungui Li Mu Wang Ying Nan Bo Pan Yanfang Pan Lizhi Wang Eddy Zeng Chao Zhan Yilin Chen Huizhong Shen Hefa Cheng Shu Tao | 2022 | National Science Review2022，9，7： | 4 |
| 9 | Materials Experiment on Tiangong-2 Space Laboratory显示文摘During the China's Tiangong-2(TG-2) flight mission, the experiments of 18 kinds of material samples were conducted in space by using a Multiple Materials Processing Furnace(MMPF) mounted in the orbital module of the TG-2 space laboratory. After the experiments of 12 kinds of samples of the first and second batches were completed successfully, astronauts packed and brought them back to the ground by ShenzhouII spacecraft. By studying processing and formation on semiconductor and optoelectronics materials, metal alloys and metastable materials, functional single-crystal, micro-and nano-composite materials encapsulated in sample ampoules both in space and on Earth, we expect to explore some physical and chemical processes and mechanism of the materials formation that are normally obscured and therefore are difficult to study quantitatively on the ground due to the gravity-induced convection, to obtain the processing and synthesis technology for preparing high quality materials, and lead to the improvement and development of materials processing techniques on Earth, and also develop the experiment device and comprehensive ability for materials experiment in microgravity environment. This report briefly introduces the main points of each research work and preliminary comparative analysis results of 12 samples carried out by scientists undertaking research task. | LI Xiangyang LU Ye MENG Xiangjian WANG Jianlu WANG Reng CHEN Lidong HUA Zile LI Xiaoya SHI Jianlin LIU Jinfeng XU Guisheng WEI Bingbo XIE Wenjun YIN Zhigang ZHANG Xingwang JIANG Hongxiang LI Hong LUO Xinghong ZHANG Haifeng ZHAO Jiuzhou WANG Binbin PAN Mingxiang | 2018 | 空间科学学报2018，38，5： | 4 |
| 10 | Spirolindemers A and B,Lindenane Sesquiterpenoid Oligomers Equipped with Oxaspiro[4.5]decane from Chloranthus henryi显示文摘Spirolindemers A and B,unprecedented lindenane sesquiterpenoid dimer(1)and trimer(2)equipped with oxaspiro[4.5]decane unit,were discovered from the medicinal plant Chloranthus henryi.Their structures including absolute configurations were achieved by HRMS,NMR,ECD,X-ray diffraction analyses,and quantum chemical calculations.Biogenetically,hetero-and homo-Diels-Alder additions may dominate the formation of oxaspiro[4.5]decane and spiro[4.5]decane skeletons,respectively.Compound 1 showed anti-inflammatory activity by inhibiting the expression of iNOS and COX-2. | Jixin Li Jun Chi Pengfei Tang Yunpeng Sun Weijia Lu Wenjun Xu Yongyue Wang Jun Luo Lingyi Kong | 2022 | Chinese Journal of Chemistry2022，40，5： | 4 |
| 11 | Real-time dynamics of soliton triplets in fiber lasers显示文摘The evolution of soliton molecules emphasizes the complex soliton dynamics akin to matter molecules.Beyond the simplest soliton molecule-a soliton pair constituted by two bound pulses-soliton molecules with more constituents have more degrees of freedom because of the temporal pulse separations and relative phases.Here we detailedly characterize the transient dynamics of soliton triplets in fiber lasers by using the dispersive Fourier transform measurement.A particular form of leading,central,and tailing pulses is constructed to shed new light on more intriguing scenarios and fuel the molecular analogy.Especially the vibrating dynamics of the central and tailing pulses are captured near the regime of equally spaced soliton triplets,which is reminiscent of the recurrent timing jitters within multi-pulse structures.Further insights enable acess into a universal form of unequally spaced soliton triplets interpreted as 2+1 soliton molecules.Different binding strengths of intramo-lecular and intermolecular bonds are validated with respect to the diverse internal motions involved in this soliton triplet molcule.All these findings unveil the transient dynamics with more degrees of freedom as well as highlight the possible application for all-optical bit storage. | YIYANG LUO RAN XIA PERRY PING SHUM WENJUN NI YUSONG LIU HUY QUOC LAM QIZHEN SUN XIAHUI TANG LUMING ZHAO | 2020 | Photonics Research2020，8，6： | 3 |
| 12 | Controlling factors of Dengying Formation reservoirs in the central Sichuan paleo-uplift显示文摘Macroscopic and microscopic characteristics revealed that the Dengying Formation reservoir in the central Sichuan paleo-uplift belonged to the compound genetic reservoir of the mound-shoal facies and karst.Development of the reservoir was controlled by the mound-shoal facies,and dissolution-enlarged or added pores(vugs)due to superimposed karstification modification were favorable reservoir spaces.The karst of the Dengying Formation in Tongwan stage was the stratabound-weathered crust karst of the early diagenesis stage,the extensive superimposition of mound-shoal facies and regional karstification in the central Sichuan paleo-uplift area was the key to develop the large-scale continuous Dengying Formation reservoirs.Due to differences in the development degree of mound-shoal facies and in the intensity of karst modification,the reservoir development degree varied in different zones in the paleouplift area.The NS-extending zone on the western side of the Gaoshiti-Moxi area was the sweet spot for reservoir development.Effective identification of mound-shoal facies and fine depiction of karst landform was the key for reservoir prediction of the Dengying Formation to discovery the superimposed area of the mound-shoal facies and the karst monadnock-karst steep slope which similar to Moxi-Gaoshiti area. | Bing Luo Yaoming Yang Wenjun Luo Long Wen Wenzhi Wang Kang Chen | 2017 | Petroleum Research2017，2，1： | 3 |
| 13 | The self-assembled nanoparticle-based trimeric RBD mRNA vaccine elicits robust and durable protective immunity against SARS-CoV-2 in mice显示文摘As COVID-19 continues to spread rapidly worldwide and variants continue to emerge,the development and deployment of safe and effective vaccines are urgently needed.Here,we developed an mRNA vaccine based on the trimeric receptor-binding domain(RBD)of the SARS-CoV-2 spike(S)protein fused to ferritin-formed nanoparticles(TF-RBD).Compared to the trimeric form of the RBD mRNA vaccine(T-RBD),TF-RBD delivered intramuscularly elicited robust and durable humoral immunity as well as a Th 1-biased cellular response.After further challenge with live SARS-CoV-2,immunization with a two-shot low-dose regimen of TF-RBD provided adequate protection in hACE2-transduced mice.In addition,the mRNA template of TF-RBD was easily and quickly engineered into a variant vaccine to address SARS-CoV-2 mutations.The TF-RBD multivalent vaccine produced broad-spectrum neutralizing antibodies against Alpha(B.1.1.7)and Beta(B.1.351)variants.This mRNA vaccine based on the encoded self-assembled nanoparticle-based trimer RBD provides a referenee for the design of mRNA vaccines targeting SARS-CoV-2. | Wenqiang Sun Lihong He He Zhang Xiaodong Tian Zhihua Bai Lei Sun Limin Yang Xiaojuan Jia Yuhai Bi Tingrong Luo Gong Cheng Wenhui Fan Wenjun Liu Jing Li | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 3 |
| 14 | Ginsenoside Rb1 Reduces D-GalN/LPS-induced Acute Liver Injury by Regulating TLR4/NF-κB Signaling and NLRP3 Inflammasome显示文摘Background and Aims:The effect of ginsenoside Rb1 on D-galactosamine(D-GalN)/lipopolysaccharide(LPS)-induced acute liver injury(ALI)is unknown.The aim of this study was to evaluate the effect of ginsenoside Rb1 on ALI and its underlying mechanisms.Methods:Mice were pretreated with ginsenoside Rb1 by intraperitoneal injection for 3 days before D-GalN/LPS treatment,to induce ALI.The survival rate was monitored every hour for 24 h,and serum biochemical parameters,hepatic index and histopathological analysis were evaluated to measure the degree of liver injury.ELISA was used to detect oxidative stress and inflammatory cytokines in hepatic tissue and serum.Immunohistochemistry staining,RT-PCR and western blotting were performed to evaluate the expression of toll-like receptor 4(TLR4),nuclear factorkappa B(NF-κB),and NLR family,pyrin domain-containing 3 protein(NLRP3)in liver tissue and Kupffer cells(KCs).Results:Ginsenoside Rb1 improved survival with D-GalN/LPS-induced ALI by up to 80%,significantly ameliorated the increased alanine and aspartate transaminase,restored the hepatic pathological changes and reduced the levels of oxidative stress and inflammatory cytokines altered by D-GalN/LPS.Compared to the control group,the KCs were increased in the D-GalN/LPS groups but did not increase significantly with Rb1 pretreatment.D-GalN/LPS could upregulate while Rb1 pretreatment could downregulate the expression of interleukin(IL)-1β,IL-18,NLRP3,apoptosis associated specklike protein containing CARD(ASC)and caspase-1 in isolated KCs.Furthermore,ginsenoside Rb1 inhibited activation of the TLR4/NF-κB signaling pathway and NLRP3 inflammasome induced by D-GalN/LPS administration.Conclusions:Ginsenoside Rb1 protects mice against D-GalN/LPS-induced ALI by attenuating oxidative stress and the inflammatory response through the TLR4/NF-κB signaling pathway and NLRP3 inflammasome activation. | Yimei Liu Ninghua Liu Yujing Liu Hongyu He Zhe Luo Wenjun Liu Nan Song Minjie Ju | 2022 | Journal of Clinical and Translational Hepatology2022，10，3： | 2 |
| 15 | Asymmetrical Quantum Encryption Protocol Based on Quantum Search Algorithm显示文摘Quantum cryptography and quantum search algorithm are considered as two important research topics in quantum information science.An asymmetrical quantum encryption protocol based on the properties of quantum one-way function and quantum search algorithm is proposed.Depending on the no-cloning theorem and trapdoor one-way functions of the publickey,the eavesdropper cannot extract any private-information from the public-keys and the ciphertext.Introducing key-generation randomized logarithm to improve security of our proposed protocol,i.e.,one privatekey corresponds to an exponential number of public-keys.Using unitary operations and the single photon measurement,secret messages can be directly sent from the sender to the receiver.The security of the proposed protocol is proved that it is informationtheoretically secure.Furthermore,compared the symmetrical Quantum key distribution,the proposed protocol is not only efficient to reduce additional communication,but also easier to carry out in practice,because no entangled photons and complex operations are required. | LUO Wenjun LIU Guanli | 2014 | China Communications2014，11，9： | 2 |
| 16 | Surpassing electrocatalytic limit of earth-abundant Fe^(4+)embedded in N-doped graphene for(photo)electrocatalytic water oxidation显示文摘Developing highly active,cost-effective,and environmental friendly oxygen evolution reaction(OER)electrocatalysts facilitates various(photo)electrochemical processes.In this work,Fe3N nanoparticles encapsulated into N-doped graphene nanoshells(Fe_(3)N@NG)as OER electrocatalysts in alkaline media were reported.Both the experimental and theoretical comparison between Fe_(3) N@NG and Fe_(3)N/NG,specifically including in situ Mossbauer analyses,demonstrated that the NG nanoshells improved interfacial electron transfer process from Fe_(3)N to NG to form high-valence Fe^(4+)ions(Fe^(4+)@NG),thus modifying electronic properties of the outer NG shells and subsequently electron transfer from oxygen intermediate to NG nanoshells for OER catalytic process.Meanwhile,the NG nanoshells also protected Fe-based cores from forming OER inactive and insulated Fe_(2)O_(3),leading to high OER stability.As a result,the as-formed Fe^(4+)@NG shows one of the highest electrocatalytic efficiency among reported Fe-based OER electrocatalysts,which can as well highly improve the photoelectrochemical water oxidation when used as the cocatalysts for the Fe_(2)O_(3) nanoarray photoanode. | Wenjia Xue Feng Cheng Menglu Li Wenjian Hu Congping Wu Bing Wang Kuowei Liao ZhenTao Yu Yingfang Yao Wenjun Luo Zhigang Zou | 2021 | Journal of Energy Chemistry2021，30，3： | 2 |
| 17 | Bortezomib in combination with dexamethasone and subsequent thalidomide for newly-diagnosed multiple myeloma: A Chinese experience显示文摘 | Weiyan Zheng Guoqing Wei Xiujin Ye Jingsong He Li Li Wenjun Wu Jimin Shi Jie Zhang Weijia Huang Wanzhuo Xie Yi Luo Xingkui Xue Maofang Lin He Huang Zhen Cai | 2009 | Leukemia Research2009，，12： | 1 |
| 18 | Enhancement of the efficiency of dye-sensitized solar cell with muki-wall car- bon nanotubes/polythiophene composite counter electrodes prepared by electrodeposition显示文摘 | Luo Jun Niu Haijun Wu Wenjun | 2012 | Solid State Sci2012，14，1： | 1 |
| 19 | A dyefree photoeleetroehemieal solar cell based on BiVO4 with a long lifetime of photogenerated carriers 显示文摘 | Zhang Jiyuan Luo Wenjun Li Wei | 2012 | Electrochemistry Communications2012，22，： | 1 |
| 20 | Safety assessment of Cry1C protein from genetically modified rice according to the national standards of PR China for a new food resource显示文摘 | Sishuo Cao Xiaoyun He Wentao Xu Wenjun Ran Lixing Liang YunBo Luo Yanfang Yuan Nan Zhang Xin Zhou Kunlun Huang | 2010 | Regulatory Toxicology and Pharmacology2010，，3： | 1 |
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