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| 1 | The altered expression of inflammation-related microRNAs with microRNA-155 expression correlates with Th17 differentiation in patients with acute coronary syndrome显示文摘MicroRNAs(miRNAs)are a novel class of small,non-coding RNAs that play a significant role in both inflammatory and cardiovascular diseases.Immune cells,especially T helper(Th)cells,are critical in the development of atherosclerosis and the onset of acute coronary syndrome(ACS).To assess whether inflammation-related miRNAs(such as miR-155,146a,21,125a-5p,125b,31)are involved in the imbalance of Th cell subsets in patients with ACS,we measured the expression of related miRNAs in patients with acute myocardial infarction(AMI),unstable angina(UA),stable angina(SA)and chest pain syndrome(CPS);analyzed the relationship between miRNA expression and the frequency of Th cell subsets;and observed the co-expression of miR-155 and IL-17A in peripheral blood mononuclear cells(PBMCs)of patients with ACS.The results showed that the expression of miR-155 in the PBMCs of patients with ACS was decreased by approximately 60%,while the expression of both miR-21 and miR-146a was increased by approximately twofold.The expression patterns of miRNAs in plasma correlated with those in PBMCs,except for miR-21,which was increased by approximately sixfold in the AMI group and showed no significant difference between the UA group and the CPS group.We also found that the expression of miR-155 inversely correlated with the frequency of Th17 cells(r520.896,P,0.01)and that miR-155 was co-expressed with IL-17A in patients with ACS.In conclusion,our study revealed the expression patterns of inflammation-related miRNAs in patients with ACS and found that miR-155 may be associated with Th17 cell differentiation. | Rui Yao Yulan Ma Youyou Du Mengyang Liao Huanhuan Li Wei Liang Jing Yuan Zhijun Ma Xian Yu Hong Xiao Yuhua Liao | 2011 | Cellular & Molecular Immunology2011，8，6： | 32 |
| 2 | Geochemistry and regional distribution of ophiolites and associated volcanics in Mianlüe suture, Qinling-Dabie Mountains显示文摘Systematic studies of the ophiolites and associated volcanics stretching more than 1500 km from the Derni-Nanping-Pipasi-Kangxian area in the west to the Qingshuihe area of the south Dabie Mountains in the east indicate the existence of a suture zone (the Mianl黣 suture) and a vanished paleo-ocean basin (the Mianl黣 paleo-ocean basin) in the region. From west to east, ophiolitic mlange associations distribute discontinuously along the suture. Rock assem-blages include ophiolite, island arc and oceanic island rock series. The Mianl黣 paleo-ocean basin experienced its major formation and expending episode during the Carboniferous-Permian period. The finding of the suture zone and the paleo-ocean basin is tectonically significant in timing the collision between the North China-Qinling and Yangtze blocks and determining the formation and evolution of the Qinling orogenic belt. | LAI Shaocong, ZHANG Guowei, DONG Yunpeng, PEI Xianzhi & CHEN Liang Key Laboratory of Continental Dynamics, Ministry of Education and Department of Geology, Northwest University, Xian 710069, China | 2004 | Science China Earth Sciences2004，47，4： | 25 |
| 3 | Direct numerical simulation of compressible turbulent flows显示文摘This paper reviews the authors' recent studies on compressible turbulence by using direct numerical simulation (DNS),including DNS of isotropic(decaying) turbulence, turbulent mixing-layer,turbulent boundary-layer and shock/boundary-layer interaction.Turbulence statistics, compressibility effects,turbulent kinetic energy budget and coherent structures are studied based on the DNS data.The mechanism of sound source in turbulent flows is also analyzed. It shows that DNS is a powerful tool for the mechanistic study of compressible turbulence. | Xin-Liang Li De-Xun Fu Yan-Wen Ma Xian Liang | 2010 | Acta Mechanica Sinica2010，26，6： | 16 |
| 4 | Genome-wide identification and characterization of odorant-binding protein (OBP) genes in the malaria vector Anopheles sinensis (Diptera: Culicidae)显示文摘疟蚊属 sinensis 是主要疟疾向量。昆虫有气味的东西绑定蛋白质(OBP ) 可以在嗅觉的系统在有气味的东西的接收工作。分类和描述一。sinensis OBP 基因系统地没被学习。在这研究, 64 通常认为的 OBP 基因在整个染色体的水平被识别一。sinensis 基于在 OBP 之间的比较保存了主题, PBP_GOBP,和种系发生的分析与一。gambiae OBP。描述一。包括主题保存,基因结构, genomic 组织和分类, sinensis OBP 被调查。新基因, AsOBP73,属于 Plus-C 亚科,与抄本和保守主题的支持被识别。这些一。sinensis OBP 基因在亚科经典著作与 37, 15 和 12 基因被分类进三个亚科,不正常并且 Plus-C 分别地。genomic 组织一。sinensis OBP 越过九不同脚手架建议聚类的分布。八基因(OBP23-28, OBP63-64 ) 可能至少在疟蚊属,一种蚊虫和豹脚蚊的分叉前通过一系列历史性的复制事件从单个基因发源。microsynteny 分析显示很高的 synteny 在之间一。sinensis 并且一。gambiae OBP。更早在 Plus-C 下面分类在的 OBP70 和 OBP71 一。gambiae 作为属于经典亚科的组 Obp59a 被认出,并且更早在 Plus-C 下面分类的 OBP69 在这研究被移动了到不正常的亚科。学习在昆虫以及在为 OBP 基因的进一步的学习建立了一个基本信息框架一。sinensis。 | Xiu He Zheng-Bo He Yu-Juan Zhang Yong Zhou Peng-Jie Xian Liang Qiao Bin Chen | 2016 | Insect Science2016，23，3： | 16 |
| 5 | 非维生素K拮抗与维生素K拮抗口服抗凝剂与脑出血患者住院死亡之间的关系显示文摘尽管非维生素K拮抗口服抗凝剂(non-vitamin K antagonist oral anticoagulants, NOACs)越来越多地应用于预防血栓栓塞性疾病,但关于NOACs相关性脑出血的数据仍然有限。 | 刘青 叶鹏 Inohara T Xian Y Liang L Matsouaka RA Saver JL Smith EE Schwamm LH Reeves MJ Hernandez AF Bhatt DL Peterson ED Fonarow GC | 2018 | 中华高血压杂志2018，26，2： | 16 |
| 6 | Molecular mechanisms of apoptosis in hepatocellular carcinoma cells induced by ethanol extracts of Solanum lyratum Thumb through the mitochondrial pathway显示文摘AIM To explore the induction effects and mechanism of Solanum lyratum Thumb(ST) on human hepatocellularcarcinoma SMMC-7721 cells through the mitochondrial pathway.METHODS The experiments were conducted on three groups: an experimental group (with ST ethanol extracts' concentration being 2.5, 5 and 10 mg/L), a negative control group (with only nutrient solution, 0 mg/L ST ethanol extracts), and a positive control group (2.5 mg/L DDP). The inhibition rate of cell proliferation was checked by using the methyl thiazolyl tetrazolium method, and cell apoptosis was tested by TUNEL method. Furthermore, RT-PCR was used to examine m RNA expression of Fas, Fas L, caspase-8, caspase-3, p53 and Bcl-2 genes.RESULTS Compared with the negative control group, the inhibition and apoptosis rates of the experimental group with different concentrations of ST extracts on human hepatocellular carcinoma SMMC-7721 cells significantly increased(P<0.05). Besides, the m RNA expression of Fas L and Bcl-2 significantly decreased(P<0.05) while the m RNA expression of Fas, caspase-8, caspase-3 and p53 increased significantly. When compared with the positive control group, the experimental groups with 5 mg/L ST ethanol extracts showed effects similar to the positive control group.CONCLUSION ST ethanol extracts induced the apoptosis of hepatocellular carcinoma SMMC-7721 cells through up-regulated Fas, caspase-8, caspse-3 and p53, and down-regulated Fas L and Bcl-2 in the mitochondrial pathway. | Xiao-Qiang Mo Hong-Yu Wei Gan-Rong Huang Ling-Yuan Xu Yu-Li Chen Jiang Qi Wei Xian Yan-Chun Qin Lian-Deng Wei Li-Juan Zhao Yan-Qiang Huang Wei Xing Hong-Qin Pu Peng-Ya Wei Chao-Gan Li Qiu-Chun Liang | 2017 | World Journal of Gastroenterology2017，23，6： | 14 |
| 7 | Use of First-phase Insulin Secretion in Early Diagnosis of Thyroid Diabetes and Type 2 Diabetes Mellitus显示文摘 | Li-Heng Meng Yao Huang Jia Zhou Xing-Huan Liang Jing Xian Li Li Ying-Fen Qin | 2017 | Chinese Medical Journal2017，，7： | 12 |
| 8 | H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2显示文摘H5N1 流行性感冒病毒的感染在所有流行性感冒病毒之中引起最高的死亡。位于如此的高病毒的致病力下面的机制不完全地被理解。这里,我们报导 H5N1 流行性感冒病毒编码象 microRNA 一样小 RNA, miR-HA-3p,它从茎被处理由 Argonaute 2 的包含环的病毒的 RNA 先锋,和戏在在 H5N1 感染期间提高 cytokine 生产的一个角色。miR-HA-3p poly 指向的机械学的学习表演(rC ) 有约束力的蛋白质 2 (PCBP2 ) 并且压制它的表达式。与 PCBP2 being 一致 RIG-I/MAVS-mediated 抗病毒的天生的免疫的一个重要否定管理者,由 miR-HA-3p 的 PCBP2 表示的抑制在感染 H5N1 的人的巨噬细胞和老鼠支持 cytokine 生产病毒。我们断定 miR-HA-3p 是首先识别的流行性感冒编码病毒的象 microRNA 一样功能的 RNA 碎片和贡献导致 H5N1 的 cytokine 暴风雨和死亡的一个新奇毒力因素。 | Xihan Li Zheng Fu Hongwei Liang Yanbo Wang Xian Qi Meng Ding Xinlei Sun Zhen Zhou Ying Huang Hongwei Gu Limin Li Xi Chen Donghai Li Quan Zhao Fenyong Li Hua Wang Jin Wang Ke Zen Chen-Yu Zhang | 2018 | Cell Research2018，28，2： | 12 |
| 9 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 10 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 11 | Determination of Trace Elements in Edible Nuts in the Beijing Market by ICP-MS显示文摘Nuts have received increased attention from the public in recent years as important sources of some essential elements,and information on the levels of elements in edible nuts is useful to consumers.Determination of the elemental distributions in nuts is not only necessary in evaluating the total dietary intake of the essential elements,but also useful in detecting heavy metal contamination in food.The aim of this study was to determine the mineral contents in edible nuts。 | YIN Liang Liang TIAN Qing SHAO Xian Zhang KONG Xiang Yin JI Yan Qin | 2015 | Biomedical and Environmental Sciences2015，28，6： | 10 |
| 12 | Improved method for inducing chronic atrophic gastritis in mice显示文摘BACKGROUND Chronic atrophic gastritis(CAG)is a common disease of the digestive system with pathological characteristics of a decreasing number,or disappearance,of inherent glands of the gastric mucosa.CAG has been defined as a precancerous condition of gastric cancer.Intestinal metaplasia or intraepithelial neoplasia accompanying atrophied glands of the stomach is regarded as one of the most important precancerous lesions of gastric cancer.As a common malignant tumour,gastric cancer remains without a satisfactory therapy and its pathogenesis remains unclear,seriously threatening human life.Therefore,some scholars have proposed to prevent the incidence of gastric cancer by avoiding precancerous lesions.If CAG can be reversed,the incidence of gastric cancer can be substantially reduced.To reverse and prevent CAG and study its pathogenesis and therapy,it is necessary to develop an ideal,safe,stable,animal model.AIM To study a rapid,stable,and safe method of establishing a mouse model of human CAG.METHODS Six-week-old Kunming mice were divided into a phosphate buffered solution control group,a Helicobacter pylori(H.pylori)group,an N-methyl-N'-nitroguanidine(MNNG)group,an ammonia water group,and a group combining H.pylori,MNNG,and ammonia water(hereinafter referred to as the combined group).The mice were administrated with drinking water containing ammonia or infected with H.pylori through gavage.At the 30th,60th,90th,and 120th day after the last H.pylori infection,mice were selected randomly to collect their gastric mucosa for hematoxylin eosin staining,terminal nick-end labelling staining detection,and immunohistochemical staining for Bax and Bcl-2.In addition,H.pylori was isolated,cultured,and identified,and its extent of colonisation calculated.Blood was collected to detect inflammatory factors interleukin(IL)-1β,IL-8,and tumor necrosis factor(TNF)-αand immune function markers CD4 and CD8 to confirm successful establishment of the CAG model.RESULTS The combined group showed slight CAG at the 90th day and moderate CAG at the 120th day,while other groups did not show CAG at that time.CONCLUSION The combination of H.pylori,MNNG,and ammonia is an effective method of developing a mouse model of human CAG. | Xian Wei Xue-Ping Feng Lu-Yao Wang Yan-Qiang Huang Ling-Ling Liang Xiao-Qiang Mo Hong-Yu Wei | 2019 | World Journal of Gastrointestinal Oncology2019，11，12： | 10 |
| 13 | Effect of heparin on apoptosis in human nasopharyngeal carcinoma CNE2 cells显示文摘In order to study the mechanism of the effect of heparin on apoptosis in carcinoma cells, the nasopharyngeal carcinoma cell line CNE2 was used to identify the effect of heparin on apoptosis associated with the expression of c-myc, bax, bcl-2 proteins by use of Hoechst 33258 staining, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL), agarose gel electrophoresis, and flow cytometry, as well as Western blot analysis. The results showed that heparin induced apoptosis of CNE2 cells including the morphologic changes such as reduction in the volume, and the nuclear chromatin condensation, as well as the “ladder pattern” revealed by agarose gel electrophoresis of DNA in a concentration-dependent manner.The number of TUNEL-positive cells was dramatically increased to 33.6±1.2% from 2.8±0.3% by treat ment with heparin in different concentrations (10~40 kU/L). The apoptotic index was increased to 32.5% from 3.5% by detecting SubG1 peaks on flow cytometry. Western blot analysis showed that levels of bcl-2,bax and c-myc were significantly overexpressed by treatment with the increase of heparin concentrations.These results suggest that heparin induces apoptosis of CNE2 cells, which may be regulated by differential expression of apoptosis-related genes. | LI HONG LIANG , KAI HE YE , HAI WEI ZHANG , YING RU LUO , XIAN DA REN, AI HUA XIONG, RUI SITU Department of Pharmacology ,Pharmacy College, Department of Pathology Medical College, Jinan University, Guangzhou 510632, China | 2001 | Cell Research2001，11，4： | 9 |
| 14 | A Facile Synthetic Route to L-Phosphinothricin显示文摘A convenient and effective method for synthesis of L-phosphinothricin was described.The highlight was involved in a simple access to the key intermediate L-2-amino-4-chlorobutyricacid derivative from the inexpensive L-methionine. | Xue Song XU Han Bing TENG Guo Fu QIU Shu Cai LIANG Xian Ming HU | 2006 | Chinese Chemical Letters2006，17，2： | 9 |
| 15 | IGF-I induced phosphorylation of PTH receptor enhances osteoblast to osteocyte transition显示文摘Parathyroid hormone(PTH) regulates bone remodeling by activating PTH type 1 receptor(PTH1R) in osteoblasts/osteocytes. Insulinlike growth factor type 1(IGF-1) stimulates mesenchymal stem cell differentiation to osteoblasts. However, little is known about the signaling mechanisms that regulates the osteoblast-to-osteocyte transition. Here we report that PTH and IGF-I synergistically enhance osteoblast-to-osteocyte differentiation. We identified that a specific tyrosine residue, Y494, on the cytoplasmic domain of PTH1R can be phosphorylated by insulin-like growth factor type I receptor(IGF1R) in vitro. Phosphorylated PTH1R localized to the barbed ends of actin filaments and increased actin polymerization during morphological change of osteoblasts into osteocytes.Disruption of the phosphorylation site reduced actin polymerization and dendrite length. Mouse models with conditional ablation of PTH1R in osteoblasts demonstrated a reduction in the number of osteoctyes and dendrites per osteocyte, with complete overlap of PTH1R with phosphorylated-PTH1R positioning in osteocyte dendrites in wild-type mice. Thus, our findings reveal a novel signaling mechanism that enhances osteoblast-to-osteocyte transition by direct phosphorylation of PTH1R by IGF1R. | Tao Qiu Janet L.Crane Liang Xie Lingling Xian Hui Xie Xu Cao | 2018 | Bone Research2018，6，1： | 9 |
| 16 | Novel SNP of EPAS1 gene associated with higher hemoglobin concentration revealed the hypoxia adaptation of yak(Bos grunniens)显示文摘Endothelial PAS domain protein 1 gene(EPAS1) is a key transcription factor that activates the expression of oxygen-regulated genes. In this study, in order to better understand the effects of EPAS1 gene on hematologic parameters in yak, we firstly quantified the tissue expression patterns for EPAS1 m RNA of yak, identified polymorphism in this gene and evaluated its association with hematologic parameters. Expression of EPAS1 m RNA was detected in all eight tissues(heart, liver, lung, spleen, pancreas, kidney, muscles and ovary). The expressions of EPAS1 in lung and pancreas were extremely higher than other tissues examined. Three novel single nucleotide polymorphisms(SNPs)(g.83052 C>T, g.83065 G>A and g.83067 C>A) within the EPAS1 were identified and genotyped in Pali(PL), Gannan(GN) and Tianzhu White(TZW) yak breeds. Significant higher frequencies of the AA and GA genotypes and A allele of the g.83065 G>A were observed in the PL and GN breeds than that in the TZW breed(P<0.01). Association analysis of the PL breed indicated that the g.83065 G>A polymorphism was significantly associated with hemoglobin(HGB) concentration in yaks(P<0.05). Individuals with genotype AA had significantly higher HGB concentration(P<0.05) than those with genotype GA and GG. All these results will help our further understanding of biological functional of yak EPAS1 gene in responding to hypoxia and also indicate EPAS1 might contribute to the hypoxia adaptation of the yak. | WU Xiao-yun DING Xue-zhi CHU Min GUO Xian BAO Peng-jia LIANG Chun-nian YAN Ping | 2015 | Journal of Integrative Agriculture2015，14，4： | 8 |
| 17 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 18 | Nonlinear spectral-like schemes for hybrid schemes显示文摘In spectral-like resolution-WENO hybrid schemes,if the switch function takes more grid points as discontinuity points,the WENO scheme is often turned on,and the numerical solutions may be too dissipative.Conversely,if the switch function takes less grid points as discontinuity points,the hybrid schemes usually are found to produce oscillatory solutions or just to be unstable.Even if the switch function takes less grid points as discontinuity points,the final hybrid scheme is inclined to be more stable,provided the spectral-like resolution scheme in the hybrid scheme has moderate shock-capturing capability.Following this idea,we propose nonlinear spectral-like schemes named weighted group velocity control(WGVC)schemes.These schemes show not only high-resolution for short waves but also moderate shock capturing capability.Then a new class of hybrid schemes is designed in which the WGVC scheme is used in smooth regions and the WENO scheme is used to capture discontinuities.These hybrid schemes show good resolution for small-scales structures and fine shock-capturing capabilities while the switch function takes less grid points as discontinuity points.The seven-order WGVC-WENO scheme has also been applied successfully to the direct numerical simulation of oblique shock wave-turbulent boundary layer interaction. | HE ZhiWei LI XinLiang LIANG Xian | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，4： | 7 |
| 19 | Molecular and functional characterization of sulfiredoxin homologs from higher plants显示文摘由在氧化 peroxiredoxin 减少 cysteine-sulfinic 酸, sulfiredoxin (Srx ) 在酵母和人的房间在氧化压力抵抗起一个重要作用。这里,我们从更高的植物报导 Srx 相当或相同的事物的第一分子、功能的描述。生物信息的分析揭示了把序列编码为两张单音的简易窄床和 dicot 植物种类的潜在的 Srx 的存在。通常认为的植物 Srx 蛋白质从酵母和人展出了重要身份到他们的 orthologs,并且为催化作用包含了保存签名顺序和残余必需品。然而,植物 Srxs 不同于酵母和人的 orthologs,都被预言在他们的主要结构拥有叶绿体运输肽。从 Arabidopsis 和米饭的 Srx 蛋白质(指定了为 AtSrx 和 OsSrx,分别地) 在 SRX1 删除酵母房间的 Srx 的补充功能的缺乏。AtSrx 的 GFP 熔化蛋白质在 Arabidopsis 叶肉原物被指向到叶绿体。AtSrx 抄写在植物、繁殖的机关发生了,并且最高的抄本水平在叶子被检测。在氧化应力下面, AtSrx 抄本水平实质地被增加,哪个有在维持被发现必要的 2-Cys peroxiredoxins 的提高的抄写的 paralleled 叶绿体氧化还原作用平衡。除了氧化应力, osmotic/water 赤字或冷处理也提起了 AtSrx 抄本水平。与上面的调查结果一致, AtSrx 的猛烈异种是显著地,产生氧化的更多比野类型 Arabidopsis 强调植物。总起来说,这个工作的结果在是必要的让工厂应付氧化应力的更高的工厂显示功能的 Srx 相当或相同的事物的存在。 | Xian Peng Liu Xue Ying Liu Juan Zhang Zong Liang Xia Xin Liu Huan Ju Qin Dao Wen Wang | 2006 | Cell Research2006，16，3： | 7 |
| 20 | DNS of a spatially evolving hypersonic turbulent boundary layer at Mach 8显示文摘This paper reports the direct numerical simulation (DNS) for hypersonic turbulent boundary layer over a flat-plate at Ma∞ =8 with the ratio of wall-to-freestream temperature equal to 1.9, which indicates an extremely cold wall condition. It is primarily used to assess the wall temperature effects on the mean velocity profile, Walz equation, turbulent intensity, strong Reynolds analogy (SRA), and compressibility. The present high Mach number with cold wall condition induces strong compressibility effects. As a result, the Morkovin's hypothesis is not fully valid and so the classical SRA is also not fully consistent. However, some modified SRA is still valid at the far-wall region. It is also verified that the semi-local wall coordinate y* is better than conventional y+ in analysis of statistics features in turbulent boundary layer (TBL) in hypersonic flow. | LIANG Xian LI XinLiang | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，7： | 6 |
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