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| 1 | Importance of fatigue and its measurement in chronic liver disease显示文摘The mechanisms of fatigue in the group of people with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis are protean. The liver is central in the pathogenesis of fatigue because it uniquely regulates much of the storage, release and production of substrate for energy generation. It is exquisitely sensitive to the feedback controlling the uptake and release of these energy generation substrates. Metabolic contributors to fatigue, beginning with the uptake of substrate from the gut, the passage through the portal system to hepatic storage and release of energy to target organs (muscle and brain) are central to understanding fatigue in patients with chronic liver disease. Inflammation either causing or resulting from chronic liver disease contributes to fatigue, although inflammation has not been demonstrated to be causal. It is this unique combination of factors, the nexus of metabolic abnormality and the inflammatory burden of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis that creates pathways to different types of fatigue. Many use the terms central and peripheral fatigue. Central fatigue is characterized by a lack of self-motivation and can manifest both in physical and mental activities. Peripheral fatigue is classically manifested by neuromuscular dysfunction and muscle weakness. Therefore, the distinction is often seen as a difference between intention (central fatigue) versus ability (peripheral fatigue). New approaches to measuring fatigue include the use of objective measures as well as patient reported outcomes. These measures have improved the precision with which we are able to describe fatigue. The measures of fatigue severity and its impact on usual daily routines in this population have also been improved, and they are more generally accepted as reliable and sensitive. Several approaches to evaluating fatigue and developing endpoints for treatment have relied of biosignatures associated with fatigue. These have been used singly or in combination and include: physical performance measures, cognitive performance measures, mood/behavioral measures, brain imaging and serological measures. Treatment with non-pharmacological agents have been shown to be effective in symptom reduction, whereas pharmacological agents have not been shown effective. | Lynn H Gerber Ali A Weinstein Rohini Mehta Zobair M Younossi | 2019 | World Journal of Gastroenterology2019，25，28： | 7 |
| 2 | Periodic orbits for convex Hamiltonian systems显示文摘 | Weinstein A | 1978 | Ann Math1978，108，4： | 2 |
| 3 | The simulation of TL processes in α-Al2O3 using different ratios between parameters of trapping and luminescent centers显示文摘 | WEINSTEIN I A POPKO E A | 2007 | Journal of Luminescence2007，，： | 1 |
| 4 | Invasive infection due to Streptococcus iniae: a new or previously unrecognized disease显示文摘 | WEINSTEIN M R LOW D E McGeer A | 1996 | Ontario CCDR1996，22，： | 1 |
| 5 | Implementation of the quantum Fourier transform显示文摘 | Weinstein Y S Pravia M A Fortunato E M | 2001 | Phys Rev Lett2001，86，： | 1 |
| 6 | Cardiac peroxynitrite formation and left ventricular dysfunction following doxorubicin treatment in mice显示文摘 | WEINSTEIN D M MIHM M J BAUER J A | 2000 | J Pharmacol Exp Ther2000，294，1： | 1 |
| 7 | Alage, lichens and fungi in La Gorce Mountains, Antarctica 显示文摘 | BROADY P A WEINSTEIN R N | 1998 | Antarctic Science1998，10，4： | 1 |
| 8 | Spinal pedicle fixation: Reliability and ralidity of roentgenogram-based assessment and surgical factors on successful screw placement显示文摘 | Spratt KF Spengler D et a | 1988 | Spine1988，13，9： | 1 |
| 9 | Activating muta- tions of the stimulatory G protein in the McCune-Albright syn- drome显示文摘 | Weinstein LS Shenker A Gejman PV | 1991 | N Engl J Med1991，325，24： | 1 |
| 10 | Estrogen receptor-[alpha] signaling in osteoblast progenitors stimulates cortical bone accrual显示文摘 | Almeida Maria Iyer Srividhya Martin-Millan Marta Bartell Shoshana M Han Li Ambrogini Elena Onal Melda Xiong Jinhu Weinstein Robert S Jilka Robert L O’Brien Charles A Manolagas Stavros C | 2013 | Journal of Clinical Investigation2013，，1： | 1 |
| 11 | Effect of cyclosporin A on DNA repair and cancer incidence in kid-ney transplant recipients 显示文摘 | Herman M Weinstein T Korzets A | 2001 | J Lab Clin Med2001，137，1： | 1 |
| 12 | Cardiac troponin T is essential in sarcomere assembly and cardiac contractility显示文摘 | Sehnert A J Huq A Weinstein BM | 2002 | Nat Genet2002，31，： | 1 |
| 13 | Morbidity after midline mandibulotomy and radiation therapy显示文摘 | Eisen MD Weinstein GS Chalian A | 2000 | Am J Otolaryngol2000，21，5： | 1 |
| 14 | Multiple functions of p27Kip1 and its alterations in tumor cells显示文摘 | Sgambato AA Cittadini A Weinstein IB | 2000 | J Cell Physiol2000，183，1： | 1 |
| 15 | Osteoprotegerin prevents glucocorticoid-induced osteocyte apoptosis in mice显示文摘 | Weinstein R S O'Brien C A Almeida M | 2011 | Endocrinology2011，152，9： | 1 |
| 16 | Acinetobacter infection显示文摘 | Munoz-Price L S Weinstein R A | 2008 | NEnglJMed2008，358，12： | 1 |
| 17 | Cardiac troponin T is essential in sarcomere assembly and cardiac contractility显示文摘 | Sehnert A J Huq A Weinstein B M | 2002 | Nat Genet2002，31，1： | 1 |
| 18 | Pyrolytic carbon an alternative implant material in orthopedic surgery显示文摘 | WEINSTEIN A M | 1984 | Mech e1984，202，： | 1 |
| 19 | Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-beta显示文摘 | Weinstein S L Finn A J Dave S H | 2000 | J Leukoc Biol2000，67，： | 1 |
| 20 | Cortical blindness:clinical and radiologic findings in reversible posterior leukoencephalopathy syndrome:case report and review of the literature显示文摘 | Kahana A Rowley HA Weinstein JM | 2005 | Ophthalmology2005，112，2： | 1 |
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