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| 1 | Distribution,Frequency and Variation of Stripe Rust Resistance Loci Yr10,Lr34/Yr18 and Yr36 in Chinese Wheat Cultivars显示文摘Wheat stripe rust is a devastating disease in many regions of the world.In wheat,49 resistance genes for stripe rust have been officially documented,but only three genes are cloned,including the race-specific resistance Yr10 candidate gene(Yr10_(CG)) and slow-rusting genes Lr34/Yr18(hereafter designated as Yr18) and Yr36.In this study,we developed gene-specific markers for these genes and used them to screen a collection of 659 wheat accessions,including 485 Chinese cultivars.Thirteen percent and eleven percent of the tested Chinese cultivars were positive for the markers for Yr10_(CG) and Yr18_(RH)(the resistant haplotype of Yr18),respectively,but none were positive for the Yr36 marker.Since there is a limited use of the Yr10 gene in Chinese wheat,the relatively high frequency of wheat varieties with the Yr10_(CG) marker suggests that the identity of the Yr10 gene is unknown.With regards to the Yr18 gene,29%of the tested cultivars that are used in the Middle and Lower Yangtze Valleys' winter wheat zone were positive for Yr18_(RH) markers.A non-functional allele of Yr18_(RH) was identified in 'Mingxian 169',a commonly used susceptible check for studying stripe rust.The data presented here will provide useful information for marker-assisted selection for wheat stripe rust resistance. | Cuiling Yuan Hui Jiang Honggang Wang Kun Li Heng Tang Xianbin Li Daolin Fu | 2012 | Journal of Genetics and Genomics2012，39，11： | 12 |
| 2 | Intrinsic apoptotic pathway and G2/M cell cycle arrest involved in tubeimoside I-induced EC109 cell death显示文摘Objective: Squamous esophageal carcinoma is highly prevalent in developing countries, especially in China. Tu Bei Mu (TBM), a traditional folk medicine, has been used to treat esophageal squamous cell carcinoma (ESCC) for a long term. tubeimoside I (TBMS1) is the main component of TBM, exhibiting great anticancer potential. In this study, we investigated the mechanism of TBMS1 cytotoxic effect on EC109 cells. Methods: Comparative nuclear proteomic approach was applied in the current study and we identified several altered protein spots. Further biochemical studies were carried out to detect the mitochondrial membrane potential, cell cycle and corresponding proteins' expression and location. Results: Subcellular proteomic study in the nucleus from EC109 cells revealed that altered proteins were associated with mitochondrial function and cell proliferation. Further biochemical studies showed that TBMS1-induced molecular events were related to mitochondria-induced intrinsic apoptosis and P21-cyclin B1/cdc2 complex-related G2/M cell cycle arrest. Conclusions: Considering the conventional application of TBM in esophageal cancer, TBMS1 therefore may have a great potential as a chemotherapeutic drug candidate for ESCC. | Yang Xu Guanghui Wang Quancheng Chen Ting Lin Zhiping Zeng Qiang Luo Jie Liu Cuiling Sun | 2013 | Chinese Journal of Cancer Research2013，25，3： | 12 |
| 3 | Forensic Automatic Speaker Recognition Based on Likelihood Ratio Using Acoustic-phonetic Features Measured Automatically显示文摘Forensic speaker recognition is experiencing a remarkable paradigm shift in terms of the evaluation framework and presentation of voice evidence.This paper proposes a new method of forensic automatic speaker recognition using the likelihood ratio framework to quantify the strength of voice evidence.The proposed method uses a reference database to calculate the within-and between-speaker variability.Some acoustic-phonetic features are extracted automatically using the software VbiceSauce.The effectiveness of the approach was tested using two Mandarin databases:A mobile telephone database and a landline database.The experimenfs results indicate that these acoustic-phonetic features do have some discriminating potential and are worth trying in discrimination.The automatic acoustic-phonetic features have acceptable discriminative performance and can provide more reliable results in evidence analysis when fused with other kind of voice features. | Huapeng Wang Cuiling Zhang | 2015 | Journal of Forensic Science and Medicine2015，1，2： | 4 |
| 4 | Lactobacillus rhamnosus GG reduces hepatic TNFα production and inflammation in chronic alcohol-induced liver injury显示文摘 | Yuhua Wang Yanlong Liu Irina Kirpich Zhenhua Ma Cuiling Wang Min Zhang Jill Suttles Craig McClain Wenke Feng | 2013 | The Journal of Nutritional Biochemistry2013，，： | 4 |
| 5 | Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody显示文摘肝炎 E 病毒(HEV ) ,一个非包的、积极感觉的、搁浅单人赛的 RNA 病毒,是伤寒肝炎的一个主要原因。分类进家庭 Hepeviridae, HEV 包括四遗传型(遗传型 1-4 ) ,它属于单个 serotype。我们描述 monoclonal 抗体(mAb ) ,有 ~ 2.53-3.45 nM 的 8G12,同等地认出 HEV 的所有四遗传型,有约束力的亲密关系。mAb 8G12 有一保护,抵销能力,它能显著地在主人房间堵住病毒感染。动物与 1, 3 和 4 证实了跨遗传型的抵销的遗传型学习 8G12 和它肝炎 E 疾病的有效预防的能力。有丰富的遗传型的 HEV E2s 领域(病毒衣壳的最耸出的区域) 的 8G12 的复杂水晶结构 1 和 4 在 4.0 和 2.3 Å 被决定;分辨率分别地。这些结构表明 8G12 在 E2s dimerization 区域通过 epitopes 认出两遗传型。有像病毒的粒子的基于结构的 mutagenesis 和房间模型试金识别了为 8G12 中立化是必要的几保存残余(Glu549, Lys554 和 Gly591 ) 。而且, 8G12 的 epitope 作为涉及病毒主人相互作用的关键 epitope 被识别。这些调查结果将帮助为 HEV 感染的最丰富的形式的预防开发普通策略。 | Ying Gu Xuhua Tang Xiao Zhang Cuiling Song Minghua Zheng Kaihang Wang Jun Zhang Mun-Hon Ng Choy-Leong Hew Shaowei Li Ningshao Xia J. Sivaraman | 2015 | Cell Research2015，25，5： | 3 |
| 6 | Baicalin inhibits inflammation of lipopolysaccharide-induced acute lung injury via toll like receptor-4/myeloid differentiation primary response 88/nuclear factor-kappa B signaling pathway显示文摘OBJECTIVE:To explore the effect and mechanism of baicalin in the treatment of acute lung injury(ALI)by in vivo and in vitro experiments.METHODS:ALI was induced by instilling 10 mg/m L lipopolysaccharide(LPS)into the airway of rats.Different doses of baicalin(50 and 100 mg·kg^(-1)·d^(-1 ))were administered by gavage one day before modeling.RESULTS:Baicalin significantly reduced the permeability of the alveolocapillary membrane,alleviated tissue injury and inflammatory infiltration,and inhibited the secretion of inflammatory factors and the infiltration of neutrophils.The decline in these inflammations was related to the inhibition of the toll like receptor-4(TLR4)/myeloid differentiation factor 88(My D88)/nuclear factor-kappa B(NF-κB)/nod-like receptor pyrin containing 3(NLRP3)signaling pathway and the mitogen-activated protein kinase(MAPK)signaling pathway.CONCLUSIONS:Baicalin inhibits the secretion of inflammatory factors by inhibiting the TLR4-My D88-NF-κB/NLRP3 pathway and the MAPK signaling pathway.Thus,it reduces lung bronchial epithelial layer,alveolar damage,and pulmonary edema as detected in the in vivo and in vitro experiments.Therefore,baicalin may be a potential preventive and therapeutic drug for ALI. | ZHU Changle FENG Cuiling FENG Feng Yao Xiaoqin WANG Guishu SHI Liangtian ZHENG Jiakun | 2022 | Journal of Traditional Chinese Medicine2022，42，2： | 3 |
| 7 | Analyzing Population Density Disparity in China with GIS-automated Regionalization: The Hu Line Revisited显示文摘The famous ’Hu Line’, proposed by Hu Huanyong in 1935, divided China into two regions(southeast and northwest) of comparable area size but drastically different in population. However, the classic Hu Line was derived manually in absence of reliable census data and computational technologies of modern days. It has been subject to criticism of lack of scientific rigor and accuracy. This research uses a GIS-automated regionalization method, termed REDCAP(Regionalization with Dynamically Constrained Agglomerative Clustering and Partitioning), to reconstruct the demarcation line based on the 2010 county-level census data in China. The results show that the logarithmic transformation of population density is a better measure of attributive homogeneity in derived regions than density itself, and produces two regions of nearly identical area size and greater contrast in population. Specifically, the revised Hu Line by Hu Huanyong in 1990 had the southeast region with 94.4% of total population and 42.9% of total land, and our delineation line yields a southeast region with 97.4% population and 50.8% land. Therefore, the population density ratio of the two regions is 27.1 by our line, much higher than the ratio of 22.4 by the Hu Line, and thus outperforms the Hu Line in deriving regions of maximum density contrast with comparable area size. Furthermore, more regions are delineated to further advance our understanding of population distribution disparity in China. | WANG Fahui LIU Cuiling XU Yaping | 2019 | Chinese Geographical Science2019，29，4： | 3 |
| 8 | Preparation and characterization of graphite nanosheets from ultrasonic powdering technique显示文摘 | Guohua Chen Wengui Weng Dajun Wu Cuiling Wu Jinrong Lu Pingping Wang Xiangfeng Chen | 2004 | Carbon2004，，4： | 2 |
| 9 | Mechanism of extensional stress-induced cell formation in polymeric foaming processes with the presence of nucleating agents显示文摘 | Siu N. Leung Anson Wong Lilac Cuiling Wang Chul B. Park | 2011 | The Journal of Supercritical Fluids2011，，： | 2 |
| 10 | Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice显示文摘 | Rui-Hong Wang Kundan Sengupta Cuiling Li Hyun-Seok Kim Liu Cao Cuiying Xiao Sangsoo Kim Xiaoling Xu Yin Zheng Beverly Chilton Rong Jia Zhi-Ming Zheng Ettore Appella Xin Wei Wang Thomas Ried Chu-Xia Deng | 2008 | Cancer Cell2008，，4： | 1 |
| 11 | Develop-ment and application of a universal TaqMan real-time PCR for quantitation of duck hepatitis B virus DNA显示文摘 | WANG Yawen LI Yiping YANG Cuiling | | 0，，1： | 1 |
| 12 | Study on the graphite nanosheets/resin shielding coating 显示文摘 | Wang Taosheng Chen Guohua Wu Cuiling | 2007 | Progress in Organic Coatings2007，59，3： | 1 |
| 13 | NAC1 regulates root ground tissue maturation by coordinating with the SCR/SHR-CYCD6;1 module in Arabidopsis显示文摘Precise spatiotemporal control of the timing and extent of asymmetric cell divisions(AcDs)is essential for plant development.In the Arabidopsis root,ground tissue maturation involves an additional AcD of the endo-dermis that maintains the inner cell layer as the endodermis and generates the middle cortex to the outside.Through regulation of the cell cycle regulator CYCLIND6;1(CYCD6;1),the transcription factors SCARECROW(SCR)and SHORT-ROOT(SHR)play critical roles in this process.In the present study,we found that loss of function of NAC1,a NAC transcription factor family gene,causes markedly increased periclinal cell divisions in the root endodermis.Importantly,NAC1 directly represses the transcription of CYCD6;1 by recruiting the co-repressor TOPLESS(TPL),creating a fine-tuned mechanism to maintain proper root ground tissue patterning by limiting production of middle cortex cells.Biochemical and genetic analyses further showed that NAC1 physically interacts with SCR and SHR to restrict excessive periclinal cell divisions in the endo-dermis during root middle cortex formation.Although NAC1-TPL is recruited to the CYCD6;1 promoter and represses its transcription in an SCR-dependent manner,NAC1 and SHR antagonize each other to regu-late the expression of CYCD6;1.Collectively,our study provides mechanistic insights into how the NAC1-TPL module integrates with the master transcriptional regulators SCR and SHR to control root ground tissue patterning by fine-tuning spatiotemporal expression of CYCD6;1 in Arabidopsis. | Chuantian Xie Cuiling Li Fengxia Wang Feng Zhang Jiajia Liu Junxia Wang Xiansheng Zhang Xiangpei Kong Zhaojun Ding | 2023 | Molecular Plant2023，16，4： | 1 |
| 14 | Mechanism of extensional stress-induced cell formation in polymeric foaming processes with the presence of nucleating agents显示文摘 | Letmg Siu N Wong Anson Wang Lilac Cuiling | 2012 | The Journal of Supercritic al F luids2012，63，： | 1 |
| 15 | Monitoring Avian In- fluenza A (H7Ng) Virus through National Influenza-like Illness Surveillance,China显示文摘 | Cuiling Xu Fiona Havers Lijie Wang | 2013 | EID2013，19，8： | 1 |
| 16 | Stable carbon isotope of black carbonin lake sediments as an indicator of terrestrial environmental changes:An evaluation on paleorecord from Daihai Lake, Inner Mongolia,China 显示文摘 | WANG X CUIL XIAO J | 2013 | Chemical Geology2013，347，： | 1 |
| 17 | IL21 and IL21R polymorphisms and their interactive effects on serum IL-21 and IgE levels in patients with chronic hepatitis B virus infection显示文摘 | Na Li Qianqian Zhu Zhu Li Qunying Han Jinghong Chen Yi Lv Yawen Wang Xiaoyan Zeng Yanping Chen Cuiling Yang Zhengwen Liu | 2013 | Human Immunology2013，，： | 1 |
| 18 | Existence and construction of compactly suppoeted biorthogonal multiple vector-valued wavelets 显示文摘 | Chen Qingjiang Cheng Zhengxing Wang Cuiling | 2006 | Journal of Applied Mathematics and Computing2006，22，3： | 1 |
| 19 | Study on the graphite nanosheets/resin shielding coatings显示文摘 | Wang Taosheng Chen Guohua Wu Cuiling | 2007 | Progress Organic Coat2007，59，2： | 1 |
| 20 | Study and Application of High Property Die Casting Al Alloy显示文摘 | Jinsong Rao Huaji Li Cuiling Wang et at | 2005 | Journal of Chongqing University(Natural Science Edition)2005，28，10： | 1 |
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