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| 1 | 海绵动物的演化意义及其生物硅的仿生应用显示文摘海绵动物是地球上最古老、最简单的动物,但对它在生物进化中的定位却经历了一个漫长而复杂的认识过程.作为“活化石”,海绵动物为生物演化研究提供了最好的证据;而对海绵动物研究更令人入胜的是近年来人们发现硅质海绵动物骨针的独特结构和良好光纤特性,从而开辟了利用纳米生物技术进行仿生合成的广泛研究领域.综述了海绵动物的发现及新的分子生物学进化证据,骨针硅蛋白催化合成生物硅的研究进展及仿生合成在纳米生物技术和医学领域的潜在应用. | Werner E G Müller 王晓红 曾令森 Heinz C Schrder | 2007 | 科学通报2007，52，12： | 4 |
| 2 | Second-generation direct-acting-antiviral hepatitis C virus treatment: Efficacy, safety, and predictors of SVR12显示文摘AIM To gather data on the antiviral efficacy and safety of second generation direct acting antiviral(DAA) treatment with respect to sustained virological response(SVR) 12 wk after conclusion of treatment, and to determine predictors of SVR12 in this setting.METHODS Two hundred and sixty patients treated with SOF combination partners PR(n = 51), R(n = 10), SMV(n = 30), DCV(n = 81), LDV(n = 73), or 3D(n = 15).144/260 were pre-treated, 89/260 had liver cirrhosis, 56/260 had portal hypertension with platelets < 100/nL, 25/260 had a MELD score ≥ 10 and 17/260 were postliver transplantation patients. 194/260 had HCV GT1, 44/260 HCV GT3.RESULTS Two hundred and forty/256(93.7%) patients achieved SVR12(m ITT); 4/260 were lost to follow-up. SVR12 rates for subgroups were: 92% for SOF/DCV, 93% for each SOF/SMV, SOF/PR, 94% for SOF/LDV, 100% for 3D, 94% for pretreated, 87% for liver cirrhosis, 82% for patients with platelets < 100/n L, 88% post-liver transplantation, 95% for GT1 a, 93% for GT1 b, 90% for GT3, 100% for GT2, 4, and 6. 12 patients suffered from relapse, 6 prematurely discontinued treatment, of which 4 died. Negative predictors of SVR12 were a platelet count < 100/nL, MELD score ≥ 10(P < 0.0001), liver cirrhosis(P = 0.005) at baseline. In Interferonfree treatment GT3 had significantly lower SVR rates than GT1(P = 0.016). Side effects were mild. CONCLUSION Excellent SVR12 rates and the favorable side-effect profile of DAA-combination therapy can be well translated into 'real-world'. Patients with advanced liver disease, signs of portal hypertension, especially with platelets < 100/n L and patients with GT3 are in special need for further research efforts to overcome comparatively higher rates of virological failure. | Christoph R Werner Julia M Schwarz Daniel P Egetemeyr Robert Beck Nisar P Malek Ulrich M Lauer Christoph P Berg | 2016 | World Journal of Gastroenterology2016，22，35： | 2 |
| 3 | Measurement of bound states in the continuum by a detector embedded in a photonic crystal显示文摘We directly measure optical bound states in the continuum(BICs)by embedding a photodetector into a photonic crystal slab.The BICs observed in our experiment are the result of accidental phase matching between incident,reflected and in-plane waves at seemingly random wave vectors in the photonic band structure.Our measurements were confirmed through a rigorously coupled-wave analysis simulation in conjunction with temporal coupled mode theory.Polarization mixing between photonic crystal slab modes was observed and described using a plane wave expansion simulation.The ability to probe the field intensity inside the photonic crystal and thereby to directly measure BICs represents a milestone in the development of integrated opto-electronic devices based on BICs. | Roman Gansch Stefan Kalchmair Patrice Genevet Tobias Zederbauer Hermann Detz Aaron M Andrews Werner Schrenk Federico Capasso Marko Lončar Gottfried Strasser | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 4 | Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation显示文摘 | Ashutosh Chaudhry Robert M. Samstein Piper Treuting Yuqiong Liang Marina C. Pils Jan-Michael Heinrich Robert S. Jack F. Thomas Wunderlich Jens C. Brüning Werner Müller Alexander Y. Rudensky | 2011 | Immunity2011，，4： | 2 |
| 5 | Does the stock market overreact显示文摘 | Bondt De Werner F M Thaler R H | 1985 | Journal of Finance1985，40，3： | 2 |
| 6 | Further evidence on investor overreaction and stock market seasonality显示文摘 | Bondt De Werner F M Thaler R H | 1987 | Journal of Finance1987，42，3： | 2 |
| 7 | Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy: comparison with intraoperative and histopathologic findings in focal liver lesions显示文摘 | Renate Hammerstingl Alexander Huppertz Josy Breuer Thomas Balzer Anthony Blakeborough Rick Carter Lluis Castells Fusté Gertraud Heinz-Peer Werner Judmaier Michael Laniado Riccardo M. Manfredi Didier G. Mathieu Dieter Müller Koenraad Mortelè Peter Reimer M | 2008 | European Radiology2008，，： | 2 |
| 8 | Two-dimensional phase unwrapping显示文摘 | Goldstein R M Zebker H A Werner C L | 1988 | Radio Sci1988，23，4： | 1 |
| 9 | Preservatio of functional and regu latory domains of expressed bcl-2 genes in non-Hodgkins lymphoma显示文摘 | Nolte M Werner M | 1996 | Lea kemia1996，10，： | 1 |
| 10 | Post-translational regulation of nitrate reductase: mechanism, physiological relevance and environmental triggers 显示文摘 | Werner M Kaiser Steven C | 2001 | Journal of Experimental Botany2001，52，363： | 1 |
| 11 | Fowl adenovirus recombinant expressing VP2 of infectious bursal disease virus induces protective immunity against bursal disease显示文摘 | Sheppard M Werner W Johnson M | 1998 | Arch Virol1998，143，： | 1 |
| 12 | The effect of metallization on the ohmic contact resistivity to heavily B-doped polycrystalline diamond films显示文摘 | WERNER M DORSCH O BAERWIND H U | 1995 | IEEE Trans Electron Devices1995，42，7： | 1 |
| 13 | Topology design,routing and capacity dimensioning for ISL networks in broadband LEO satellite systems显示文摘 | Werner M Reings J Wauquiez F | 2001 | International Journal of Satellite Communication2001，，： | 1 |
| 14 | A Dynamic Routing Concept for ATM-based Satellite Personal Communication Networks显示文摘 | Werner M | 1997 | IEEE Journal on Selected Areas in Communications1997，15，8： | 1 |
| 15 | A novel hybrid seed sys- tem for plants显示文摘 | GILS M MARILLONNET S WERNER S | 2008 | Plant Biotechnol2008，6，3： | 1 |
| 16 | Comparison of the rapid proapoptotic effect of trans-beta-nitrostyrenes with delayed apoptosis induced by the standard agent 5-fluorouracil in colon cancer cells显示文摘 | Werner M Eger K Jurgen-Steinfelder H | | 0，，： | 1 |
| 17 | The impact of LH-containing gonadotropins on diploidy rates in preimplantation embryos: long protocol stimulation 显示文摘 | ANDREA W SANTIAGO M WERNER B | 2008 | Hum Reprod2008，23，： | 1 |
| 18 | Histochemical visualization of lymphatic capillaries in the rat: a comparison of methods demonstrated at the posterior pharyngeal surface 显示文摘 | Schunke M Tillmann B | 1987 | Arch Histol Jap1987，50，5： | 1 |
| 19 | Pharmacology and structure-activity relationships of bioactive polycyclic cage compounds:a focus on pentacycloundecane derivatives显示文摘 | WERNER G SAREL M JEFFREY B | 2005 | Medicinal Research Reviews2005，25，1： | 1 |
| 20 | Adenocarcinoma of the esophagogastric junction显示文摘 | Siewert JR Feith M Werner M | 2000 | Annals Of Surgery2000，232，3： | 1 |
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