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| 1 | CT diagnosis of recurrence after pancreatic cancer:Is there a pattern?显示文摘AIM:To investigate predilection sites of recurrence of pancreatic cancer by computed tomography(CT)in follow-up after surgery. METHODS:Seventy seven patients with recurrence after pancreatic cancer surgery were retrospectively identified.The operative technique,R-status,T-stage and development of tumor markers were evaluated. Two radiologists analyzed CT scans with consensus readings.Location of local recurrence,lymph node recurrence and organ metastases were noted.Surgery and progression of findings on follow-up CT were con-sidered as reference standard. RESULTS:The mean follow-up interval was 3.9± 1.8 mo,with a mean relapse-free interval of 12.9± 10.4 mo.The predominant site of recurrence was local (65%),followed by lymph node(17%),liver metastasis (11%)and peritoneal carcinosis(7%).Local recurrence emerged at the superior mesenteric artery(n=28),the hepatic artery(n=8),in an area defined by the surrounding vessels:celiac trunk,portal vein,inferior vena cava(n=22),and in a space limited by the mesenteric artery,portal vein and inferior vena cava(n=17). Lymph node recurrence occurred in the mesenteric root and left lateral to the aorta.Recurrence was confirmed by surgery(n=22)and follow-up CT(n=55).Tumor markers[carbohydrate antigen 19-9(CA19-9),carcinoembryonic antigen(CEA)]increased in accordance with signs of recurrence in most cases(86%CA19-9;79.2% CEA). CONCLUSION:Specific changes of local and lymph node recurrence can be found in the course of the cardinal peripancreatic vessels.The superior mesenteric artery is the leading structure for recurrence. | Tobias Heye Nicola Zausig Miriam Klauss Reinhard Singer Jens Werner Gtz Martin Richter Hans-Ulrich Kauczor Lars Grenacher | 2011 | World Journal of Gastroenterology2011，17，9： | 6 |
| 2 | 海绵动物的演化意义及其生物硅的仿生应用显示文摘海绵动物是地球上最古老、最简单的动物,但对它在生物进化中的定位却经历了一个漫长而复杂的认识过程.作为“活化石”,海绵动物为生物演化研究提供了最好的证据;而对海绵动物研究更令人入胜的是近年来人们发现硅质海绵动物骨针的独特结构和良好光纤特性,从而开辟了利用纳米生物技术进行仿生合成的广泛研究领域.综述了海绵动物的发现及新的分子生物学进化证据,骨针硅蛋白催化合成生物硅的研究进展及仿生合成在纳米生物技术和医学领域的潜在应用. | Werner E G Müller 王晓红 曾令森 Heinz C Schrder | 2007 | 科学通报2007，52，12： | 4 |
| 3 | Improved guided bone regeneration by combined application of unmodified, fresh autologous adipose derived regenerative cells and plasma rich in growth factors:A first-in-human case report and literature review显示文摘BACKGROUND Novel strategies are needed for improving guided bone regeneration(GBR) in oral surgery prior to implant placement, particularly in maxillary sinus augmentation(GBR-MSA) and in lateral alveolar ridge augmentation(LRA). This study tested the hypothesis that the combination of freshly isolated, unmodified autologous adipose-derived regenerative cells(UA-ADRCs), fraction 2 of plasma rich in growth factors(PRGF-2) and an osteoinductive scaffold(OIS)(UAADRC/PRGF-2/OIS) is superior to the combination of PRGF-2 and the same OIS alone(PRGF-2/OIS) in GBR-MSA/LRA.CASE SUMMARY A 79-year-old patient was treated with a bilateral external sinus lift procedure as well as a bilateral lateral alveolar ridge augmentation. GBR-MSA/LRA was performed with UA-ADRC/PRGF-2/OIS on the right side, and with PRGF-2/OIS on the left side. Biopsies were collected at 6 wk and 34 wk after GBRMSA/LRA. At the latter time point implants were placed. Radiographs(32 mo follow-up time) demonstrated excellent bone healing. No radiological or histological signs of inflammation were observed. Detailed histologic,histomorphometric, and immunohistochemical analysis of the biopsies evidenced that UA-ADRC/PRGF-2/OIS resulted in better and faster bone regeneration than PRGF-2/OIS.CONCLUSION GBR-MSA with UA-ADRCs, PRGF-2, and an OIS shows effectiveness without adverse effects. | ?nder Solakoglu Werner G?tz Maren C Kiessling Christopher Alt Christoph Schmitz Eckhard U Alt | 2019 | World Journal of Stem Cells2019，11，2： | 3 |
| 4 | Phylogenetic position of sponges in early metazoan evolution and bionic applications of siliceous sponge spicules显示文摘Sponges are the oldest and the simplest but not primitive multicellular animals. They represent the earliest evolutionary metazoan phylum still extant. It was a long and painful scientific process to posi-tion the most enigmatic and mysterious metazoan,the Porifera,into their correct phylogenetic place among the eukaryotes in general and multicellular animals in particular. As living fossils,sponges provide the best evidence for the early evolution of Metazoa. More recently,interest has been focused on the bionic applications of sponges' siliceous spicules,after the discovery of their unique structure and high fiber performance. In this review,the emergence of sponges,evolutionary novelties found in sponges,and the phylogenetic position of sponges in early metazoan evolution are highlighted. In ad-dition,the present state of knowledge on silicatein-mediated 'biosilica' formation in marine sponges,including the involvement of other molecules in silica metabolism and their potential application in nanobiotechnology and medicine,is given. | Werner E G MULLER WANG XiaoHong ZENG LingSen Heinz C SCHRODER | 2007 | Chinese Science Bulletin2007，52，22： | 3 |
| 5 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 2 |
| 6 | Quantification of character- impact odour compounds of roasted beef 显示文摘 | Cerny C Werner G | 1993 | Z Lebensm Unters Forseh1993，196，： | 1 |
| 7 | Influence of anesthesia proce dure on malignant tumor outcome显示文摘 | Fukui K Werner C Pestel G | 2012 | Anaesthesist2012，61，3： | 1 |
| 8 | Preparation of ultrathin free-standing porous metal films显示文摘 | XU Hui Werner A G | 2005 | Small2005，1，： | 1 |
| 9 | Would you mind if I get more? An experimental study of the envy game显示文摘 | Sandro Casal Werner Güth Mofei Jia Matteo Ploner | 2012 | Journal of Economic Behavior and Organization2012，，3： | 1 |
| 10 | Pharmacology and structure-activity relationships of bioactive polycyclic cage compounds:a focus on pentacycloundecane derivatives显示文摘 | WERNER G SAREL M JEFFREY B | 2005 | Medicinal Research Reviews2005，25，1： | 1 |
| 11 | Wound repair and regeneration显示文摘 | Gurtner G C Werner S Barrandon Y | 2008 | Nature2008，453，7193： | 1 |
| 12 | S3-Leitlinie ?Exokrines Pankreaskarzinom” 2007显示文摘 | G Adler T Seufferlein S Bischoff H.-J Brambs S Feuerbach G Grabenbauer S Hahn V Heinemann W Hohenberger J Langrehr M Lutz O Micke H Neuhaus P Neuhaus H Oettle P Schlag R Schmid W Schmiegel K Schlottmann J Werner B Wiedenmann I Kopp | 2007 | Z Gastroenterol2007，，06： | 1 |
| 13 | Multiplex PCR assay for simultaneous detection of nine clinically relevant antibiotic resistance genes in Staphylococcus aureus显示文摘 | STROMMENGER B KETTLITZ C WERNER G | 2003 | J Clin Microbiol2003，41，9： | 1 |
| 14 | A disaggregate box-cox logit mode choice model of intercity passenger travel in germany and its implications for high-speed rail demand forecasts显示文摘 | Benedikt M Marc G Werner R | 1997 | The Annals of Regional Science1997，31，： | 1 |
| 15 | Low Pressure CO2 Storage of Raw Milk:Microbiological Effects显示文摘 | RAJAGOPAL M WERNER B G HOTCHKISS J H | 2005 | Journal of Dairy Science2005，88，： | 1 |
| 16 | Combinatory effects of temperature stress and nonionic organic pollutants on stress protein (hsp70)gene expression in the freshwater sponges Ephydatia Fluviatilis 显示文摘 | Werner E G Muller | 1995 | Environmental Toxicology and Chemistry1995，14，7： | 1 |
| 17 | Towards Supporting the Life Cycle of Large Scale Scientific Experiments 显示文摘 | Mattoso M Werner C Travassos G H | 2010 | International Journal of Business Process Integration and Management2010，5，： | 1 |
| 18 | Immunohistochemical localization of the small proteoglycans decorin and biglycan in human intervertebral discs显示文摘 | Werner G?tz Sabine Barnert Rudolf Bertagnoli Nicolai Miosge Hans Kresse Rainer Herken | 1997 | Cell & Tissue Research1997，，1： | 1 |
| 19 | Application of broadrange 16SrRNA PCR amplification and DGGE fingerprinting for detection of tick-infecting bacteria显示文摘 | Claudia S G Werner L Sabine R | 2003 | J Microbiol Methods2003，52，： | 1 |
| 20 | The multi- modulus blind equalization and its generalized algo- rithms显示文摘 | YANG J WERNER J J DUMONT G A | 2002 | IEEE journal on selected areas in commu- nications2002，20，5： | 1 |
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