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| 1 | 猪乳中一组高分子量蛋白的多态性及其与繁殖性能关系的研究显示文摘采用十二烷基硫酸钠 聚丙烯酰胺凝胶不连续垂直板电泳 (SDS PAGE)对 16 2头二花脸母猪乳中一组高分子量蛋白质 (HMWP)进行了检测 ,计算了该位点的基因型频率、等位基因频率和遗传多样性指数等 ,并运用线性模型统计方法分析了该位点的不同基因型与母猪繁殖性能的关系。结果表明 ,在二花脸猪种群 ,乳中HMWP存在B(M :11480 0± 40 0 )和D(M :10 140 0± 6 0 0 )两种带 ,分别受二个等位基因HB 和HD 控制。BB、BD和DD三种基因型频率分别为 0 6 6 6 7、0 2 716和 0 0 6 17,两个等位基因HB 和HD 频率分别为 0 80 2 5和 0 1975 ,遗传多样性指数为0 3170。在三种HMWP基因型中 ,不同基因型母猪的繁殖性能在活仔数和窝重上存在着显著差异 (P <0 0 5 ) ,但在初生仔猪个体重和 2 0日龄窝重上未达到显著水平 (P >0 0 5 )。 | 秦宜德 徐银学 邹思湘 Walter L Hurley | 2002 | 畜牧兽医学报2002，33，5： | 9 |
| 2 | Titanium dioxide induced inflammation in the small intestine显示文摘AIM:To investigate the effects of titanium dioxide (TiO2) nanoparticles (NPTiO 2 ) and microparticles (MPTiO 2 ) on the inflammatory response in the small intestine of mice. METHODS: Bl 57/6 male mice received distilled water suspensions containing TiO 2 (100 mg/kg body weight) as NPTiO 2 (66 nm), or MPTiO 2 (260 nm) by gavage for 10 d, once a day; the control group received only distilled water. At the end of the treatment the duodenum, jejunum and ileum were extracted for assessment of cytokines, inflammatory cells and titanium content. The cytokines interleukin (IL)-1b, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-17, IL-23, tumor necrosis factor-α (TNF-α), intracellular interferon-γ (IFN-γ) and transforming growth factor-β (TGF-β) were evaluated by enzyme-linked immunosorbent assay in segments of jejunum and ileum (mucosa and underlying muscular tissue). CD4 + and CD8 + T cells, natural killer cells, and dendritic cells were evaluated in duodenum, jejunum and ileum samples fixed in 10% formalin by immuno-histochemistry. The titanium content was determined by inductively coupled plasma atomic emission spectrometry. RESULTS: We found increased levels of T CD4 + cells (cells/mm 2 ) in duodenum:NP 1240 ± 139.4, MP 1070 ± 154.7 vs 458 ± 50.39 (P < 0.01); jejunum:NP 908.4 ± 130.3, MP 813.8 ± 103.8 vs 526.6 ± 61.43 (P < 0.05); and ileum:NP 818.60 ± 123.0, MP 640.1 ± 32.75 vs 466.9 ± 22.4 (P < 0.05). In comparison to the control group, the groups receiving TiO 2 showed a statistically significant increase in the levels of the inflammatory cytokines IL-12, IL-4, IL-23, TNF-α, IFN-γ and TGF-β. The cytokine production was more pronounced in the ileum (mean ± SE):IL-12: NP 33.98 ± 11.76, MP 74.11 ± 25.65 vs 19.06 ± 3.92 (P < 0.05); IL-4: NP 17.36 ± 9.96, MP 22.94 ± 7.47 vs 2.19 ± 0.65 (P < 0.05); IL-23: NP 157.20 ± 75.80, MP 134.50 ± 38.31 vs 22.34 ± 5.81 (P < 0.05); TNFα: NP 3.71 ± 1.33, MP 5.44 ± 1.67 vs 0.99± 019 (P < 0.05); IFNγ: NP 15.85 ± 9.99, MP 34.08 ± 11.44 vs 2.81 ± 0.69 (P < 0.05); and TGF-β: NP 780.70 ± 318.50, MP 1409.00 ± 502.20 vs 205.50 ± 63.93 (P < 0.05). CONCLUSION:Our findings indicate that TiO2 particles induce a Th1-mediated inflammatory response in the small bowel in mice. | Carolina Maciel Nogueira Walter Mendes de Azevedo Maria Lucia Zaidan Dagli Sérgio Hiroshi Toma AndréZonetti de Arruda Leite Maria Laura Lordello Iêda Nishitokukado Carmen Lúcia Ortiz-Agostinho Maria IrmaSeixas Duarte Marcelo Alves Ferreira Aytan Miranda Sipahi | 2012 | World Journal of Gastroenterology2012，18，34： | 8 |
| 3 | Ovarian cancer stem cells: Can targeted therapy lead to improved progression-free survival?显示文摘Despite significant effort and research funds, epithelial ovarian cancer remains a very deadly disease. There are no effective screening methods that discover early stage disease; the majority of patients are diagnosed with advanced disease. Treatment modalities consist primarily of radical debulking surgery followed by taxane and platinum-based chemotherapy. Newer therapies including limited targeted agents and intraperitoneal delivery of chemotherapeutic drugs have improved disease-free intervals, but failed to yield longlasting cures in most patients. Chemotherapeutic resistance, particularly in the recurrent setting, plagues the disease. Targeting the pathways and mechanisms behind the development of chemoresistance in ovarian cancer could lead to significant improvement in patient outcomes. In many malignancies, including blood and other solid tumors, there is a subgroup of tumor cells, separate from the bulk population, called cancer stem cells(CSCs). These CSCs are thought to be the cause of metastasis, recurrence and resistance. However, todate, ovarian CSCs have been difficult to identify, isolate, and target. It is felt by many investigators that finding a putative ovarian CSC and a chemotherapeutic agent to target it could be the key to a cure for this deadly disease. This review will focus on recent advances in this arena and discuss some of the controversies surrounding the concept. | Christen L Walters Haygood Rebecca C Arend J Michael Straughn Donald J Buchsbaum | 2014 | World Journal of Stem Cells2014，6，4： | 7 |
| 4 | Parenting preschoolers with autism: Socioeconomic influences on wellbeing and sense of competence显示文摘BACKGROUND Previous research suggests that parents raising a child with autism experience higher levels of psychological distress than parents of typically developing children and parents of children with other developmental disorders. Little is known, however, about the intersection between the effects of socioeconomic status(SES) on the wellbeing and sense of parental competency of parents of preschoolers with autism and how it relates to child symptom severity.AIM To examine the relationship between their child's symptom severity, SES, as measured by neighbourhood advantage and occupational status, on the psychological wellbeing and perceived parenting competence among parents of preschoolers with autism.METHODS Parents of 117 preschool-aged children with a diagnosis of autism spectrum disorder(ASD), 107 mothers and 54 fathers, completed questionnaires about their child's symptoms of ASD and functioning, their own perceptions of their wellbeing and parental competence on entry to an early intervention program in Sydney, Australia. Parents also provided demographic information pertaining to their occupation, level of education attained and address(postcode). All children were also assessed for their severity of symptoms using the Autism Diagnostic Observation Schedule. The Australian Socioeconomic Index of occupationalstatus as a measure of familial SES and the Index of Relative Socio-economic Advantage and Disadvantage as a measure of neighbourhood advantage were used to examine the impact of SES on parental sense of competence and wellbeing.RESULTS Compared to normative populations, both mothers and fathers in our sample reported significantly higher levels of parenting sense of efficacy but lower levels of interest in the parenting role. Mothers also displayed higher levels of satisfaction. Both mothers and fathers displayed higher levels of depression than normative populations with mothers also reporting greater levels of stress and anxiety. Child symptom severity was associated with maternal parenting competency with these relationships amplified among mothers with higher familial SES and who lived in areas of greater neighbourhood advantage.Increased adaptive functioning was associated with better maternal wellbeing,particularly among mothers who lived in areas of greater neighbourhood advantage. Contrastingly, paternal parenting competence was generally not influenced by child adaptive functioning or symptom severity, although for those in higher familial SES brackets, children's symptom severity and maladaptive symptoms were negatively related to paternal sense of parenting efficacy. There was a trend towards moderate relationships between lower familial SES and greater depression, stress and anxiety among fathers, but no relationship with their child's ASD symptom severity or functioning.CONCLUSION SES differentially impacts wellbeing and sense of parenting competence and its relationship to the impact of child symptoms for mothers and fathers of preschoolers with autism. | Nisha E Mathew Karen L O Burton Anne Schierbeek Rudi ?rn?ec Amelia Walter Valsamma Eapen | 2019 | World Journal of Psychiatry2019，9，2： | 6 |
| 5 | 猪乳中乳成分变化的曲线拟合显示文摘以 10 0头二花脸母猪作为试验动物 ,对猪乳中蛋白质、乳糖、IGF- 、EGF和胰岛素含量在泌乳 1~ 2 1d阶段的变化进行了曲线拟合 ,并分析了这些乳成分的变化规律。结果表明 ,倒数曲线为乳蛋白、IGF- 、EGF和胰岛素随泌乳时间变化的最优拟合曲线。乳蛋白、IGF- 、EGF和胰岛素含量随时间的延续而下降 ,其拟合方程分别为 :y=33.74 4+85 .80 3÷ x(g· L- 1 ) ,y=4 2 .5 94 +2 90 .0 2 3÷ x(μg· L- 1 ) ,y=132 .84 1+6 38.5 98÷ x(ng· L- 1 ) ,y=18.0 73+316 .92 3÷ x(U·m L- 1 ) ,其中 x为泌乳天数。乳糖的最优拟合曲线为对数曲线 ,乳糖含量随时间的延续而上升 ,其拟合方程为 :y=32 .2 2 3+9.6 2 6 lnx(g· L- 1 ) ,x为泌乳天数。猪乳成分变化最为剧烈的是在初乳期 。 | 秦宜德 徐银学 邹思湘 Walter L Hurley | 2004 | 中国兽医学报2004，24，3： | 4 |
| 6 | Genomic prediction of fruit texture and training population optimization towards the application of genomic selection in apple显示文摘Texture is a complex trait and a major component of fruit quality in apple.While the major effect of MdPG1,a gene controlling firmness,has already been exploited in elite cultivars,the genetic basis of crispness remains poorly understood.To further improve fruit texture,harnessing loci with minor effects via genomic selection is therefore necessary.In this study,we measured acoustic and mechanical features in 537 genotypes to dissect the firmness and crispness components of fruit texture.Predictions of across-year phenotypic values for these components were calculated using a model calibrated with 8,294 SNP markers.The best prediction accuracies following cross-validations within the training set of 259 genotypes were obtained for the acoustic linear distance(0.64).Predictions for biparental families using the entire training set varied from low to high accuracy,depending on the family considered.While adding siblings or half-siblings into the training set did not clearly improve predictions,we performed an optimization of the training set size and composition for each validation set.This allowed us to increase prediction accuracies by 0.17 on average,with a maximal accuracy of 0.81 when predicting firmness in the‘Gala’בPink Lady’family.Our results therefore identified key genetic parameters to consider when deploying genomic selection for texture in apple.In particular,we advise to rely on a large training population,with high phenotypic variability from which a‘tailored training population’can be extracted using a priori information on genetic relatedness,in order to predict a specific target population. | Morgane Roth Hélène Muranty Mario Di Guardo Walter Guerra Andrea Patocchi Fabrizio Costa | 2020 | Horticulture Research2020，7，1： | 4 |
| 7 | ICC density predicts bacterial overgrowth in a rat model of post-infectious IBS显示文摘AIM:To investigate the interstitial cells of Cajal(ICC) number using a new rat model.METHODS:Sprague-Dawley rats were assigned to two groups.The first group received gavage with Campylobacter jejuni(C.jejuni) 81-176.The second group was gavaged with placebo.Three months after clearance of Campylobacter from the stool,precise segments of duodenum,jejunum,and ileum were ligated in self-contained loops of bowel that were preserved in anaerobic bags.Deep muscular plexus ICC(DMP-ICC) were quantified by two blinded readers assessing the tissue in a random,coded order.The number of ICC per villus was compared among controls,Campylobacter recovered rats without small intestinal bacterial overgrowth(SIBO),and Campylobacter recovered rats with SIBO.RESULTS:Three months after recovery,27% of rats gavaged with C.jejuni had SIBO.The rats with SIBO had a lower number of DMP-ICC than controls in the jejunum and ileum.Additionally there appeared to be a density threshold of 0.12 DMP-ICC/villus that was associated with SIBO.If ileal density of DMP-ICC was < 0.12 ICC/villus,54% of rats had SIBO compared to 9% among ileal sections with > 0.12(P<0.05).If the density of ICC was < 0.12 DMP-ICC/villus in more than one location of the bowel,88% of these had SIBO compared to 6% in those who did not(P<0.001).CONCLUSION:In this post-infectious rat model,the development of SIBO appears to be associated with a reduction in DMP-ICC.Further study of this rat model might help understand the pathophysiology of postinfectious irritable bowel syndrome. | Sam-Ryong Jee Walter Morales Kimberly Low Christopher Chang Amy Zhu Venkata Pokkunuri Soumya Chatterjee Edy Soffer Jeffrey L Conklin Mark Pimentel | 2010 | World Journal of Gastroenterology2010，16，29： | 3 |
| 8 | 猪乳中一组高分子量蛋白质的表达量与母猪泌乳性能关系的研究显示文摘通过设计的数学模型,分析了162头二花脸母猪和50头大约克母猪乳中一组高分子量蛋白质(HMWP)的基因表达量(HMWP浓度)与母猪泌乳性能的关系。结果表明,初乳和常乳中HMWP的基因表达量与乳中蛋白质和表皮生长因子(EGF)含量存在显著相关(P<0.05或P<0.01),其中常乳中HMWP的基因表达量与乳蛋白存在极显著正向线性相关(P<0.01)。常乳中HMWP基因表达量与乳糖含量也有正向线性相关的趋势(P<0.1),但与类胰岛素样生长因子-1(IGF-I)和胰岛素含量无显著相关性(P>0.1)。 | 秦宜德 徐银学 邹思湘 Walter L Hurley | 2004 | 畜牧兽医学报2004，35，3： | 3 |
| 9 | Acute surgical emergencies in inflammatory bowel disease显示文摘 | Dale F Berg Anil M Bahadursingh Donald L Kaminski Walter E Longo | 2002 | The American Journal of Surgery2002，，： | 2 |
| 10 | 斯洛伐克西喀尔巴阡山脉内侧Veporicum地区的地球动力学演化序列与菱镁矿和滑石矿床成因(英文)显示文摘本文总结并报导了斯洛伐克西喀尔巴阡山脉内侧的石炭纪岩石中产出的菱镁矿和滑石成因的最新资料.这些矿床赋存于Veporicum构造超单元中和该超单元与Gemericum的接触带中.北部Sinec成矿带是主要的菱镁矿和滑石矿化区,产出的主要矿床有Kokava,Sinec,Samo,Hnsta-Mutnik等矿床.而南部的Ochtina成矿带只产有菱镁矿床,主要矿床包括在Dubrava地体上的Dubrava,Mikov?JedL'vec;Luben韐,Ochtina,Kosice-Bankov,Banisko,Medvedia等矿床.菱镁矿形成于变质M1期石炭系中方解石被白云石和菱镁矿连续交代过程(北矿带成矿温度为280~400℃,南矿带成矿温度为370~420℃;Radvanec&Prochska,2001;Kodera&Radvanec,2002).Permoscythian蒸发卤水提供了Mg.成矿事件和华力西期碰撞后运动有关.拉伸构造和高热流值促使成矿热液系统的产生.滑石矿化则形成于稍晚的不同期变质事件(M2),成矿流体来源也与菱镁矿化不同.构造的、微构造的、变质的以及地质年代学的数据将滑石成矿作用和阿尔卑斯上白垩系的构造地热事件AD2联系在一起.AD2事件是阿尔卑斯碰撞(AD1)地壳加厚和变质核杂岩体起源的结果,体现在地壳不整合面上的区域拉伸,及开放系统中大规模热液流动.这一过程在更靠近Veporic热穹的北带区域(Sinec剪切带)很显著,而向着Veporic热穹的周围部分(南Ochtina带),M2变质过程和块滑石化则逐渐减弱.Sinec剪切带是北Sinec带中突出的AD2-AD3结构,白云石/菱镁矿透镜体(在M1期交代造成的)和相伴随的岩石夹杂在AD1中更坚硬的基底岩石之中.本研究证明了AD2中块滑石化的普遍性,滑石和白云石2形成于拉伸显微构造中(变质过程M2;温度为490~540℃,压力为240~330MPa).在Sinec带中AD3阶段的对偶剪切作用形成了该带中的滑石矿.它是AD2事件从去顶到区域扭压剪切的动力学转变过程的逐步延续.北Sinec带使AD3变形处于由坚硬岩石包围的软岩石的狭窄的剪切带中,而在南Ochtina带中AD3变形产生在由里面漂浮着坚硬碳酸盐块的软的岩石柱中.在Ochtina带中,在AD2和AD3阶段由于M2期较低的P-T条件和变形梯度导致了该区有经济价值的滑石矿化不发育.总之,现有的研究结果能用作阿尔卑斯型地体中菱镁矿和滑石找矿的基本标志. | Zoltán NMETH Walter PROCHASKA Martin RADVANEC Martin KOV■IK Ján MADARAS Peter KOD■RA L'ubomír HRA■KO | 2004 | 岩石学报2004，20，4： | 2 |
| 11 | 猪乳中一组高分子量蛋白质的多态性及其与泌乳性能的关系显示文摘采用SDS PAGE法对 16 2头二花脸母猪和 5 0头大约克母猪乳中一组高分子量蛋白质 (HMWP)进行了检测 ,计算了该位点基因型频率、等位基因频率和遗传多样性指数 ,并运用线性模型统计方法分析二花脸母猪该位点不同基因型与母猪泌乳性能的关系。结果表明 ,在猪种群中 ,乳中HMWP存在A (相对分子质量 14 6 80 0± 14 0 0 ) ,B ( 114 80 0± 4 0 0 ) ,C ( 10 86 0 0 )和D ( 10 14 0 0± 6 0 0 ) 4种带型 ,分别受 4个等位基因HA、HB、HC 和HD 控制。在二花脸猪乳中HMWP表现出BB、BD和DD 3种基因型 ,其频率分别为 0 6 6 6 7,0 2 716和 0 0 6 17;两个等位基因HB 和HD 频率分别为 0 80 2 5和0 1975 ;遗传多样性指数为 0 3170。大约克猪乳中HMWP表现出BB、AB和BC 3种基因型 ,其频率分别为 0 880 0 ,0 10 0 0和 0 0 2 0 0 ;等位基因HA、HB 和HC 的频率分别为 0 0 5 0 0 ,0 94 0 0和 0 0 10 0 ;遗传多样性指数为 0 1138。在二花脸猪种群中 ,不同HMWP基因型在乳糖浓度上存在显著差异 (P <0 0 5 ) ,但在乳蛋白浓度差异不显著 (P >0 0 5 )。 | 秦宜德 徐银学 邹思湘 Walter L Hurley | 2003 | 南京农业大学学报2003，26，3： | 2 |
| 12 | Oxidative Stress and Matrix Metalloproteinase-9 in Acute Ischemic Stroke: The Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) Study显示文摘 | Peter J. Kelly Jason D. Morrow MingMing Ning Walter Koroshetz Eng H. Lo Erin Terry Ginger L. Milne Jane Hubbard Hang Lee Elizabeth Stevenson Megan Lederer Karen L Furie | 2008 | Stroke2008，，1： | 2 |
| 13 | 老年高血压患者服用别嘌呤醇后血压的变化显示文摘尿酸可降低青少年血压,表明其在高血压发生发展的病理生理过程中可能起到直接的作用。但是其在老年人高血压中是否扮演同样的角色尚不清楚。该研究通过分析英国临床实践研究数据库的资料,以确定服用别嘌呤醇后血压的改变。方法:纳入〉65岁的使用别嘌呤醇治疗、且有治疗前和治疗时血压读数记录的高血压患者。同时纳入具有可比性的人群作为对照。 | 刘莉 叶鹏 Beattie CJ Fulton RL Higgins P Padmanabhan S McCallum L Walters MR Dominiczak AF Touyz RM Dawson J | 2014 | 中华高血压杂志2014，22，10： | 2 |
| 14 | Naming and outline of Dothideomycetes-2014 including proposals for the protection or suppression of generic names显示文摘Article 59.1,of the International Code of Nomenclature for Algae,Fungi,and Plants(ICN;Melbourne Code),which addresses the nomenclature of pleomorphic fungi,became effective from 30 July 2011.Since that date,each fungal species can have one nomenclaturally correct name in a particular classification.All other previously used names for this species will be considered as synonyms.The older generic epithet takes priority over the younger name.Any widely used younger names proposed for use,must comply with Art.57.2 and their usage should be approved by the Nomenclature Committee for Fungi(NCF).In this paper,we list all genera currently accepted by us in Dothideomycetes(belonging to 23 orders and 110 families),including pleomorphic and nonpleomorphic genera.In the case of pleomorphic genera,we follow the rulings of the current ICN and propose single generic names for future usage.The taxonomic placements of 1261 genera are listed as an outline.Protected names and suppressed names for 34 pleomorphic genera are listed separately.Notes and justifications are provided for possible proposed names after the list of genera.Notes are also provided on recent advances in our understanding of asexual and sexual morph linkages in Dothideomycetes.A phylogenetic tree based on four gene analyses supported 23 orders and 75 families,while 35 families still lack molecular data. | Nalin N.Wijayawardene Pedro W.Crous Paul M.Kirk David L.Hawksworth Saranyaphat Boonmee Uwe Braun Dong-Qin Dai Melvina J.D’souza Paul Diederich Asha Dissanayake Mingkhuan Doilom Singang Hongsanan E.B.Gareth Jones Johannes Z.Groenewald Ruvishika Jayawardena James D.Lawrey Jian-Kui Liu Robert Lücking Hugo Madrid Dimuthu S.Manamgoda Lucia Muggia Matthew P.Nelsen Rungtiwa Phookamsak Satinee Suetrong Kazuaki Tanaka Kasun M.Thambugala Dhanushka N.Wanasinghe Saowanee Wikee Ying Zhang Andre Aptroot H.A.Ariyawansa Ali H.Bahkali D.Jayarama Bhat Cécile Gueidan Putarak Chomnunti G.Sybren De Hoog Kerry Knudsen Wen-Jing Li Eric H.C.McKenzie Andrew N.Miller Alan J.L.Phillips Marcin Piatek Huzefa A.Raja Roger S.Shivas Bernad Slippers Joanne E.Taylor Qing Tian Yong Wang Joyce H.C.Woudenberg Lei Cai Walter M.Jaklitsch Kevin D.Hyde | 2014 | Fungal Diversity2014，，6： | 2 |
| 15 | Electron microscope study of the structure of cold rolled and annealed (100) crystals of high-purity silicon-iron显示文摘 | Walter J L Koch E F | 1962 | Acta Metallurgica1962，10，11： | 1 |
| 16 | Dietary glycemic load and atherothrombotic risk显示文摘 | Simin L Walter C | 2002 | Current Atherosclerosis Reports2002，4，： | 1 |
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| 20 | Guaranteed recursive nonlin-ear state bounding using interval analysis显示文摘 | KIEFFER M JAULIN L WALTER E | 2002 | International Journal of Adaptive Control and Signal Processing2002，16，19： | 1 |
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