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| 1 | Nutritional evaluation of caseins and whey proteins and their hydrolysates from Protamex显示文摘Whey protein concentrate (WPC 80) and sodium caseinate were hydrolyzed by Protamex to 5%, 10%, 15%, and 20% degree of hydrolysis (DH). WPC 80, sodium caseinate and their hydrolysates were then analyzed, compared and evaluated for their nutritional qualities. Their chemical composition, protein solubility, amino acid composition, essential amino acid index (EAA index), biological value (BV), nutritional index (NI), chemical score, enzymic protein efficiency ratio (E-PER) and in vitro protein digestibility (IVPD) were determined. The results indicated that the enzymatic hydrolysis of WPC 80 and sodium caseinate by Protamex improved the solubility and IVPD of their hydrolysates. WPC 80, sodium caseinate and their hydrolysates were high-quality proteins and had a surplus of essential amino acids compared with the FAO/WHO/UNU (1985) reference standard. The nutritive value of WPC 80 and its hydrolysates was superior to that of sodium caseinate and its hydrolysates as indicated by some nutritional parameters such as the amino acid composition, chemical score, EAA index and predicted BV. However, the E-PER was lower for the WPC hydrolysates as compared to unhydrolyzed WPC 80 but sodium caseinate and its hydrolysates did not differ significantly. The nutritional qualities of WPC 80, sodium caseinate and their hydrolysates were good and make them appropriate for food formulations or as nutritional supplements. | SINDAYIKENGERA Séverin 夏文水 | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，2： | 12 |
| 2 | 食品中乳蛋白的重要作用显示文摘乳蛋白具有许多令人关注的特性,包括营养、理化、功能、工艺、生理保健等特性.被广泛地应用于乳制品、乳饮料和保健食品等.作者首先介绍了乳蛋白的一些特性,然后描述了富含蛋白质的主要乳制品,包括产量较大的干酪、乳粉和产量较小的特殊制品如酪蛋白和乳清蛋白制品. | 夏文水 Sindayikengera Séverin | 2005 | 食品与生物技术学报2005，24，6： | 9 |
| 3 | Donation after cardio-circulatory death liver transplantation显示文摘The renewed interest in donation after cardio-circulatory death (DCD) started in the 1990s following the limited success of the transplant community to expand the donation after brain-death (DBD) organ supply and following the request of potential DCD families. Since then, DCD organ procurement and transplantation activities have rapidly expanded, particularly for nonvital organs, like kidneys. In liver transplantation (LT), DCD donors are a valuable organ source that helps to decrease the mortality rate on the waiting lists and to increase the availability of organs for transplantation despite a higher risk of early graft dysfunction, more frequent vascular and ischemia-type biliary lesions, higher rates of re-listing and re-transplantation and lower graft survival, which are obviously due to theinevitable warm ischemia occurring during the declaration of death and organ retrieval process. Experimental strategies intervening in both donors and recipients at different phases of the transplantation process have focused on the attenuation of ischemia-reperfusion injury and already gained encouraging results, and some of them have found their way from pre-clinical success into clinical reality. The future of DCD-LT is promising. Concerted efforts should concentrate on the identification of suitable donors (probably Maastricht category Ⅲ DCD donors), better donor and recipient matching (high risk donors to low risk recipients), use of advanced organ preservation techniques (oxygenated hypothermic machine perfusion, normothermic machine perfusion, venous systemic oxygen persufflation), and pharmacological modulation (probably a multi-factorial biologic modulation strategy) so that DCD liver allografts could be safely utilized and attain equivalent results as DBD-LT. | Hieu Le Dinh Arnaud de Roover Abdour Kaba Séverine Lauwick Jean Joris Jean Delwaide Pierre Honoré Michel Meurisse Olivier Detry | 2012 | World Journal of Gastroenterology2012，18，33： | 6 |
| 4 | 不同蛋白酶水解酪蛋白及其对产物功能性质的影响(英文)显示文摘采用Alcalase2.4L和Protamex两种蛋白酶分别水解酪蛋白酸钠(蛋白质含量88.03%)至5%、10%、15%和20%等不同的水解度(DH),并对酪蛋白酸钠及其水解产物的各种功能性质进行了分析测定。结果表明:酪蛋白酸钠经水解后,蛋白质、水分和灰分含量发生变化,游离氨基量增加且增加与DH相关;水解产物中的多肽分子量较小,平均分子量小于8103D,并且分子量随DH的增大而减小,在DH为15%和20%的水解产物中多肽分子量均低于5043D;水解产物的溶解性随DH的增大而增强,在pH4.0~5.0、DH10%~20%的范围内产物溶解度84.8%~98%,说明在等电点条件下,酪蛋白酸钠水解后溶解性得到改善;与酪蛋白酸钠相比,水解产物的乳化性和起泡性减弱;不同水解产物的氨基酸组成差异不是很大,与酪蛋白酸钠也很接近。 | SINDAYIKENGERA Sé verin 夏文水 | 2006 | 食品科学2006，27，2： | 6 |
| 5 | Hepatic arterial infusion of gemcitabine-oxaliplatin in a large metastasis from colon cancer显示文摘Hepatic arterial infusion (HAI) of chemotherapy can be performed in cases of liver-confined metastatic disease,resulting in increased local drug concentrations.Here we report the case of a 61-year-old man who presented with an isolated large unresectable liver metastasis of colon cancer after failure of surgery and multiple administration of systemic chemotherapy.The patient was treated with a combination of gemcitabine and oxaliplatin using HAI.The tolerance was excellent and a radiological complete response was obtained after 8 cycles of HAI.The rationale for the use of gemcitabine and oxaliplatin as well as that for the combination of the 2 drugs is discussed in this paper.HAI of gemcitabine-oxaliplatin should be evaluated in further clinical trials. | Boris Guiu Julie Vincent Séverine Guiu Sylvain Ladoire Pablo Ortega-Deballon Jean-Pierre Cercueil Bruno Chauffert Franois Ghiringhelli | 2010 | World Journal of Gastroenterology2010，16，9： | 4 |
| 6 | A Rapid and Cost-Effective Method for Genotyping Genome-Edited Animals:A Heteroduplex Mobility Assay Using Microfluidic Capillary Electrophoresis显示文摘The recent emergence and application of engineered endonucleases have led to the development of genome editing tools capable of rapidly implementing various targeted genome editions in a wide range of species.Moreover,these novel tools have become easier to use and have resulted in a great increase of applications.Whilst gene knockout(KO) or knockin(KI) animal models are relatively easy to achieve,there is a bottleneck in the detection and analysis of these mutations.Although several methods exist to detect these targeted mutations,we developed a heteroduplex mobility assay on an automated microfluidic capillary electrophoresis system named HMA-CE in order to accelerate the genotyping process.The HMA-CE method uses a simple PCR amplification of genomic DNA(gDNA) followed by an automated capillary electrophoresis step which reveals a heteroduplexes(HD) signature for each mutation.This allows efficient discrimination of wild-type and genome-edited animals down to the single base pair level. | Vanessa Chenouard Lucas Brusselle Jean-Marie Heslan Séverine Remy Séverine Ménoret Claire Usal Laure-Hélène Ouisse Tuan Huy NGuyen Ignacio Anegon Laurent Tesson | 2016 | Journal of Genetics and Genomics2016，43，5： | 4 |
| 7 | Lanreotide in Metastatic Enteropancreatic Neuroendocrine Tumors显示文摘 | Martyn E. Caplin Marianne Pavel Jaros?aw B. ?wik?a Alexandria T. Phan Markus Raderer Eva Sedlá?ková Guillaume Cadiot Edward M. Wolin Jaume Capdevila Lucy Wall Guido Rindi Alison Langley Séverine Martinez Jo?lle Blumberg Philippe Ruszniewski | 2014 | The New England Journal of Medicine2014，，： | 3 |
| 8 | Light-Regulated Plant Growth and Development显示文摘 | Chitose Kami Séverine Lorrain Patricia Hornitschek Christian Fankhauser | 2010 | Current Topics in Developmental Biology2010，，： | 2 |
| 9 | Regulators of endothelial and epithelial barrier integrity and function in acute lung injury显示文摘 | Rudolf Lucas Alexander D. Verin Stephen M. Black John D. Catravas | 2009 | Biochemical Pharmacology2009，，12： | 2 |
| 10 | Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease显示文摘 | Gentric Géraldine Maillet Vanessa Paradis Valérie Couton Dominique L’Hermitte Antoine Panasyuk Ganna Fromenty Bernard Celton-Morizur Séverine Desdouets Chantal | 2015 | Journal of Clinical Investigation2015，，： | 2 |
| 11 | Genetic Risk Profiling and Prediction of Disease Course in Crohn’s Disease Patients显示文摘 | Liesbet Henckaerts Kristel Van Steen Isabel Verstreken Isabelle Cleynen Andre Franke Stefan Schreiber Paul Rutgeerts Séverine Vermeire | 2009 | Clinical Gastroenterology and Hepatology2009，，9： | 2 |
| 12 | Ornidazole for prophylaxis of postoperative Crohn’s disease recurrence: A randomized, double-blind, placebo-controlled trial显示文摘 | Paul Rutgeerts Gert van Assche Séverine Vermeire Geert D’Haens Filip Baert Maja Noman Isolde Aerden Gert de Hertogh Karel Geboes Martin Hiele Andre D’Hoore Freddy Penninckx | 2005 | Gastroenterology2005，，4： | 2 |
| 13 | Determination of angptl4 mRNA as a diagnostic marker of primary and metastatic clear cell renal-cell carcinoma 显示文摘 | Verine J Lehmann-Che J Soliman H | 2010 | PLoS One2010，5，10： | 1 |
| 14 | Fingolimod potentiates the effects of sunitinib malate in a rat breast cancer model显示文摘 | Yoanne Mousseau Séverine Mollard Karine Faucher-Durand Laurence Richard Angélique Nizou Jeanne Cook-Moreau Yasser Baaj Hao Qiu Xavier Plainard Laurent Fourcade Benoit Funalot Franck G. Sturtz | 2012 | Breast Cancer Research and Treatment2012，，1： | 1 |
| 15 | Gamma-irradia- tion markedly inhibits the hydrated collagen gel contra-diction by arterial smooth muscle cells 显示文摘 | Keller P F Verin V Ziegler T | 2001 | J Invest Med2001，49，3： | 1 |
| 16 | Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction显示文摘 | Petrache I Verin AD Crow MT | | 0，，06： | 1 |
| 17 | Intraarterial beta irradiation induces smooth muscle cell apoptosis and reduces medial cellularity in a hypercholesterolemic rabbit restenosis model显示文摘 | Verin V Popowski Y Bochaton-Piallat ML | 2000 | Int J Radiat Oncol Biol Phys2000，46，3： | 1 |
| 18 | Endoluminal-radiation therapy for the prevention of coronary restenosis after balloon angioplasty 显示文摘 | Verin V Popowski Y de Bruyne B | 2001 | N Engl J Med2001，344，： | 1 |
| 19 | Differential regulation of diverse physiological responses to VEGF in pulmonary endothelial cells显示文摘 | Becker PM Verin AD Booth MA | 2001 | Am J Physiol Lung Cell Mol Physiol2001，281，： | 1 |
| 20 | Regulators of endothelial andepithelial barrier integrity and function in acute lung injury显示文摘 | Lucas R Verin AD Black SM | 2009 | Biochem Pharmacol2009，77，12： | 1 |
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