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| 1 | Lanreotide in Metastatic Enteropancreatic Neuroendocrine Tumors显示文摘 | Martyn E. Caplin Marianne Pavel Jaros?aw B. ?wik?a Alexandria T. Phan Markus Raderer Eva Sedlá?ková Guillaume Cadiot Edward M. Wolin Jaume Capdevila Lucy Wall Guido Rindi Alison Langley Séverine Martinez Jo?lle Blumberg Philippe Ruszniewski | 2014 | The New England Journal of Medicine2014，，： | 3 |
| 2 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 3 | PI3K/Akt/mTOR pathway inhibitors in the therapy of pancreatic neuroendocrine tumors显示文摘 | Edward M. Wolin | 2013 | Cancer Letters2013，，1： | 2 |
| 4 | The La protein显示文摘 | Wolin SL Cedervall T | 2002 | Annu Rev Biochem2002，71，： | 1 |
| 5 | The effect of body mass index on PSA levels and the development,screening and treatment of prostate cancer显示文摘 | SKOLARUS T A WOLIN K Y GRUBB R R | 2007 | Nat Clin Pract Urol2007，4，11： | 1 |
| 6 | Nitric oxide: pathophysiological mechanisms 显示文摘 | Gross SS Wolin MS | 1995 | Annu Rev Physiol1995，57，1： | 1 |
| 7 | Exposure of mice to chronic hypoxia attenuates pulmonary arterial contractile respons- es to acute hypoxia by increases in extracellular hydrogen peroxide 显示文摘 | Patel D Alhawaj R Wolin MS | 2014 | Am J Physiol Regul Integr Comp Physiol2014，307，4： | 1 |
| 8 | Characteristics of methanogens isolated from bovine rumen 显示文摘 | Miller T T Wolin M J Zhao H X | 1986 | Applied and Environment Microbiolo- gy1986，51，1： | 1 |
| 9 | A serum bottle modification of the Hungate technique for cultivating obligate anaerobes显示文摘 | Miller T L Wolin M J | 1974 | Appl Microbiol1974，27，5： | 1 |
| 10 | Inhibidon of growth of methane-producing bacteria of the ruminant forestomach by hydroxymethylglutaryl-SCoA reductase inhibitors显示文摘 | Miller T L Wolin M J | 2001 | J Dairy Sci2001，84，： | 1 |
| 11 | Inhibition of growth of methaneproducing bacteria of the ruminant forestomach by hydroxymethylglutaryl- SCoA reductase inhibitors显示文摘 | Miller T L Wolin M J | 2001 | J Dairy Sci2001，84，： | 1 |
| 12 | A perinucleolar compartment contains several RNA polymerase Ⅲ transcripts as well as the polypyrirnidine tract - binding protein, hnRNP I 显示文摘 | Matera A G Frey M R Margelot K Wolin S L | 1995 | J Cell Biol1995，129，： | 1 |
| 13 | Humoral hypercalcemia of malig- nancy caused by parathyroid hormone-related peptlde-secreting neuroendocrine tumors: report of six cases 显示文摘 | Milanesi A Yu R Wolin EM | 2013 | Pancreatology2013，13，3： | 1 |
| 14 | An investigation of the reduction in fire resistance of steel columns caused by loss of spray applied fire proteetion显示文摘 | Ryder N L Wolin S D Milke J A | 2002 | Journl of Fire Protection Engineering2002，12，1： | 1 |
| 15 | A possible role for the 60 - kD Ro autoantigen in a discard pathway for defective 5S rRNA precusors 显示文摘 | O'Brien CA Wolin SL | 1994 | Genes Dev1994，8，23： | 1 |
| 16 | Interrelations of position and occupational and leisure-time physical activity in the National Health and Nutrition Examination Survey 显示文摘 | Wolin KY Bennett GG | 2008 | J Phys Act Health2008，5，2： | 1 |
| 17 | PI3K/Akt/mTOR pathway inhibitors in the therapy of pancreatic neuroendocrine tumors 显示文摘 | Wolin EM | 2013 | Cancer Lett2013，335，1： | 1 |
| 18 | Rol fibonucleoproteins contribute to the resistance of Deinococcus radiodurans to ultraviolet irradiation 显示文摘 | Chen X Quinn AM Wolin SL | 2000 | Genes Dev2000，14，7： | 1 |
| 19 | Methanobacillus omelianskii, a symbiotic association of two species of bacteria 显示文摘 | Bryant MP Wolin EA Wolin M J Wolfe RS | 1967 | Arch Microbiol1967，59，1： | 1 |
| 20 | A possible role for the 60-kD Ro autoantigen in a discard pathway for defective 5S ribosomal RNA precursors显示文摘 | O'Brien C A and Wolin S L | 1994 | Genes1994，8，： | 1 |
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