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| 1 | Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells显示文摘Liver fibrosis is a consequence of chronic liver disease,causing morbidity and mortality.Interleukin-33(IL-33)is a critical mediator of inflammation,which may be involved in the development of liver fibrosis.Here,we investigated the role of IL-33 in human patients and experimental bile-duct ligation(BDL)-induced fibrosis in mice.We report increased hepatic IL-33 expression in the murine BDL model of fibrosis and in surgical samples obtained from patients with liver fibrosis.Liver injury,inflammatory cell infiltration and fibrosis were reduced in the absence of the IL-33/ST2 receptor,and the activation of hepatic stellate cells(HSCs)was decreased in ST2-deficient mice.Recombinant IL-33 activated HSCs isolated from C57BL/6 mice,leading to the expression of IL-6,TGF-β,α-SMA and collagen,which was abrogated in the absence of ST2 or by pharmacological inhibition of MAPK signaling.Finally,administration of recombinant IL-33 significantly increased hepatic inflammation in sham-operated BL6 mice but did not enhance BDL-induced hepatic inflammation and fibrosis.In conclusion,BDL-induced liver inflammation and fibrosis are dependent on ST2 signaling in HSCs,and therefore,the IL-33/ST2 pathway may be a potential therapeutic target in human patients with chronic hepatitis and liver fibrosis. | Zhongming Tan Qianghui Liu Runqiu Jiang Long Lv Siamak S Shoto Isabelle Maillet Valerie Quesniaux Junwei Tang Wenjie Zhang Beicheng Sun Bernhard Ryffel | 2018 | Cellular & Molecular Immunology2018，15，4： | 24 |
| 2 | Hepatic complications induced by immunosuppressants and biologics in inflammatory bowel disease显示文摘The incidence of inflammatory bowel diseases(IBD)is rising worldwide.The therapeutic options for IBD are expanding,and the number of drugs with new targets will rapidly increase in coming years.A rapid step-up approach with close monitoring of intestinal inflammation is extensively used.The fear of side effects represents one the most limiting factor of their use.Despite a widespread use for years,drug induced liver injury(DILI)management remains a challenging situation with Azathioprine and Methotrexate.DILI seems less frequent with anti-tumor necrosis factor agents and new biologic therapies.The aim of this review is to report incidence,physiopathology and practical guidelines in case of DILI occurrence with the armamentarium of old and new drugs in the field of IBD. | My-Linh Tran-Minh Paula Sousa Marianne Maillet Matthieu Allez Jean-Marc Gornet | 2017 | World Journal of Hepatology2017，9，13： | 3 |
| 3 | Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease显示文摘 | Gentric Géraldine Maillet Vanessa Paradis Valérie Couton Dominique L’Hermitte Antoine Panasyuk Ganna Fromenty Bernard Celton-Morizur Séverine Desdouets Chantal | 2015 | Journal of Clinical Investigation2015，，： | 2 |
| 4 | Evaluation of copper availability to plants in copper-contaminated vineyard soils显示文摘 | BRUNL A MAILLET J HINSINGER P | 2001 | Environmental Pollution2001，111，： | 1 |
| 5 | Mini-and micro-channels:influence of axial conduction in the walls显示文摘 | Maranzana G Perry I Maillet D | 2004 | International Journal of Heat and Mass Transfer2004，47，1718： | 1 |
| 6 | Cardiovascular andhormonal response during a 4-week head-down tilt with and without exercise and LBNP countermeasures 显示文摘 | Maillet A Fagette S Allevard AM | 1996 | J Gravit Physiol1996，3，1： | 1 |
| 7 | An- tifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis 显示文摘 | WOLLIN L MAILLET I QUESNIAUX V | 2014 | J Pharmacol Exp Ther2014，349，2： | 1 |
| 8 | The IP3 reeeptor regulates cardiae hypertrophy in response to select stimuli 显示文摘 | Nakayama H Bodi I Maillet M | 2010 | Cire Res2010，107，5： | 1 |
| 9 | Twenty - three novel BRCA1 and BRCA2 sequence variations identified in a cohort of Swiss breast and ovarian cancer families显示文摘 | Philippe Maillet PO M | 2006 | Cancer Genetic and Cytogenesis2006，169，1： | 1 |
| 10 | Evaluation of copper availability to plants in copper-contaminated vineyard soils显示文摘 | BRUN L A MAILLET J HINSINGER P | 2001 | Environmental Pollution2001，111，： | 1 |
| 11 | Geodynamics of an arc-ridge junction:the case of the New Hebrides Arc/North Fiji Basin显示文摘 | Maillet P Monzier M Eissen J | | 0，，： | 1 |
| 12 | Evaluation of copper availability to plants in copper-contaminated vineyard soils 显示文摘 | Brun L Maillet J Hinsinger P | 2001 | Environ Pollut2001，111，2： | 1 |
| 13 | Evaluation of copper availability to plants in copper contaminated vineyard soils显示文摘 | Bran L A Maillet J Hinsinger P | 2001 | Environmental Pollution2001，111，2： | 1 |
| 14 | Twenty-three novel BRCA1 and BRCA2 sequence variations identified in a cohort of Swiss breast and ovarian cancer families显示文摘 | Philippe Maillet Pierre Olivier Chappuis Mary KhoshbeenBoudal | 2006 | Cancer Genetics and Cytogenetics2006，169，1： | 1 |
| 15 | ATM alterations in childhood non-Hodgkin lymphoma 显示文摘 | Gumy-Pause F Wacker P Maillet P | 2006 | Cancer Genet Cytogenet2006，166，2： | 1 |
| 16 | Effects of starvation on the frequencyofFormation and width of growth increments in sagitae of laboratory-reared Atlantic menhaden Brevoortiaty rannuslarvae显示文摘 | MAILLET G L CHECKLEY D M | 1990 | Fish Bull1990，80，： | 1 |
| 17 | Endocrine responses to 7 days of head-down bed rest and orthostatic tests in men and women显示文摘 | Millet C Custaud MA Maillet A | 2001 | Clinical Physiology2001，21，2： | 1 |
| 18 | Quantification by real-time PCR of eellulolytic bacteria in the rumen of sheep after supplementation of a forage diet with readily fermentable carbohydrates: effect of a yeast additive显示文摘 | Mosoni P Chaucheyras-Durand F Bera -Maillet C | 2007 | J Appl Microbiol2007，103，6： | 1 |
| 19 | Comparative study of Thoracoscopy versus thoracotomy in esophageal atresia显示文摘 | Allal H Perez-Bertolez S Maillet O | 2009 | Cir Pediatr2009，22，4： | 1 |
| 20 | Pathology of acute and chronic pancreatitis显示文摘 | Kloppel G Maillet B | 1993 | Pancreas1993，8，： | 1 |
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