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| 1 | Sphincter of Oddi dysfunction and pancreatitis显示文摘Sphincter of Oddi dysfunction (SOD) is a term used to describe a group of heterogenous pain syndromes caused by abnormalities in sphincter contractility. Biliary and pancreatic SOD are each sub-classified as typeⅠ,Ⅱ or Ⅲ,according to the Milwaukee classification. SOD appears to carry an increased risk of acute pancreatitis as well as rates of post ERCP pancreatitis of over 30%. Various mechanisms have been postulated but the exact role of SOD in the pathophysiology of acute pancreatitis is unknown. There is also an association between SOD and chronic pancreatitis but it is still unclear if this is a cause or effect relationship. Management of SOD is aimed at sphincter ablation,usually by endoscopic sphincterotomy (ES). Patients with typeⅠSOD will benefit from ES in 55%-95% of cases. Sphincter of Oddi manometry is not necessary before ES in typeⅠ SOD. For patients with types Ⅱ and Ⅲ the benefit of ES is lower. These patients should be more thoroughly evaluated before performing ES. Some researchers have found that manometry and ablation of both the biliary and pancreatic sphincters is required to adequately assess and treat SOD. In pancreatic SOD up to 88% of patients will benefit from sphincterotomy. Therefore,there have been calls from some quarters for the current classification system to be scrapped in favour of an overall system encompassing both biliary and pancreatic types. Future work should be aimed at understanding the mechanisms underlying the relationship between SOD and pancreatitis and identifying patient factors that will help predict benefit from endoscopic therapy. | MT McLoughlin RMS Mitchell | 2007 | World Journal of Gastroenterology2007，13，47： | 37 |
| 2 | 《过敏性鼻炎及其对哮喘的影响(ARIA)》指南2019版过敏性鼻炎管理路径(中国版)显示文摘2018年12月3日,慢性疾病管理大会在巴黎召开,经过与会的过敏科学及气道疾病领域的专家和患者组织讨论,针对未来鼻炎和哮喘的管理,推荐采用真实世界综合管理路径评估系统,旨在实现数字化、综合化、以人为本的管理。本文是该文件的摘要版,其中也介绍了中国过敏性鼻炎和哮喘的流行状况以及《过敏性鼻炎及其对哮喘的影响》(ARIA)在中国应用的具体情况。 | Bachert C Fokkens WJ Haahtela T Hellings PH Klimek L Papadopoulos N Pham-Thi N PfaarO Valiulis A Ventura MT Onorato G Czarlewski W Bedbrook A Bousquet J 王向东(编译) 王成硕(编译) 郑铭(编译) 杜崑(编译) 张罗(编译) | 2019 | 中国耳鼻咽喉头颈外科2019，26，12： | 23 |
| 3 | 缺血性脑卒中和出血性脑卒中患者发病前后血压的变化显示文摘《中国高血压防治指南2010》指出,急性脑卒中的血压处理缺乏足够的临床试验证据,参考建议如下:急性脑卒中溶栓前血压应控制在<185/110mm Hg(1mm Hg=0.133kPa)。对急性缺血性脑卒中发病24h内血压升高的患者应谨慎处理,收缩压≥180mm Hg或舒张压≥100mm Hg或伴有严重心功能不全、主动脉夹层、高血压脑病者,一般不予降压。降压的合理目标是24h内血压降低约15%。有高血压病史且正在服用降压药物者,如神经功能平稳,可于脑卒中发病后24h开始使用降压药物。因此,了解脑卒中患者发病前后的血压情况对临床治疗有重要的意义。Fischer等研究者探讨缺血性脑卒中和出血性脑卒中患者发病前后血压的变化情况。结果表明,缺血性脑卒中患者发病后首次测量的收缩压低于出血性脑卒中。与发病前比较,缺血性脑卒中发病后收缩压略升高(约10.6mm Hg),24h内轻度降低(约13.6mm Hg);而出血性脑卒中发病后,收缩压明显升高(约40.7mm Hg),24h内明显下降(约41.1mm Hg)。出血性脑卒中发病前几天及几周的平均收缩压逐渐增加,而缺血性脑卒中无明显变化。出血性脑卒中患者发病3h内的最高收缩压比发病前高50.0 mm Hg,而缺血性脑卒中则低5.2mm Hg。综上所述,与发病前比较,出血性脑卒中发病后收缩压升高,而缺血性脑卒中无明显变化。 | Fischer U Cooney MT Bull LM Silver LE Chalmers J Anderson CS Mehta Z Rothwell PM 林东杰 叶鹏 | 2014 | 中华高血压杂志2014，22，4： | 13 |
| 4 | 肥胖患者的冠状动脉微血管功能障碍和心血管病风险显示文摘全世界有〉5亿的肥胖人群,其心血管病风险增加的病理生理机制是复杂的,并且可能涉及脂肪细胞相关因子的过量分泌,导致血管氧化应激增加,神经激素活性上调,以及低度全身炎症,可能导致交感神经系统激活增加,血管张力改变,冠状动脉微血管功能障碍(coronary microvascular dysfunction, CMD) 。 | Bajaj NS Osborne MT Gupta A Tavakkoli A Bravo PE Vita T Bibbo CF Hainer J Dorbala S Blankstein R Bhatt DL Di Carli MF Taqueti VR 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 11 |
| 5 | 澳大利亚临床共识指南:儿童卒中的诊断和急性期处理显示文摘卒中是导致儿童死亡的十大原因之一,幸存的致残患儿将面临几十年的残疾生活,给患儿及其家庭带来了巨大负担。由于安全性和有效性的证据有限,以及诊断的延误,目前卒中患儿无法接受再灌注治疗。儿童卒中诊断和急性期处理的澳大利亚临床共识指南,旨在最大限度地减少临床诊疗中的不确定性,并记录与成人卒中不同的危险因素、病因和假性卒中情况的最佳证据。临床问题的阐述来自于对2007年至2017年数据库的系统检索,但仅限于英语和儿科研究。该指南应用SIGN方法和国家健康与医学研究委员会系统对证据进行筛选和分类,通过推荐、评估、发展和评价系统(GRADE系统)对推荐进行强弱分级。该指南提供了60多项基于证据的推荐,以帮助参与院前和急症处理的临床医师快速识别儿童卒中,选择最合适的初步检查方案来确定诊断、明确病因,并选择最恰当的干预措施以挽救脑组织、预防复发。同时,指南也提供了颅内压和先天性心脏病管理方面的推荐。该指南的实施需要将院前和急诊系统重组,包括建立区域性卒中网络,建立儿科卒中疾病编码,快速MRI,以及对能够提供再灌注治疗的初级儿科卒中中心进行认证。该指南能够审核治疗的基准时间线,获得急性期的干预措施及预后判断。它还将促进澳大利亚儿童卒中登记的发展,并与国际登记处建立数据联系,以便准确收集卒中发病率、治疗和结果相关的数据。 | Medley TL Miteff C Andrews I Ware T Cheung M Monagle P Mandelstam S Wray A Pridmore C Troedson C Dale RC Fahey M Sinclair A Walsh P Stojanovski S Macka MT 徐佳丽(译) 吴川杰(译) 肖潇(译) 吕俊萱(译) 张博维(译) 吉训明(译) | 2019 | 中国脑血管病杂志2019，16，4： | 9 |
| 6 | Telomerase activity in colorectal cancer,prognostic factor and implications in the microsatellite instability pathway显示文摘AIM: To determine whether the telomerase activity is related to the Microsatellite instability (MSI) genetic pathway and whether it means a difference in the survival. METHODS: The population consisted of 97 colorectal cancer patients. MSI determination was performed in accordance with the NCI criteria using PCR and Genescan. Telomerase activity was determined by the TRAP-assay, an ELISA procedure based on the amplification of telomeric repeat sequences. RESULTS: 6.2% showed high MSI (MSI-H), 10.3% showed low MSI (MSI-L) and 83.5% did not show this alteration (MSS). Positive telomerase activity was detected in 92.8% of the patients. 83.3% of MSI-H tumors showed positive telomerase against 93.8% of MSS tumors. In the overall survival analysis the absence of telomerase activity conferred a better prognosis. CONCLUSION: Previous works have shown that tumors which develop via the MSI pathway present a better prognosis. No link between telomerase activity and MSI status is observed, although sample sizes are small. Patients with telomerase negative tumors had better overall survival than patients with telomerase positive tumors. | M Vidaurreta ML Maestro S Rafael S Veganzones MT Sanz-Casla J Cerdán M Arroyo | 2007 | World Journal of Gastroenterology2007，13，28： | 8 |
| 7 | 新生儿重症监护室医院感染预防策略显示文摘新生儿是医院感染的易感人群,医院感染能增加新生儿重症监护室(NICU)患儿的患病率、死亡率,延长住院时间,增加医疗费用,本文阐述了关于新生儿医院感染的预防和管理策略。
一、手卫生
手卫生是医务人员洗手、卫生手消毒、外科手消毒的总称。手卫生是降低医院感染最有效的方法。以下情况应遵守手卫生:接触患儿前后;从患儿污染的部位到清洁部位;进行侵袭性操作之前;接触患儿体液、排泄物、破损的皮肤、伤口敷料之后;直接接触患儿周围环镜后;摘除无菌或被污染的手套后。 | 卜祥芳 张欣 Polin RA Denson S Brady MT | 2014 | 中国新生儿科杂志2014，29，6： | 7 |
| 8 | A型行为与健康显示文摘一、A型行为与危险性1978年,一组生物医学家和行为学家讨论了A型行为结构和冠心病的关系,证实“在美国受雇的中年居民中,A型行为与临床发生冠心病的危险性增加密切相关。它比年龄、收缩压升高、血浆胆固醇升高或者吸烟的危险性更大”。50年代后期,心脏病学家Friedman和Rosenman报道了大多数冠心病人都有共同的行为模式和情绪反应,称为A型行为模式(Type A Behavior Pattern,TABP)。 | Ivancevich JM Matteson MT 季建林 | 1988 | 中国心理卫生杂志1988，2，6： | 7 |
| 9 | 阿尔茨海默病患者脑血流的动态调节显示文摘脑自动调节和压力反射敏感性是维持脑血流量的关键机制。该研究评估了这些调控机制在阿尔茨海默病导致的痴呆和轻度认知障碍患者中是否受到影响,因为这会增加降压治疗的风险。 | 刘青 叶鹏 de Heus RAA de Jong DLK Sanders ML van Spijker GJ Oudegeest-Sander MH Hopman MT Lawlor BA Olde Rikkert MGM Claassen JAHR | 2018 | 中华高血压杂志2018，26，8： | 4 |
| 10 | Cefpodoxime Proxetil 的药代动力学显示文摘Cefpodoxime Proxetil(CPDX-PR)是一种口服吸收的广谱第三代头孢菌素。它属于一种在体内脱酯得其活性代谢产物 Cefp-odoxime(CPDX)的前药。CPDX 通过与青霉素结合蛋白的结合起作用,引起异常的细菌细胞壁合成和溶解。本品在体内对于广范围的革兰氏阳性和阴性菌都有活性,包括葡萄球菌、链球菌、流感嗜血菌、 | Borin MT 赵永致 | 1993 | 国外医药(抗生素分册)1993，14，6： | 3 |
| 11 | Primary pancreatic anaplastic large cell lymphoma, ALK negative: A case report显示文摘We present the fourth case of a primary pancreatic anaplastic large cell lymphoma (ALCL), ALK-. An 80-year-old man was admitted to our clinic for further investigation of a fever of unknown origin. He noted anorexia, weight loss and fatigue. His laboratory tests showed anemia and a great elevation of ESR, LDH, and β2 microglobulin. In CT and MRI scan, a soft tissue mass in the pancreas was observed. A repeated endoscopy after his admission revealed an ulcerated mass-like deformity of the duodenal bulb. Explorative laparotomy confirmed a diffuse spread of an unresectable malignant pancreatic mass extending to the adjacent organs. Duodenal and surgical biopsies identified an ALCL of T-cell lineage, ALK-. The patient died in the Intensive Care Unit due to hemodynamic instability.Our case is the first one indicating that primary pancreatic lymphoma should be suspected in a patient with pancreatic mass and elevated serum LDH and β2 microglobulin. | Christos G Savopoulos NE Tsesmeli GD Kaiafa AT Zantidis MT Bobos AI Hatzitolios ST Papavramidis IS Kostopoulos | 2005 | World Journal of Gastroenterology2005，11，39： | 3 |
| 12 | Non-invasive versus invasive mechanical ventilation for respiratory failure in severe acute respiratory syndrome显示文摘Background Severe acute respiratory syndrome is frequently complicated by respiratory failure requiringventilatory support.We aimed to compare the efficacy of non-invasive ventilation against invasive mechanicalventilation treating respiratory failure in this disease.Methods Retrospective analysis was conducted on all respiratory failure patients identified from the HongKong Hospital Authority Severe Acute Respiratory Syndrome Database.Intubation rate, mortality and secondaryoutcome of a hospital utilizing non-invasive ventilation under standard infection control conditions ( NIVHospital) were compared against13 hospitals using solely invasive ventilation (IMVHospitals).Multiple logisticregression analyses with adjustments for confounding variables were performed to test for association betweenoutcomes and hospital groups.Results Both hospital groups had comparable demographics and clinical profiles, but NIV Hospital (42patients) had higher lactate dehydrogenase ratio and worse radiographic score on admission and ribavirin-corticosteroid commencement.Compared to IMV Hospitals (451 patients), NIV Hospital had lower adjustedodds ratios for intubation (0.36, 95% CI 0.164 -0.791,P=0.011) and death (0.235, 95% CI 0.077 -0.716,P=0.011), and improved earlier after pulsed steroid rescue.There were no instances of transmission ofsevere acute respiratory syndrome among health care workers due to the use of non-invasive ventilation.Conclusion Compared to invasive mechanical ventilation, non-invasive ventilation as initial ventilatory supportfor acute respiratory failure in the presence of severe acute respiratory syndrome appeared to be associated withreduced intubation need and mortality. | Loretta YC Yam Alfred YF Chan Thomas MT Cheung Eva LH Tsui Jane CK Chan Vivian CW Wong | 2005 | Chinese Medical Journal2005，，17： | 3 |
| 13 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 14 | 以Cr(Ⅲ)作为媒染剂消除媒染残浴中的Cr(Ⅵ)显示文摘探讨了在媒染阶段采用Cr(Ⅲ)的配合物作为媒染剂从而完全消除媒染残浴中的Cr(Ⅵ).选用5-磺基水杨酸钠盐(SSA)作为特效配位体,使其与Cr(Ⅲ)结合后形成一种特殊的配位化合物(SS-Cr(Ⅲ)).它能携带Cr(Ⅲ)到羊毛上并将Cr(Ⅲ)转交给已经上染的媒介染料从而使媒染过程成为可能.通过大量的实验研究确定了SSA与Cr(Ⅲ)的最佳摩尔配比以及SSA对羊毛上染百分率的测试方法.实验结果表明,与羊毛的传统媒染方法相比,此法可获得满意的色泽及牢度,且染品的手感有明显的改善.考虑在减溶解度测试过程中SSA自来品上解吸这一因素,经新法媒染的染品碱溶解度与传统媒染的类似. | Paii.,MT 邢建伟 | 1994 | 西北纺织工学院学报1994，8，3： | 2 |
| 15 | Effect of copper tube casing on strain distribution and mechanical properties of Al-7075 alloy processed by equal channel angular pressing显示文摘 | MH Shaeri F Djavanroodi M Sedighi S Ahmadi MT Salehi SH Seyyedein | 2013 | The Journal of Strain Analysis for Engineering Design2013，，8： | 2 |
| 16 | A simple technique for quantitation of low levels of DNA damage in individual cells显示文摘 | Singh NP Mccoy MT Tice RR | 1988 | Exp Cell Res1988，，175： | 2 |
| 17 | 机器人辅助与腹腔镜子宫全切术对照研究显示文摘目的比较机器人辅助腹腔镜子宫全切术与腹腔镜子宫全切术用于良性疾病患者的手术结果。方法通过回顾病历审查机器人(41例)和与之匹配的腹腔镜(100例)患者行子宫全切术的手术结果,统计方法采用Fisher确切概率法及卡方检验。两组年龄(P=0.65)、体重指数(P=032)、妊娠次数(P=0.21)、既往盆腹腔手术(P=0.25)以及子宫大小(P=0.65)均相匹配。观察数据包括手术时间、术中出血量、并发症、术后住院时间。结果机器人组与腹腔镜组平均手术时间(82.51min、80.98min),平均出血量(55.05ml、73.25ml),术中并发症(0例、0例)术后并发症(2例、3例),住院天数超过2d(0例、0例),再住院及症状两组之间无显着差异。两组无1例转开腹手术。结论机器人组与腹腔镜组子宫全切术短期结果相似,长期结果并没有评估。机器人技术被成功地用于子宫切除术与腹腔镜组有相似的手术结果。 | 何晓琴 PAREKH MT | 2011 | 现代诊断与治疗2011，22，3： | 2 |
| 18 | 血压变异性加大与认知功能减退相关显示文摘由于预期寿命增加,越来越多的人将面临与增龄相关的认知困难。因此,确定认知障碍的可改变的风险因素非常重要。极短期到中期的血压变异性(blood pressure variability,BPV)可能就是这样一个因素,因为它可能导致脑缺血。 | Zhou TL Kroon AA van Sloten TT van Boxtel MPJ Verhey FRJ Schram MT Kohler S Stehouwer CDA Henry RMA 刘莉(译) 叶鹏(摘、审校) | 2019 | 中华高血压杂志2019，0，3： | 2 |
| 19 | 前蛋白转化酶枯草溶菌素9变异、低密度脂蛋白胆固醇与神经认知功能损害的关系显示文摘尽管之前的研究引发了对抑制前蛋白转化酶枯草溶菌素9(proprotein convertase subtilisin/kexintype9,PCSK9)造成神经认知功能损害事件的关注,但近期一个第3期随机试验并没有发现药物性PCSK9抑制与神经认知损害有关。 | 黄洁 叶鹏 Mefford MT Rosenson RS Cushman M Farkouh ME McClure LA Wadley VG Irvin MR Bittner VA Safford MM Somaratne R Monda KL Muntner P Levitan EB | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 20 | Effect of aqueous extract of Leonotis leonurus (L.) R. Br. leaves in male Wistar rats显示文摘 | Oyedemi SO Yakubu MT Afolayan AJ | 2010 | Human and Experimental Toxicology2010，，5： | 2 |
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