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| 1 | Severe scrub typhus infection: Clinical features, diagnostic challenges and management显示文摘Scrub typhus infection is an important cause of acute undifferentiated fever in South East Asia. The clinical picture is characterized by sudden onset fever with chills and non-specific symptoms that include headache, myalgia, sweating and vomiting. The presence of an eschar, in about half the patients with proven scrub typhus infection and usually seen in the axilla, groin or inguinal region, is characteristic of scrub typhus. Common laboratory findings are elevated liver transaminases, thrombocytopenia and leukocytosis. About a third of patients admitted to hospital with scrub typhus infection have evidence of organ dysfunction that may include respiratory failure, circulatory shock, mild renal or hepatic dysfunction, central nervous system involvement or hematological abnormalities. Since the symptoms and signs are non-specific and resemble other tropical infections like malaria, enteric fever, dengue or leptospirosis, appropriate laboratory tests are necessary to confirm diagnosis. Serological assays are the mainstay of diagnosis as they are easy to perform; the reference test is the indirect immunofluorescence assay(IFA) for the detection of Ig M antibodies. However in clinical practice, the enzyme-linked immuno-sorbent assay is done due to the ease of performing this test and a good sensitivity and sensitivity when compared with the IFA. Paired samples, obtained at least two weeks apart, demonstrating a ≥ 4 fold rise in titre, is necessary for confirmation of serologic diagnosis. The mainstay of treatment is the tetracycline group of antibiotics or chloramphenicol although macrolides are used alternatively. In mild cases, recovery is complete. In severe cases with multi-organ failure, mortality may be as high as 24%. | John Victor Peter Thomas I Sudarsan John Anthony J Prakash George M Varghese | 2015 | World Journal of Critical Care Medicine2015，4，3： | 13 |
| 2 | 人HCN4通道的滞后现象:影响窦房结起搏的潜在决定因素(英文)显示文摘超极化活化环核苷酸门控(hyperpolarization-activated cyclic-nucleotide-gated,HCN)通道参与调制心脏跳动的节律和速率。与HCN1和HCN2有所不同,慢通道HCN4可能不存在电压依赖的滞后现象。本研究采用单细胞膜片钳方法,在稳定转染hHCN4的HEK293细胞上进行电生理记录,观察hHCN4通道是否存在滞后现象,以及cAMP对其的调制作用;同时采用实时定量RT-PCR方法检测窦房结和心房组织中HCNs的表达。电压钳实验结果显示hHCN4电流(Ih)激活随着保持电位超极化的变化而向去极化方向移动。三角电位变化钳(triangular ramp)和动作电位钳的结果也显示了hHCN4的滞后现象。cAMP增加Ih电流幅度,且使电流激活向去极化方向移动,从而改变内源性hHCN4滞后行为。RT-PCR结果显示,人窦房结组织主要表达HCN4,占75%,HCN1占21%,HCN2占3%,HCN3占0.7%。以上结果提示,人窦房结组织主要表达HCN4亚型,hHCN4的Ih存在电压依赖性的滞后现象,且受cAMP调制。由此推断,hHCN4通道的滞后现象可能在窦房结起搏活动中起到了关键作用。 | 萧永福 Natalie Chandler Halina Dobrzynski Eric S.Richardson Erica M.TenBroek Joshua J.Wilhelm Vinod Sharma Anthony Varghese Mark R.Boyett Paul A.Iaizzo Daniel C.Sigg | 2010 | 生理学报2010，62，1： | 10 |
| 3 | Mechanisms of dysregulation of low-density lipoprotein receptor expression in HepG2 cells induced by inflammatory cytokines显示文摘背景低密度的脂蛋白( LDL )受体通常经由依赖于细胞内部的胆固醇 levels.We 的一个反馈系统被调整证明了 cytokines 破坏调停胆固醇的 LDL 受体反馈规定引起在外部 cells.Liver 的未修改的 LDL 的细胞内部的累积是 centraI 机关因为这研究的类脂化合物 homeostasis.The 目的是调查规定胆固醇经由在人的 h 的 LDL | CHEN Ya-xi RUAN Xiong-zhong HUANG Ai-long LI Qiu John F. Moorhead Zac Varghese | 2007 | Chinese Medical Journal2007，，24： | 5 |
| 4 | Roles of G protein-coupled receptors in inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD)is a complex disease with multiple pathogenic factors.Although the pathogenesis of IBD is still unclear,a current hypothesis suggests that genetic susceptibility,environmental factors,a dysfunctional immune system,the microbiome,and the interactions of these factors substantially contribute to the occurrence and development of IBD.Although existing and emerging drugs have been proven to be effective in treating IBD,none can cure IBD permanently.G protein-coupled receptors(GPCRs)are critical signaling molecules implicated in the immune response,cell proliferation,inflammation regulation and intestinal barrier maintenance.Breakthroughs in the understanding of the structures and functions of GPCRs have provided a driving force for exploring the roles of GPCRs in the pathogenesis of diseases,thereby leading to the development of GPCR-targeted medication.To date,a number of GPCRs have been shown to be associated with IBD,significantly advancing the drug discovery process for IBD.The associations between GPCRs and disease activity,disease severity,and disease phenotypes have also paved new avenues for the precise management of patients with IBD.In this review,we mainly focus on the roles of the most studied proton-sensing GPCRs,cannabinoid receptors,and estrogen-related GPCRs in the pathogenesis of IBD and their potential clinical values in IBD and some other diseases. | Zhen Zeng Arjudeb Mukherjee Adwin Pidiyath Varghese Xiao-Li Yang Sha Chen Hu Zhang | 2020 | World Journal of Gastroenterology2020，26，12： | 5 |
| 5 | Valgus osteotomy for nonunion and neglected neck of femur fractures显示文摘Nonunion neck of femur can be a difficult problem to treat, particularly in the young, and is associated with high complication rates of avascular necrosis due to the precarious blood supply and poor biomechanics.The various treatment options that have been described can be broadly divided according to the aim of improving either biology or biomechanics. Surgeries aimed at improving the biology, such as vascularized fibula grafting, have good success rates but require high levels of expertise and substantial resources. A popular surgical treatment aimed at improving the biomechanics-valgus intertrochanteric osteotomyoptimizes conditions for fracture healing by converting shear forces across the fracture site into compressive forces. Numerous variations of this surgical procedure have been developed and successfully applied in clinical practice. As a result, the proximal femoral orientation for obtaining a good functional outcome has evolved over the years, and the present concept of altering the proximal femoral anatomy as little as possible has arisen. This technical objective supports attaining union as well as a good functional outcome, since excessive valgus can lead to increased joint reaction forces. This review summarizes the historical and current literature on valgus intertrochanteric osteotomy treatment of nonunion neck of femur, with a focus on factors predictive of good functional outcome and potential pitfalls to be avoided as well as controversies surrounding this procedure. | Viju Daniel Varghese Abel Livingston P R Boopalan Thilak S Jepegnanam | 2016 | World Journal of Orthopedics2016，7，5： | 4 |
| 6 | Quality of life after surgical and endoscopic management of severe acute pancreatitis: A systematic review显示文摘BACKGROUND Treatment for severe acute severe pancreatitis(SAP)can significantly affect Health-related quality of life(HR-QoL).The effects of different treatment strategies such as endoscopic and surgical necrosectomy on HR-QoL in patients with SAP remain poorly investigated.AIM To critically appraise the available evidence on HR-QoL following surgical or endoscopic necrosectomy in patient with SAP.METHODS A literature search was performed on PubMed,Google^(TM) Scholar,the Cochrane Library,MEDLINE and Reference Citation Analysis databases for studies that investigated HR-QoL following surgical or endoscopic necrosectomy in patients with SAP.Data collected included patient characteristics,outcomes of interventions and HR-QoL-related details.RESULTS Eleven studies were found to have evaluated HR-QoL following treatment for severe acute pancreatitis including 756 patients.Three studies were randomized trials,four were prospective cohort studies and four were retrospective cohort studies with prospective follow-up.Four studies compared HR-QoL following surgical and endoscopic necrosectomy.Several metrics of HR-QoL were used including Short Form(SF)-36 and EuroQol.One randomized trial and one cohort study demonstrated significantly improved physical scores at three months in patients who underwent endoscopic necrosectomy compared to surgical necrosectomy.One prospective study that examined HR-QoL following surgical necrosectomy reported some deterioration in the functional status of the patients.On the other hand,a cohort study that assessed the long-term HR-QoL following sequential surgical necrosectomy stated that all patients had SF-36>60%.In the only study that examined patients following endoscopic necrosectomy,the HR-QoL was also very good.Three studies investigated the quality adjusted life years suggesting that endoscopic and surgical approaches to management of pancreatic necrosis were comparable in cost effectiveness.Finally,regarding HR-QoL between open necrosectomy and minimally invasive approaches,patients who underwent the later had a significantly better overall quality of life,vitality and mental health.CONCLUSION This review would suggest that the endoscopic approach might offer better HR-QoL compared to surgical necrosectomy.However,the available comparative literature was very limited.More randomized trials powered to detect differences in HR-QoL are required. | Emmanouil Psaltis Chris Varghese Sanjay Pandanaboyana Manu Nayar | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，7： | 3 |
| 7 | Effects of carbohydrate addition on production in extensive shrimp culture systems显示文摘 | B. Hari B. Madhusoodana Kurup Johny T. Varghese J.W. Schrama M.C.J Verdegem | 2004 | Aquaculture2004，，1： | 2 |
| 8 | Utilization of metabolomics to identify serum biomarkers for hepatocellular carcinoma in patients with liver cirrhosis显示文摘 | Habtom W. Ressom Jun Feng Xiao Leepika Tuli Rency S. Varghese Bin Zhou Tsung-Heng Tsai Mohammad R. Nezami Ranjbar Yi Zhao Jinlian Wang Cristina Di Poto Amrita K. Cheema Mahlet G. Tadesse Radoslav Goldman Kirti Shetty | 2012 | Analytica Chimica Acta2012，，： | 2 |
| 9 | Intravenous Mannitol reduces intracompartmental pressure following tibia fractures: A randomized controlled trial显示文摘Purpose:Impending compartment syndrome is a common event following closed tibia fractures,which can progress to sinister compartment syndrome.Fasciotomy is the only definitive treatment available,though it has its own drawbacks and complications.Medical management at present consists of limb elevation and adequate hydration.This study aims at determining whether intravenous administration of Mannitol reduced the intracompartmental pressure in patients with closed tibial fractures.Methods:This is a double blinded,randomized control trial done in a single tertiary care center in India.Forty-five patients were recruited between February 2012 and October 2012.Forty patients who presented to the emergency department with isolated,closed,high velocity,and proximal 2/3 tibia fractures were included in this study.Patients with contraindication to Mannitol were excluded.They were allocated into 2 groups by the investigator using computer generated randomization.The pressure in the anterior compartment of the leg was measured with a handheld Stryker pressure monitor.Then either 20%Mannitol or 0.9%normal saline as given intravenously in a blinded manner,based on the randomization.The intracompartmental pressure was measured at 0,1 and 3 h after the infusion.The participant,investigator and statistician were masked to the group assessment.Results:There was no difference in intracompartmental pressures at 1 or 3 h,between the groups.However,in patients with the baseline of compartmental pressures30 mmHg,Mannitol showed a marked reduction in pressure of 8.5 mmHg at 1 h compared to almost no change in pressure in the saline group.There were no adverse events with the use of Mannitol.Conclusions:This preliminary study appears to show that Mannitol is useful in the management of the increased compartment pressure.The limitations of this study were that it only involved a small group of patients and the baseline pressures in both the groups were not comparable.More studies are required before the use of Mannitol as a standard of care in the management of compartment syndrome can be established. | Jerry Nesaraj Viju Daniel Varghese P.R.Boopalan Manasseh Nithyananth Thambu David Sudarsanam Thilak Samuel Jepegnanam | 2021 | Chinese Journal of Traumatology2021，24，2： | 2 |
| 10 | Theorizing Language Teacher Identity: Three Perspectives and Beyond显示文摘 | Manka Varghese Brian Morgan Bill Johnston Kimberly A. Johnson | 2005 | Journal of Language Identity & Education2005，，1： | 2 |
| 11 | Efficient fair queuing using deficit round robin 显示文摘 | Shreedhar M Varghese G | 1996 | IEEE/ACM Transactions on Networking1996，4，3： | 2 |
| 12 | The molecular pathogenic role of inflammatory stress in dysregulation of lipid homeostasis and hepatic steatosis显示文摘Non-alcoholic Fatty Liver Disease(NAFLD)is becoming the leading cause of chronic liver injury in developed countries and China.Chronic systemic inflammation plays a decisive role and is fundamental in the progression of NAFLD from simple steatosis(SS)toward higher risk nonalcoholic steatohepatitis(NASH)states.However,the exact mechanisms by which inflammation leading to NASH are incompletely understood.In this review,we focus the role of the cross talk between inflammation and lipid homeostasis on the progression of NAFLD. | Yaxi Chen Zac Varghese Xiong Z.Ruan | 2014 | Genes & Diseases2014，1，1： | 2 |
| 13 | Epoxy-modified, unsaturated polyester hybrid networks显示文摘 | A. Benny Cherian Lity Alen Varghese Eby Thomas Thachil | 2007 | European Polymer Journal2007，，4： | 2 |
| 14 | Ameliorative effect of alkaloid extract of Cyclea peltata(Poir.) Hook.f.& Thoms.roots(ACP) on APAP/CC1_4 induced liver toxicity in Wistar rats and in vitro free radical scavenging property显示文摘Objective:To evaluate the hepatoprotective and antioxidant properties of alkaloid extract of Cyclea peltata(C.peltata) against paracetamol/carbon tetra chloride induced liver damage in Wistar rats.Methods:In viro paracetamol/carbon tetrachloride induced liver damage in Wistar rats,in vitro free radical scavenging studies,HPTLC estimation of letrandrine and direct analysis in real timemass spectrometry of alkaloid extract of C.peltata were used for the validation.Results:The results showed that pretreatment with alkaloid extract of C.peltata caused significant reduction of serum glutamate pyruvate transaminase,serum glutamate oxaloacetate transaminase,serum alkaline phosphatase,serum cholesterol,liver malondialdehyde levels.The reduced glutathione,catalase,superoxide dismutase levels in liver were increased with alkaloid extract of C.peltata treatment.These results were almost comparable to silymarin and normal control.Histopathological studies also substantiated the biochemical findings.The in vitro hydroxyl,superoxide and DPPH scavenging study of alkaloid extract of C. peltata showed significant free radical scavenging property.Conclusions:The hepatoprotective property of alkaloid extract of C.peltata against paracetamol/carbon tetrachloride may be due the synergistic action of alkaloids especially tetrandrine,fangchinoline through free radical scavenging and thus preventing oxidative stress. | Varghese Jancy Shine Panikamparambil Gopalakrishnan Latha Somasckharan Nair Rajam Suja Gangadharan Indira Anuja Gopan Raj Sreedharan Nair Rajasekharan | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，2： | 2 |
| 15 | Evidence for rapid ''metabolic switching'' through lipoprotein lipase occupation of endothelial-binding sites显示文摘 | PULINILKUNNI L T ABRAHANI A VARGHESE J | 2003 | J Mol Cell Cardiol2003，35，9： | 2 |
| 16 | Packet classification using tuple space search显示文摘 | Srinivasan V Suri S Varghese G | 1999 | Proceedings of ACM Sigcomm Communication Review Archive1999，29，4： | 2 |
| 17 | Endoplasmic reticulum stress is involved in acetylated low-density lipoprotein induced apoptosis in THP-1 differentiated macrophages显示文摘背景心血管的疾病在有在先进动脉粥样硬化的死亡支持的长期的肾 disease.Macrophage 的病人是死亡和病态的一个主要原因从腹巨噬细胞表演 apoptosis 的坏死和匾 destabilization.In vitro 数据通过 endoplasmic 蜂窝胃被触发(嗯)免费胆固醇累积引起的应力玩我们使用了的重要 role.Here THP-1 房间旁边区分了为是的五天的 phorbol 12十四酸盐13醋酸盐( PMA )的 100 ng/ml 一在里面 vitro 模型。 | TAO Jian-ling RUAN Xiong-zhong LI Hang LI Xue-mei John E Moorhead Zac Varghese LI Xue-wang | 2009 | Chinese Medical Journal2009，，15： | 2 |
| 18 | Experience with hemoadsorption (CytoSorb~?) in the management of septic shock patients显示文摘BACKGROUND Cytokines and inflammatory mediators are the hallmarks of sepsis.Extracorporeal cytokine hemoadsorption devices are the newer clinical support system to overcome the cytokine storm during sepsis.AIM To retrospectively evaluate the clinical outcomes of patients admitted in intensive care unit with septic shock with different etiologies.METHODS The laboratory parameters including biomarkers such as procalcitonin,serum lactate and C-reactive protein;and the hemodynamic parameters;mean arterial pressure,vasopressor doses,sepsis scores,cytokine levels and other vital parameters were evaluated.We evaluated these outcomes among survivors and non-survivors.RESULTS Of 100 patients evaluated,40 patients survived.Post treatment,the vasopressors dosage remarkably decreased though it was not statistically different;34.15%(P=0.0816)for epinephrine,20.5%for norepinephrine(P=0.3099)and 51%(P=0.0678)for vasopressin.In the survivor group,a remarkable reduction of biomarkers levels;procalcitonin(65%,P=0.5859),C-reactive protein(27%,P=0.659),serum lactate(27%,P=0.0159)and bilirubin(43.11%;P=0.0565)were observed from baseline after CytoSorb^® therapy.A significant reduction in inflammatory markers;interleukin 6 and interleukin 10;(87%and 92%,P<0.0001)and in tumour necrosis factor(24%,P=0.0003)was also seen.Overall,28(28%)patients who were given CytoSorb^® therapy less than 48 h after onset of septic shock survived and the maximum duration of stay for 70%of these patients in intensive care unit was less than 15 d.CONCLUSION CytoSorb^® is a safe and well tolerated rescue therapy option in patients with septic shock.However,early(preferably within<48 h after onset of septic shock)initiation could result in better clinical outcomes.Further randomized trials are needed to define the potential benefits of this new treatment modality. | Yatin Mehta Chitra Mehta Ashish Kumar Joby Varghese George Aditi Gupta Saurabh Nanda Gourav Kochhar Arun Raizada | 2020 | World Journal of Critical Care Medicine2020，9，1： | 2 |
| 19 | A Rare Presentation of Subacute Progressive Ascending Myelopathy Secondary to Cement Leakage in Percutaneous Vertebroplasty显示文摘 | Rohit Prakash Bhide Apurba Barman Shiela Mary Varghese Ahana Chatterjee Suraj Mammen Jacob George Raji Thomas | 2014 | American Journal of Physical Medicine & Rehabilitation2014，，5： | 2 |
| 20 | Milliwatt terahertz harmonic generation from topological insulator metamaterials显示文摘Achieving effcient,high-power harmonic generation in the terahertz spectral domain has technological applications,for example,in sixth generation(6G)communication networks.Massless Dirac fermions possess extremely large terahertz nonlinear susceptibilities and harmonic conversion effciencies.However,the observed maximum generated harmonic power is limited,because of saturation effects at increasing incident powers,as shown recently for graphene.Here,we demonstrate room-temperature terahertz harmonic generation in a Bi_(2)Se_(3) topological insulator and topological-insulator-grating metamaterial structures with surface-selective terahertz field enhancement.We obtain a third-harmonic power approaching the miliwatt range for an incident power of 75 mW-an improvement by two orders of magnitude compared to a benchmarked graphene sample.We establish a framework in which this exceptional performance is the result of thermodynamic harmonic generation by the massless topological surface states,benefiting from ultrafast dissipation of electronic heat via surface-bulk Coulomb interactions.These results are an important step towards on-chip terahertz(opto)electronic applications. | Klaas-Jan Tielrooij Alessandro Principi David Saleta Reig Alexander Block Sebin Varghese Steffen Schreyeck Karl Brunner Grzegorz Karczewski Igor Ilyakov Oleksiy Ponomaryov Thales V.A.G.de Oliveira Min Chen Jan-Christoph Deinert Carmen Gomez Carbonell Sergio O.Valenzuela Laurens W.Molenkamp Tobias Kiessling Georgy V.Astakhov Sergey Kovalev | 2022 | Light(Science & Applications)2022，11，11： | 2 |
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