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| 1 | Potential triggering factors of acute liver failure as a first manifestation of autoimmune hepatitis-a single center experience of 52 adult patients显示文摘AIM To investigate potential triggering factors leading to acute liver failure(ALF) as the initial presentation of autoimmune hepatitis(AIH).METHODS A total of 565 patients treated at our Department between 2005 and 2017 for histologically-proven AIH were retrospectively analyzed. However, 52 patients(9.2%) fulfilled the criteria for ALF defined by the 'American Association for the Study of the Liver(AASLD)'. According to this definition, patients with 'acute-on-chronic' or 'acute-on-cirrhosis' liver failure were excluded. Following parameters with focus on potential triggering factors were evaluated: Patients' demographics, causation of liver failure, laboratory data(liver enzymes, MELD-score, autoimmune markers, virus serology), liver histology, immunosuppressive regime, and finally, outcome of our patients.RESULTS The majority of patients with ALF were female(84.6%) and mean age was 43.6 ± 14.9 years. Interestingly, none of the patients with ALF was positive for antiliver kidney microsomal antibody(LKM). We could identify potential triggering factors in 26/52(50.0%) of previously healthy patients presenting ALF as their first manifestation of AIH. These were drug-induced ALF(57.7%), virus-induced ALF(30.8%), and preceding surgery in general anesthesia(11.5%), respectively. Unfortunately, 6 out of 52 patients(11.5%) did not survive ALF and 3 patients(5.7%) underwent liver transplantation(LT). Comparing data of survivors and patients with non-recovery following treatment, MELDscore(P < 0.001), age(P < 0.05), creatinine(P < 0.01), and finally, ALT-values(P < 0.05) reached statistical significance. CONCLUSION Drugs, viral infections, and previous surgery may trigger ALF as the initial presentation of AIH. Advanced age and high MELD-score were associated with lethal outcome. | Matthias Buechter Paul Manka Falko Markus Heinemann Monika Lindemann Hideo Andreas Baba Martin Schlattjan Ali Canbay Guido Gerken Alisan Kahraman | 2018 | World Journal of Gastroenterology2018，24，13： | 8 |
| 2 | Proteome analysis of human mesenchymal stem cells undergoing chondrogenesis when exposed to the products of various magnesium-based materials degradation显示文摘Treatment of physeal fractures(15%–30%of all paediatric fractures)remains a challenge as in approximately 10%of the cases,significant growth disturbance may occur.Bioresorbable Magnesium-based implants represent a strategy to minimize damage(i.e.,load support until bone healing without second surgery).Nevertheless,the absence of harmful effects of magnesium-implants and their degradation products on the growth plate should be confirmed.Here,the proteome of human mesenchymal stem cells undergoing chondrogenesis was evaluated when exposed to the products of various Magnesium-based materials degradation.The results of this study indicate that the materials induced regulation of proteins associated with cell chondrogenesis and cartilage formation,which should be beneficial for cartilage regeneration. | Adela Helvia Martínez Sánchez Maryam Omidi Marcus Wurlitzer Marceline Manka Fuh Frank Feyerabend Hartmut Schlüter Regine Willumeit-Römer Bérengère J.C.Luthringer | 2019 | Bioactive Materials2019，4，1： | 2 |
| 3 | Theorizing Language Teacher Identity: Three Perspectives and Beyond显示文摘 | Manka Varghese Brian Morgan Bill Johnston Kimberly A. Johnson | 2005 | Journal of Language Identity & Education2005，，1： | 2 |
| 4 | Pulsed second-harmonic generation in nonlinear,one dimensional,periodic structures 显示文摘 | SCALORA M BLOEMER M J MANKA A S | 1997 | Phys Rev1997，56，： | 2 |
| 5 | Absence of p-selectin,but not intercellular adhesion molecule-1,attenuates neointimal growth after arterial injury in apolipoprotein e-deficient mice显示文摘 | MANKA D COLLINS R G LEY K | 2001 | Circulation2001，103，7： | 1 |
| 6 | The relative importance of large mammal species for tourism in Amboseli national park, Kenya 显示文摘 | Okello M M Manka S G Amour D E D | 2008 | Tourism Management2008，29，4： | 1 |
| 7 | Pulsed second-harmonic generation in nonlinear, one-dimensional, periodic structures显示文摘 | Scalora M Bloemer M J Manka A S | 1997 | Phys Rev1997，56，4： | 1 |
| 8 | Transplanted perivascular adipose tissue accelerates injury-induced neointi- mal hyperplasia: role of monocyte chemoattractant protein- 1 显示文摘 | Manka D Chatterjee TK Stoll LL | 2014 | Artefioscler Thromb Vasc Biol2014，34，8： | 1 |
| 9 | Classification of Organics in Secondary Effluents 显示文摘 | Menahem Rebhun Josepha Manka | 1971 | Environmental Science and Technology1971，5，7： | 1 |
| 10 | Intracoronary injection of bone marrow-derived mononuclear cells early or late after acute myocardial infarction: effects on global left ventricular function显示文摘 | SURDER D MANKA R Lo CICERO V | 2013 | Circulation2013，127，19： | 1 |
| 11 | Absence of p - selectin, but not intercellular adhesion molecule - 1 , attenuates neointimal growth after arterial injury in apolipoprotein e - deficient mice 显示文摘 | Manka D Collins RG Ley K | 2001 | Circulation2001，103，7： | 1 |
| 12 | Rayleigh-Taylor instability growth rates in targets accelerated with a laser beam smoothed by induced spatial incoherence显示文摘 | Grun J Emery M H Manka C K | 1987 | Physical Review Letters1987，58，25： | 1 |
| 13 | The role of dobutamine stress cardiovas- cular magnetic resonance in the clinical management of patients with suspected and known coronary artery disease 显示文摘 | Gebker R Jahnke C Manka R | 2011 | J Cardiovasc Magn Reson2011，13，2： | 1 |
| 14 | Increased frequency of transient lower esophageal sphincter relaxation induced by gastric distention in reflux patients with hiatal hernia显示文摘 | Kahrilas PJ Shi G Manka M | | 0，，04： | 1 |
| 15 | Altered diaphragm contractile properties with controlled mechanical ventilation显示文摘 | Sassoon CS Caiozzo VJ Manka A | 2002 | J Appl Physiol2002，92，6： | 1 |
| 16 | Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation Mter arterial injury显示文摘 | Schober A Manka D von Hundelshausen P | 2002 | Cir- culation2002，106，12： | 1 |
| 17 | The relative importance of large mammal species for tourism in Amboseli National Park,Kenya显示文摘 | Okello M M Manka S G D'Amour D E | 2008 | Tourism Management2008，29，4： | 1 |
| 18 | Formation and distribution of haloacetic acids, TI-IM and TOX in chlorination of bromide-rich lake water 显示文摘 | HELLER-GROSSMAN L MANKA J LIMONI-RELISE B | 1993 | Water Res1993，27，8： | 1 |
| 19 | Linezolid for the treatment of patients with endocarditis: a systematic review of the published evidence 显示文摘 | Falagas M E Manka K G Ntziora F | 2006 | J Antimicrob Chemother2006，58，： | 1 |
| 20 | Organic groups and molecular weight distribution in tertiary efflents and renovated waters 显示文摘 | Manka J Rebhun M | 1982 | Waters1982，16，3： | 1 |
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