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| 1 | 皮肤神经鞘粘液瘤显示文摘皮肤神经鞘粘液瘤是近年来提出的较少见的良性软组织肿瘤。为了探讨该病的病变特点,我们报告18例并进行组织病理学、免疫组织化学观察及临床随访。结果示本病主要见于青少年,皮损常位于上肢和面部。组织病理学为一位于真皮和皮下的多结节状粘液性病变,丰富的粘液背景上分布梭形和星形的肿瘤细胞,似神经的环层小体。绝大部分病例S100蛋白为强阳性,支持其为神经鞘起源。有随访结果者无一复发。我们认为本病是一具有特征性病理变化的皮肤神经源性肿瘤,在一系列的命名中,我们认为以神经鞘粘液瘤为佳,能较准确地概括其主要病理变化。该病呈良性经过,局部手术切除即可获较好的治疗效果。 | 范钦和 Alen P.W. | 1996 | 中华皮肤科杂志1996，29，4： | 14 |
| 2 | Endoclips vs large or small-volume epinephrine in peptic ulcer recurrent bleeding显示文摘AIM:To compare the recurrent bleeding after endoscopic injection of different epinephrine volumes with hemoclips in patients with bleeding peptic ulcer.METHODS:Between January 2005 and December 2009,150 patients with gastric or duodenal bleeding ulcer with major stigmata of hemorrhage and nonbleeding visible vessel in an ulcer bed(Forrest Ⅱa) were included in the study.Patients were randomized to receive a small-volume epinephrine group(15 to 25 mL injection group;Group 1,n = 50),a large-volume epinephrine group(30 to 40 mL injection group;Group 2,n = 50) and a hemoclip group(Group 3,n = 50).The rate of recurrent bleeding,as the primary outcome,was compared between the groups of patients included in the study.Secondary outcomes compared between the groups were primary hemostasis rate,permanent hemostasis,need for emergency surgery,30 d mortality,bleeding-related deaths,length of hospital stay and transfusion requirements.RESULTS:Initial hemostasis was obtained in all patients.The rate of early recurrent bleeding was 30%(15/50) in the small-volume epinephrine group(Group 1) and 16%(8/50) in the large-volume epinephrine group(Group 2)(P = 0.09).The rate of recurrent bleeding was 4%(2/50) in the hemoclip group(Group 3);the difference was statistically significant with regard to patients treated with either small-volume or large-volume epinephrine solution(P = 0.0005 and P = 0.045,respectively).Duration of hospital stay was significantly shorter among patients treated with hemoclips than among patients treated with epinephrine whereas there were no differences in transfusion requirement or even 30 d mortality between the groups.CONCLUSION:Endoclip is superior to both small and large volume injection of epinephrine in the prevention of recurrent bleeding in patients with peptic ulcer. | Neven Ljubicic Ivan Budimir Alen Biscanin Marko Nikolic Vladimir Supanc Davor Hrabar Tajana Pavic | 2012 | World Journal of Gastroenterology2012，18，18： | 11 |
| 3 | Scoring systems for peptic ulcer bleeding: which one to use?显示文摘AIM To compare the Glasgow-Blatchford score(GBS), Rockall score(RS) and Baylor bleeding score(BBS) in predicting clinical outcomes and need for interventions in patients with bleeding peptic ulcers. METHODS Between January 2008 and December 2013, 1012consecutive patients admitted with peptic ulcer bleeding(PUB) were prospectively followed. The pre-endoscopic RS, BBS and GBS, as well as the post-endoscopic diagnostic scores(RS and BBS) were calculated for all patients according to their urgent upper endoscopy findings. Area under the receiver-operating characteristics(AUROC) curves were calculated for the prediction of lethal outcome, rebleeding, needs for blood transfusion and/or surgical intervention, and the optimal cutoff values were evaluated.RESULTS PUB accounted for 41.9% of all upper gastrointestinal tract bleeding, 5.2% patients died and 5.4% patients underwent surgery. By comparing the AUROC curves of the aforementioned pre-endoscopic scores, the RS best predicted lethal outcome(AUROC 0.82 vs 0.67 vs0.63, respectively), but the GBS best predicted need for hospital-based intervention or 30-d mortality(AUROC0.84 vs 0.57 vs 0.64), rebleeding(AUROC 0.75 vs 0.61 vs 0.53), need for blood transfusion(AUROC 0.83 vs0.63 vs 0.58) and surgical intervention(0.82 vs 0.63 vs 0.52) The post-endoscopic RS was also better than the post-endoscopic BBS in predicting lethal outcome(AUROC 0.82 vs 0.69, respectively).CONCLUSION The RS is the best predictor of mortality and the GBS is the best predictor of rebleeding, need for blood transfusion and/or surgical intervention in patients with PUB. There is no one 'perfect score' and we suggest that these two tests be used concomitantly. | Ivan Budimir Sanja Stojsavljevic Neven Barsic Alen Biscanin Gorana Mirosevic Sven Bohnec Lora Stanka Kirigin Tajana Pavic Neven Ljubicic | 2017 | World Journal of Gastroenterology2017，23，41： | 6 |
| 4 | LJItrasensitive H2S gas sensors based on p-type WS2 hybrid materials显示文摘 | Georgies Alene Asrest Jose J. Baldovi Aron Dombovari Topias Jarvinen Gabriela Simone Lorite Melinda Mohl Andrey Shchukarev Alejandro Perez Paz Lede Xian Jyri-Pekka Mikkola Anita Lloyd Spetz Heli Jantunen Angel Rubio Krisztian Kordas | 2018 | Nano Research2018，11，8： | 3 |
| 5 | Biliary leakage after urgent cholecystectomy: Optimization of endoscopic treatment显示文摘AIM: To investigate the results of endoscopic treatment of postoperative biliary leakage occurring after urgent cholecystectomy with a long-term follow-up.METHODS: This is an observational database study conducted in a tertiary care center. All consecutive patients who underwent endoscopic retrograde cholangiography(ERC) for presumed postoperative biliary leakage after urgent cholecystectomy in the period between April 2008 and April 2013 were considered for this study. Patients with bile duct transection and biliary strictures were excluded. Biliary leakage was suspected in the case of bile appearance from either percutaneous drainage of abdominal collection or abdominal drain placed at the time of cholecystectomy. Procedural and main clinical characteristics of all consecutive patients with postoperative biliary leakage after urgent cholecystectomy, such as indication for cholecystectomy, etiology and type of leakage, ERC findings and post-ERC complications, were collected from our electronic database. All patients in whom the leakage was successfully treated endoscopically were followed-up after they were discharged from the hospital and the main clinical characteristics, laboratory data and common bile duct diameter were electronically recorded. RESULTS: During a five-year period, biliary leakage was recognized in 2.2% of patients who underwent urgent cholecystectomy. The median time from cholecystectomy to ERC was 6 d(interquartile range, 4-11 d). Endoscopic interventions to manage biliary leakage included biliary stent insertion with or without biliary sphincterotomy. In 23(77%) patients after first endoscopic treatment bile flow through existing surgical drain ceased within 11 d following biliary therapeutic endoscopy(median, 4 d; interquartile range, 2-8 d). In those patients repeat ERC was not performed andthe biliary stent was removed on gastroscopy. In seven(23%) patients repeat ERC was done within one to fourth week after their first ERC, depending on the extent of the biliary leakage. In two of those patients common bile duct stone was recognized and removed. Three of those seven patients had more complicated clinical course and they were referred to surgery and were excluded from long-term follow-up. The median interval from endoscopic placement of biliary stent to demonstration of resolution of bile leakage for ERC treated patients was 32 d(interquartile range, 28-43 d). Among the patients included in the follow-up(median 30.5 mo, range 7-59 mo), four patients(14.8%) died of severe underlying comorbid illnesses.CONCLUSION: Our results demonstrate the great efficiency of the endoscopic therapy in the treatment of the patients with biliary leakage after urgent cholecystectomy. | Neven Ljubii Alen Bianin Tajana Pavi Marko Nikoli Ivan Budimir August Miji Ana Duzel | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，5： | 3 |
| 6 | Esophagogastric anastomosis in rats: Improved healing by BPC 157 and L-arginine, aggravated by L-NAME显示文摘AIM To cure typically life-threatening esophagogastric anastomosis in rats, lacking anastomosis healing and sphincter function rescue, in particular. METHODS Because we assume esophagogastric fistulas represent a particular NO-system disability, we attempt to identify the benefits of anti-ulcer stable gastric pentadecapeptide BPC 157, which was in trials for ulcerative colitis and currently for multiple sclerosis, in rats with esophagocutaneous fistulas. Previously, BPC 157 therapies have promoted the healing of intestinal anastomosis and fistulas, and esophagitis and gastric lesions, along with rescued sphincter function. Additionally, BPC 157 particularly interacts with the NOsystem. In the 4 d after esophagogastric anastomosis creation, rats received medication(/kg intraperitoneallyonce daily: BPC 157(10 μg, 10 ng), L-NAME(5 mg), or L-arginine(100 mg) alone and/or combined or BPC 157(10 μg, 10 ng) in drinking water). For rats underwent esophagogastric anastomosis, daily assessment included progressive stomach damage(sum of the longest diameters, mm), esophagitis(scored 0-5), weak anastomosis(m L H2 O before leak), low pressure in esophagus at anastomosis and in the pyloric sphincter(cm H2O), progressive weight loss(g) and mortality. Immediate effect assessed blood vessels disappearance(scored 0-5) at the stomach surface immediately after anastomosis creation. RESULTS BPC 157(all regimens) fully counteracted the perilous disease course from the very beginning(i.e., with the BPC 157 bath, blood vessels remained present at the gastric surface after anastomosis creation) and eliminated mortality. Additionally, BPC 157 treatment in combination with L-NAME nullified any effect of L-NAME that otherwise intensified the regular course. Consistently, with worsening(with L-NAME administration) and amelioration(with L-arginine), either L-arginine amelioration prevails(attenuated esophageal and gastric lesions) or they counteract each other(L-NAME + L-arginine); with the addition of BPC 157(L-NAME + L-arginine + BPC 157), there was a marked beneficial effect. BPC 157 treatment for esophagogastric anastomosis, along with NOS-blocker L-NAME and/or NOS substrate L-arginine, demonstrated an innate NO-system disability(as observed with L-arginine effectiveness). BPC 157 distinctively affected corresponding events: worsening(obtained with L-NAME administration that was counteracted); or amelioration(L-arginine + BPC 157-rats correspond to BPC 157-rats).CONCLUSION Innate NO-system disability for esophagogastric anastomoses, including L-NAME-worsening, suggests that these effects could be corrected by L-arginine and almost completely eliminated by BPC 157 therapy. | Zeljko Djakovic Ivka Djakovic Vedran Cesarec Goran Madzarac Tomislav Becejac Goran Zukanovic Domagoj Drmic Lovorka Batelja Anita Zenko Sever Danijela Kolenc Alen Pajtak Nikica Knez Mladen Japjec Kresimir Luetic Dinko Stancic-Rokotov Sven Seiwerth Predrag Sikiric | 2016 | World Journal of Gastroenterology2016，22，41： | 3 |
| 7 | UV Spectrophotometic Determination of Lignin From Alkaline Pulping Liquors显示文摘 | Raimo Alen Timo Hartus | 1988 | Cellulose Chem Technol1988，22，： | 2 |
| 8 | 腹腔妊娠临床分析显示文摘目的探讨腹腔妊娠的临床特点及诊断治疗。方法回顾性分析2000年6月至2002年6月在赤道几内亚巴塔医院妇产科收治腹腔妊娠2例病例的临床表现、诊断及处理。结果2例均为继发性腹腔妊娠,孕早期出现腹痛及阴道流血等症状,其中1例为活婴,2例处理均为手术治愈且痊愈。结论腹腔妊娠是严重的急腹症,在基层医院早期诊断困难,掌握其临床特点,确诊后尽快手术是惟一处理原则。 | 林霞 Alene | 2006 | 中国基层医药2006，13，3： | 2 |
| 9 | Epoxy-modified, unsaturated polyester hybrid networks显示文摘 | A. Benny Cherian Lity Alen Varghese Eby Thomas Thachil | 2007 | European Polymer Journal2007，，4： | 2 |
| 10 | 6周有氧运动训练和节食对不经常运动的超重和肥胖的绝经前女性的代谢反应:一项随机试验(英文)显示文摘背景:本研究旨在比较为期6周的短期中等强度有氧训练和节食对绝经前女性血清代谢组学和心脏代谢风险因素的作用。方法:将90名先前体力活动水平低的超重和肥胖女性(BMI 25-35 kg/m^2)随机分为两组:6周北欧式健步走计划组(n=45)和饮食控制组(n=45),在实验开始前和最后一次训练结束7天以后分别测量其身体成分、血糖、胰岛素和血脂等指标,用核磁共振光谱分析血清低分子量代谢物和腊质成分。结果:6周有氧训练组对于体重和脂肪量未见改变,而运动可以引起血清自由脂肪酸(-34.7%,95%CI:-50--18,p<0.001)、血糖(-9.6%,95%CI:-15--4,p<0.001)、胰岛素抵抗指数(HOMA-IR)(-28.7%,95%CI:-48--10,p=0.005)的显著降低。相反,饮食控制组可见体重降低,但自由脂肪酸、空腹血糖、HOMA-IR均无改变。结论:结果显示,对于体力活动较少的超重和肥胖女性,体重轻微降低对健康的益处并不显著,而短期有规律的有氧运动即使在体重没有变化的情况下也能促进糖和脂的代谢。 | Petri Wiklund Markku Alen Eveliina Munukk Shu Mei Cheng Bo Yu Satu Pekkala Sulin Cheng | 2014 | Journal of Sport and Health Science2014，3，3： | 2 |
| 11 | Minimally Invasive Approach Provides at Least Equivalent Results for Surgical Correction of Mitral Regurgitation: A Propensity Matched Comparison显示文摘 | Andrew B. Goldstone Pavan Atluri Wilson Y. Szeto Alen Trubelja Jessica L. Howard John W. MacArthur Craig Newcomb Joseph P. Donnelly Dale M. Kobrin Mary A. Sheridan Christiana Powers Robert C. Gorman Joseph H. Gorman Alberto Pochettino Joseph E. Bavaria Mi | 2012 | The Journal of Thoracic and Cardiovascular Surgery2012，，： | 2 |
| 12 | Irritable bowel syndrome in female patients is associated with alterations in structural brain networks显示文摘 | Jennifer S. Labus Ivo D. Dinov Zhiguo Jiang Cody Ashe-McNalley Alen Zamanyan Yonggang Shi Jui-Yang Hong Arpana Gupta Kirsten Tillisch Bahar Ebrat Sam Hobel Boris A. Gutman Shantanu Joshi Paul M. Thompson Arthur W. Toga Emeran A. Mayer | 2014 | Pain2014，，1： | 2 |
| 13 | Non-adherence to anti-tu- berculosis treatment and determinant factors among patients with tu- berculosis in northwest Ethiopia显示文摘 | Adane AA Alene KA Koye DN | 2013 | PLOS One2013，8，78： | 1 |
| 14 | The Impact of Ageing on theTourism Industry : An Approach to the Senior TouristProfile显示文摘 | Elisa Alen Nieves Losada | 2016 | Social Indicators Research2016，，1： | 1 |
| 15 | Formation of hydroxy carboxylic acids from softwood polysaccharides during alkaline pulping显示文摘 | Alen R Lahtela M Niemela K | 1985 | Holzforschung1985，39，4： | 1 |
| 16 | Prognostic value of patho log ic corn plete response after neoadjuvant the rapy in locallyad vanced recta 1 cancer: long termanalysis of 566 ypCR patients显示文摘 | Capirci C V alen tiniV CioniniL | 2008 | Int J Radiat Onco 1 B io 1 Phys2008，72，1： | 1 |
| 17 | Gas-liquid chromatographic determination of volatile fatty acids C1 -C6, and lactic acid as their benzyl esters on a fused-silica capillary column显示文摘 | ALEN R JANNARI P SJOSTROM E | 1985 | Finn Chem Lett1985，12，5： | 1 |
| 18 | Gas-liquid chromatographic separation of hydroxy monocarboxylic acid and dicarboxylic acids on a fused-silica capillary column显示文摘 | ALEN R NIEMELA K SJOSTROM E | 1984 | Chromatogr1984，301，4： | 1 |
| 19 | Comparison between perimesencephalic nonaneurysmal subarachnoid hemorrhage and subarachnoid hemorrhage caused by posterior circulation aneurysms 显示文摘 | ALEN J F LAGARES A LOBATO R D | 2003 | J Neurosurg2003，98，3： | 1 |
| 20 | Kinetics of osmotic dehydration of redbell peppersas influenced by pulsed electric field pretreatment显示文摘 | B I O A de - Omowaye P T alens A A ngersbach | 2003 | Food Research International2003，36，： | 1 |
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