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| 1 | Liver transplantation for Wilson disease显示文摘The aim of this paper is to review the current status of liver transplantation (LT) for Wilson disease (WD), focusing on indications and controversies, especially in patients with neuropsychiatric disease, and on identification of acute liver failure (ALF) cases related to WD. LT remains the treatment of choice for patients with ALF, as initial presentation of WD or when anti-copper agents are stopped, and for patients with chronic liver disease progressed to cirrhosis, unresponsive to chelating medications or not timely treated with copper chelating agents. The indication for LT in WD remains highly debated in patients with progressive neurological deterioration and failure to improve with appropriate medical treatment. In case of Wilsonian ALF, early identification is key as mortality is 100% without emergency LT. As many of the copper metabolism parameters are believed to be less reliable in ALF, simple biochemical tests have been proposed for diagnosis of acute WD with good sensitivity and specificity. LT corrects copper metabolism and complications resulting from WD with excellent 1 and 5 year survival. Living related liver transplantation represents an alternative to deceased donor LT with excellent long-term survival, without disease recurrence. Future options mayinclude hepatocyte transplantation and gene therapy. Although both of these have shown promising results in animal models of WD, prospective human studies are much needed to demonstrate their long-term beneficial effects and their potential to replace the need for medical therapy and LT in patients with WD. | Andreea M Catana Valentina Medici | 2012 | World Journal of Hepatology2012，4，1： | 4 |
| 2 | 指南儿童毛细支气管炎:NICE指南概要显示文摘本文是英国医学杂志发布的基于现有最佳证据得出的系列新指南概要之一。它们重点对临床实践提供重要建议,尤其是尚无定论或存有争议的领域。 | Valentina Ricci research fellow Vanessa Delgado Nunes senior research fellow and guideline lead M Stephen Murphy clinical director for children's guidelines Steve Cunningham consultant and honorary reader in paediatric respiratory medicine 许菲 梁志欣 | 2015 | 英国医学杂志中文版2015，0，12： | 4 |
| 3 | Innate immunity–the hallmark of Helicobacter pylori infection in pediatric chronic gastritis显示文摘BACKGROUND Innate immunity was found to be associated with both persistence of Helicobacter pylori(H.pylori)infection and increased risk of gastric cancer.AIM To identify the risk factors associated with H.pylori infection and to establish the role of TLR9 rs352140 in suppressing or promoting inflammation related to this infection in children.METHODS We performed a study of 155 children with digestive symptoms,who were divided into two groups according to the histopathological exam:Group 1–48 children with H.pylori-induced chronic gastritis,and Group 2–control group.RESULTS Rural area and poor living conditions were significantly associated with H.pylori chronic gastritis(P=0.0042/P<0.0001).Both positive immunoglobulin A anti H.pylori and the rapid urease test were significantly associated with H.pylori infection(P<0.0001).Significantly higher values of leukocytes and neutrophils within the peripheral blood were found in children with H.pylori chronic gastritis(P=0.111/P=0.284).We found a significant positive correlation between the variant TT genotype of TLR9 rs352140 polymorphism and both leucocytes and neutrophils(P=0.0225/P=0.0292).CONCLUSION Variant TT genotype carriers of the TLR9 rs352140 gene polymorphism might have a more severe degree of inflammation. | Lorena Elena Meliț Cristina Oana Mărginean Maria Oana Săsăran Simona Mocan Dana Valentina Ghiga Alina Bogliş Carmen Duicu | 2021 | World Journal of Clinical Cases2021，9，23： | 2 |
| 4 | Water-immersion Technique During Standard Upper Endoscopy May Be Useful to Drive the Biopsy Sampling of Duodenal Mucosa in Children With Celiac Disease显示文摘 | Giovanni Cammarota Alessia Cazzato Orazio Genovese Adriano Pantanella Gianluca Ianiro Valentina Giorgio Massimo Montalto Fabio M Vecchio Luigi M Larocca Giovanni Gasbarrini Carlo Fundarò | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，4： | 2 |
| 5 | The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life显示文摘 | Stefano Romeo Federica Sentinelli Valentina M Cambuli Michela Incani Tiziana Congiu Vanessa Matta Sabrina Pilia Isabel Huang-Doran Efisio Cossu Sandro Loche Marco G Baroni | 2010 | Journal of Hepatology2010，，2： | 1 |
| 6 | The S100B protein in biological fluids:more than a lifelong biomarker of brain distress显示文摘 | Fabrizio M Valentina C | 2012 | Journal of Neurochemistry2012，120，6： | 1 |
| 7 | An investigation of acoustic emission to monitoring flat lappimg with non -replenished slurry显示文摘 | Crichigno J M Teixeira C k Valentina L V O D | 2007 | IntJ of Advanced Manufacturing Technology2007，33，： | 1 |
| 8 | Technology and international competitiveness:the interdependence between manufacturing and producer services 显示文摘 | PAOLO G VALENTINA M | 2005 | Structural Change and Economic Dynamics2005，，16： | 1 |
| 9 | Processing and properties of Ti (C, N)-WC-based materials显示文摘 | Alida B Valentina M Fredric M | 2001 | Journal of the American Ceramic Society2001，84，11： | 1 |
| 10 | Technology and international competitiveness: the interdependence between manufacturing and producer services 显示文摘 | Paolo G Valentina M | 2005 | Structural Change and Economic Dynamics2005，16，4： | 1 |
| 11 | Microstructure of hot-pressed Ti (C, N)-based cermets显示文摘 | Frederic M Valentina M Alida B | 2002 | Journal of the European Ceramic Society2002，22，： | 1 |
| 12 | Benfotiamine counteracts glutoxicity effects on endothelial progenitor cell differentiation via Akf O signaling显示文摘 | Valentina M Rossella M Stefano R | 2006 | Diabetes2006，55，8： | 1 |
| 13 | A high-frequency (95 GHz) electron paramagnctic resonance study of B-doped Ti02 photocatalysts显示文摘 | MARIA F A VALENTINA G B TIZIANO M B PAOLO F | 2008 | Inorganica Chimica Acta2008，361，： | 1 |
| 14 | Efficacy and tolerability of olanzapine in patients with schizophre- nia in lithuania: a 13-week, multicenter, open-label, non- randomized Study显示文摘 | Valentinas M Istvan B Raimundas M | 2004 | Current Therapeutic Research2004，65，1： | 1 |
| 15 | Antioxidant activity of some substituted 1,2,4-triazo-5-thione schiff base显示文摘 | Valentina P Ilango K Deepthi M | 2009 | J Pharm Sci and Res2009，1，2： | 1 |
| 16 | Pd and Pt-Ru anode electrocatalysts supported on multi-walled carbon nanotubes and their use in passive end active direct alcohol fuel cells with an anion-exchange membrane (alcohol=methanol,ethanol,glycerol)显示文摘 | Valentina B Clandio B Andrea M | 2009 | J Power Sources2009，190，2： | 1 |
| 17 | Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair显示文摘 | Chang Goo Huh Valentina M Factor Aranzazu Sanchez | 2004 | PNAS2004，101，13： | 1 |
| 18 | 显示文摘 | Branislava M Majstorovi? Snezana Simi? Branko D Milakovi? Dragan S Vucovi? Valentina V Aleksi | 1900 | Srpski arhiv za celokupno lekarstvo1900，138，： | 1 |
| 19 | Technology and International Competitiveness: The Interdependence between Manufacturing and Producer Services 显示文摘 | Paolo G Valentina M | 2005 | Structural Change and Economic Dynamics2005，，16： | 1 |
| 20 | Tailoring high-cut-off membranes and feasible application in sepsis-associated acute renal failure:in vitro studies显示文摘 | Filippo M Valentina F Giacomo L | 2005 | Nephrol Dial Transplant2005，20，： | 1 |
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