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| 1 | The potential of natural products for targeting PPARα显示文摘Peroxisome proliferator activated receptors(PPARs) α,-γ and-β/δ are ligand-activated transcription factors and members of the superfamily of nuclear hormone receptor. These receptors play key roles in maintaining glucose and lipid homeostasis by modulating gene expression. PPARs constitute a recognized druggable target and indeed several classes of drugs used in the treatment of metabolic disease symptoms, such as dyslipidemia(fibrates, e.g. fenofibrate and gemfibrozil) and diabetes(thiazolidinediones, e.g. rosiglitazone and pioglitazone) are ligands for the various PPAR isoforms. More precisely, antidiabetic thiazolidinediones act on PPARγ, while PPARα is the main molecular target of antidyslipidemic fibrates. Over the past few years, our understanding of the mechanism underlying the PPAR modulation of gene expression has greatly increased. This review presents a survey on terrestrial and marine natural products modulating the PPARα system with the objective of highlighting how the incredible chemodiversity of natural products can provide innovative leads for this 'hot' target. | Daniela Rigano Carmina Sirignano Orazio Taglialatela-Scafati | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 9 |
| 2 | Enteropathic spondyloarthropathy:A common genetic background with inflammatory bowel disease?显示文摘The association between spondyloarthropathy and in flammatory bowel disease(IBD) is largely established, although prevalence is variable because of different population selection and diagnostic methodologies.Most studies indicate that as many as 10%15% of cases of IBD are complicated by ankylosing spondylitis(AS) or other forms of spondylarthritis(SpA).Of note, ileal inflammation resembling IBD has been reported in up to two thirds of cases of SpA, and it has been suggested that the presence of ileitis is associated with the chronic ity of articular complications.Although this observation is of interest to unravel the pathophysiology of the disease, systematic screening of patients with SpA by ileocolonos copy is not indicated in the absence of gut symptoms, as only a small proportion of patients with subclinical gut inflammation will develop overt IBD over time.The existence of familial clustering of both IBD and AS, the coexistence of both conditions in a patient, the evidence of an increased risk ratio among f irstand seconddegree relatives of affected AS or IBD patients and f inally, the increased crossrisk ratios between AS and IBD, strongly suggest a shared genetic background.So far, however, IL23R is the only identified susceptibility gene shared by both IBD and AS.Although functional studies are still needed to better understand its pathogenic role, great ef fort is being spent therapeutically targeting this pathway that may prove effective for both disorders. | Elisabetta Colombo Anna Latiano Orazio Palmieri Fabrizio Bossa Angelo Andriulli Vito Annese | 2009 | World Journal of Gastroenterology2009，15，20： | 4 |
| 3 | Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult-and pediatric-onset inflammatory bowel disease in Italy显示文摘AIM: To investigate gene variants in a large Italian inflammatory bowel disease (IBD) cohort, and to analyze the correlation of sub-phenotypes (including age at diagnosis) and epistatic interaction with other IBD genes. METHODS: Total of 763 patients with Crohn's disease (CD, 189 diagnosed at age < 19 years), 843 with ulcerative colitis (UC, 179 diagnosed <19 years), 749 healthy controls, and 546 healthy parents (273 trios) were included in the study. The rs2241880 [autophagy-related 16-like 1 (ATG16L1)], rs11209026 and rs7517847 [interleukin 23 receptor (IL23R)], rs2066844, rs2066845, rs2066847 (CARD15), rs1050152 (OCTN1), and rs2631367 (OCTN2) gene variants were genotyped. RESULTS: The frequency of G allele of ATG16L1 SNP (Ala197Thr) was increased in patients with CD compared with controls (59% vs 54% respectively) (OR = 1.25, CI = 1.08-1.45, P = 0.003), but not in UC (55%). The frequency of A and G (minor) alleles of Arg381Gln, rs11209026 and rs7517847 variants of IL23R were reduced significantly in CD (4%, OR = 0.62, CI = 0.45-0.87, P = 0.005; 28%, OR = 0.64, CI = 0.55-0.75, P < 0.01), compared with controls (6% and 38%, respectively). The A allele (but not G) was also reduced signifi cantly in UC (4%, OR = 0.69, CI = 0.5-0.94, P = 0.019). No association was demonstrated with sub-phenotypes and interaction with CARD15 , and OCTN1/2 genes, although both gene variants were associated with pediatric-onset disease. CONCLUSION: The present study confirms the association of IL23R polymorphisms with IBD, and ATG16L1 with CD, in both adult- and pediatric-onset subsets in our study population. | Anna Latiano Orazio Palmieri Maria Rosa Valvano Renata D'Incà Salvatore Cucchiara Gabriele Riegler Anna Maria Staiano Sandro Ardizzone Salvatore Accomando Gian Luigi de Angelis Giuseppe Corritore Fabrizio Bossa Vito Annese | 2008 | World Journal of Gastroenterology2008，14，29： | 3 |
| 4 | Water-immersion Technique During Standard Upper Endoscopy May Be Useful to Drive the Biopsy Sampling of Duodenal Mucosa in Children With Celiac Disease显示文摘 | Giovanni Cammarota Alessia Cazzato Orazio Genovese Adriano Pantanella Gianluca Ianiro Valentina Giorgio Massimo Montalto Fabio M Vecchio Luigi M Larocca Giovanni Gasbarrini Carlo Fundarò | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，4： | 2 |
| 5 | Botulinum toxin associated with fissurectomy and anoplasty for hypertonic chronic anal fissure: A case-control study显示文摘BACKGROUND Lateral internal sphincterotomy is still the approach of choice for the treatment of chronic anal fissure(CAF)with internal anal sphincter(IAS)hypertonia,but it is burdened by high-risk postoperative faecal incontinence(FI).Sphincter saving procedures have recently been reconsidered as treatments to overcome this risk.The most employed procedure is fissurectomy with anoplasty,eventually associated with pharmacological sphincterotomy.AIM To evaluate whether fissurectomy and anoplasty with botulinum toxin injection improves the results of fissurectomy and anoplasty alone.METHODS We conducted a case-control study involving 30 male patients affected by CAF with hypertonic IAS who underwent fissurectomy and anoplasty with V-Y cutaneous flap advancement.The patients were divided into two groups:Those in group I underwent surgery alone,and those in group II underwent surgery and a botulinum toxin injection directly into the IAS.They were followed up for at least 2 years.The goals were to achieve complete healing of the patient and to assess the FI and recurrence rate along with manometry parameters.RESULTS The intensity and duration of post-defecatory pain decreased significantly in both groups of patients starting with the first defecation,and this reduction was higher in group II.Forty days after surgery,we achieved complete wound healing in all the patients in group II but only in 80%of the patients in group I(P<0.032).We recorded 2 cases of recurrence,one in each group,and both healed with conservative therapy.We recorded one temporary and low-grade postoperative case of“de novo”FI.Manometry parameters reverted to the normal range earlier for group II patients.CONCLUSION The injection of botulinum toxin A in association with fissurectomy and anoplasty with a V-Y advancement flap improves the results of surgery alone in patients affected by CAF with IAS hypertonia. | Beatrice D'Orazio Girolamo Geraci Fausto Famà Gloria Terranova Gaetano Di Vita | 2021 | World Journal of Clinical Cases2021，9，32： | 2 |
| 6 | Helicobacter pylori infection and the risk of myocardial infarction :role of fibrinogen and its genetic control 显示文摘 | Zito F Di Castelnuovo A D orazio A | 1999 | Thromb Haemost1999，82，： | 1 |
| 7 | A new algorithm for ball recognition using circle Hough transform and neural classifier显示文摘 | 'ORAZIO T D GUARAGNELLA C LEO M | 2004 | Pattern Recognition2004，37，： | 1 |
| 8 | Antimi- crohial activity of commercial Olea europaea (olive) leaf extract显示文摘 | Sudjana A N D'Orazio C Ryan V | 2009 | International Journal of Antimicrobial Agents2009，33，5： | 1 |
| 9 | Optimization of acyclic bandwidth allocation exploiting the priority mechanism in the fieldbus data link layer, 0278-0046/93,1993显示文摘 | Salvatore Cavalieri Antonella Di Stefano Orazio Mirabella | 1993 | IEEE1993，，： | 1 |
| 10 | Field and laboratory studies on the movement and fate of tetrachlo-dibenzo-p-dioxin in soil 显示文摘 | Kapila S Yanders A F Orazio C E | 1989 | Chemosphere1989，18，13： | 1 |
| 11 | Detection of antigens recognized by a novel monoclonal antibody in tissue and serum from patients with breast cancer 显示文摘 | Iacobelli S Amo E D'Orazio A | 1986 | Cancer Res1986，46，6： | 1 |
| 12 | Morphology properties relationships in binary polyamide 6/rubber blends: influence of the addition of a functionalized rubber 显示文摘 | Cimmino S D Orazio L Greco R | 1984 | Polymer Engineering and Science1984，24，1： | 1 |
| 13 | Phase II anti Ⅲ trials:comparison of four ehemntherapy regimens in advanced nnn small-cell lung cancer (ECOG1594)显示文摘 | Fisher MD D'Orazio A | 2000 | Clin Lung Cancer2000，2，1： | 1 |
| 14 | A novel role for TGF-β and IL-10 in the induction of immune privilege显示文摘 | D'Orazio T J Niederkorn J Y | 1998 | J Immunol1998，160，5： | 1 |
| 15 | Chemical and mechanical treatments to improve the surface properties of shape memory NiTi wires显示文摘 | S. Rossi F. Deflorian A. Pegoretti D. D’Orazio S. Gialanella | 2007 | Surface & Coatings Technology2007，，10： | 1 |
| 16 | The Pali Aike Volcanic Field, Patagonia: Slab-window magmatism near the tip of South America显示文摘 | D'Orazio M Agostini S Mazzarini F | 2000 | Tectonophysics2000，321，： | 1 |
| 17 | Impact of 3rd gen eration drugs on the activity of first-line chemotherapy in ad ranted non small cell lung cancer (NSCLC): a meta analyti cal approach: BE 07显示文摘 | Francesco G Carlotta D Orazio V | 2007 | J Thorac Oncol2007，2，8： | 1 |
| 18 | Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities显示文摘 | Eleni Pontiki Dimitra Hadjipavlou-Litina Konstantinos Litinas Orazio Nicolotti Angelo Carotti | 2010 | European Journal of Medicinal Chemistry2010，，1： | 1 |
| 19 | Complete periprostatic anatomy preservation during robot-assisted laparo scopic radical prostatectomy (RALP) : the new pubovesical complex-sparing technique 显示文摘 | Asimakopoulos AD Annino F D'Orazio A | 2010 | Eur Urol2010，58，： | 1 |
| 20 | The flavonoids of leek, Allium porrum 显示文摘 | Ernesto Fattorusso Virginia Lanzotti Orazio TaglialatelaScafati | 2001 | Phytochemistry2001，57，： | 1 |
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