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| 1 | Aquaporins:Their role in cholestatic liver disease显示文摘This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and cholestasis.Canalicular bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8.The question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of cholestasis.Studies in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein downregulation.The combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water flow.Thus cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability. | Guillermo L Lehmann Maria C Larocca Leandro R Soria Raúl A Marinelli | 2008 | World Journal of Gastroenterology2008，14，46： | 8 |
| 2 | The Water Immersion Technique is Easy to Learn for Routine Use During EGD for Duodenal Villous Evaluation: A Single-Center 2-year Experience显示文摘 | Giovanni Cammarota Paola Cesaro Alessia Cazzato Rossella Cianci Paolo Fedeli Veronica Ojetti Maria Certo Lucia Sparano Silvia Giovannini Luigi M. Larocca Fabio M. Vecchio Giovanni Gasbarrini | 2009 | Journal of Clinical Gastroenterology2009，，3： | 2 |
| 3 | Water-immersion Technique During Standard Upper Endoscopy May Be Useful to Drive the Biopsy Sampling of Duodenal Mucosa in Children With Celiac Disease显示文摘 | Giovanni Cammarota Alessia Cazzato Orazio Genovese Adriano Pantanella Gianluca Ianiro Valentina Giorgio Massimo Montalto Fabio M Vecchio Luigi M Larocca Giovanni Gasbarrini Carlo Fundarò | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，4： | 2 |
| 4 | Efficacy and safety of once- weekly bortezomib in multiple myeloma patients 显示文摘 | Bringhen S Larocca A Rossi D | 2010 | Blood2010，116，23： | 1 |
| 5 | Efficacy and safety of once-weekly bortezomib in multiple myeloma patients 显示文摘 | Bringhen S Larocca A Rossi D | 2010 | Blood2010，116，23： | 1 |
| 6 | P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries 显示文摘 | Andre P Delaney SM LaRocca T | 2003 | J Clin Invest2003，112，3： | 1 |
| 7 | A highly accurate method for monitoring histological recovery in patients with celiac disease on a gluten-free diet using an endoscopic approach that avoids the need for biopsy: a double-center study显示文摘 | G. Cammarota L. Cuoco P. Cesaro L. Santoro A. Cazzato M. Montalto R. La Mura L. Larocca F. Vecchio A. Gasbarrini M. Salvagnini G. Gasbarrini | 2007 | Endoscopy2007，，01： | 1 |
| 8 | Integrated design and analysis of intakes and nozzles in air- breathing engines显示文摘 | FERLAUTO M LAROCCA F & ZANNETTI L | 2002 | Journal of Propulsion and Power2002，18，1： | 1 |
| 9 | Rehabilitation of intimacy and sexual dysfunction in couples with multiple sclerosis显示文摘 | Foley FW Larocca NG Sanders AS | 2001 | Mult Scler2001，7，6： | 1 |
| 10 | The water channel aquaporin-8 is mainly intracellular in rat hepatocytes,and its plasma membrane insertion is stimulated by cyclic AMP显示文摘 | Garcia F Kierbel A Larocca MC | 2001 | J Biol Chem2001，276，12： | 1 |
| 11 | The laminectomy membrane:stadies in its evolution,characteristics,effects and prophylaxis in dogs显示文摘 | Larocca H Macnab J | 1974 | J Bone Joint Surg(Br)1974，56，： | 1 |
| 12 | Complete response correlates with long-term progression-free and overall survival in elderly myeloma treated with novel agents: analysis of 1175 patients显示文摘 | Gay F Larocca A Wijermans P | 2011 | Blood2011，117，11： | 1 |
| 13 | Optimal band imaging system: a new tool for enhancing the duodenal villous pattern in celiac disease显示文摘 | Giovanni Cammarota Paola Cesaro Alessia Cazzato Paolo Fedeli Lucia Sparano Fabio M. Vecchio Luigi M. Larocca Giovanni Gasbarrini | 2008 | Gastrointestinal Endoscopy2008，，2： | 1 |
| 14 | The impact of first trimester phthalate and phenol exposure on IGF2/H19 genomic imprinting and birth outcomes显示文摘 | LaRocca J Binder AM Mc Elrath TF Michels KB | 2014 | Environ Res2014，133，： | 1 |
| 15 | Quercetin inhibition of tumor invasion via suppressing PKC Int J显示文摘 | Ranelletti FO Ricci R Larocca LM | 1992 | Cancer1992，50，3： | 1 |
| 16 | Development and evaluation of a patient decision aid for pediatric interval appendectomy显示文摘Objective One option for the treatment of perforated appendicitis in pediatric patients is interval appendectomy(IA).A patient decision aid(PDA)can be useful in the decision-making process regarding IA.The purpose of this study was to evaluate parents’decisional conflict before and after engaging with a developed PDA.Methods Participants included(a)parents who are considering IA surgery for their child,(b)have not yet had their follow-up appointment postdischarge,and(c)were fluent in either the official languages of English or French.This study used a pretest and post-test design to measure participants’decisional conflict and treatment option choice.Perceptions and acceptability of the PDA were also assessed.Results A total of 18 participants completed the study(16 mothers).Major findings include significant decreases in all Decisional Conflict Scale items from pre-PDA to post-PDA engagement,except for one item.The majority of participants perceived the PDA to be useful,easy to find information regarding risks and provided enough information to help them make a decision regarding their child’s treatment.Conclusions This is the first study to develop and evaluate a PDA among parents who are making a decision regarding IA surgery.The results showed a significant decrease in decisional conflict after using the PDA.The results also showed that the PDA was generally accepted among parents and had positive perceptions regarding length,content,and balance.The use of PDA for this population can help ease feelings of decisional conflict and equip parents with the information to make informed decisions. | Victoria Larocca Irina Oltean Viviane Grandpierre Ahmed Nasr | 2022 | World Journal of Pediatric Surgery2022，5，4： | 1 |
| 17 | Quercetin Inhibits the Growth of Leukemic Progenitors and Induces the Expression of Transforming Growth Factor-β1 in These Cells 显示文摘 | Larocca L M Teofili L Sica S | 1995 | Blood1995，，： | 1 |
| 18 | Expression and signal transduction of the glucagon receptor in betaTC3 cells显示文摘 | Li J Larocca JN Rodriguez-Gabin AG Charron MJ | 1997 | Biochim Biophys Acta1997，1356，2： | 1 |
| 19 | Mitochondria‐targeted antioxidant (MitoQ) ameliorates age‐related arterial endothelial dysfunction in mice显示文摘 | Rachel A. Gioscia‐Ryan Thomas J. LaRocca Amy L. Sindler Melanie C. Zigler Michael P. Murphy Douglas R. Seals | 2014 | J Physiol2014，，12： | 1 |
| 20 | Current treatment strategies with lenalidomide in multiple myeloma and future perspectives 显示文摘 | Larocca A Cavallo F Mina R | 2012 | Future Oncol2012，8，10： | 1 |
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