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| 1 | Gut microbiota in autism and mood disorders显示文摘The hypothesis of an important role of gut microbiota in the maintenance of physiological state into the gastrointestinal(GI)system is supported by several studies that have shown a qualitative and quantitative alteration of the intestinal flora in a number of gastrointestinal and extra-gastrointestinal diseases.In the last few years,the importance of gut microbiota impairment in the etiopathogenesis of pathology such as autism,dementia and mood disorder,has been raised.The evidence of the inflammatory state alteration,highlighted in disorders such as schizophrenia,major depressive disorder and bipolar disorder,strongly recalls the microbiota alteration,highly suggesting an important role of the alteration of GI system also in neuropsychiatric disorders.Up to now,available evidences display that the impairment of gut microbiota plays a key role in the development of autism and mood disorders.The application of therapeutic modulators of gut microbiota to autism and mood disorders has been experienced only in experimental settings to date,with few but promising results.A deeper assessment of the role of gut microbiota in the development of autism spectrum disorder(ASD),as well as the advancement of the therapeutic armamentarium for the modulation of gut microbiota is warranted for a better management of ASD and mood disorders. | Francesca Mangiola Gianluca Ianiro Francesco Franceschi Stefano Fagiuoli Giovanni Gasbarrini Antonio Gasbarrini | 2016 | World Journal of Gastroenterology2016，22，1： | 23 |
| 2 | Role of Helicobacter pylori infection on nutrition and metabolism显示文摘Helicobacter pylori(H. pylori) is a gram-negative pathogen that is widespread all over the world, infecting more than 50% of the world's population. It is etiologically associated with non-atrophic and atrophic gastritis, peptic ulcer and shows a deep association with primary gastric B-cell lymphoma and gastric adenocarcinoma. Recently, the medical research focused on the modification of the gastric environment induced by H. pylori infection, possibly affecting the absorption of nutrients and drugs as well as the production of hormones strongly implicated in the regulation of appetite and growth. Interestingly, the absorption of iron and vitamin B12 is impaired by H. pylori infection, while infected subjects have lower basal and fasting serum levels of ghrelin and higher concentration of leptin compared to controls. Since leptin is an anorexigenic hormone, and ghrelin stimulates powerfully the release of growth hormone in humans, H. pylori infection may finally induce growth retardation if acquired very early in the childhood and in malnourished children. This review is focused on the nutritional effects of H. pylori infection, such as the reduced bioavailability or the malabsorbption of essential nutrients, and of gastrointestinal hormones, as well as on the relationship between H. pylori and the metabolic syndrome. | Francesco Franceschi Tortora Annalisa Di Rienzo Teresa D'Angelo Giovanna Gianluca Ianiro Scaldaferri Franco Gerardi Viviana Tesori Valentina Lopetuso Loris Riccardo Gasbarrini Antonio | 2014 | World Journal of Gastroenterology2014，20，36： | 11 |
| 3 | 2016年欧洲粪菌移植共识介绍显示文摘粪菌移植(fecal microbiota transplantation,FMT)是治疗艰难梭菌感染的一个重要选择。研究表明,FMT也可能在管理与肠道微生物群变化相关的其他疾病方面发挥作用。虽然医疗界正在用最新的观点评估FMT,且患者正在变得越来越了解FMT,但在将非标准化的治疗方案转化为安全和管理恰当的临床实践中存在技术和后勤问题。鉴于此,需要一个基于证据的指南来推动FMT的实际实施。在这个欧洲共识会议上,来自10个国家的28名专家,分成多个小组并通过循证过程对以下事项提供了指南:FMT适应证、供体选择、粪便材料的准备、临床管理和移植实施,以及建立一个FMT中心的基本要求。每个小组提出的指南经过全体成员的评估和投票,首先通过Delphi电子流程,随后经过全体共识会议。指南根据现有最佳证据提出,目的是为计划进行FMT的医师提供指导,以期支持这种疗法的广泛适用性,探讨与FMT有关的其他事项并促进未来在肠道菌群操作领域的临床研究。共识报告强烈建议建立治疗艰难梭菌感染的FMT中心,并提供技术、标准、管理和实验室相关要求。 | 李超 谈路轩 张馨梅 汪志兵 张振玉 Cammarota G Ianiro G Tilg H | 2017 | 胃肠病学和肝病学杂志2017，26，9： | 10 |
| 4 | Endoscopic tools for the diagnosis and evaluation of celiac disease显示文摘Celiac disease(CD)is an autoimmune disease of the small bowel induced by ingestion of wheat,rye and barley.Current guidelines indicate histological analysis on at least four duodenal biopsies as the only way to diagnose CD.These indications are based on the conception of the inability of standard endoscopy to make diagnosis of CD and/or to drive biopsy sampling.Over the last years,technology development of endoscopic devices has greatly ameliorated the accuracy of macroscopic evaluation of duodenal villous pattern,increasing the diagnostic power of endoscopy of CD.The aim of this paper is to review the new endoscopic tools and procedures proved to be useful in the diagnosis of CD,such as chromoendoscopy,Fujinon Intelligent Chromo Endoscopy,Narrow Band Imaging,Optical Coherence Tomography,Water-Immersion Technique,confocal laser endomicroscopy,high-resolution magnification endoscopy,capsule endoscopy and I-Scan technology. | Gianluca Ianiro Antonio Gasbarrini Giovanni Cammarota | 2013 | World Journal of Gastroenterology2013，19，46： | 5 |
| 5 | Microscopic colitis显示文摘Microscopic colitis may be defined as a clinical syndrome, of unknown etiology, consisting of chronic watery diarrhea, with no alterations in the large bowel at the endoscopic and radiologic evaluation. Therefore, a definitive diagnosis is only possible by histological analysis. The epidemiological impact of this disease has become increasingly clear in the last years, with most data coming from Western countries. Microscopic colitis includes two histological subtypes [collagenous colitis (CC) and lymphocytic colitis (LC)] with no differences in clinical presentation and management. Collagenous colitis is characterized by a thickening of the subepithelial collagen layer that is absent in LC. The main feature of LC is an increase of the density of intra-epithelial lymphocytes in the surface epithelium. A number of pathogenetic theories have been proposed over the years, involving the role of luminal agents, autoimmunity, eosinophils, genetics (human leukocyte antigen), biliary acids, infections, alterations of pericryptal fibroblasts, and drug intake; drugs like ticlopidine, carbamazepine or ranitidine are especially associated with the development of LC, while CC is more frequently linked to cimetidine, non-steroidal antiinflammatory drugs and lansoprazole. Microscopic colitis typically presents as chronic or intermittent watery diarrhea, that may be accompanied by symptoms such as abdominal pain, weight loss and incontinence. Recent evidence has added new pharmacological options for the treatment of microscopic colitis:the role of steroidal therapy, especially oral budesonide, has gained relevance, as well as immunosuppressive agents such as azathioprine and 6-mercaptopurine. The use of anti-tumor necrosis factoragents, infliximab and adalimumab, constitutes a new, interesting tool for the treatment of microscopic colitis, but larger, adequately designed studies are needed to confirm existing data. | Gianluca Ianiro Giovanni Cammarota Luca Valerio Brigida Eleonora Annicchiarico Alessandro Milani Massimo Siciliano Antonio Gasbarrini | 2012 | World Journal of Gastroenterology2012，18，43： | 4 |
| 6 | Culture-guided treatment approach for Helicobacter pylori infection:Review of the literature显示文摘The progressive loss of efficacy of standard eradication therapies has made the treatment of Helicobacter pylori(H.pylori)more challenging than ever.Endoscopicguided antibiotic susceptibility testing had previously been suggested to guide treatment after failure of second-line therapies.However,its role has expanded over the years,in accordance with the current Maastricht Guidelines.Several authors have dealt with this topic,developing both efficacy trials and cost-effectiveness trials against resistant H.pylori infections as well as infections in nave patients.However,results are not homogeneous enough to provide definite advice,because antibiotic resistance is not the only reason for treatment failure.Moreover,the culture-guided approach is surrounded by many practical issues,such as the availability of both endoscopy units and microbiology laboratories,and the need for a standard of quality that cannot be satisfied everywhere.Finally,pre-treatment susceptibility testing should be partand not the only weapon-of a targeted,personalized strategy to overcome H.pylori infection. | Giovanni Cammarota Gianluca Ianiro Stefano Bibbò Teresa Antonella Di Rienzo Luca Masucci Maurizio Sanguinetti Antonio Gasbarrini | 2014 | World Journal of Gastroenterology2014，20，18： | 3 |
| 7 | Biofilm Demolition and Antibiotic Treatment to Eradicate Resistant Helicobacter pylori : A Clinical Trial显示文摘 | Giovanni Cammarota Giovanna Branca Fausta Ardito Maurizio Sanguinetti Gianluca Ianiro Rossella Cianci Riccardo Torelli Giovanna Masala Antonio Gasbarrini Giovanni Fadda Raffaele Landolfi Giovanni Gasbarrini | 2010 | Clinical Gastroenterology and Hepatology2010，，9： | 3 |
| 8 | Water-immersion Technique During Standard Upper Endoscopy May Be Useful to Drive the Biopsy Sampling of Duodenal Mucosa in Children With Celiac Disease显示文摘 | Giovanni Cammarota Alessia Cazzato Orazio Genovese Adriano Pantanella Gianluca Ianiro Valentina Giorgio Massimo Montalto Fabio M Vecchio Luigi M Larocca Giovanni Gasbarrini Carlo Fundarò | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，4： | 2 |
| 9 | Gut microbiota and metabolic syndrome显示文摘 | Francesca D’Aversa Annalisa Tortora Gianluca Ianiro Francesca Romana Ponziani Brigida Eleonora Annicchiarico Antonio Gasbarrini | 2013 | Internal and Emergency Medicine2013，，1： | 1 |
| 10 | Effect of an ex- tra-virgin olive oil enriched with probiotics or antioxidants on functional dyspepsia: a pilot study显示文摘 | Ianiro G Pizzoferrato M Franceschi F | 2013 | European Review for Medical Pharmacological Sciences2013，17，15： | 1 |
| 11 | Can chronic gastritis cause an increase in fecal calprotectin concentrations?显示文摘AIM:To evaluate fecal calprotectin concentrations(FCCs) in subjects with chronic gastritis and the correlation between FCCs and gastritis activity score.METHODS:FCCs were measured in 61 patients with histological diagnosis of gastritis and in 74 healthy volunteers.Histological grading of gastritis was performed according to the updated Sydney gastritis classification.Patients were subdivided into 2 groups according to the presence/absence of an active gastritis.Patients with chronic active gastritis were divided into 3 subgroups on the basis of the activity score(mild,moderate,marked).FFCs in relation to Helicobacter pylori(H.pylori) infection and proton pump inhibitor(PPI) use were also evaluated.RESULTS:FCCs in patients with chronic active gastritis were not significantly different to FCCs either in subjects with non active gastritis or in healthy controls.Among patients with chronic active gastritis(even marked),FCCs did not significantly differ according to activity score.No significant differences in FCCs were found when considering H.pylori,as well as when considering PPI chronic use.CONCLUSION:FCCs were not significantly increased in subjects with chronic gastritis,even in those patients with a marked neutrophil infiltration. | Massimo Montalto Antonella Gallo Gianluca Ianiro Luca Santoro Ferruccio D Onofrio Riccardo Ricci Giovanni Cammarota Marcello Covino Monica Vastola Antonio Gasbarrini Giovanni Gasbarrini Ricca rdo Ricci | 2010 | World Journal of Gastroenterology2010，16，27： | 1 |
| 12 | Measurement of surfacetemperature and emissivity with stereo dual-wavelengthIR thermography 显示文摘 | IANIRO A CARDONE G | 2010 | Journal of Modem Optics ’2010，57，18： | 1 |
| 13 | Rotavirus genotypes in sewage treatment plants and in children hospitalized with acute diarrhea in Italy in 2010 and 2011 显示文摘 | Ruggeri FM Bonomo P Ianiro GA | 2015 | Applied and Environmental Microbiology2015，81，1： | 1 |
| 14 | Fecal microbiota trans- plantation for the treatment of Clostridium difficile infection:a systematic review 显示文摘 | Cammarota G Ianiro G Gasbarrini A | 2014 | J Clin Gastroenterol2014，48，1： | 1 |
| 15 | Fecal microbiota transplanta-tion in inflammatory bowel disease: beyond the excitement 显示文摘 | Ianiro G Bibbo S Scaldaferri F | 2014 | Med-icine2014，93，19： | 1 |
| 16 | Effect of an extra-virgin olive oil enriched with probiotics or antioxidants on functionaldyspep- sia: a pilot study显示文摘 | Ianiro G Pizzoferrato M Franceschi F | 2013 | Eur Rev Med Pharmacol Sci2013，17，15： | 1 |
| 17 | The involve- ment of gut microbiota in inflammatory bowel disease pathogenesis: Potential for therapy 显示文摘 | CAMMAROTA G IANIRO G CIANCI R | 2015 | Pharmacology & Therapeutics2015，149，： | 1 |
| 18 | The effect of Lactobacillus reuteri supplementation in adults with chronic functional constipation: a randomized, double-blind, placebo-controlled trial 显示文摘 | Ojetti V Ianiro G Tortora A | 2014 | J Gastrointestin Liver Dis2014，23，4： | 1 |
| 19 | Genomic characterization of uncommon human G3P rotavirus strains causing diarrhea in children in Italy in 2009 显示文摘 | Ianiro G Delogu R Fiore L | 2015 | Infect Genet Evol2015，33，： | 1 |
| 20 | Biofilm Demolition and Antibiotic Treatment to Eradicate Resistant Helicobacter pylori : A Clinical Trial显示文摘 | Giovanni Cammarota Giovanna Branca Fausta Ardito Maurizio Sanguinetti Gianluca Ianiro Rossella Cianci Riccardo Torelli Giovanna Masala Antonio Gasbarrini Giovanni Fadda Raffaele Landolfi Giovanni Gasbarrini | 2010 | Clinical Gastroenterology and Hepatology2010，，9： | 1 |
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