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| 1 | Viral degradasome hijacks mitochondria to suppress innate immunity显示文摘在主人和病原体的能力的天生的免疫之间的平衡影响致病和毒力强烈躲避它。二 nonstructural (NS ) 蛋白质, NS1 和 NS2,呼吸 syncytial,病毒(RSV ) 极其为 RSV 被要求毒力。一起,他们强烈压制类型我干扰素(IFN ) 调停了由降级或禁止多重细胞的因素的主人房间的天生的免疫为 IFN 正式就职或反应要求了小径包括 RIG-I, IRF3, IRF7, TBK1 和 STAT2。这里,我们为 NS 蛋白质装配的大、异构的 degradative 建筑群的存在提供证据,我们把它称为 “ NS-degradasome”(NSD ) 。NSD 是粗略地,在尺寸的 ~ 300-750 kD,和它的 degradative 活动被净化的线粒体的增加在 vitro 提高。在房间, NS 蛋白质的多数和到在 RSV 感染之上的线粒体的 NSD translocated 的底层内。基因并且药理学证据证明天生的豁免的最佳的抑制要求 mitochondrial MAVS 和 mitochondrial 活动性。一起,我们建议在的一个新奇范例线粒体,知道为主人的天生的有免疫力的激活重要,为天生的免疫的病毒的抑制也是重要的。 | Ramansu Goswami Tanmay Majumdar Jayeeta Dhar Saurabh Chattopadhya3~ Sudip K Bandyopadhyay Valentina Verbovetskaya Ganes C Sen Sailen Barik | 2013 | Cell Research2013，23，8： | 6 |
| 2 | T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression显示文摘 | Elena Klyushnenkova Joseph D Mosca Valentina Zernetkina Manas K Majumdar Kirstin J Beggs Donald W Simonetti Robert J Deans Kevin R McIntosh | 2005 | Journal of Biomedical Science2005，，1： | 2 |
| 3 | Analysis of trace elements in scalp hair of healthy people,hyperplasia and breast cancer patients with XRF method显示文摘 | YURIY K VALENTINA K ALEXANDER C | 2000 | Nuclear Lnstruments and Methods in Physics Research A2000，448，12： | 1 |
| 4 | Mesorectal lymph nodes:their location and distribution within the mesorectum显示文摘 | Boris T Robert A Valentina K | 2003 | Dis Colon Rectum2003，46，6： | 1 |
| 5 | An investigation of acoustic emission to monitoring flat lappimg with non -replenished slurry显示文摘 | Crichigno J M Teixeira C k Valentina L V O D | 2007 | IntJ of Advanced Manufacturing Technology2007，33，： | 1 |
| 6 | Antioxidant activity of some substituted 1,2,4-triazo-5-thione schiff base显示文摘 | Valentina P Ilango K Deepthi M | 2009 | J Pharm Sci and Res2009，1，2： | 1 |
| 7 | Prognostic value of pathologic complete response after primary chemotherapy in relation to hormone receptor status and other factors 显示文摘 | Valentina G Kristine B Shu-Wan K | 2006 | J Clin Oncol2006，24，7： | 1 |
| 8 | Embryonic stem cell trials for macular degeneration: a preliminary report显示文摘 | Steven D Schwartz Jean-Pierre Hubschman Gad Heilwell Valentina Franco-Cardenas Carolyn K Pan Rosaleen M Ostrick Edmund Mickunas Roger Gay Irina Klimanskaya Robert Lanza | 2012 | The Lancet2012，，9817： | 1 |
| 9 | 显示文摘 | Natalya B Nikolay K Valentina K | 2003 | J Virol2003，77，11： | 1 |
| 10 | Serotonin reuptake transporter(SERT)plays a critical role in the onset of fructose-in- duced hepatic steatosis in mice显示文摘 | Synia H Giridhar K Valentina V | 2010 | Am J Physiol Gastrointest Liver Physiol2010，298，3： | 1 |
| 11 | Glomerular filtration:still sympathetic to endothelin′s influence显示文摘 | Tracy EH Valentina K | 2009 | J Am Soc Nephrol2009，20，5： | 1 |
| 12 | Coordinate induction of glyathione biosynthesis and glutathione-metabolizing enzymes is correlated with salt tolerance in tomato显示文摘 | Valentina Mittova Frederica L Theodoulou G K | 2003 | FEBS Letters2003，，554： | 1 |
| 13 | Multiple core-shell functionalized colloidal mesoporous silica nanoparticles显示文摘 | Valentina C Axel S Johann K | 2009 | J Am Chem Soc2009，131，11： | 1 |
| 14 | PR interval identifies clinical response in patients with non-left bundle branch block a multicenter automatic defibrillator implantation trial cardiac re- synchronization therapy substudy 显示文摘 | Valentina K Martin S Brian O | 2014 | Circ Arrhythm Electro- physiol2014，7，4： | 1 |
| 15 | A novel LXR-α activator identified from the natural product Gynostemma pentaphyllum显示文摘 | Tom H H Valentina R N Noeris K S | | 0，，09： | 1 |
| 16 | Determination of anthocyanins in four Croatian cuhivars of sour cher- ries(Prunus cerasus)显示文摘 | Valentina S Spomenka K Dajana G | 2005 | European Food Research and Technology2005，220，： | 1 |
| 17 | Embryonic stem cell trials for macular degeneration: a preliminary report显示文摘 | Steven D Schwartz Jean-Pierre Hubschman Gad Heilwell Valentina Franco-Cardenas Carolyn K Pan Rosaleen M Ostrick Edmund Mickunas Roger Gay Irina Klimanskaya Robert Lanza | 2012 | The Lancet . 2012 (9817)2012，，9817： | 1 |
| 18 | 3D Seismic characterization of submarine landslides on a Miocene carbonate platform (Lucania Province, Malaysia) 显示文摘 | Valentina Z Wolfgang S Jan-Henk van K | 2004 | Sedimentary Research2004，74，6： | 1 |
| 19 | Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting显示文摘 | Westenskow Peter D Kurihara Toshihide Aguilar Edith Scheppke Elizabeth L Moreno Stacey K Wittgrove Carli Marchetti Valentina Michael Iacovos P Anand Sudarshan Nagy Andras Cheresh David Friedlander Martin | 2013 | Journal of Clinical Investigation2013，，11： | 1 |
| 20 | A novel LXR - a activator identified from the natural product gynostemma pentaphyllum 显示文摘 | Tom H - W H Valentina R - N Noeris K S | 2005 | Biochemical Pharmacology2005，70，9： | 1 |
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