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| 1 | Immunohistochemical expression of SP-NK-1R-EGFR pathway and VDR in colonic inflammation and neoplasia显示文摘AIM:To determine the expression of neurokinin-1receptor(NK-1R),phosphorylated epidermal growth factor receptor(p EGFR),cyclooxygenase-2(Cox-2),and vitamin D receptor(VDR)in normal,inflammatory bowel disease(IBD),and colorectal neoplasia tissues from Puerto Ricans.METHODS:Tissues from patients with IBD,colitisassociated colorectal cancer(CAC),sporadic dysplasia,and sporadic colorectal cancer(CRC),as well as normal controls,were identified at several centers in Puerto Rico.Archival formalin-fixed,paraffin-embedded tissues were de-identified and processed by immunohistochemistry for NK-1R,p EGFR,Cox-2,and VDR.Pictures of representative areas of each tissues diagnosis were taken and scored by three observers using a4-point scale that assessed intensity of staining.Tissues with CAC were further analyzed by photographing representative areas of IBD and the different grades of dysplasia,in addition to the areas of cancer,within each tissue.Differences in the average age between the five patient groups were assessed with one-way analysis of variance and Tukey-Kramer multiple comparisons test.The mean scores for normal tissues and tissues with IBD,dysplasia,CRC,and CAC were calculatedand statistically compared using one-way analysis of variance and Dunnett’s multiple comparisons test.Correlations between protein expression patterns were analyzed with the Pearson’s product-moment correlation coefficient.Data are presented as mean±SE.RESULTS:On average,patients with IBD were younger(34.60±5.81)than normal(63.20±6.13,P<0.01),sporadic dysplasia(68.80±4.42,P<0.01),sporadic cancer(74.80±4.91,P<0.001),and CAC(57.50±5.11,P<0.05)patients.NK-1R in cancer tissue(sporadic CRC,1.73±0.34;CAC,1.57±0.53)and sporadic dysplasia(2.00±0.45)were higher than in normal tissues(0.73±0.19).p EGFR was significantly increased in sporadic CRC(1.53±0.43)and CAC(2.25±0.47)when compared to normal tissue(0.07±0.25,P<0.05,P<0.001,respectively).Cox-2 was significantly increased in sporadic colorectal cancer(2.20±0.23 vs 0.80±0.37 for normal tissues,P<0.05).In comparison to normal(2.80±0.13)and CAC(2.50±0.33)tissues,VDR was significantly decreased in sporadic dysplasia(0.00±0.00,P<0.001 vs normal,P<0.001 vs CAC)and sporadic CRC(0.47±0.23,P<0.001 vs normal,P<0.001 vs CAC).VDR levels negatively correlated with NK-1R(r=-0.48)and p EGFR(r=-0.56)in normal,IBD,sporadic dysplasia and sporadic CRC tissue,but not in CAC.CONCLUSION:Immunohistochemical NK-1R and p EGFR positivity with VDR negativity can be used to identify areas of sporadic colorectal neoplasia.VDR immunoreactivity can distinguish CAC from sporadic cancer. | Raymond A Isidro Myrella L Cruz Angel A Isidro Axel Baez Axel Arroyo William A González-Marqués Carmen González-Keelan Esther A Torres Caroline B Appleyard | 2015 | World Journal of Gastroenterology2015，21，6： | 7 |
| 2 | Systematic analysis of the safety and benefits of transvaginal hybrid-NOTES cholecystectomy显示文摘AIM: To evaluate transvaginal hybrid-NOTES cholecystectomy(TVC) during its clinical establishment and compare it with the traditional laparoscopic technique(LC).METHODS: The specific problems and benefits of TVC were reviewed using a registry analysis,a comparative cohort study and a randomized clinical trial. At first,feasibility,safety and specific complications of the TVC were analyzed based on the first 488 data sets of the German NOTES Registry(GNR). Hereafter,we compared the early postoperative results of our first 50 TVC-patients with those of 50 female LCpatients matched by age,BMI and ASA classification. The same cohort was contacted an average of two years later to evaluate long-term results concerning pain and satisfaction with the aesthetic results and the overall postoperative results as well as sexual intercourse by means of two domains of the German version of the Female Sexual Function Index(FSFI-d). Consequently,we performed a randomized clinical trial comparing 20 TVC-patients with 20 needlescopic/3-trocar cholecystectomies(NC) also concerning the early postoperative results as well as pain,satisfaction and quality of life by means of the Eypasch Gastrointestinal Quality of Life Index(GIQLI) in the later course. Finally,we discussed the results in accordance with other published studies.RESULTS: The complication(3.5%) and conversion rates(4.1%) for TVC were low in the GNR and comparable to those of the LC. Access related intraoperative complications included injuries to the bladder(n = 4; 0.8%) and bowel(n = 3; 0.6%). The study cohort revealed less postoperative pain after TVC comparing to the LC-patients on the day of surgery(NRS,1.5/10 vs 3.1/10,P = 0.003),in the morning(NRS,1.9/10 vs 2.8/10,P = 0.047) and in the evening(NRS,1.1/10 vs 1.8/10,P = 0.025) of postoperative day(POD) one. The randomized clinical trial consistently found less cumulative pain until POD 2(NRS,8/40 vs 14/40,P = 0.043),as well as until POD 10(NRS,22/190 vs 41/190,P = 0.010). Furthermore,the TVC-patients had a better quality of life on POD 10 than did the LC-patients(GIQLI,124/144 vs 107/144,P = 0.028). The complication rates were comparable and no specific problems were detected in the long-term follow-up for sexual intercourse for either group. The TVC-patients were more satisfied with the aesthetic result in the long-term course in the matched cohort analysis(1.00 vs 1.88,P < 0.001) as well as in the randomized clinical trial(1.00 vs 1.70,P < 0.001) when compared with the LC-patients.CONCLUSION: TVC is a feasible procedure with a high safety profile and has advantages in regard to postoperative pain and aesthetic results when compared with LC or NC. | Dirk R Bulian Jurgen Knuth Kai S Lehmann Axel Sauerwald Markus M Heiss | 2015 | World Journal of Gastroenterology2015，21，38： | 3 |
| 3 | First performance evaluation of a dual-source CT (DSCT) system显示文摘 | Thomas G. Flohr Cynthia H. McCollough Herbert Bruder Martin Petersilka Klaus Gruber Christoph Sü? Michael Grasruck Karl Stierstorfer Bernhard Krauss Rainer Raupach Andrew N. Primak Axel Küttner Stefan Achenbach Christoph Becker Andreas Kopp Bernd M. Ohnes | 2006 | European Radiology2006，，6： | 3 |
| 4 | Ileocolic intussusception due to intestinal metastatic melanoma. Case report and review of the literature显示文摘 | Fernando A. Alvarez Matías Nicolás Jeremías Goransky Carlos A. Vaccaro Axel Beskow Demetrio Cavadas | 2011 | International Journal of Surgery Case Reports2011，，6： | 2 |
| 5 | Correlation coefficient of the heart rate turbulence slope: an independent risk stralifier in post-infarction patients 显示文摘 | Petra B Raphael S Axel B | 2001 | Circulation2001，104，17： | 1 |
| 6 | Survival of patients with advanced colorectal cancer improves with the availability of flu- orouraeil-leucovorin, irinotecan, and oxaliplatin in the course of treatment显示文摘 | Axel G Daniel S Goldlrg RM et el | 2004 | J Clin Oncol2004，22，7： | 1 |
| 7 | First performance evaluation of a dual-source CT (DSCT) system显示文摘 | Thomas G. Flohr Cynthia H. McCollough Herbert Bruder Martin Petersilka Klaus Gruber Christoph Süβ Michael Grasruck Karl Stierstorfer Bernhard Krauss Rainer Raupach Andrew N. Primak Axel Küttner Stefan Achenbach Christoph Becker Andreas Kopp Bernd M. Ohnes | 2006 | European Radiology2006，，2： | 1 |
| 8 | Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells显示文摘 | Zhen S Jens D Axel H | 2003 | Cancer Res2003，63，9： | 1 |
| 9 | Marine mammal Brucella isolates with different genomic characteristics dlsplay a differential response when infecting human macrophages in culture显示文摘 | Marianne M Michel S Z Axel C | 2009 | Microbes and Infection2009，11，： | 1 |
| 10 | Transaction costs of the kyoto mechanisms 显示文摘 | Axel M Mareus S | 2003 | Climate Policy2003，，3： | 1 |
| 11 | Visualizing neuromodulation in vivo:TANGO-mapping of dopamine signaling reveals appetite control of sugar sensing显示文摘 | Inagaki Hidehiko K Ben-Tabou de-Leon S Wong AM Jagadish S Ishimoto H Barnea G Kitamoto T Axel R Anderson David J | | 0，，03： | 1 |
| 12 | Optical characterization of two-dimensional photonic crystal cavities with indium arsenide quantum dot emitters显示文摘 | TOMOYUKI Y AXEL S CHEN Hao | 2001 | Appl Phys Let2001，79，1： | 1 |
| 13 | Ischemic preconditioning improves post-ischemic skeletal muscle function显示文摘 | Lorenz G Axel M Paul M S | 1996 | Am J Sury1996，62，： | 1 |
| 14 | Cineromycins, y-butyrolactonesand ansamycins by analysis of the secondary metabo- lite pattern created by a single strain of Streptomyces 显示文摘 | HANS J S AXEL Z | 1999 | J Antibiot1999，52，7： | 1 |
| 15 | Contemporary Management of Regional Nodes in Penile Cancer—Improvement of Survival?显示文摘 | Rosa S. Djajadiningrat Niels M. Graafland Erik van Werkhoven Wim Meinhardt Axel Bex Henk G. van der Poel Hester H. van Boven Renato A. Valdés Olmos Simon Horenblas | 2014 | The Journal of Urology2014，，： | 1 |
| 16 | From micro- to nanofabrication with soft materials显示文摘 | STEPHEN R Q AXEL S | 2000 | Science2000，290，24： | 1 |
| 17 | Using a fiber stretcher as a fast phase modulator in a continuous wave terahertz spectrometer显示文摘 | Axel R Komalavalli T Holger S | 2012 | J Opt SocAmB2012，29，4： | 1 |
| 18 | The Ethics Statement of the Vancouver Forum on the Live Lung, Liver, Pancreas, and Intestine Donor显示文摘 | Timothy L. Pruett Annika Tibell Abdulmajeed Alabdulkareem Mahendra Bhandari David C. Cronin Mary Amanda Dew Arturo Dib-Kuri Thomas Gutmann Arthur Matas Lisa McMurdo Axel Rahmel S Adibul Hasan Rizvi Linda Wright Francis L. Delmonico | 2006 | Transplantation2006，，10： | 1 |
| 19 | Axitinib for the treatment of patients with advanced metastatic renal cell carcinoma (mRCC) after failure of prior systemic treatment 显示文摘 | Viktor Griinwald Axel S Merseburger | 2012 | Onco Targets Ther2012，5，： | 1 |
| 20 | The influence of project autonomy on project success 显示文摘 | HANS GEORG GEMtiNDEN S REN SALOMO AXEL KRIEGER | 2005 | International Journal of Project Management2005，，23： | 1 |
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