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| 1 | Endoscopic ultrasound elastography for evaluation of lymph nodes and pancreatic masses:A multicenter study显示文摘AIM:To evaluate the ability of endoscopic ultrasound(EUS) elastography to distinguish benign from malignant pancreatic masses and lymph nodes.METHODS:A multicenter study was conducted and included 222 patients who underwent EUS examination with assessment of a pancreatic mass(n=121) or lymph node(n=101).The classification as benign or malignant,based on the real time elastography pattern,was compared with the classif ication based on the B-mode EUS images and with the fi nal diagnosis obtained by EUS-guided fi ne needle aspiration(EUS-FNA) and/or by surgical pathology.An interobserver study was performed.RESULTS:The sensitivity and specificity of EUS elastography to differentiate benign from malignant pancreatic lesions are 92.3% and 80.0%,respectively,compared to 92.3% and 68.9%,respectively,for the conventional B-mode images.The sensitivity and specificity of EUS elastography to differentiate benign from malignant lymph nodes was 91.8% and 82.5%,respectively,compared to 78.6% and 50.0%,respectively,for the B-mode images.The kappa coefficient was 0.785 for the pancreatic masses and 0.657 for the lymph nodes.CONCLUSION:EUS elastography is superior compared to conventional B-mode imaging and appears to be able to distinguish benign from malignant pancreatic masses and lymph nodes with a high sensitivity,specificity and accuracy.It might be reserved as a second line examination to help characterise pancreatic masses after negative EUS-FNA and might increase the yield of EUS-FNA for lymph nodes. | Marc Giovannini Botelberge Thomas Bories Erwan Pesenti Christian Caillol Fabrice Esterni Benjamin Monges Geneviève Arcidiacono Paolo Deprez Pierre Yeung Robert Schimdt Walter Schrader Hanz Szymanski Carl Dietrich Christoph Eisendrath Pierre Van Laethem Jean-Luc Devière Jacques Vilmann Peter Saftoiu Andrian | 2009 | World Journal of Gastroenterology2009，15，13： | 48 |
| 2 | Feasibility and yield of a novel 22-gauge histology EUS needle in patients with pancreatic masses: a multicenter prospective cohort study显示文摘 | Alberto Larghi Julio Iglesias-Garcia Jan-Werner Poley Geneviève Monges Maria Chiara Petrone Guido Rindi Ihab Abdulkader Paolo Giorgio Arcidiacono Guido Costamagna Katharina Biermann Erwan Bories Claudio Doglioni J. Enrique Dominguez-Mu?oz Cesare Hassan Ma | 2013 | Surgical Endoscopy2013，，10： | 3 |
| 3 | Endoscopic-ultrasound-guided endoscopic transmural drainage of pancreatic pseudocysts and abscesses显示文摘 | Cesar Vivian Lopes Christian Pesenti Erwan Bories Fabrice Caillol Marc Giovannini | 2007 | Scandinavian Journal of Gastroenterology2007，，4： | 3 |
| 4 | Torque Characteristics of High Torque Density Partitioned PM Consequent Pole Flux Switching Machines With Flux Barriers显示文摘Unique double salient structure of Permanent Magnet Flux Switching Machines(PMFSM)with both Concentrated Armature inding(CAW)and Permanent Magnet(PM)on stator attract researcher's interest for high speed brushless application when high torque density(T den)and power density(P den)are the primal requirements.However,despite of stator leakage flux,high rare-earth PM usage,PMFSM is subjected to slot effects due to presence of both PM and CAW in stator and partial saturation due to double salient structure which generates cogging torque(T cog),torque ripples(Trip)and lower average torque(T avg).To overcomne aforesaid demerits,this paper presents Partitioned PM(PPM)Consequent Pole Flux Switching Machine(PPM-CPFSM)with flux barriers to enhance flux mnodulation,curtail PM usage and diminish stator leakage flux which reduces slotting effects and partial saturation to ultimately reduces T cog and Trip In comparison with the existing state of the art,proposed PPM-CPFSM reduces 46.5390 of the total PM volumne and offer Tavg higher up to 88.8%,suppress Trip naximun up to 24.8%,diminish Tcog up to 22.74%and offer 2.45 times Tden and Pden.Furthermore,torque characteristics of proposed PPM-CPFSM is investigated utilizing space harmonics injection i.e.inverse cosine,inverse cosine with 3rd harmonics and rotor pole shaping techniques i.e.,ecce ntric circle,chanfering and notching.Detailed electromagnetic perfornance analysis reveals that harmonics injection suppressed Tcog maximun up to 83.5%,Trip up to 40.72%at the cost of 4.71%Tavg.Finally,rotor mnechanical stress analysis is utilized for rotor withstand capability and 3D-FEA based Coupled Elctromagnetic Thermal Analysis(CETA)for thermal behavior of the developed PPM CPFSM.CETA reveals that open space along PPM act as cooling duct that inprove heat dissipation. | Wasiq Ullah Faisal Khan Erwan Sulaiman Muhammad Umair | 2020 | CES Transactions on Electrical Machines and Systems2020，4，2： | 3 |
| 5 | Local transgene expression and whole-body transgenesis to model brain diseases in nonhuman primate显示文摘Animal model is an essential tool in the life sciences research, notably in understanding the pathogenesis of the diseases and for further therapeutic intervention success. Rodents have been the most frequently used animals to model human disease since the establishment of gene manipulation technique. However, they remain inadequate to fully mimic the pathophysiology of human brain disease, partially due to huge differences between rodents and humans in terms of anatomy, brain function, and social behaviors. Nonhuman primates are more suitable in translational perspective. Thus, genetically modified animals have been generated to investigate neurologic and psychiatric disorders. The classical transgenesis technique is not efficient in that model; so, viral vector-mediated transgene delivery and the new genome-editing technologies have been promoted. In this review, we summarize some of the technical progress in the generation of an ad hoc animal model of brain diseases by gene delivery and real transgenic nonhuman primate. | Lucie Chansel-Debordeaux Erwan Bezard | 2019 | Animal Models and Experimental Medicine2019，2，1： | 3 |
| 6 | 茶多酚对6-OHDA诱导的SH-SY5Y细胞凋亡的保护作用显示文摘茶多酚在体内具有广泛的生物活性和药理作用,有助于预防与氧化应激相关的疾病,比如癌症,心血管疾病,神经退行性疾病和衰老.氧化应激参与了帕金森病(PD)的病理进程.活性氧在PD的发病机制中发挥了重要的作用,氧自由基直接损伤细胞膜引起脂质过氧化,损伤蛋白质和各种功能酶引起蛋白质沉淀,诱导促凋亡因子的表达,损伤DNA,最终导致了细胞的凋亡.然而,关于茶多酚对PD的预防和治疗作用目前还不清楚.本文应用氧化应激诱导的PD病理细胞模型,评价了茶多酚的神经保护作用.结果表明茶多酚这类植物天然抗氧化剂对氧化应激诱导的细胞凋亡具有明确的抑制作用.实验中我们选择了6-OHDA诱导的SH-SY5Y细胞作为细胞模型,运用了MTT、流式细胞术、荧光显微成相,竞争性ELISA和蛋白质杂交等方法研究了SH-SY5Y细胞的凋亡特性.结果表明,6-OHDA对SH-SY5Y有时间-浓度依赖性细胞毒性,100μmol/L6-OHDA处理24 h,细胞活力减少50%,同时伴随着活性氧增加(用ESR),线粒体膜电位降低,细胞内钙离子和一氧化氮增加,nNOS和iNOS表达量上升及蛋白结合的硝基酪氨酸水平升高.单独茶多酚处理对细胞没有太大的影响,而茶多酚预处理可显著降低6-OHDA所产生的细胞毒性.溶液实验证明,茶多酚对6-OHDA的自氧化有浓度-时间依赖性抑制作用(用ESR).本研究表明茶多酚可能是通过活性氧-一氧化氮途径,减少过氧亚硝基的生成来对6-OHDA诱导的细胞凋亡表现保护作用的.本文的实验结果提示茶多酚在治疗PD等慢性神经退行性疾病上可能是一种有着潜在疗效的药物. | 郭树红 BEZARD Erwan 赵保路 | 2006 | 波谱学杂志2006，23，4： | 2 |
| 7 | PNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis显示文摘 | Erwan Guyot Angela Sutton Pierre Rufat Christelle Laguillier Abdellah Mansouri Richard Moreau Nathalie Ganne-Carrié Michel Beaugrand Nathalie Charnaux Jean-Claude Trinchet Pierre Nahon | 2012 | Journal of Hepatology2012，，： | 2 |
| 8 | EUS-Guided Biliary Drainage显示文摘 | Marc Giovannini Erwan Bories Fauze Maluf-Filho | 2011 | Gastroenterology Research and Practice2011，，： | 2 |
| 9 | Capital structure, credit risk, and macroeconomic conditions显示文摘 | Dirk Hackbarth Jianjun Miao Erwan Morellec | 2006 | Journal of Financial Economics2006，，3： | 2 |
| 10 | Second order centrality: Distributed assessment of nodes criticity in complex networks显示文摘 | Anne-Marie Kermarrec Erwan Le Merrer Bruno Sericola Gilles Trédan | 2010 | Computer Communications2010，，5： | 2 |
| 11 | Microdialysis in awake macaque monkeys for central nervous system pharmacokinetics显示文摘Background: The brain bioavailability of novel small molecules developed to address central nervous system disease is classically documented through ex vivo or in vivo analyses conducted in rodent models. Data acquired in rodent models are, however,not easily transferrable to human as the pharmacokinetic and pharmacodynamics profiles of the species are quite different.Methods: Using drugs selected for their differential transport across the blood-brain barrier, we here demonstrate the feasibility of brain microdialysis in normal vigil macaque monkey by measuring brain extracellular fluid bioavailability of carbamazepine, digoxin, oxycodone, and quinidine.Results: All drugs, but digoxin, were found in dialysate samples. Drugs that are substrate of P-glycoprotein show a difference of bioavailability or brain pharmacokinetic parameters between rodents and primates.Conclusion: Data suggest that brain microdialysis in vigil macaque monkey, the species of choice for classic pharmacokinetic/pharmacodynamics studies could help predicting human brain bioavailability of a small molecule depending on the protein involved in the efflux transport from the brain. | Thibaud Thiollier Caisheng Wu Gregory Porras Erwan Bezard Qin Li Jinlan Zhang Hugues Contamin | 2018 | Animal Models and Experimental Medicine2018，1，4： | 2 |
| 12 | Vitamin D reduces the inflammatory response and restores glucose uptake in adipocytes显示文摘 | Julie Marcotorchino Erwan Gouranton Beatrice Romier Franck Tourniaire Julien Astier Christiane Malezet Marie‐Josèphe Amiot Jean‐Fran?ois Landrier | 2012 | Food Res2012，，12： | 2 |
| 13 | Thermo - elasto - hydro - dynamic modeling of hydrostatic seals in reactor coolant pumps 显示文摘 | Erwan G lsabelle P D | 2007 | Tribology Transactions2007，50，： | 1 |
| 14 | Abrupt axial variations along the slow to ultra-slow spreading centers of the northern North Fiji Basin (SW Pacific) : Evidence for short wave heterogeneities in a back-arc mantle显示文摘 | Erwan Garell Yves Lagabrielle Bernard Pelletier | 2003 | Marine Geophysical Researches2003，4，： | 1 |
| 15 | Bandelet Image Approximation and Compression显示文摘 | Erwan Le Pannec Stephane Mallat | 2005 | SIAM Journal of Multiscale Modeling and Simulation2005，4，3： | 1 |
| 16 | Thermo-elasto-hydro- dynamic modeling of hydrostatic seals in reactor coolant pumps 显示文摘 | ERWAN G ISABELLE P D | 2007 | Tribology Transactions2007，50，： | 1 |
| 17 | Design and implementation of a low--cost observer--based attitude and heading reference system 显示文摘 | Philippe Martin Erwan Salaum | 2010 | Control Engineering Practice2010，7，18： | 1 |
| 18 | Interferometric imaging polarimeter 显示文摘 | Mujat Mircea Baleine Erwan Dogariu Aristide | 2004 | Journal of theOptical Society of America A2004，21，11： | 1 |
| 19 | EUS-guided pancreatogastrostomy and pancreatobulbostomy for the treatment of pain in patients with pancreatic ductal dilatation inaccessible for transpapillary endoscopic therapy显示文摘 | Geneviève Tessier Erwan Bories Marianna Arvanitakis Axel Hittelet Christian Pesenti Olivier Le Moine Marc Giovannini Jacques Devière | 2007 | Gastrointestinal Endoscopy2007，，2： | 1 |
| 20 | Thermo - elasto - hydro - dynamicmodeling of hydrostatic seals in reactor coolant pumps 显示文摘 | Erwan G Isabellep D | 2007 | Tribology Transactions2007，50，4： | 1 |
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