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| 1 | Intraductal ultrasound substantiates diagnostics of bile duct strictures of uncertain etiology显示文摘AIM:To report the largest patient cohort study investigating the diagnostic yield of intraductal ultrasound (IDUS) in indeterminate strictures of the common bile duct.METHODS:A patient cohort with bile duct strictures of unknown etiology was examined by IDUS.Sensitivity,specificity and accuracy rates of IDUS were calculated relating to the definite diagnoses proved by histopathology or long-term follow-up in those patients who did not undergo surgery.Analysis of the endosonographic report allowed drawing conclusions with respect to the T and N staging in 147 patients.IDUS staging was compared to the postoperative histopathological staging data allowing calculation of sensitivity,specificity and accuracy rates for T and N stages.The endoscopic retrograde cholangio-pancreatography and IDUS procedures were performed under fluoroscopic guidance using a side-viewing duodenoscope (Olympus TJF 160,Olympus,Ltd.,Tokyo,Japan).All procedures were performed under conscious sedation (propofol combined with pethidine) according to the German guidelines.For IDUS,a 6 F or 8 F ultrasound miniprobe was employed with a radial scanner of 15-20 MHz at the tip of the probe (Aloka Co.,Tokyo,Japan).RESULTS:A total of 397 patients (210 males,187 females,mean age 61.43 ± 13 years) with indeterminate bile duct strictures were included.Two hundred and sixty-four patients were referred to the department of surgery for operative exploration,thus surgical histopathological correlation was available for those patients.Out of 264 patients,174 had malignant disease proven by surgery,in 90 patients benign disease was found.In these patients decision for surgical exploration was made due to suspicion for malignant disease in multimodal diagnostics (computed tomography scan,endoscopic ultrasound or magnetic resonance imaging).Twenty benign bile duct strictures were misclassified by IDUS as malignant while 14 patients with malignant strictures were initially misdiagnosed by IDUS as benign resulting in sensitivity,specificity and accuracy ratesof 93.2%,89.5% and 91.4%,respectively.In the subgroup analysis of malignancy prediction,IDUS showed best performance in cholangiocellular carcinoma as underlying disease (sensitivity rate,97.6%) followed by pancreatic carcinoma (93.8%),gallbladder cancer (88.9%) and ampullary cancer (80.8%).A total of 133 patients were not surgically explored.32 patients had palliative therapy due to extended tumor disease in IDUS and other imaging modalities.Ninety-five patients had benign diagnosis by IDUS,forceps biopsy and radiographic imaging and were followed by a surveillance protocol with a follow-up of at least 12 mo;the mean follow-up was 39.7 mo.Tumor localization within the common bile duct did not have a significant influence on prediction of malignancy by IDUS.The accuracy rate for discriminating early T stage tumors (T1) was 84% while for T2 and T3 malignancies the accuracy rates were 73% and 71%,respectively.Relating to N0 and N1 staging,IDUS procedure achieved accuracy rates of 69% for N0 and N1,respectively.Limitations:Pretest likelihood of 52% may not rule out bias and overinterpretation due to the clinical scenario or other prior performed imaging tests.CONCLUSION:IDUS shows good results for accurate diagnostics of bile duct strictures of uncertain etiology thus allowing for adequate further clinical management. | Tobias Meister Hauke S Heinzow Carina Woestmeyer Philipp Lenz Josef Menzel Torsten Kucharzik Wolfram Domschke Dirk Domagk | 2013 | World Journal of Gastroenterology2013，19，6： | 19 |
| 2 | European evidence based consensus for endoscopy in inflammatory bowel disease显示文摘 | Vito Annese Marco Daperno Matthew D. Rutter Aurelien Amiot Peter Bossuyt James East Marc Ferrante Martin G?tz Konstantinos H. Katsanos Ralf Kie?lich Ingrid Ordás Alessandro Repici Bruno Rosa Shaji Sebastian Torsten Kucharzik Rami Eliakim | 2013 | Journal of Crohn’s and Colitis2013，，12： | 7 |
| 3 | How to perform gastrointestinal ultrasound: anatomy and normal findings显示文摘Gastrointestinal ultrasound is a practical, safe, cheap and reproducible diagnostic tool in inflammatorybowel disease gaining global prominence amongst clinicians. Understanding the embryological processes of the intestinal tract assists in the interpretation of abnormal sonographic findings. In general terms, the examination principally comprises interrogation of the colon, mesentery and small intestine using both lowfrequency and high-frequency probes. Interpretation of findings on GIUS includes assessment of bowel wall thickness, symmetry of this thickness, evidence of transmural changes, assessment of vascularity using Doppler imaging and assessment of other specific features including lymph nodes, mesentery and luminal motility. In addition to B-mode imaging, transperineal ultrasonography, elastography and contrast-enhanced ultrasonography are useful adjuncts. This supplement expands upon these features in more depth. | Nathan S S Atkinson Robert V Bryant Yi Dong Christian Maaser Torsten Kucharzik Giovanni Maconi Anil K Asthana Michael Blaivas Adrian Goudie Odd Helge Gilja Dieter Nuernberg Dagmar Schreiber-Dietrich Christoph F Dietrich | 2017 | World Journal of Gastroenterology2017，23，38： | 5 |
| 4 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 2 |
| 5 | Pyridinyl polythiazole class peptide antiriotic microtic micrococcin pi, Secreted by foodbornh staphylococcus e guorm Ws2733, is biosynthesized nonribosomally显示文摘 | Markus C C Torsten S Kevin P F | 2001 | Eu J Biochem2001，268，： | 1 |
| 6 | Performance and limitations of the Hilbert-Huang transformation (HHT) with an application to irregular water waves显示文摘 | Marcus D Torsten S | 2004 | Ocean Engineering2004，31，9： | 1 |
| 7 | Performance and limitations of the Hilbert-Huang transformation (HHT) with an application to irregular water显示文摘 | Marcus D Torsten S | 2004 | Ocean Engineering2004，31，： | 1 |
| 8 | Distinct genetic pattern can be identified in acute monoblastic and acute monocytic leukaemia (FAB AML M5a and M5b):a study of 124 patients显示文摘 | TORSTEN H CLAUDIA S SUSANNE S | 2002 | Br J Hematol2002，118，： | 1 |
| 9 | Performance and limitations of the Hilbert-Huang Transformation(HHT) with an application to irregular water waves显示文摘 | Marcus D Torsten S | 2004 | Ocean Engineering2004，31，1415： | 1 |
| 10 | Variations of the ^44Ca/^40Ca ratio in seawater during the past 24 million years: Evidence from δ44Ca and δ^18O values of Miocene phosphates显示文摘 | Anne-Désirée S Peter S Torsten V | 2003 | Geochimica et Cosmochimica Acta2003，67，14： | 1 |
| 11 | Performance and lim- itations of the Hilbert-Huang transformation (HHT) with an application to irregular water waves 显示文摘 | MARCUS D TORSTEN S | 2004 | Ocean Engineering2004，31，1415： | 1 |
| 12 | Structure of ituinA, a peptidolipid antibiotic from Bacillus subtilis 显示文摘 | Frank L Torsten H S Barbel K | 1978 | Biochemistry1978，17，19： | 1 |
| 13 | Mediators of inflammation and acute phase response in the liver 显示文摘 | Konrad L S Torsten W Christian K | 2001 | Cell Mol Biol2001，47，4： | 1 |
| 14 | Relia- bility of computed tomography measurements in assessment of thigh muscle cross-sectional area and attenuation 显示文摘 | Strandberg S ren Wretling Marie-Louise Wredmark Torsten | 2013 | BMC Medical Imaging2013，10，1： | 1 |
| 15 | IGF-I has a direct proliferative effect in adult hippocampal progenitor cells显示文摘 | Maria A.I ?berg N.David ?berg Theo D Palmer Ann-Marie Alborn Christine Carlsson-Skwirut Peter Bang Lars E Rosengren Torsten Olsson Fred H Gage Peter S Eriksson | 2003 | Molecular and Cellular Neuroscience2003，，1： | 1 |
| 16 | Thiol-disulfide oxidoreductases are essential for the production of the lantibiotic sublancin 168显示文摘 | RONALD D TORSTEN S JORRIT K | 2002 | The Journal of Biological Chemistry2002，277，16： | 1 |
| 17 | Performance and limitations of the Hilbert-Huang transformation (HHT) with an application to irregular water waves 显示文摘 | Marcus D Torsten S | 2004 | Ocean Engineering (S0029-8018)2004，31，1415： | 1 |
| 18 | Differential expression of cancer-related genes by single and permanent exposure to bone morphogenetic protein 2显示文摘 | Susanne S Torsten K C Taubert I | 2008 | J Cancer Res Clin Oncol2008，134，11： | 1 |
| 19 | Performance and limitations of the Hilbert-Huang transformation (HHT) with an application to irregular water waves显示文摘 | Marcus D Torsten S | 2004 | Ocean Engineering2004，，1415： | 1 |
| 20 | Mutated Desmoglein‐2 Proteins are Incorporated into Desmosomes and Exhibit Dominant‐Negative Effects in Arrhythmogenic Right Ventricular Cardiomyopathy显示文摘 | Torsten B. Rasmussen Johan Palmfeldt Peter H. Nissen Raffaela Magnoni S?ren Dalager Uffe B. Jensen Won Y. Kim Lene Heickendorff Henning M?lgaard Henrik K. Jensen Ulrik T. Baandrup Peter Bross Jens Mogensen | 2013 | Human Mutation2013，，5： | 1 |
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