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| 1 | Percutaneous left atrial appendage closure:Technical aspects and prevention of periprocedural complications with the watchman device显示文摘Transcatheter closure of the left atrial appendage has been developed as an alternative to chronic oral anticoagulation for stroke prevention in patients with atrial fibrillation, and as a primary therapy for patients with contraindications to chronic oral anticoagulation. The promise of this new intervention compared with warfarin has been supported by several, small studies and two pivotal randomized trial with the Watchman Device. The results regarding risk reduction for stroke have been favourable although acute complications were not infrequent. Procedural complications, which are mainly related to transseptal puncture and device implantation, include air embolism, pericardial effusions/tamponade and device embolization. Knowledge of nature, management and prevention of complications should minimize the risk of complications and allow transcatheter left atrial appendage closure to emerge as a therapeutic option for patients with atrial fibrillation at risk for cardioembolic stroke. | Sven M bius-Winkler Nicolas Majunke Marcus Sandri Norman Mangner Axel Linke Gregg W Stone Ingo D hnert Gerhard Schuler Peter B Sick | 2015 | World Journal of Cardiology2015，7，2： | 14 |
| 2 | Preferential CTL targeting of Gag is associated with relative viral control in long-term surviving HIV-1 infected former plasma donors from China显示文摘它通常被相信细胞毒素的 T 淋巴细胞(CTL ) 玩的那 CD8 + 在限制人的免疫不全病毒类型 1 的复制(HIV-1 ) 并且在决定感染的结果,和这效果可以部分优先地取决于产品是哪个 HIV 的一个关键角色指向了。在以前的血浆施主(FPD ) 的一个队探讨在 HIV-1-specific CTL 回答和病毒复制之间的关联,天真的 FPD 与 HIV-1 clade B' 紧张感染了的 143 antiretroviral 治疗与 IFN-γ 为 HIV-1-specific CTL 回答被估计;在由使用盖住整个一致 clade B proteome 的重叠的肽(OLP ) 的单个肽水平的 Elispot 试金。由使用一个枪兵的等级关联分析,当是断然相关到 CD4 计数时,我们发现在全部的病毒特定的 CTL 活动之中的作呕特定的 CTL 回答的比例相反地与病毒的负担被相关,与与增加的病毒的负担被联系并且减少的Pol特定、Env特定的回答对比, CD4 数。另外, Vpr-specifc CTL 回答显示出类似的保护的效果与作呕回答,但是与识别的低得多的频率。显著地,我们也观察了在 HLA 之间的一个协会 --*30/B*13/Cw*06 haplotype 和可能由于的更低的病毒的负担限制了作呕特定的 CTL 回答。因此,我们的数据在疾病控制表明作呕特定的 CTL 回答的突出的角色。HLA 的优点 -- 在病毒的控制的 *30/B*13/Cw*06 haplotype 可以在学习个人与作呕特定的 CTL 回答的贡献被联系。 | Mingming Jia Kunxue Hong Jianping Chen Yuhua Ruan Zhe Wang Bing Su Guoliang Ren Xiaoqing Zhang Zhen Liu Quanbi Zhao Dan Li Hong Peng Marcus Altfeld Bruce D Walker Xu G Yu Yiming Shao | 2012 | Cell Research2012，22，5： | 3 |
| 3 | Efficacy of SpyGlass^(TM)-directed biopsy compared to brush cytology in obtaining adequate tissue for diagnosis in patients with biliary strictures显示文摘AIM: To evaluate the diagnostic yield(inflammatory activity) and efficiency(size of the biopsy specimen) of SpyGlassTM-guided biopsy vs standard brush cytology in patients with and without primary sclerosing cholangitis(PSC).METHODS: At the University Medical Center Mainz, Germany, 35 consecutive patients with unclear biliarylesions(16 patients) or long-standing PSC(19 patients) were screened for the study. All patients underwent a physical examination, lab analyses, and abdominal ultrasound. Thirty-one patients with non-PSC strictures or with PSC were scheduled to undergo endoscopic retrograde cholangiography(ERC) and subsequent per-oral cholangioscopy(POC). Standard ERC was initially performed, and any lesions or strictures were localized. POC was performed later during the same session. The Boston Scientific SpyGlass SystemTM(Natick, MA, United States) was used for choledochoscopy. The biliary tree was visualized, and suspected lesions or strictures were biopsied, followed by brush cytology of the same area. The study endpoints(for both techniques) were the degree of inflammation, tissue specimen size, and the patient populations(PSC vs non-PSC). Inflammatory changes were divided into three categories: none, low activity, and high activity. The specimen quantity was rated as low, moderate, or sufficient.RESULTS: SpyGlassTM imaging and brush cytology with material retrieval were performed in 29 of 31(93.5%) patients(23 of the 29 patients were male). The median patient age was 45 years(min, 20 years; max, 76 years). Nineteen patients had known PSC, and 10 showed non-PSC strictures. No procedure-related complications were encountered. However, for both methods, tissues could only be retrieved from 29 pa-tients. In cases of inflammation of the biliary tract, the diagnostic yield of the SpyGlassTM-directed biopsies was greater than that using brush cytology. More tissue material was obtained for the biopsy method than for the brush cytology method(P = 0.021). The biopsies showed significantly more inflammatory characteristics and greater inflammatory activity compared to the cy-tological investigation(P = 0.014). The greater quantity of tissue samples proved useful for both PSC and non-PSC patients.CONCLUSION: SpyGlassTM imaging can be recom-mended for proper inflammatory diagnosis in PSC pa-tients. However, its value in diagnosing dysplasia wasnot addressed in this study and requires further investi-gation. | Johannes Wilhelm Rey Torsten Hansen Sebastian Dümcke Achim Tresch Katja Kramer Peter Robert Galle Martin Goetz Marcus Schuchmann Ralf Kiesslich Arthur Hoffman | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 2 |
| 4 | Semiclassical Calculation of Bound States in a Multidimensional System for Nearly 1:1 Degenerate Systems显示文摘 | Noid D W Marcus R A | 1977 | J Chem Phys1977，67，2： | 1 |
| 5 | Summarization beyond sentence extraction: a probabilistic approach to sentence compression显示文摘 | KNIGHT K MARCU D | 2002 | Artificial Intelligence2002，139，1： | 1 |
| 6 | Normal polysomnographic values for children and ado- lescents显示文摘 | MARCUS C L OMLIN K J BASINSIKI D J | 1992 | Am Rev Respir Dis1992，156，： | 1 |
| 7 | On the Explosive Properties of 1H-benzotriazole and IH-I, 2, 3-triazole显示文摘 | MARCUS M KLAUS D | 2007 | Tetrahedron Letters2007，48，7： | 1 |
| 8 | The visual scoring of sleep and arousal in infants and children显示文摘 | Grigg-Damberger M Gozal D Marcus CL | 2007 | J Clin Sleep Med2007，3，2： | 1 |
| 9 | The rhetorical parsing of unrestricted texts: A surface- based approach 显示文摘 | Marcu D | 2000 | Computational Linguistics2000，，3： | 1 |
| 10 | Structural and mechanistic investigation of a phosphatemodified HZSM-5 catalyst for methanol conversion显示文摘 | Abubakar S M Marcus D M Lee J C Ehresmann J O Chen C Y Kletnieks P W Guenther D R Hayman M J Pavlova M Nicholas J B Haw J F | | 0，，10： | 1 |
| 11 | Neonatal, postneonatal, childhood, and under-5 mortality for 187 countries, 1970-2010 : a systematic analysis of progress to- wards Millennium Development Goal 4 显示文摘 | Rajaratnam J K Marcus J R Flaxman A D | 2010 | Lancet2010，375，9730： | 1 |
| 12 | Self-report of gas- trointestinal side effects after bariatric surgery显示文摘 | Kalarchian M A Marcus M D Courcoulas A D | 2014 | Surg Obes Relat Dis2014，10，6： | 1 |
| 13 | Analysis of a risk-sensitive control problem for hidden Markov chains显示文摘 | Hernandez-Hernandez D Marcus S I Fard P J | 1999 | IEEE Transactions on Automatic Control1999，44，5： | 1 |
| 14 | Calculations Related to Quantum Stochasticity, an Example of Overlapping Avoided Crossings显示文摘 | Noid D W Koszykowski M L Marcus R A | 1980 | Chem Phys Lett1980，73，2： | 1 |
| 15 | The mechanism of methanol to hydrocarbon catalysis 显示文摘 | HAW J F SONG W G MARCUS D M | 2003 | Acc Chem Res2003，36，： | 1 |
| 16 | High-risk neuroblastoma treated with tandem autologous peripheral-blood stem cell-supported transplantation: long-term survival update 显示文摘 | George RE Li S Medeiros-Nancarrow C Neuberg D Marcus K Shamberger RC | 2006 | J Clin Oncol2006，24，18： | 1 |
| 17 | Chicken interferon gene:cloning,expression,and analysis显示文摘 | Sekellick M J Ferrandino A F Hopkins D A Marcus P I | 1994 | J Interferon Res1994，14，2： | 1 |
| 18 | Effects of synthetic and naturally occurring flavonoids on metabolic activation of benzopyrene in hamster embryo cell cultures显示文摘 | CHAE Y H HO D K CASSADY J M COOK V M MARCUS C B BAIRD W M | 1992 | Chemico-biological Interactions1992，82，2： | 1 |
| 19 | Performance and limitations of the Hilbert-Huang transformation (HHT) with an application to irregular water waves显示文摘 | Marcus D Torsten S | 2004 | Ocean Engineering2004，31，9： | 1 |
| 20 | The mechanism of methanol to hydrocarbon catalysis显示文摘 | Haw J F Song W G Marcus D M | 2003 | Accoun Chem Res2003，36，： | 1 |
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