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| 1 | European evidence based consensus for endoscopy in inflammatory bowel disease显示文摘 | Vito Annese Marco Daperno Matthew D. Rutter Aurelien Amiot Peter Bossuyt James East Marc Ferrante Martin G?tz Konstantinos H. Katsanos Ralf Kie?lich Ingrid Ordás Alessandro Repici Bruno Rosa Shaji Sebastian Torsten Kucharzik Rami Eliakim | 2013 | Journal of Crohn’s and Colitis2013，，12： | 7 |
| 2 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 3 | 采用Linux与DSP/B_OSRTOS实施双OS信号处理技术显示文摘在系统性能与编程简易性之间的权衡折中是通用操作系统与实时操作系统之间的主要区分点之一。
GPOS(通用操作系统)倾向于提供较高程度的资源抽象,这不仅可通过支持软件模块与资源隔离来提高应用的便携性、简化开发流程,同时还能增强系统的稳健性,这使GPOS成为诸如网络、用户界面以及显示管理等通用系统组件的理想选择。 | Steve Preissig David Beal Aurelien Jacquiot | 2009 | 电子设计技术 EDN CHINA2009，，3： | 4 |
| 4 | Epidemiology of onchocerciasis-associated epilepsy in the Mbam and Sanaga river valleys of Cameroon:impact of more than 13 years of ivermectin显示文摘Background:A high epilepsy prevalence has been reported in several onchocerciasis-endemic villages along the Mbam and Sanaga river valleys in Cameroon,including Bilomo and Kelleng.We sought to determine the prevalence of epilepsy in these two villages following more than 13 years of community-directed treatment with ivermectin(CDTI).Methods:Door-to-door surveys were performed on the entire resident population in the villages in August 2017 and January 2018.Epilepsy was diagnosed using a 2-step approach:administration of a standardized 5-item questionnaire followed by confirmation by a neurologist.Previously published diagnostic criteria for onchocerciasis-associated epilepsy(OAE)were used.Ov16 serology was done for children aged 7-10 years to assess onchocerciasis transmission.Findings were compared with previous data from these two villages.Results:A total of 1525 individuals(1321 in Bilomo and 204 in Kelleng)in 233 households were surveyed in both villages.The crude prevalence of epilepsy was 4.6%in Bilomo(2017)and 7.8%in Kelleng(2018),including 12(15.6%of cases)persons with epilepsy(PWE)with nodding seizures.The age and sex-standardized prevalence in Kelleng decreased from 13.5%in 2004 to 9.3%in 2018(P<0.001).The median age of PWE shifted from 17(IQR:12-22)years to 24(IQR:20-30)years in Bilomo(P<0.001);and slightly from 24(IQR:14-34)years to 28(IQR:21.25-36.75)years in Kelleng(P=0.112).Furthermore,47.6%of all tested children between 7 and 10 years had Ov16 antibodies.Conclusions:There is a decrease in epilepsy prevalence after 13 years and more of CDTI in both villages.The age-shift observed in PWE suggests that ivermectin may prevent OAE in younger residents.Ov16 seropositivity in children indicates ongoing onchocerciasis transmission possibly due to suboptimal control measures.Our findings support the existence of OAE in Cameroon and highlight the need to strengthen onchocerciasis elimination programs. | Joseph Nelson Siewe Fodjo Godwin Tatah Earnest Njih Tabah Leonard Ngarka Leonard Njamnshi Nfor Samuel Eric Chokote Michel KMengnjo Fidele Dema Aurelien Tele Sitouok Grace Nkoro Felicien ENtone Anne-Cecile Zoung-Kanyi Bissek Cedric BChesnais Michel Boussinesq Robert Colebunders Alfred K.Njamnshi | 2018 | Infectious Diseases of Poverty2018，7，1： | 3 |
| 5 | Freezing on demand: A new concept for mine safety and energy savings in wet underground mines显示文摘The artificial ground freezing(AGF)systems are designed to operate continuously for an extended period of time to control the groundwater seepage and to strengthen the groundwater structure surrounding excavation areas.This mode of operation requires a massive amount of energy to sustain the thickness of the frozen body.Therefore,it is of great interest to propose new concepts to reduce energy consumption while providing sufficient structural stability and safe operation.This paper discusses the principle of the freezing on demand(FoD)by means of experiment and mathematical model.A lab-scale rig that mimics the AGF process is conceived and developed.The setup is equipped with more than 80 thermocouples,flow-meters,and advanced instrumentation system to analyze the performance of the AGF process under the FoD concept.A mathematical model has been derived,validated,and utilized to simulate the transient FoD concept.The results suggest that the overall energy saving notably depends on the coolant’s temperature;the energy saving increases while decreasing the coolant inlet temperature.Moreover,applying the FoD concept in an AGF system leads to a significant drop in energy consumption. | Mahmoud A.Alzoubi Ahmad Zueter Aurelien Nie-Rouquette Agus P.Sasmito | 2019 | International Journal of Mining Science and Technology2019，29，4： | 3 |
| 6 | Saturable plasmonic metasurfaces for laser mode locking显示文摘Metamaterials are artificial materials made of subwavelength elementary cells that give rise to unexpected wave properties that do not exist naturally.However,these properties are generally achieved due to 3D patterning,which is hardly feasible at short wavelengths in the visible and near-infrared regions targeted by most photonic applications.To overcome this limitation,metasurfaces,which are the 2D counterparts of metamaterials,have emerged as promising platforms that are compatible with planar nanotechnologies and thus mass production,which platforms the properties of a metamaterial into a 2D sheet.In the linear regime,wavefront manipulation for lensing,holography,and polarization control has been achieved recently.Interest in metasurfaces operating in the nonlinear regime has also increased due to the ability of metasurfaces to efficiently convert incident light into harmonic frequencies with unusual polarization properties.However,to date,the nonlinear absorption of metasurfaces has been mostly ignored.Here,we demonstrate that plasmonic metasurfaces behave as saturable absorbers with modulation performances superior to the modulation performance of other 2D materials and exhibit unusual polarimetric nonlinear transfer functions.We quantify the link between saturable absorption,the plasmonic resonances of the unit cell and their distribution in a 2D metasurface,and finally provide a practical implementation by integrating the metasurfaces into a fiber laser cavity operating in pulsed regimes driven by the metasurface properties.As such,this work provides new perspectives on ultrathin nonlinear saturable absorbers for applications where tunable nonlinear transfer functions are needed,such as in ultrafast lasers or neuromorphic circuits. | Jiyong Wang Aurelien Coillet Olivier Demichel Zhiqiang Wang Davi Rego Alexandre Bouhelier Philippe Grelu Benoit Cluzel | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 7 | Loss of OPAl perturbates the mitochondrial inner membrane structure and integrity, leading to eytochrome C release and apoptosis 显示文摘 | Aurelien Olichon Lanrent Baricault Nicole Gas | 2003 | Biol Chem2003，278，2： | 1 |
| 8 | Photonic-crystal GaN light-emitting diodes with tailored guided modes distribution显示文摘 | Aurelien David Rajat Sharma T F Kelly McGroddy | 2006 | Applied Physics Letters2006，88，061124： | 1 |
| 9 | Peroxisome proliferator-activated receptor structures: Ligand specificity, molecular switch and interactions with regulators显示文摘 | Vincent Zoete Aurelien Grosdidier Olivier Michielin | 2007 | BBA - Molecular and Cell Biology of Lipids2007，，8： | 1 |
| 10 | Blood Loss During Transurethral Resection of the Prostate as Measured by the Chromium-51Method显示文摘 | Aurelien Descazeaud Abdel Rahmene Azzousi Charles Ballereau | 2010 | Journal of endourology2010，11，： | 1 |
| 11 | Characteristic and performance of 500 F asymmetric cybrid advanced supercapaeitor protoypes 显示文摘 | Aurelien P Irene P Gural J | 2003 | Power Sources2003，113，： | 1 |
| 12 | AmberFFC,a flexible program to convert amber and glycam force fields for use with commercial molecular modeling packages显示文摘 | AURELIEN D PIOTR C NICOLAS H | 2001 | Molecular Modeling Annual2001，7，11： | 1 |
| 13 | Role of retinoic acid in the sta- bility of the T-helper-type 1 lineage and impli- cations for autoimmunity显示文摘 | Brown Chrysothemis Esterhazy Daria Sarde Aurelien | 2015 | Lancet2015，385，2： | 1 |
| 14 | Sporad- ic dsoid tumor 显示文摘 | Aurelien Amiot Safi Dokmak Alain Sauvant | 2008 | An Exceptional Cause of Cystic Pancreas (online)2008，9，： | 1 |
| 15 | Extracellular vesicles:General features and usefulness in diagnosis and therapeutic management of colorectal cancer显示文摘In the world,among all type of cancers,colorectal cancer(CRC)is the third most commonly diagnosed in males and the second in females.In most of cases,(RP1)patients’prognosis limitation with malignant tumors can be attributed to delayed diagnosis of the disease.Identification of patients with early-stage disease leads to more effective therapeutic interventions.Therefore,new screening methods and further innovative treatment approaches are mandatory as they may lead to an increase in progression-free and overall survival rates.For the last decade,the interest in extracellular vesicles(EVs)research has exponentially increased as EVs generation appears to be a universal feature of every cell that is strongly involved in many mechanisms of cell-cell communication either in physiological or pathological situations.EVs can cargo biomolecules,such as lipids,proteins,nucleic acids and generate transmission signal through the intercellular transfer of their content.By this mechanism,tumor cells can recruit and modify the adjacent and systemic microenvironment to support further invasion and dissemination.This review intends to cover the most recent literature on the role of EVs production in colorectal normal and cancer tissues.Specific attention is paid to the use of EVs for early CRC diagnosis,follow-up,and prognosis as EVs have come into the spotlight of research as a high potential source of‘liquid biopsies’.The use of EVs as new targets or nanovectors as drug delivery systems for CRC therapy is also summarized. | Aurelien Mammes Jennifer Pasquier Olivier Mammes Marc Conti Richard Douard Sylvain Loric | 2021 | World Journal of Gastrointestinal Oncology2021，13，11： | 1 |
| 16 | Characteristics and performance of 500 F asymmetric hybrid advanced supercapacitor prototypes 显示文摘 | Aurelien D P Plitz I Gural J | 2003 | J Power Sources2003，113，1： | 1 |
| 17 | Dynamics and Clinical Evolution of Bacterial Gut Microflora in Extremely Premature Patients显示文摘 | Aurelien Jacquot Dorine Neveu Fabien Aujoulat Gregoire Mercier Hélène Marchandin Estelle Jumas-Bilak Jean-Charles Picaud | 2011 | The Journal of Pediatrics2011，，3： | 1 |
| 18 | Comparison of the latest commercial short and long oligonucleotide microarray technologies显示文摘 | Aurelien de Reynies Daniela Geromin Jean-Michel Cayuela | 2006 | BMC Genomies2006，7，： | 1 |
| 19 | Use of modified silica nanoparticle for fixation and elimination of coiloidal and dissolred substances from white water显示文摘 | Aurelien G Claude D Bruno C | 2006 | Nordic Pulp and Paper Research Journal2006，21，5： | 1 |
| 20 | An asymmetric hybrid nonaqueous energy storage cell显示文摘 | Glenn G A Fadwa B Aurelien D P | 2001 | J Electrochem Soc2001，148，8： | 1 |
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