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| 1 | How to perform gastrointestinal ultrasound: anatomy and normal findings显示文摘Gastrointestinal ultrasound is a practical, safe, cheap and reproducible diagnostic tool in inflammatorybowel disease gaining global prominence amongst clinicians. Understanding the embryological processes of the intestinal tract assists in the interpretation of abnormal sonographic findings. In general terms, the examination principally comprises interrogation of the colon, mesentery and small intestine using both lowfrequency and high-frequency probes. Interpretation of findings on GIUS includes assessment of bowel wall thickness, symmetry of this thickness, evidence of transmural changes, assessment of vascularity using Doppler imaging and assessment of other specific features including lymph nodes, mesentery and luminal motility. In addition to B-mode imaging, transperineal ultrasonography, elastography and contrast-enhanced ultrasonography are useful adjuncts. This supplement expands upon these features in more depth. | Nathan S S Atkinson Robert V Bryant Yi Dong Christian Maaser Torsten Kucharzik Giovanni Maconi Anil K Asthana Michael Blaivas Adrian Goudie Odd Helge Gilja Dieter Nuernberg Dagmar Schreiber-Dietrich Christoph F Dietrich | 2017 | World Journal of Gastroenterology2017，23，38： | 5 |
| 2 | Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing显示文摘Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing. | Mubashir Ahmad Benjamin Thilo Krüger Torsten Kroll Sabine Vettorazzi Ann-Kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann | 2022 | Bone Research2022，10，3： | 2 |
| 3 | Variations of the ^44Ca/^40Ca ratio in seawater during the past 24 million years: Evidence from δ44Ca and δ^18O values of Miocene phosphates显示文摘 | Anne-Désirée S Peter S Torsten V | 2003 | Geochimica et Cosmochimica Acta2003，67，14： | 1 |
| 4 | The association of tooth loss with all-cause and circulatory mortality. Is there a benefit of replaced teeth? A systematic review and meta-analysis显示文摘 | Ines Polzer Christian Schwahn Henry V?lzke Torsten Mundt Reiner Biffar | 2012 | Clinical Oral Investigations2012，，2： | 1 |
| 5 | Effect of speciation on equilibrium fractionations and rates of oxygen i- sotope exchange between (PO4)aq and H2 O 显示文摘 | JAMES R O TORSTEN W V WILLIAM F M | 2003 | Geoehim Cosmoehim AC2003，67，17： | 1 |
| 6 | The influence of vari- ous light curing units on the cytotoxicity of dental adhesives 显示文摘 | Bernd W Torsten P Andrea V | 2009 | Dent Mater2009，24，： | 1 |
| 7 | Neutrophil transmigration in inflammatory bowel disease is associated with differential expression of epithelial intercellular junction proteins显示文摘 | Torsten Kucharzik Shaun V Walsh Jason Chen | 2001 | American Journal of Pathology2001，159，： | 1 |
| 8 | Micro total analysis systems recent developments显示文摘 | TORSTEN V DIRK J ANDREAS M | 2004 | Analytical Chemistry2004，，76： | 1 |
| 9 | Investigation of non-Darcy flow in tight-gas reservoirs with fractured wells显示文摘 | Torsten F Hans D V | 2006 | Journal of Petroleum Science and Engineering2006，54，34： | 1 |
| 10 | Investigation of non-Darcy flow intight-gas reservoirs with fractured wells显示文摘 | Torsten F Hans D V | 2006 | Journal of PetroleumScience and Engineering2006，54，： | 1 |
| 11 | A Monitoring Tool for the Provision of Accessible and Attractive Urban Green Spaces显示文摘 | Ann V H Torsten W | 2003 | Landscape and Urban Planning2003，，63： | 1 |
| 12 | Investigation of non-Darcy flow in tight-gas reservoirs with fractured wells 显示文摘 | Torsten F Hans-Dieter V | 2006 | Journal of Petroleum Science and Engineering2006，64，2： | 1 |
| 13 | Investigation of non-Darcy flow in tight-gas reservoirs with fractured wells 显示文摘 | Torsten F Hans D V | 2006 | Journal of Pe- troleum Science and Engineering2006，，54： | 1 |
| 14 | P2-type layered high-entropy oxides as sodium-ion cathode materials显示文摘P2-type layered oxides with the general Na-deficient composition Na_(x)TMO_(2)(x<1,TM:transition metal)are a promising class of cathode materials for sodium-ion batteries.The open Na+transport pathways present in the structure lead to low diffusion barriers and enable high charge/discharge rates.However,a phase transition from P2 to O2 structure occurring above 4.2 V and metal dissolution at low potentials upon discharge results in rapid capacity degradation.In this work,we demonstrate the positive effect of configurational entropy on the stability of the crystal structure during battery operation.Three different compositions of layered P2-type oxides were synthesized by solid-state chemistry,Na_(0.67)(Mn_(0.55)Ni_(0.21)Co_(0.24))O_(2),Na_(0.67)(Mn_(0.45)Ni_(0.18)Co_(0.24)Ti_(0.1)Mg_(0.03))O_(2) and Na_(0.67)(Mn_(0.45)Ni_(0.18)Co_(0.18)Ti_(0.1)Mg_(0.03)Al_(0.04)Fe_(0.02))O_(2) with low,medium and high configurational entropy,respectively.The high-entropy cathode material shows lower structural transformation and Mn dissolution upon cycling in a wide voltage range from 1.5 to 4.6 V.Advanced operando techniques and post-mortem analysis were used to probe the underlying reaction mechanism thoroughly.Overall,the high-entropy strategy is a promising route for improving the electrochemical performance of P2 layered oxide cathodes for advanced sodium-ion battery applications. | Junbo Wang Sören L Dreyer Kai Wang Ziming Ding Thomas Diemant Guruprakash Karkera Yanjiao Ma Abhishek Sarkar Bei Zhou Mikhail V Gorbunov Ahmad Omar Daria Mikhailova Volker Presser Maximilian Fichtner Horst Hahn Torsten Brezesinski Ben Breitung Qingsong Wang | 2022 | Materials Futures2022，1，3： | 0 |
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