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| 1 | Development of osteomalacia in a post-liver transplant patient receiving adefovir dipivoxil显示文摘We report the case of a patient treated with living donor-related liver transplantation who suffered from osteomalacia during adefovir dipivoxil (ADV)-containing antiviral therapy for lamivudine-resistant hepatitis B virus infection. The patient had generalized bone pain,with severe hypophosphatemia after 20 mo of ADV therapy. Radiographic studies demonstrated the presence of osteomalacia. The peak plasma ADV level was 38 ng/mL after administration of ADV at 10mg/day. It was also found that ADV affected the metabolism of tacrolimus,a calcineurin-inhibitor,and caused an increase in the plasma levels of tacrolimus. The disability was reversed with the withdrawal of ADV and with mineral supplementation. ADV can cause an elevation of plasma tacrolimus levels,which may be associated with renal dysfunction. High levels of ADV and tacrolimus can cause nephrotoxicity and osteomalacia. This case highlights the importance of considering a diagnosis of osteomalacia in liver transplantation recipients treated with both ADV and tacrolimus. | Masami Minemura Yoshiharu Tokimitsu Kazuto Tajiri Yasuhiro Nakayama Kengo Kawai Hiroshi Kudo Katsuharu Hirano Yoshinari Atarashi Yutaka Yata Satoshi Yasumura Terumi Takahara Toshiro Sugiyama | 2010 | World Journal of Hepatology2010，2，12： | 13 |
| 2 | IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro显示文摘 | Shoichi Kaneshiro Kosuke Ebina Kenrin Shi Chikahisa Higuchi Makoto Hirao Michio Okamoto Kota Koizumi Tokimitsu Morimoto Hideki Yoshikawa Jun Hashimoto | 2014 | Journal of Bone and Mineral Metabolism2014，，4： | 2 |
| 3 | Sulfated Polysaccharides, but Not Cellulose, Increase Colonic Mucus in Rats with Loperamide-Induced Constipation显示文摘 | Akira Shimotoyodome Shinichi Meguro Tadashi Hase Ichiro Tokimitsu Takashi Sakata | 2001 | Digestive Diseases and Sciences2001，，7： | 1 |
| 4 | Variability in toxicity of the dinoflagellate Alexandrium tamarense isolated from Hiroshima Bay,western Japan,as a reflection of changing environmental conditions显示文摘 | Hamasaki K Horie M Tokimitsu A | 2001 | J Plank Res2001，23，： | 1 |
| 5 | Metabolic charaeteristics of diacylglyeerol显示文摘 | MATSUO N TOKIMITSU I | 2001 | Inform2001，12，11： | 1 |
| 6 | Variability in toxicity of the dinoflagellate Alexandrium tamarense isolated from Hiroshima Bay,western Japan,as a reflection of changing environmental conditions显示文摘 | Hamasaki K Horie M Tokimitsu S | 2001 | Journal of plankton research2001，23，3： | 1 |
| 7 | Supplementation with alpha-linolenic acid rich diacylglycerol suppresses fatty liver formation accom-panied by an upregulation of β-oxidation in Zucker fatty rats显示文摘 | MURASE T IOKI M TOKIMITSU I | 2005 | Biochimica et Biophysica Acta2005，1733，23： | 1 |
| 8 | Supplementation with al- pha-linolenic acid-rich diacylglycerol suppresses fatty liver formation accompanied by an up-regulation of beta-oxidation in Zucker fatty rats 显示文摘 | Murase T Aoki M Tokimitsu I | 2005 | Biochim Biophys Acta2005，1733，： | 1 |
| 9 | Hydroxyhydroquinone-free coffee: A double-blind, randomized controlled dose–response study of blood pressure显示文摘 | Tohru Yamaguchi Akiro Chikama Kenta Mori Takuya Watanabe Yasushi Shioya Yoshihisa Katsuragi Ichiro Tokimitsu | 2007 | Nutrition Metabolism and Cardiovascular Diseases2007，，6： | 1 |
| 10 | Macromolecules显示文摘 | Tokimitsu T Yasuda H | 2000 | 33(21): 7679-76812000，33，21： | 1 |
| 11 | Dietary diacylglycerol in a typical meal suppresses postprandial increases in serum lipid levels compared with dietary riacylglycerol显示文摘 | Tomonobu K Hase T Tokimitsu I | 2006 | Nutrition2006，22，2： | 1 |
| 12 | Elastin synthesis is inhibited by angiotensin II but not by plateletderived growth factor in arterial smooth muscle cells 显示文摘 | Kato H Wachi H | 1994 | Biochim Biophys Axta1994，1207，： | 1 |
| 13 | A green tea extract high in catechins reduces body fat and cardiovascular risks in humans 显示文摘 | NAGAO T HASE T TOKIMITSU I | 2007 | Obesity2007，15，6： | 1 |
| 14 | First controlled block copolymerizations of higher 1-olefins with polar monomers using metallocene type single component lanthanide initiators显示文摘 | Desurmont G Tokimitsu T Yasuda H | 2000 | Macromolecules2000，33，21： | 1 |
| 15 | Saliva-promoted adhesion of Streptococcus mutans MT8148 associates with dental plaque and caries experience显示文摘 | Shimotayodome A Kobayashi IL Tokimitsu I | 2007 | Caries Res2007，41，3： | 1 |
| 16 | Dietary diacylglycerol suppresses high fat diet-induced hepatic fat accumulation and microsomal triacylglycerol transfer protein activity in rats显示文摘 | Hiroyuki Taguchi Toshiko Omachi Tomonori Nagao Noboru Matsuo Ichiro Tokimitsu Hiroshige Itakura | 2002 | The Journal of Nutritional Biochemistry2002，，11： | 1 |
| 17 | A green tea extract high in catechins reduces body fat and cardiovascular risks in hu- mans显示文摘 | NAGAO T HASE T TOKIMITSU I | 2007 | Obesity2007，15，6： | 1 |
| 18 | A green tea extract high in catechins reduces body fat and cardiovascular risks in humans显示文摘 | Nagao T Hase T Tokimitsu I | 2007 | Obesity2007，15，6： | 1 |
| 19 | Dietary diacylglycerol in a typical meal suppresses postprandial increases in serum lipid levels compared with dietary triacylglycerol显示文摘 | Kazuichi Tomonobu MS Tadashi Hase MS Ichiro Tokimitsu | 2006 | Nutrition2006，22，2： | 1 |
| 20 | Effects of tea catechins on lipid metabolism and body fat accumulation显示文摘 | TOKIMITSU I | 2004 | Biofactors2004，22，14： | 1 |
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