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| 1 | Prognostic roles of preoperative α-fetoprotein and des-γ-carboxy prothrombin in hepatocellular carcinoma patients显示文摘AIM:To clarify the utility of using des-γ-carboxy prothrombin(DCP)andα-fetoprotein(AFP)levels to predict the prognosis of hepatocellular carcinoma(HCC)in patients with hepatitis B virus(HBV)and the hepatitis C virus(HCV)infections.METHODS:A total of 205 patients with HCC(105patients with HBV infection 100 patients with HCV infection)who underwent primary hepatectomy between January 2004 and May 2012 were enrolled retrospectively.Preoperative AFP and DCP levels were used to create interactive dot diagrams to predict recurrence within 2 years after hepatectomy,and cutoff levels were calculated.Patients in the HBV and HCV groups were classified into three groups:a group with low AFP and DCP levels(LL group),a group in which one of the two parameters was high and the other was low(HL group),and a group with high AFP and DCP levels(HH group).Liver function parameters,the postoperative recurrence-free survival rate,and postoperative overall survival were compared between groups.The survival curves were compared by logrank test using the Kaplan-Meier method.Multivariate analysis using a Cox forward stepwise logistic regression model was conducted for a prognosis.RESULTS:The preoperative AFP cutoff levels for recurrence within 2 years after hepatectomy in the HBV and HCV groups were 529.8 ng/m L and 60 m AU/m L,respectively;for preoperative DCP levels,the cutoff levels were 21.0 ng/m L in the HBV group and 67 m AU/m L in the HCV group.The HBV group was significantly different from the other groups in terms of vascular invasion,major hepatectomy,volume of intraoperative blood loss,and surgical duration.Significant differences were found between the LL group,the HL group,and the HH group in terms of both mean disease-free survival time(MDFST)and mean overall survival time(MOST):64.81±7.47 vs 36.63±7.62 vs 18.98±6.17mo(P=0.001)and 85.30±6.55 vs 59.44±7.87 vs46.57±11.20 mo(P=0.018).In contrast,the HCV group exhibited a significant difference in tumor size,vascular invasion,volume of intraoperative blood loss,and surgical duration;however,no significant difference was observed between the three groups in liver function parameters except for albumin levels.In the LL group,the HL group,and the HH group,the MDFST was 50.09±5.90,31.01±7.21,and 14.81±3.08 mo(log-rank test,P<0.001),respectively,and the MOST was 79.45±8.30,58.82±7.56,and 32.87±6.31 mo(log-rank test,P<0.001),respectively.CONCLUSION:In the HBV group,the prognosis was poor when either AFP or DCP levels were high.In the HCV group,the prognosis was good when either or both levels were low;however,the prognosis was poor when both levels were high.High levels of both AFP and DCP were an independent risk factor associated with tumor recurrence in the HBV and HCV groups.The relationship between tumor marker levels and prognosis was characteristic to the type of viral hepatitis. | Makoto Meguro Toru Mizuguchi Toshihiko Nishidate Kenji Okita Masayuki Ishii Shigenori Ota Tomomi Ueki Emi Akizuki Koichi Hirata | 2015 | World Journal of Gastroenterology2015，21，16： | 16 |
| 2 | Propensity score analysis demonstrated the prognostic advantage of anatomical liver resection in hepatocellular carcinoma显示文摘AIM:To compare the prognoses of hepatocellular carcinoma(HCC)patients that underwent anatomic liver resection(AR)or non-anatomic liver resection(NAR)using propensity score-matched populations.METHODS:Between January 2002 and December2010,268 consecutive HCC patients,including 110 and158 patients that underwent AR and NAR,respectively,were retrospectively enrolled in this study.Forty-four patients from each group were selected and matched using logistic multivariate analysis followed by propensity score analysis.RESULTS:In the whole analysis set,the histological background of the liver,liver function,and tumor marker levels differed significantly among the groups.Although the overall survival(OS)and recurrence-free survival rates of the two groups did not differ significantly in the whole analysis set,the OS of the AR group was significantly longer than that of the NAR group after propensity matching(76.2±6.3 mo vs 58.9±6.3mo;P=0.0039).Although AR(HR=0.456,P=0.039)was found to be a prognostic factor in the univariate analysis,only vascular invasion(HR=0.228,P=0.002)and the hepatocyte growth factor level(HR=52.366,P=0.035)were subsequently found to be independent prognostic factors.CONCLUSION:AR conveys a survival advantage over NAR in specific subpopulations of HCC patients with tumors of less than 5 cm in diameter,single tumor,and good liver function. | Masayuki Ishii Toru Mizuguchi Masaki Kawamoto Makoto Meguro Shigenori Ota Toshihiko Nishidate Kenji Okita Yasutohsi Kimura Thomas T Hui Koichi Hirata | 2014 | World Journal of Gastroenterology2014，20，12： | 12 |
| 3 | Comprehensive review of post-liver resection surgical complications and a new universal classification and grading system显示文摘Liver resection is the gold standard treatment for certain liver tumors such as hepatocellular carcinoma and metastatic liver tumors. Some patients with such tumors already have reduced liver function due to chronic hepatitis, liver cirrhosis, or chemotherapy-associated steatohepatitis before surgery. Therefore, complications due to poor liver function are inevitable after liver resection. Although the mortality rate of liver resection has been reduced to a few percent in recent case series, its overall morbidity rate is reported to range from 4.1% to 47.7%. The large degree of variation in the post-liver resection morbidity rates reported in previous studies might be due to the lack of consen-sus regarding the definitions and classification of postliver resection complications. The Clavien-Dindo(CD) classification of post-operative complications is widely accepted internationally. However, it is hard to apply to some major post-liver resection complications because the consensus definitions and grading systems for posthepatectomy liver failure and bile leakage established by the International Study Group of Liver Surgery are incompatible with the CD classification. Therefore, a unified classification of post-liver resection complications has to be established to allow comparisons between academic reports. | Masayuki Ishii Toru Mizuguchi Kohei Harada Shigenori Ota Makoto Meguro Tomomi Ueki Toshihiko Nishidate Kenji Okita Koichi Hirata | 2014 | World Journal of Hepatology2014，6，10： | 3 |
| 4 | Preoperative liver function assessments to estimate the prognosis and safety of liver resections显示文摘 | Toru Mizuguchi Masaki Kawamoto Makoto Meguro Thomas T. Hui Koichi Hirata | 2014 | Surgery Today2014，，1： | 2 |
| 5 | Development of large single crystal diamond growth process 显示文摘 | Meguro K Nishibayashi Y Imai T | 2003 | Sumitomo Electric Technical Review2003，，163： | 1 |
| 6 | Immediate surgery reduces mortality in deeply comatose patients with spontaneous carebellar hemorrhage显示文摘 | Yanaka K Meguro K Fujita K | 2000 | Neurol Med Chir2000，40，6： | 1 |
| 7 | Acute brain swelling during evacuation of subdural hematoma caused by delayed contra-lateral extradural hematoma: report of two cases显示文摘 | Meguro K Kobayashi E Maki Y | 1987 | Neurosurg1987，20，： | 1 |
| 8 | Fracture behavior of AIN ceramics with rare earth oxides显示文摘 | TERAO R TATAMI J MEGURO T KOMEYA K | 2002 | Journal of the European Ceramic Society2002，22，7： | 1 |
| 9 | Prevalence of idiopathic normal-pressure hydrocephalus in the elderly population of a Japanese rural community显示文摘 | Hiraoka K Meguro K Mori E | 2008 | Neurol Med Chit (Tokyo)2008，48，5： | 1 |
| 10 | Association of Toll-like re-ceptor 4 gene polymorphisms with normal tension glaucoma 显示文摘 | Shibuya E Meguro A Ota M | 2008 | Invest Ophthalmol Vis Sci2008，49，10： | 1 |
| 11 | Prevalence of idiopathic normal pressure hydrocephalus in the elderly population of a Japanese rural community 显示文摘 | HIRAOKA K MEGURO K MORI E | 2008 | Neurol Med Chir (Tokyo)2008，48，5： | 1 |
| 12 | Preparation of fine particles of spinel-type Mn-Co-Ni oxide by freeze-drying显示文摘 | Torikai N Meguro T Sasamoto T | 1984 | Journal of the Chemical Society of Japan1984，6，： | 1 |
| 13 | Sulfated Polysaccharides, but Not Cellulose, Increase Colonic Mucus in Rats with Loperamide-Induced Constipation显示文摘 | Akira Shimotoyodome Shinichi Meguro Tadashi Hase Ichiro Tokimitsu Takashi Sakata | 2001 | Digestive Diseases and Sciences2001，，7： | 1 |
| 14 | Key technologies for high-accuracy large mesh antenna reflectors显示文摘 | MEGURO A HARADA S WATANABE M | 2003 | Acta Astronautica2003，53，11： | 1 |
| 15 | Isolation and char- acterization of polybromlnated diphenyl ethers as inhibitors of mi- crotubule assembly from the marine sponge Phyllospongia dendyicolleered at Palau显示文摘 | LIU H NAMIKOSHI M MEGURO S | 2004 | J Nat Prod2004，67，3： | 1 |
| 16 | Effect of external stenting and systemic hypertension on intimal hyperplasia in rat vein grafts显示文摘 | Meguro T Nakashima H Kawada S | 2000 | Neurosurgery2000，46，4： | 1 |
| 17 | Behavioral neurology in language and aphasia: from basic studies to clinical applications 显示文摘 | Meguro K | 2012 | Acta Med In- dones2012，44，4： | 1 |
| 18 | Prognosis and predictors of surgical complications in hepatocellular carcinoma patients with or without cirrhosis after hepatectomy显示文摘 | Mizuguchi T Kawamoto M Meguro M | 2013 | World J Surg2013，37，6： | 1 |
| 19 | Coffee polyphenols exert hypochole-sterolemic effects in zebrafish fed a high-cholestarol diet 显示文摘 | Meguro S Hasumura T Hase T | 2013 | Nutrition & Metabolism2013，10，1： | 1 |
| 20 | The Lowest Surface Free Energy Based on - CF3 Alignment 显示文摘 | Nishino T Meguro M Nakamae K | 1999 | Langmuir1999，15，13： | 1 |
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