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| 1 | TGF-β family co-receptor function and signaling显示文摘转变生长因素 --(TGF-) 家庭成员,它包括 TGF-s, activins 和骨头形态基因的蛋白质,是多种的 cytokines 得到细胞类型特定的效果在一高度在许多不同纸巾的上下文依赖者举止。经由 single-transmembrane 类型的这些分泌蛋白质 ligands 信号我和类型 II serine/threonine kinase 受体和细胞内部的 SMAD 抄写因素。在发信号的解除管制在疾病的一个宽广数组被含有,并且含有对复杂罚款在细胞的发信号的回答调节的需要。TGF- 家庭受体发信号紧张,持续时间,特性和差异被调整或调停的一重要出现机制通过房间表面合作受体。这里,我们提供为 TGF- 家庭成员被识别了的合作受体的概述。当一些看起来对 TGF- 家庭成员特定时,其它与另外的小径被分享并且为信号集成提供可能的方法。这评论集中于 TGF- 家庭合作受体的新奇功能,它继续发现。 | Joachim Nickel Peter ten Dijke Thomas D. Mueller | 2018 | Acta Biochimica et Biophysica Sinica2018，50，1： | 26 |
| 2 | Increased liver stiffness in alcoholic liver disease:Differentiating fibrosis from steatohepatitis显示文摘AIM:To test if inflammation also interferes with liver stiffness (LS) assessment in alcoholic liver disease (ALD) and to provide a clinical algorithm for reliable fibrosis assessment in ALD by FibroScan (FS).METHODS:We first performed sequential LS analysis before and after normalization of serum transaminases in a learning cohort of 50 patients with ALD admitted for alcohol detoxification. LS decreased in almost all patients within a mean observation interval of 5.3 d. Six patients (12%) would have been misdiagnosed with F3and F4 fibrosis but LS decreased below critical cut-off values of 8 and 12.5 kPa after normalization of trans-aminases. RESULTS:Of the serum transaminases,the decrease in LS correlated best with the decrease in glutamic oxaloacetic transaminase (GOT). No significant chang-es in LS were observed below GOT levels of 100 U/L. After establishing the association between LS and GOT levels,we applied the rule of GOT < 100 U/L for reliable LS assessment in a second validation cohort of 101 patients with histologically confi rmed ALD. By ex-cluding those patients with GOT > 100 U/L at the time of LS assessment from this cohort,the area under the receiver operating characteristic (AUROC) for cirrhosis detection by FS improved from 0.921 to 0.945 while specificity increased from 80% to 90% at a sensitivity of 96%. A similar AUROC could be obtained for lower F3 fibrosis stage if LS measurements were restricted to patients with GOT < 50 U/L. Histological grading of inflammation did not further improve the diagnostic accuracy of LS.CONCLUSION:Coexisting steatohepatitis markedly increases LS in patients with ALD independent of fibrosis stage. Postponing cirrhosis assessment by FS during alcohol withdrawal until GOT decreases to < 100 U/mL signif icantly improves the diagnostic accuracy. | Sebastian Mueller Gunda Millonig Lucie Sarovska Stefanie Friedrich Frank M Reimann Maria Pritsch Silke Eisele Felix Stickel Thomas Longerich Peter Schirmacher Helmut Karl Seitz | 2010 | World Journal of Gastroenterology2010，16，8： | 10 |
| 3 | PEComa of the colon resistant to sirolimus but responsive to doxorubicin/ifosfamide显示文摘A 23-year-old male presented with a three-week-history of crampy abdominal pain and melaena.Colonoscopy revealed a friable mass filling the entire lumen of the cecum;histologically,it was classified as perivascular epithelioid cell tumor(PEComa).An magnetic resonance imaging scan showed,in addition to the primary tumor,two large mesenteric lymph node metastases and four metastatic lesions in the liver.The patient underwent right hemicolectomy and left hemihepatectomy combined with wedge resections of metastases in the right lobe of the liver,the resection status was R0.Subsequently,the patient was treated with sirolimus.After 4 mo of adjuvant mammalian target of rapamycin inhibition he developed two new liver metastases and a local pelvic recurrence.The visible tumor formations were again excised surgically,this time the resection status was R2 with regard to the pelvic recurrence.The patient was treated with 12 cycles of doxorubicin and ifosfamide under which the disease was stable for 9 mo.The clinical course was then determined by rapid tumor growth in the pelvic cavity.Second line chemotherapy with gemcitabine and docetaxel was ineffective,and the patient died 23 mo after the onset of disease.This case report adds evidence that,in malignant PEComa,the mainstay of treatment is curative surgery.If not achievable,the effects of adjuvant or palliative chemotherapy are unpredictable. | Wolfgang Scheppach Nikolaus Reissmann Thomas Sprinz Ekkehard Schippers Bjoern Schoettker Justus G Mueller | 2013 | World Journal of Gastroenterology2013，19，10： | 8 |
| 4 | Salt Stress Triggers Phosphorylation of the Arabidopsis Vacuolar K+ Channel TPK1 by Calcium-Dependent Protein Kinases (CDPKs)显示文摘 | Andreas Latz Norbert Mehlmer Simone Zapf Thomas D. Mueller Bernhard Wurzinger Barbara Pfister Edina Csaszar Rainer Hedrich Markus Teige Dirk Becker | 2013 | Molecular Plant2013，6，4： | 5 |
| 5 | Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inlammatory bowel disease显示文摘AIM:To determine free and conjugated serum bile acid (BA) levels in in? ammatory bowel disease (IBD) subgroups with defi ned clinical manifestations.METHODS: Comprehensive serum BA profiling was performed in 358 IBD patients and 310 healthy controls by liquid chromatography coupled to electrospray ionization tandem mass spectrometry.RESULTS: Serum levels of hyodeoxycholic acid, the CYP3A4-mediated detoxification product of the secondary BA lithocholic acid (LCA), was increased significantly in Crohn's disease (CD) and ulcerative colitis (UC), while most other serum BA species were decreased significantly. Total BA, total BA conjugate, and total BA glycoconjugate levels were decreased only in CD, whereas total unconjugated BA levels were decreased only in UC. In UC patients with hepatobiliary manifestations, the conjugated primary BAs glycocholic acid, taurocholic acid, and glycochenodeoxycholic acid were as significantly increased as the secondary BAs LCA, ursodeoxycholic acid, and tauroursodeoxycholic acid compared to UC patients without hepatobiliary manifestations. Finally, we found that in ileocecal resected CD patients, the unconjugated primary BAs, cholic acid and chenode-oxycholic acid, were increased significantly compared to controls and patients without surgical interventions.CONCLUSION: Serum BA profiling in IBD patients that indicates impaired intestinal barrier function and increased detoxification is suitable for advanced diagnostic characterization and differentiation of IBD subgroups with defined clinical manifestations. | Carsten Gnewuch Gerhard Liebisch Thomas Langmann Benjamin Dieplinger Thomas Mueller Meinhard Haltmayer Hans Dieplinger Alexandra Zahn Wolfgang Stremmel Gerhard Rogler Gerd Schmitz | 2009 | World Journal of Gastroenterology2009，15，25： | 4 |
| 6 | Liver stiffness reversibly increases during pregnancy and independently predicts preeclampsia显示文摘AIM To study liver stiffness(LS) during pregnancy and its association with complications during pregnancy.METHODS In this observational, diagnostic study, 537 pregnant women were prospectively enrolled at the Department of Obstetrics and Gynecology, University hospital Heidelberg and Salem Medical Center. LS was measured using the Fibroscan device(Echosens, Paris) in all women and in 41 cases 24 h after delivery. Clinical and morphological data were recorded and abdominal ultrasound and standard laboratory tests were performed. No complications were observed in 475 women(controls) while preeclampsia and intrahepatic cholestasis of pregnancy(ICP) developed in 22 and 40 women, respectively.RESULTS In controls, LS increased significantly from initially 4.5 ± 1.2 kPa in the second trimester to 6.0 ± 2.3 kPa(P < 0.001) in the third trimester. In the third trimester, 41% of women had a LS higher than 6 kPa. Elevated LS in controls was significantly correlated with alkaline phosphatase, leukocytes, gestational age and an increase in body weight and body mass index(BMI). In women with pregnancy complications, LS was significantly higher as compared to controls(P < 0.0001). Moreover, in multivariate analysis, LS was an independent predictor for preeclampsia with an odds ratio of 2.05(1.27-3.31) and a cut-off value of 7.6 kPa. In contrast, ICP could not be predicted by LS. Finally, LS rapidly decreased in all women within 24 h after delivery from 7.2 ± 3.3 kPa down to 4.9 ± 2.2 kPa(P < 0.001).CONCLUSION During pregnancy, LS significantly and reversibly increases in the final trimester of pregnant women without complications. In women with preeclampsia, LS is significantly elevated and an independent noninvasive predictor. | Franziska J Ammon Anna Kohlhaas Omar Elshaarawy Johannes Mueller Thomas Bruckner Christof Sohn Gabriele Fluhr Herbert Fluhr Sebastian Mueller | 2018 | World Journal of Gastroenterology2018，24，38： | 2 |
| 7 | 从天然提取物或分离部位中以碳酸酐酶II为靶点的抗骨质疏松活性筛选(英文)显示文摘目的是以碳酸酐酶II (CAII)为靶点筛选其抑制剂 ,以期寻找抗骨质疏松活性样品。实验是在 96孔酶标板上对来源于 1 78个科、 60 8个属、 1 0 2 0种动植物 2 91 9个提取物或分离部位样品在CA II模型上进行了批量筛选。结果表明在 1 0 μg ml浓度下发现了来源于 40个科、61个属、72个种的 1 0 0个样品有活性 ,其中 5个样品的IC50 小于 2 50 μg ml,2 2个样品的IC50 在 2 51~ 5 0 0 μg ml范围 ,73个样品的IC50 在 5 0 1~1 0 0 0 μg ml范围。通过以上工作我们认为以碳酸酐酶II为分子靶点的体外筛选方法稳定、方便、快速、微量、有效 ,特别适用于天然产物的抗骨质疏松活性筛选。 | 付祥 谭宁华 姜立花 贾锐锐 嵇长久 LANDRO James FEKETE Alexander MUELLER Hartwig HENKEL Thomas | 2003 | 云南植物研究2003，25，6： | 2 |
| 8 | Optimisation of p-doped I~c-Si: H emitter layers in crystalline-amorphous silicon heterojunction solar cells 显示文摘 | Ling Zhipeng Ge Jia Mueller Thomas | 2012 | Energy Procedia2012，15，1： | 1 |
| 9 | Antiatherosclerotic activity of inhibitors of 3-hydroxy-3methylglutaryl coenzyme A reductase in cholesterol-fed rabbits:a biochemical and morphological evaluation显示文摘 | Thomas MA Bacan Michelle J Mazur Sandra Back Mueller | 1994 | Atherosclerosis1994，111，： | 1 |
| 10 | Differential expression of chemokines in normal pancreas and in chronic pancreatitis显示文摘 | Leslie Saurer Peter Reber Thomas Schaffner Markus W. Büchler Caroline Buri Andreas Kappeler Alfred Walz Helmut Friess Christoph Mueller | 2000 | Gastroenterology2000，，2： | 1 |
| 11 | Head-to-head comparison of the diagnostic utility of BNP and NT-proBNP in symptomatic and asymptomatic structural heart diaease 显示文摘 | Thomas Mueller Alfons Gegenhuber Wemer Poelz | 2004 | Clinica Chimica Acta2004，341，： | 1 |
| 12 | The Presage ST2 Assay: analytical considerations and clinical applications fora high-sensitivity assay for measurement of soluble ST2 显示文摘 | Thomas Mueller Benjamin Dieplinger | 2003 | Expert Rev Mol Diagn2003，13，1： | 1 |
| 13 | Decreased effector memory CD45RA^+ CD62L^- CD8 ^+ T cells and increased central memory CD45SRA^- CD62L^+ CD8^+ T cells in peripheral blood of rheumatoid arthritis patients 显示文摘 | Maldonado A Mueller YM Thomas P | 2003 | Arthritis Res Ther2003，5，2： | 1 |
| 14 | Altered Activation of Endothelial Anti- and Proapoptotic Pathways by High-Density Lipoprotein from Patients with Coronary Artery Disease: Role of High-Density Lipoprotein–Proteome Remodeling显示文摘 | Meliana Riwanto Lucia Rohrer Bernd Roschitzki Christian Besler Pavani Mocharla Maja Mueller Damir Perisa Kathrin Heinrich Lukas Altwegg Arnold von Eckardstein Thomas F. Lüscher Ulf Landmesser | 2013 | Circulation2013，，8： | 1 |
| 15 | Decreased effector memory CD45RA+ CD62L-CD8+T cells and increased central memory CD45RA-CD62L+ CD8+T cells in peripheral blood of rheumatoid arthritis patients显示文摘 | Maldonado A Mueller YM Thomas P | 2003 | Arthritis Res Ther2003，5，2： | 1 |
| 16 | Ionothermal synthesis of crystalline,condensed,graphitic carbon nitride显示文摘 | Bojdys M J Mueller J O Antonietti M Thomas A | 2008 | Chemistry A Europe Journal2008，14，27： | 1 |
| 17 | 从天然提取物或分离部位中以烯醇式丙酮酸转移酶为靶点的抗细菌活性筛选(英文)显示文摘目的是以烯醇式丙酮酸转移酶 (EPT)为靶点筛选其抑制剂 ,以期寻找抗细菌活性样品。实验是在 96孔酶标板上对来源于 16 9个科、 5 6 0个属、 916种动植物 2 4 90个提取物或分离部位样品在EPT模型上进行了批量筛选。结果表明在 96 15 μg/ml浓度下发现了来源于 80个科、 16 9个属、 2 18个种的 30 9个样品有活性 ,其中 14个样品的IC50 小于 10 0 0 μg/ml,4 0个样品的IC50 在 10 0 1~ 30 0 0 μg/ml范围 ,83个样品的IC50 在 30 0 1~ 5 0 0 0 μg/ml范围 ,172个样品的IC50 在 5 0 0 1~ 96 15 μg/ml范围。通过以上工作我们认为以烯醇式丙酮酸转移酶为分子靶点的体外筛选方法稳定、方便、快速、微量、有效 。 | 姜立花 谭宁华 杨亚滨 汪俊松 付祥 Lars JOHANNSEN Hartwig MUELLER Thomas HENKEL | 2003 | 云南植物研究2003，25，1： | 1 |
| 18 | Long-term stability of endogenous B-type natriuretic peptide (BNP) and amino terminal proBNP (NT-proBNP) in frozen plasma samples显示文摘 | Thomas Mueller Alfons Gegenhuber Benjamin Dieplinger Werner Poelz Meinhard Haltmayer | 2004 | Clinical Chemistry and Laboratory Medicine2004，，8： | 1 |
| 19 | Structure and Function of TPC1 Vacuole SV Channel Gains Shape显示文摘在内涵体的植物和动物操作 TPC1/SV-type 阳离子隧道。所有植物怀有至少一 TPC1 基因。尽管编码 SV 隧道二十年以前第一在植物液泡膜被发现,它的生物功能仍然保持神秘。最近,植物 TPC1/SV 隧道蛋白质的结构是坚定的。进 3D 拓扑学的卓见现在指导了指导地点的变化途径,启用流的 TPC1/SV 隧道的结构功能分析 ? 更早的调查结果上的新光。带 TPC1 的一种活动过度的变异的形式的 Fou2 植物发展伤害压力显型。有缺乏功能的 TPC1 的 fou2 和异种的最近的研究在本地、长途的应力发信号揭示了不正常的特征,提供新存取给在 planta 的这种 vacuolar 阳离子隧道类型的以前神秘的生物学。 | Rainer Hedrich Thomas D. Mueller Dirk Becker Irene Marten | 2018 | Molecular Plant2018，11，6： | 1 |
| 20 | Low-density lipoprotein receptor variants are associated with spontaneous and treatment-induced recovery from hepatitis C virus infection显示文摘 | Andreas Mas Marques Tobias Mueller Justus Welke Stefan Taube Christoph Sarrazin Manfred Wiese Juliane Halangk Heiko Witt Golo Ahlenstiel Ulrich Spengler Uwe Goebel Eckart Schott Viola Weich Beate Schlosser Hermann E. Wasmuth Frank Lammert Thomas Berg Ecka | 2009 | Infection, Genetics and Evolution2009，，5： | 1 |
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