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| 1 | Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inlammatory bowel disease显示文摘AIM:To determine free and conjugated serum bile acid (BA) levels in in? ammatory bowel disease (IBD) subgroups with defi ned clinical manifestations.METHODS: Comprehensive serum BA profiling was performed in 358 IBD patients and 310 healthy controls by liquid chromatography coupled to electrospray ionization tandem mass spectrometry.RESULTS: Serum levels of hyodeoxycholic acid, the CYP3A4-mediated detoxification product of the secondary BA lithocholic acid (LCA), was increased significantly in Crohn's disease (CD) and ulcerative colitis (UC), while most other serum BA species were decreased significantly. Total BA, total BA conjugate, and total BA glycoconjugate levels were decreased only in CD, whereas total unconjugated BA levels were decreased only in UC. In UC patients with hepatobiliary manifestations, the conjugated primary BAs glycocholic acid, taurocholic acid, and glycochenodeoxycholic acid were as significantly increased as the secondary BAs LCA, ursodeoxycholic acid, and tauroursodeoxycholic acid compared to UC patients without hepatobiliary manifestations. Finally, we found that in ileocecal resected CD patients, the unconjugated primary BAs, cholic acid and chenode-oxycholic acid, were increased significantly compared to controls and patients without surgical interventions.CONCLUSION: Serum BA profiling in IBD patients that indicates impaired intestinal barrier function and increased detoxification is suitable for advanced diagnostic characterization and differentiation of IBD subgroups with defined clinical manifestations. | Carsten Gnewuch Gerhard Liebisch Thomas Langmann Benjamin Dieplinger Thomas Mueller Meinhard Haltmayer Hans Dieplinger Alexandra Zahn Wolfgang Stremmel Gerhard Rogler Gerd Schmitz | 2009 | World Journal of Gastroenterology2009，15，25： | 4 |
| 2 | Prognostic value of established and novel biomarkers in patients with shortness of breath attending an emergency department显示文摘 | DIEPLINGER B GEGENHUBER A KAAR G | | 0，，09： | 1 |
| 3 | A cold-active extracellular metalloprotease from Pedobacter cryoconitisproduction and properties显示文摘 | Margesin R Dieplinger H Hofmann J | 2005 | Research in Microbiology2005，156，4： | 1 |
| 4 | Increased plasma concentrations of soluble ST2are predictive for 1-year mortality in patients with acute destabilized heart failure显示文摘 | Mueller T Dieplinger B Gegenhuber A | 2008 | Clin Chem2008，54，4： | 1 |
| 5 | Prognostic value of soluble ST2 in an unselected cohort of patients admitted to an intensive care unit-The Linz Intensive Care Unit (LICU) study显示文摘 | DIEPLINGER B EGGER M KOEHLER W | | 0，，5： | 1 |
| 6 | Comparative evaluation of B-type natriuretic peptide, mid-regional pro-A-type natriuretic peptide, mid-regional pro-adrenomedullin, and copeptin to predictl-yearmortality in patients with acute destabilized heart failure显示文摘 | Gegenhuber A Struck J Dieplinger B | 2007 | Card Fail2007，13，： | 1 |
| 7 | The vitamin E-binding protein afamin increases in maternal serum during pregnancy显示文摘 | Michael Hubalek Hannes Buchner Manfred G. M?rtl Dietmar Schlembach Berthold Huppertz Branka Firulovic Wolfgang K?hler Erich Hafner Benjamin Dieplinger Ludwig Wildt Hans Dieplinger | 2014 | Clinica Chimica Acta2014，，： | 1 |
| 8 | Value of adiponectin as predictor of 5-year all-cause mortality in patients with symptomatic pe- ripheral arterial disease: results from the Linz Peripheral Arterial Dis- ease (LIPAD) study显示文摘 | Dieplinger B Haltmayer M Poelz W | 2009 | Clin Chim Acta2009，408，12： | 1 |
| 9 | Increased plasma concentrations of soluble ST2 are predictive for 1-year mortality in patients with acute destabilized heart failure显示文摘 | Mueller T Dieplinger B Gegenhuber A | 2008 | Clin Chem2008，4，： | 1 |
| 10 | The Presage ST2 Assay: analytical considerations and clinical applications fora high-sensitivity assay for measurement of soluble ST2 显示文摘 | Thomas Mueller Benjamin Dieplinger | 2003 | Expert Rev Mol Diagn2003，13，1： | 1 |
| 11 | The Presage? ST2 Assay: analytieal con- siderations and clinical applications for a high-sensitivity assay for measurement of soluble ST2显示文摘 | Mueller T Dieplinger t3 | 2013 | Expert Rev Mol Diagn2013，13，1： | 1 |
| 12 | HypoAdiponectininemia is associated with symptomatic atherosclerotic peripheral arterial disease 显示文摘 | Dieplinger B Poelz W Haltmayer M | 2006 | Clin Chem Lab Med2006，44，7： | 1 |
| 13 | Increased plasma concentrations of soluble ST2 are predictive for 1-year mortality in patients with acute destabilized heart failure显示文摘 | Mueller T Dieplinger B Gegenhuber A | 2008 | Clin Chem2008，54，： | 1 |
| 14 | Hypoadiponectinemia is associated with symptonmtic atherosclerotic peripheral arterial disease显示文摘 | Dieplinger B Poelz W Haltmayer M | 2006 | Clin Chem Lab Med2006，44，7： | 1 |
| 15 | Hypoadiponectinemia is associated with symptomatic atherosclerotic peripheral arterial disease 显示文摘 | Dieplinger B Poelz W Hahrnayer M | 2006 | Clin Chem Lab Med2006，44，7： | 1 |
| 16 | Comparative evaluation of B - type natriuretie peptide, mid - regional pro - A - type natriuretic peptide, _mid - regional pro - adrenomedullin, and Copeptin to predict 1 - year mortality in patients with acute destabilized heart failure 显示文摘 | Gegenhuber A Struck J Dieplinger B et at | 2007 | J Card Fail2007，13，1： | 1 |
| 17 | Long-term stability of endogenous B-type natriuretic peptide (BNP) and amino terminal proBNP (NT-proBNP) in frozen plasma samples显示文摘 | Thomas Mueller Alfons Gegenhuber Benjamin Dieplinger Werner Poelz Meinhard Haltmayer | 2004 | Clinical Chemistry and Laboratory Medicine2004，，8： | 1 |
| 18 | Plasma B-type natriuretic peptide in patients with pleural effusions:preliminary observations显示文摘 | Gegenhuber A Mueller T Dieplinger B | 2006 | Chest2006，129，2： | 1 |
| 19 | Serum total 8-iso-prostaglandin F2alpha:a new and independent predictor of peripheral arterial disease 显示文摘 | MUELLER T DIEPLINGER B GEGENHU B E R A | 2004 | J Vase Surg2004，40，： | 1 |
| 20 | Increased serum lipoprotein(a) concentrations and low molecular weight phenotypes of apolipoprotein ( a ) are associated with symptomatic peripheral arterial disease 显示文摘 | Dieplinger B Lingenhel A Baumgartner N | 2007 | Clin Chem2007，53，7： | 1 |
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