| 2 | Screening and docking studies of natural phenolic inhibitors of carbonic anhydrase Ⅱ显示文摘Carbonic anhydrase Ⅱ (CAⅡ) is an important enzyme complex with Zn2+,which is involved in many physiological and pathological processes, such as calcification, glaucoma and tumorigenicity. In order to search for novel inhibitors of CAⅡ, inhibition assay of carbonic anhydrase Ⅱ was performed, by which seven natural phenolic compounds, including four phenolics (grifolin, 4-O-methyl-grifolic acid, grifolic acid, and isovanillic acid) and three flavones (eriodictyol, quercetin and puerin A), showed in-hibitory activities against CAⅡ with IC50s in the range of 6.37-71.73 μmol/L. Grifolic acid is the most active one with IC50 of 6.37 μmol/L. These seven phenolic compounds were proved to be novel natural carbonic anhydrase Ⅱ inhibitors, which were obtained in flexible docking study with GOLD 3.0 soft-ware. Results indicated that the aliphatic chain and polar groups of hydroxyl and carboxyl are impor-tant to their inhibitory activities, providing a new insight into study on CA Ⅱ potent inhibitors. | HUANG HuoQiang1, 2, PAN XuLin1, JI ChangJiu1, 2, ZENG GuangZhi1, JIANG LiHua1, FU Xiang1, LIU JiKai1, HAO XiaoJiang1, ZHANG YingJun1 & TAN NingHua1 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China 2 Graduate University of the Chinese Academy of Sciences, Beijing 100049, China | 2009 | Science China Chemistry2009，52，3： | 0 |
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