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| 1 | 人参皂甙对CD_(34)^+造血干/祖细胞的增殖和分化作用显示文摘目的 :探索人参皂甙 (GS)对CD34 +造血干 /祖细胞的刺激增殖和诱导分化作用。方法 :采用免疫磁珠法 (MACS)分离纯化脐血CD34 +细胞 ,在造血细胞半固体和液体培养体系中加入不同浓度的GS ,检测对CD34 +造血干 /祖细胞增殖 ,形成祖细胞集落的提高率 ,并用流式细胞仪检测液体培养后细胞表面标记的变化。结果 :GS( 5~ 50 μg/ml)能提高BFU E、CFU E、CFU GM、CFU GEMM集落产率 ( % ) ,分别为87 6± 2 6、63 3± 2 8、58 0± 3 1和 96 3± 5 5(均P <0 0 1)。GS 2 5μg/ml是液体培养刺激CD34 +细胞体外增殖的最佳浓度。GS诱导细胞 14天后 ,细胞表面表达CD33+细胞随GS的浓度升高而增加 ,在GS 50 μg/ml时以CD15+细胞数最高 ,CD71+细胞和G A+细胞数仅在 2 5μg/ml时高于未加GS的对照组。结论 :GS不但能促进CD34 +造血干 /祖细胞的增殖 ,并且能诱导定向分化 ,具有类生长因子和协同生长因子的作用。 | 金锦梅 Tao Helen 高瑞兰 BH Chong | 2000 | 中国中西医结合杂志2000，20，9： | 43 |
| 2 | High-strength mineralized collagen artificial bone显示文摘 | Zhi-Ye QIU Chun-Sheng TAO Helen CUI Chang-Ming WANG Fu-Zhai CUI | 2014 | Frontiers of Materials Science2014，8，1： | 10 |
| 3 | Small extracellular vesicles in combination with sleep-related circRNA3503:A targeted therapeutic agent with injectable thermosensitive hydrogel to prevent osteoarthritis显示文摘Osteoarthritis(OA),characterized by chondrocyte apoptosis and disturbance of the balance between catabolism and anabolism of the extracellular matrix(ECM),is the most common age-related degenerative joint disease worldwide.As sleep has been found to be beneficial for cartilage repair,and circular RNAs(circRNAs)have been demonstrated to be involved in the pathogenesis of OA,we performed RNA sequencing(RNA-seq),and found circRNA3503 was significantly increased after melatonin(MT)-induced cell sleep.Upregulation of circRNA3503 expression completely rescued the effects of interleukin-1β(IL-1β),which was used to simulate OA,on apoptosis,ECM degradation-and synthesis-related genes.Mechanistically,circRNA3503 acted as a sponge of hsa-miR-181c-3p and hsa-let-7b-3p.Moreover,as we previously showed that small extracellular vesicles(sEVs)derived from synovium mesenchymal stem cells(SMSCs)can not only successfully deliver nucleic acids to chondrocytes,but also effectively promote chondrocyte proliferation and migration,we assessed the feasibility of sEVs in combination with sleep-related circRNA3503 as an OA therapy.We successfully produced and isolated circRNA3503-loaded sEVs(circRNA3503-OE-sEVs)from SMSCs.Then,poly(D,L-lactide)-b-poly(ethylene glycol)-b-poly(D,L-lactide)(PDLLA-PEG-PDLLA,PLEL)triblock copolymer gels were used as carriers of sEVs.Through in vivo and in vitro experiments,PLEL@circRNA3503-OE-sEVs were shown to be a highly-effective therapeutic strategy to prevent OA progression.Through multiple pathways,circRNA3503-OE-sEVs alleviated inflammation-induced apoptosis and the imbalance between ECM synthesis and ECM degradation by acting as a sponge of hsa-miR-181c-3p and hsa-let-7b-3p.In addition,circRNA3503-OE-sEVs promoted chondrocyte renewal to alleviate the progressive loss of chondrocytes.Our results highlight the potential of PLEL@circRNA3503-OE-sEVs for preventing OA progression. | Shi-Cong Tao Ji-Yan Huang Yuan Gao Zi-Xiang Li Zhan-Ying Wei Helen Dawes Shang-Chun Guo | 2021 | Bioactive Materials2021，6，12： | 6 |
| 4 | Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis显示文摘 | Emilie A. Bard-Chapeau Shuangwei Li Jin Ding Sharon S. Zhang Helen H. Zhu Frederic Princen Diane D. Fang Tao Han Beatrice Bailly-Maitre Valeria Poli Nissi M. Varki Hongyang Wang Gen-Sheng Feng | 2011 | Cancer Cell2011，，5： | 2 |
| 5 | Antipsychotic Medications in Major Depression and the Association with Treatment Satisfaction and Quality of Life: Findings of Three National Surveys on Use of Psychotropics in China Between 2002 and 2012显示文摘 | Yu-Xi Wang Yu-Tao Xiang Yun-Ai Su Qian Li Liang Shu Chee H Ng Gabor S Ungvari Helen FK Chiu Yu-Ping Nin Gao-Hua Wang Pei-Shen Bai Tao Li Li-Zhong Sun Jian-Guo Shi Xian-Sheng Chen Qi-Yi Mei Ke-Qing Li Xin Yu Tian-Mei Si | 2015 | Chinese Medical Journal2015，，14： | 2 |
| 6 | Ma cytokine-induced stable neuronal differentiation of human bone marrow mesenchymal stem cells in a serum/feeder cellfree condition显示文摘 | Helen Tao Renuka Rao David DF | 2005 | Develop Growth Differ2005，47，： | 1 |
| 7 | Long term serial passage and neuronal differentiation capability of human bone marrow rnesenchymal stem cells显示文摘 | Khoo Melissa L M Shen Bojiang Tao Helen | 2008 | Stem Cells Dev2008，17，5： | 1 |
| 8 | STAT5b is required for GH-Induced liver IGF-I gene expression显示文摘 | HELEN W D TAO X MICHAEL J M | 2001 | Endocrinology2001，142，： | 1 |
| 9 | Cord blood is better than bone marrow for generating megakaryocytic progenitor cells显示文摘 | Helen Tao Leoine Gaudry Alision R | 1999 | Exp hemator1999，27，： | 1 |
| 10 | Hyperbilirubinemia in Appendicitis: A New Predictor of Perforation显示文摘 | Joaquin J. Estrada MD Mikael Petrosyan MD Jordan Barnhart Matthew Tao Helen Sohn MD Shirin Towfigh MD Rodney J. Mason MD PhD | 2007 | Journal of Gastrointestinal Surgery2007，，6： | 1 |
| 11 | Direct synthesis of ultrafine tetragonal BaTiO 3 nanoparticles at room temperature显示文摘 | Jian Quan Qi Tao Peng Yong Ming Hu Li Sun Yu Wang Wan Ping Chen Long Tu Li Ce Wen Nan Helen Lai Wah Chan | 2011 | Nanoscale Research Letters2011，，： | 1 |
| 12 | 活性RAG转座子的发现揭示V(D)J重排的起源显示文摘有颌类脊椎动物适应性免疫起源的关键事件之一是介导抗体基因V(D)J重排机制的RAG1和RAG2蛋白的出现。有科学家认为RAG1/2源自一个古老的转座元件,但在此之前一直没有确切的证据证明这一点。 | Shengfeng Huang Xin Tao Shaochun Yuan Yuhang Zhang Peiyi Li Helen A.Beilinson Ya Zhang Wenjuan Yu Pierre Pontarotti Hector Escriva Yann Le Petillon Xiaolong Liu Shangwu Chen David G.Schatz 徐安龙 | 2017 | 科学新闻2017，19，4： | 0 |
| 13 | Double-network hydrogel enhanced by SS31-loaded mesoporous polydopamine nanoparticles:Symphonic collaboration of near-infrared photothermal antibacterial effect and mitochondrial maintenance for full-thickness wound healing in diabetes mellitus显示文摘Diabetic wound healing has become a serious healthcare challenge.The high-glucose environment leads to persistent bacterial infection and mitochondrial dysfunction,resulting in chronic inflammation,abnormal vascular function,and tissue necrosis.To solve these issues,we developed a double-network hydrogel,constructed with pluronic F127 diacrylate(F127DA)and hyaluronic acid methacrylate(HAMA),and enhanced by SS31-loaded mesoporous polydopamine nanoparticles(MPDA NPs).As components,SS31,a mitochondria-targeted peptide,maintains mitochondrial function,reduces mitochondrial reactive oxygen species(ROS)and thus regulates macrophage polarization,as well as promoting cell proliferation and migration,while MPDA NPs not only scavenge ROS and exert an anti-bacterial effect by photothermal treatment under near-infrared light irradiation,but also control release of SS31 in response to ROS.This F127DA/HAMA-MPDA@SS31(FH-M@S)hydrogel has characteristics of adhesion,superior biocompatibility and mechanical properties which can adapt to irregular wounds at different body sites and provide sustained release of MPDA@SS31(M@S)NPs.In addition,in a diabetic rat full thickness skin defect model,the FH-M@S hydrogel promoted macrophage M2 polarization,collagen deposition,neovascularization and wound healing.Therefore,the FH-M@S hydrogel exhibits promising therapeutic potential for skin regeneration. | Qing-Song Deng Yuan Gao Bi-Yu Rui Xu-Ran Li Po-Lin Liu Zi-Yin Han Zhan-Ying Wei Chang-Ru Zhang Fei Wang Helen Dawes Tong-He Zhu Shi-Cong Tao Shang-Chun Guo | 2023 | Bioactive Materials2023，，9： | 0 |
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