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| 1 | USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors显示文摘(K63 ) 离氨酸 63 连接了 RIG-I 戏的 ubiquitination 在类型的激活的一个关键角色我干扰素小径,然而,为它的 deubiquitination 负责的分子的机制仍然糟糕被理解。这里,我们报导 deubiquitination 酶 ubiquitin 特定的朊酶(USP3 ) 3 否定地调整类型的激活我干扰素由指向 RIG-I 发信号。USP3 击倒 RIG-I 的明确地提高的连接 K63 的 ubiquitination, upregulated IRF3 的 phosphorylation 并且扩充了类型的生产我干扰素 cytokines 和抗病毒的免疫。我们进一步证明在 unstimulated 或 uninfected 房间在 USP3 和 RIG-I-like 受体( RLR )之间没有相互作用,但是在病毒的感染或 ligand 刺激之上, USP3 绑在 RLR 的 caspase 激活招募领域然后通过它的锌手指的合作劈开 polyubiquitin 链Ub有约束力的领域和 USP 催化领域。变化分析表明到 RIG-I 上的 polyubiquitin 链的 USP3 的那绑定是为它 polyubiquitin 链的劈开的前提步。我们的调查结果在 RIG-I 激活识别 USP3 的一个以前未被认出的角色并且提供卓见进 USP3 由禁止 RIG-I 发信号和抗病毒的免疫的机制。 | Jun Cui Yanxia Song Yinyin Li Qingyuan Zhu Peng Tan Yunfei Qin Helen Y Wang Rong-Fu Wang | 2014 | Cell Research2014，24，4： | 20 |
| 2 | Enhanced TLR-induced NF-KB signaling and type I interferon responses in NLRC5 deficient mice显示文摘 | Yanzheng Tong Jun Cui Qingtian Li Jia Zou Helen Y Wang Rong-Fu Wang | 2012 | Cell Research2012，22，5： | 14 |
| 3 | High-strength mineralized collagen artificial bone显示文摘 | Zhi-Ye QIU Chun-Sheng TAO Helen CUI Chang-Ming WANG Fu-Zhai CUI | 2014 | Frontiers of Materials Science2014，8，1： | 10 |
| 4 | Mineralized collagen artificial bone repair material products used for fusing the podarthral joints with internal fixation—a case report显示文摘In this study,we reported a case with collapse and subluxation of metatarsal-cuneiform joint,navicular-cuneiform joint with subluxed the right first metatarsophalangeal joint.The injured medial column was internally fixed with compression arthrodesis.The fusion site was firmed up with BonGoldVR Bone Sponge and Bone Putty.The prognosis of fused navicular-cuneiform joint and metatarsal-cuneiform joint were examined by X-ray shortly after surgical operation and followed up 2,4,6,9 and 13 weeks after the surgical operation.Themedial column was perfectly fused by compression arthrodesis.These results justified and favored the application of mineralized collagen as an excellent alternative to autograft in fusing the podarthral joints with internal fixation. | Nihar S.Ghate Helen Cui | 2017 | Regenerative Biomaterials2017，4，5： | 4 |
| 5 | A three-year experiment confirms continuous immobilization of cadmium and lead in contaminated paddy field with biochar amendment显示文摘 | Rongjun Bian Stephen Joseph Liqiang Cui Genxing Pan Lianqing Li Xiaoyu Liu Afeng Zhang Helen Rutlidge Singwei Wong Chee Chia Chris Marjo Bin Gong Paul Munroe Scott Donne | 2014 | Journal of Hazardous Materials2014，，： | 2 |
| 6 | NLRX1 negatively reg- ulates TLR-induced NFkappaB signaling by targeting TRAF6 and IKK显示文摘 | Xia Xiaojun Cui Jun Helen Y | 2011 | Immunity2011，34，6： | 1 |
| 7 | Outward foreign direct investment of publicly listed firms from China: A corporate governance perspective显示文摘 | Helen Wei Hu Lin Cui | 2013 | International Business Review2013，，： | 1 |
| 8 | NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways显示文摘 | Jun Cui Liang Zhu Xiaojun Xia Helen Y. Wang Xavier Legras Jun Hong Jiabing Ji Pingping Shen Shu Zheng Zhijian J. Chen Rong-Fu Wang | 2010 | Cell2010，，3： | 1 |
| 9 | NLRX1 Negatively Regulates TLR-Induced NF-κB Signaling by Targeting TRAF6 and IKK显示文摘 | Xiaojun Xia Jun Cui Helen Y. Wang Liang Zhu Satoko Matsueda Qinfu Wang Xiaoang Yang Jun Hong Zhou Songyang Zhijian J. Chen Rong-Fu Wang | 2011 | Immunity2011，，6： | 1 |
| 10 | The role of crystallinity on differential attachment/ proliferation of osteoblasts and fibroblasts on poly (caprolactone-co-glycolide) polymeric surfaces显示文摘现在的学习的目的是系统地在成纤维细胞和造骨细胞粘附和增长上评估聚合物 crystallinity 的角色用一系列 poly (caprolactone-co-glycolide )( 打印机控制语言 / 针网阵列) 聚合物。自从他们反映高度水晶、非结晶的材料,打印机控制语言 / 针网阵列聚合物被选择。打印机控制语言 / 针网阵列聚合材料被塑造进薄电影的压缩制作。从到在 25:75, 35:65 和 45:55 的比率的打印机控制语言 / 针网阵列的中间的 copolymeric 作文的打印机控制语言或针网阵列,五篇作文被学习。当共聚物是非结晶的时,纯打印机控制语言和针网阵列代表了水晶的材料。聚合物 / 共聚物用 DSC 被描绘为 nanotopography 估计 crystallinity,为 hydrophobicity 的接触角度测量,和 AFM。而他们在 crystallinity 显著地不同,打印机控制语言 / 针网阵列电影表明了类似的 hydrophobicity 和 nanotopography。对的房间粘附和打印机控制语言 / 针网阵列电影和增长研究上的增长用造骨细胞和 NIH-3T3 成纤维细胞被执行。高度水晶、僵硬的打印机控制语言和针网阵列表面是,这被观察显著地在支持成纤维细胞生长更有效,而非结晶 / 灵活的打印机控制语言 / 针网阵列 35:65 是显著地在支持造骨细胞的生长更有效。这研究证明当化学作文, hydrophobicity 和打印机控制语言 / 针网阵列聚合物的表面粗糙被保持经常时,打印机控制语言 / 针网阵列的 crystallinity 和刚硬在决定房间回答起了主要作用。 | Helen CUI Patrick J.SINKO | 2012 | Frontiers of Materials Science2012，6，1： | 0 |
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