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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | Combination of repeated single-session percutaneous ethanol injection and transarterial chemoembolisation compared to repeated single-session percutaneous ethanol injection in patients with non-resectable hepatocellular carcinoma显示文摘瞄准:为病人评估经皮的乙醇注射(PEI ) 的治疗效果与先进, non-resectable HCC 与 transarterial chemoembolisation 的联合相比(不作声) 并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。方法:在学习时期期间接受了 PEI 治疗的所有病人根据物理地位和肿瘤程度被包括并且成层到下列治疗形式之一:联合不作声并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。包括Okuda分类,门静脉血栓的存在,腹水的存在,肿瘤的数字,最大的肿瘤直径,和假胆硷酯酶( CHE )的临床的参数的预示的价值,以及孩子呸上演, alpha-fetoprotein (法新社),发烧,复杂并发症的发生在这些组之间被估计并且比较。幸存用 Kaplan-Meier 被决定,多,变量回归分析。结果:所有病人的 1 年、 3 年的幸存是 73% 和 47% 。在亚群分析,联合不作声, PEI (1 ) 与更长的幸存被联系(1- , 3- , 5 年的幸存:90% , 52% ,和 43%) 与 PEI 治疗相比独自一个(2 )(1- , 3- , 5 年的幸存:65% , 50% ,和 37%) 。(3 ) 在起始的层化以后的第二等的 PEI 产出可比较的结果不作声(1- , 3- , 5 年的幸存:91% , 40% ,和 30%) 当在到最好的支持的照顾(4 ) 的层化以后的 PEI 与减少的幸存被联系时(1- , 3- , 5 年的幸存:50% , 23% , 12%) 。除了选择治疗形式,为更好的幸存的预言者是肿瘤数字(n <
5 ) ,肿瘤尺寸(<
5 厘米) ,在 PEI 前的没有腹水,和在 PEI 以后的稳定的假胆硷酯酶(P <
0.05 ) 。在在 PEI 以后的 2 wk 以内的死亡是 2.8%(n = 3 ) 。有 24 (8.9%) 主修在包括部分肝梗塞,焦点的肝坏死,和肝脓肿的 PEI 以后的复杂并发症。所有复杂并发症能非通过手术被管理。结论:重复单个会议的 PEI 在有以可接受、可管理的复杂并发症率的先进 HCC 的病人是有效的。病人们成层到联合不作声, PEI 能比那些独自成层到重复 PEI 期望更长的幸存。而且,有在好临床的地位的大或多重的肿瘤的病人可以也从联合获利不作声并且为第二等的 PEI 的再考虑。 | Arne Dettmer Timm D Kirchhoff Michael Gebel Lars Zender Nisar P Malek Bernhard Panning Ajay Chavan Herbert Rosenthal Stefan Kubicka Susanne Krusche Sonja Merkesdal Michael Galanski Michael P Manns Joerg S Bleck | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 3 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 4 | Implications for human health of the extensive bisphenol A literature showing adverse effects at low doses: A response to attempts to mislead the public 显示文摘 | Vom S F Nagel S C Timms B G | 2005 | Toxicology2005，212，23： | 1 |
| 5 | Promising preclinical activity of 2-methoxyestradiol in multiple myeloma 显示文摘 | Dingli D Timm M Russell S J | 2002 | Clin Cancer Res2002，8，： | 1 |
| 6 | Corporate control and bank efficiency 显示文摘 | Pi L Timme S | 1993 | Journal of Banking and Finance1993，17，： | 1 |
| 7 | Thiamine pyrophosphate effect and erythrocyte transketolase activity during severe alcohol with-drawal syndrome显示文摘 | Nordentofi M Timm S Hasselbalch E | 1993 | Acta Psychiatrica Scandinavica1993，88，： | 1 |
| 8 | Impact of disaster on patient flow in a pediatric emergency department 显示文摘 | Timm N Kennebeck S | 2008 | Acad Emerg Med2008，15，6： | 1 |
| 9 | Incidence and outcome of BRCA mutations in unselected patients with triple recep- tor- negative breast cancer 显示文摘 | Gonzalez-Angulo AM Timms KM Liu S | 2011 | Clin Cancer Res2011，17，5： | 1 |
| 10 | Incidence and out- come of BRCA mutations in unselected patients with triple recep- tor-negative breast cancer显示文摘 | Gonzalez-Angulo AM Timms KM Liu S | 2011 | Clinical Cancer Research2011，17，5： | 1 |
| 11 | Expression of VEGF and its receptors by myeloma cells 显示文摘 | Kumar S Witzig TE Timm M | 2003 | Leukemia2003，17，10： | 1 |
| 12 | Co-transformed,diploid Lolium perenne (perennial ryegrass),Lolium multiflorm (Italian ryegrass) and Lolium temulentum (darnel) plants produced by microprojectile bombardment显示文摘 | Dalton S J Bettany A J E Timms E | 1999 | Plant Cell Reports1999，18，： | 1 |
| 13 | A mil- limeter-wave antenna amplitude and phase measurement system 显示文摘 | SMITH S L ARCHER J W TIMMS G P | 2012 | IEEE Transactions on Antennas & Propaga- tion2012，60，4： | 1 |
| 14 | The financial-SCM connection 显示文摘 | T S C Williams Timme | 2000 | Supply Chain Management Review2000，4，2： | 1 |
| 15 | Radio{re- quency ablation (coblation): a promising new tech- nique {or laryngeal papillomata显示文摘 | TIMMS M S BRUCE I A PATEL N K | 2007 | J Laryngol Otol2007，121，： | 1 |
| 16 | Additive electro- plating technology as a post CMOS process for the production of MEMS acceleration threshold switches for transportation applica- tions 显示文摘 | MICHAELIS S TIMME H J WYCISK M | 2000 | Journal of Mieromechanies and Microengineering2000，10，2： | 1 |
| 17 | Prostateenlargement in mice due to fetal exposure to low doses of estradiol ordiethylstilbestrol and opposite effects at high doses显示文摘 | vom SAAL F S TIMMS B G MONTANO M M | 1997 | Proceedings ofthe National Academy of Sciences1997，94，5： | 1 |
| 18 | Additive electroplating technology as a post-CMOS process for the production of MEMS accelerationthreshold switches for transportation applications显示文摘 | Michaelis S Timme H J Wycisk M el al | 2000 | Journal of Micromechanics and Microengineering2000，10，2： | 1 |
| 19 | Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by o steoprotegerin l igand显示文摘 | Hsu H Lacey DL Dunstan CR Solovyev I Colombero A Timms E Tan HL Elliott G Kelley MJ Sarosi I Wang L Xia XZ Elliott R Chiu L Black T Scully S Capparelli C Morony S Shimamoto G Bass MB Boyle WJ | | 0，，： | 1 |
| 20 | Transgenic plants of Lolium multiflorum,Lolium perenne,Festuca arundinacea and Agrostis stolonifera by silicon carbide fibre-mediated transformation of cell suspension cultures显示文摘 | Dalton S J Bettany A J E Timms E | 1998 | Plant Science Limerick1998，132，1： | 1 |
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