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| 1 | Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson's disease by activation of adenosine A1 receptor显示文摘 | Liu HQ Zhang WY Luo XT Ye Y Zhu XZ | 2006 | 中国生物学文摘2006，20，10： | 34 |
| 2 | Metabolic profiling analysis of a D-galactosamine/lipopolysaccharide- induced mouse model of fulminant hepatic failure显示文摘 | Feng, B Wu, SM Lv, S Liu, F Chen, HS Yan, XZ Li, Y Dong, FT Wei, L | 2007 | 中国生物学文摘2007，21，11： | 23 |
| 3 | Effect of Helicobacter pylori infection on gastric epithelial cell proliferation显示文摘INTRODUCTION Helicobacter pylori(H.pylori)infection is one ofthe main pathogens of chronic gastritis and duodenalulcer(DU),and it may be considered as a riskfactor in the incidence of gastric cancer.H.pylori infection may lead to the anomaly of gastricepithelial cell proliferation which is closely relatedto the development of gastric cancer.Vacuolatingcytotoxin(VacA)is an important virulence andvacA subtype determines the toxic activity.According to its signal sequence,it can be groupedinto type sla,slb,slc and s2.Strains harboringvacAsla are more closely related with digestivediseases and may be the strains with high toxicity.The effect of H.pylori infection on | Gao H Wang JY Shen XZ Liu JJ | 2000 | World Journal of Gastroenterology2000，6，3： | 14 |
| 4 | 特利加压素治疗肝硬化腹水不伴肝肾综合征的效果显示文摘【据《Can J Gastroenterol Hepatol》2020年6月报道】题:特利加压素治疗肝硬化腹水不伴肝肾综合征患者的作用:一项针对现有证据的系统评价(作者Bai ZH等)腹水是肝硬化患者的常见并发症,肝硬化伴腹水患者易发生急性肾损伤或肝肾综合征,并可能在腹腔穿刺术后并发循环功能障碍。目前,特利加压素并非肝硬化腹水的主要治疗选择。本研究旨在系统回顾有关特利加压素在肝硬化腹水不伴肝肾综合征患者中使用的证据。 | BAI ZH AN Y GUO XZ 白朝辉 祁兴顺 | 2020 | 临床肝胆病杂志2020，36，8： | 9 |
| 5 | Nuclear transcription factors and lipid homeostasis in liver显示文摘The liver plays a major role in the regulation ofglucose,lipid and energy metabolism.Increasedhepatic fat deposit is a very common feature in obese,insulin-resistant patients,in metabolic syndrome,alcoholic steatohepatitis(ASH)and nonalchoholic fattyliver disaseas(NAFLD).As a central organ for wholebody lipid metabolism,disruption of the normalmechanisms for synthesis,transport and removal/ | CHEN Ya-xi HUANG Ai-long RUAN Xiong-zhong Centre for Lipid Research,Key Laboratory of Molecular Biology on Infectious Diseases,Ministry of Education Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China(Chen YX,Huang AL and Ruan XZ) | 2007 | Chinese Medical Journal2007，，24： | 8 |
| 6 | Mechanism of frost heave by film water migration under temperature gradient显示文摘IT is well known that there exists unfrozen film water in frozen soils due to the action of sur-face energy among soil particles and frost heave occurs by water migration under the tempera-ture gradient. The problem is how to determine the amount of frost heave quantitatively. The amount of frost heave induced by ice segregation can be calculated by the following e-quations: | Xu, XZ Wang, JC Zhang, LX Deng, YS Chuvilin, EM Yershov, ED Ishizaki, T Fukuda, M | 1997 | Chinese Science Bulletin1997，42，15： | 6 |
| 7 | A clinical evaluation of serological diagnosis for pancreatic cancer显示文摘AclinicalevaluationofserologicaldiagnosisforpancreaticcancerZHAOXiaoYan,YUShiYuan,DAShiPing,BAILi,GUOXiaoZhong,DAIXiaoJ... | Zhao, XY Yu, SY Da, SP Bai, L Guo, XZ Dai, XJ Wang, YM | 1998 | World Journal of Gastroenterology1998，4，2： | 6 |
| 8 | Zircon U-Pb dating of Shuiquangou alkaline complex intrusives, northwestern Hebei Province显示文摘SUPER large gold deposits related to alkaline intrusions have been found in America,Canada,Australia,Papua New Guinea and elsewhere.Dongping gold deposit with superlarge potentialhas also been found in Shuiquangou alkaline complex intrusions,northwestern Hebei Province,China.One of the keys to resolving the possible genetic relationship between gold deposits andore-host alkaline intrusions is to determine their formation ages.This note dates the Shuiquan-gou intrusions with zircon U-Pb method. | Mo, CH Liang, HY Wang, XZ Cheng, JP Li, HM | 1997 | Chinese Science Bulletin1997，42，9： | 6 |
| 9 | Sequence variations of the S7 ribosomal protein gene in primitive cyprinid fishes: Implication on phylogenetic analysis显示文摘Cyprinidae is the largest fish family in the world and contains about 210 genera and 2010 species. Appropriate DNA markers must be selected for the phylogenetic analyses of Cyprinidae. In present study, the 1st intron of the S7 ribosomal protein (r-protein) gene is first used to examine the relationships among cyprinid fishes. The length of the 1st intron obtained by PCR amplification ranges from 655 to 859 bp in the 16 cyprinid species investigated, and is 602 bp in Myxocyprinus asiaticus. Out of the alignment of 925 nucleotide sites obtained, the parsimony informative sites are 499 and occupy 54% of the total sites. The results indicate that the 1st intron sequences of the S7 r-protein gene in cyprinids are rich in informative sites and vary remarkably in sequence divergence from 2.3% between close species to 66.6% between distant species. The bootstrap values of the interior nodes in the NJ (neighbor-joining) and MP (most-parsimony) trees based on the present S7 r-protein gene data are higher than | Wang, XZ He, SP Chen, YY | 2002 | Chinese Science Bulletin2002，47，19： | 5 |
| 10 | Radiotherapy of double primary esophageal carcinoma显示文摘INTRODUCTIONDouble primary esophageal carcinoma is defined ashaving two loci of squamous cell cancersimultaneously or consecutively developing indifferent sites of esophagus.This rare diseaseappears mostly in the literature as case reports,reports about its treatment are even moreinfrequent.Here we present our experiences | Xiao ZF Yang ZY Zhou ZM Yin WB Gu XZ | 2000 | World Journal of Gastroenterology2000，6，1： | 4 |
| 11 | 胰腺疾病相关门静脉高压的消化道出血显示文摘【据《Gastroenterol Res Pract》2020年3月报道】题:胰腺疾病相关门静脉高压的消化道出血(作者:Zheng KX等)左侧门静脉高压症(LSPH)是一种罕见的主因脾静脉阻塞、狭窄或血栓形成引起的门静脉高压症。胰腺疾病是LSPH最常见的病因。本研究旨在报告我们的临床经验,探讨胰腺疾病相关门静脉高压患者的临床表现、治疗及预后。 | 郑可心 祁兴顺 GUO XZ FENG J | 2020 | 临床肝胆病杂志2020，36，6： | 3 |
| 12 | REAL-VALUED PERIODIC WAVELETS: CONSTRUCTION ANDRELATION WITH FOURIER SERIES显示文摘1.IntroductionWaveletshaverecentlyreceivedagreatdealofattentioninsuchareasassignalprocessingandimageprocessing([12],[8]).Variousmethodstoconstructwaveletshavebeengiven([14],[13],[9],[7]).Itiswellknownthatinmathematicsandmathematicphysicsmanyperiodicp... | Chen, HL Liang, XZ Peng, SL Xiao, SL | 1999 | Journal of Computational Mathematics1999，17，5： | 3 |
| 13 | Isolation of tomato proteinase inhibitor Ⅱ gene and the function of its intron显示文摘The genomic DNA sequence of tomato pro-teinase inhibitor II gene (named tin2i, whose accession number in GenBank is AF007240) was isolated by PCR techniques. The intron sequence (TPI), with a length of 109 bp, owns typical structures of GT/AG dinucieotides at both ends and high content of AT base pairs which accounts for 80.7% of the total nucleotides. As shown by recombination experiment, the TPI sequence could efficiently promote the expression of the reporter gene gusA and this effect was independent of the position and orientation of the intron, thus showing its role as an enhancer. Such experiments as gel retardation assays, GUS histochemical staining and GUS fluorometric assays further demonstrated that TPI sequence maybe has promoter-like activity. | Xie, XZ Wu, NH | 2002 | Chinese Science Bulletin2002，47，10： | 2 |
| 14 | Subvellerolactone C, a New Lactarane Sesquiterpene from Lactarius Subvellereus显示文摘SubvellerolactoneC,aNewLactaraneSesquiterpenefromLactariusSubvellereus￥JingZHANGandXiaoZhaoFENG(InstituteofMateriaMedica,Chin... | Zhang, J Feng, XZ | 1996 | Chinese Chemical Letters1996，7，12： | 2 |
| 15 | Design,synthesis,and anti-inflammatory evaluation of a series of novel amino acid-binding 1,5-diarylpyrazole derivatives显示文摘Aim: To design and synthesize a series of novel amino acid-binding 1,5-diarylpyrazole derivatives, which are intended to act as prodrugs with better aqueous solubility than celecoxib, and which will exert potent anti-inflammatory activi-ties after being converted to their parent compounds in vivo. Methods: To introduce an amino acid, celecoxib analogs containing amino or methylamino group were synthesized first through multi-step chemical reactions. All the synthesized compounds were screened in an intact cell-based assay in vitro and in carrageenan-induced mouse paw edema in vivo. Some active compounds were selected for further evaluation in a carrageenan-induced rat paw edema model. The preliminary pharmacokinetics experiments were conducted using high performance liquid chromatography/mass spectrometry (HPLC/MS). Results: Celecoxib, 6 of the 1,5-diarylpyrazole class of celecoxib analogs, and their amino acid derivatives (hydrochloride salts) were synthesized. In vitro screening, the hydrochloride salts showed decreased inhibitory effects on cyclooxygenase (COX)- 1 and COX-2 compared with their parent compounds, but some exhibited potent anti-inflammatory activity in vivo. Compound 4a was selected for further evaluation, and its anti-inflammatory effect was equivalent to that of celecoxib after oral administration in the carrageenan-induced rat paw edema model. At three doses (25 mg/kg, 50 mg/kg, and 100 mg/kg) the percentage inhibition on edema was 20.7%, 52.6%, and 62.6% (for compound 4a) and 27.8%, 38.4%, and 40.1% (for celecoxib), respectively. Preliminary pharmacokinetic evaluations support the hypothesis that compound 4a was actually converted to its parent compound, compound 4. Conclusion: The compound bound with amino acid acts like prodrug, which can exert anti-inflammatory effect similar to celecoxib after being converted to its parent compound. This finding will be of great benefit in carrying out structural modifications of prodrug-like selective COX-2 inhibitors. | Li MH Yin LL Cai MJ Zhang WY Huang Y Wang X Zhu XZ Shen JK | 2005 | Acta Pharmacologica Sinica2005，26，7： | 2 |
| 16 | Vulnerability to unidirectional conduction block and reentry in rabbit left ventricular wedge preparation: effect of stimulation sequence and location 显示文摘 | Chen XZ Zhang H Jin YB | 2009 | Chinese J Physiol2009，52，： | 1 |
| 17 | Apiganin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest显示文摘 | Ujiki MB Ding XZ Salabat MB | 2006 | Mol Cancer2006，5，： | 1 |
| 18 | Effect of atrial natriuretic peptide on coronary collateral blood flow 显示文摘 | Foreman B Dai XZ Homans DC | 1989 | Cite Res1989，65，6： | 1 |
| 19 | Long-term prognosis after recovery from acute myocardial infarction显示文摘 | Weng XZ He J Su AM | 1990 | Zhonghua Nei Ke Za Zhi1990，29，7： | 1 |
| 20 | Prevention of filtering surgery failure by subconjunctival injection of a novel peptide hydrogel into rabbit eyes显示文摘 | Liang L Xu XD Zhang XZ | 2010 | Biomed Mater2010，5，4： | 1 |
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