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| 1 | Function of apoptosis and expression of the proteins Bcl-2,p53 and C-myc in the development of gastric cancer显示文摘INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 and C-myc protein expression in the development of gastric cancer . | An Gao Xu Shao Guang Li Ji Hong Liu Ai Hua Gan Research Laboratory of Digestive Disease,Huizhou Central People’s Hospital,Huizhou 516001,Guangdong Province,ChinaDr.An Gao Xu graduated from Guangdong Medical College in 1984.He is an associate physician-in-chief,specializing in the research and treatment of gastrointestinal and liver tumors.He has published 24 papers and 1 book. | 2001 | World Journal of Gastroenterology2001，7，3： | 91 |
| 2 | 激光剥蚀信号在线平滑和去汞装置:原位微区铅同位素准确分析利器显示文摘激光原位微区分析可在微观尺度上完成样品的元素定量分析或同位素组成测定,为研究成岩、成矿物质来源和追踪地壳与地幔演化历史提供了独特的观察视野。但是,激光剥蚀等离子体质谱的一些缺陷阻碍了地质样品的高精度、高空间分辨率分析,比如:剥蚀池的位置效应、低剥蚀速率下信号波动影响、激光剥蚀脉动式信号导致的光谱螺纹效应、高频激光剥蚀造成的元素分馏效应等。为此,一些学者设计了不同规格和样式的激光剥蚀信号平滑装置来克服这些问题。但是,这些信号平滑装置普遍还存在气体吹扫时间过长和降低激光剥蚀信号灵敏度等问题。因此,研制新型的信号平滑装置对改善LA—ICP—MS的数据质量具有重要的意义。 | Hu Z Zhang W Liu Y Gao S Li M Zong K Chen H Hu S 刘勇胜 | 2015 | 矿物岩石地球化学通报2015，34，4： | 114 |
| 3 | YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA显示文摘 | Hailing Shi Xiao Wang Zhike Lu Boxuan S Zhao Honghui Ma Phillip J HSU Chang Liu Chuan He | 2017 | Cell Research2017，27，3： | 156 |
| 4 | Draining Tangjiashan Barrier Lake after Wenchuan Earthquake and the flood propagation after the dam break显示文摘Tangjiashan Barrier Lake is one of the largest barrier lakes caused by the Wenchuan Earthquake. Its risk analysis, emergency plan and effect of the emergency plan are introduced in this paper. The dam height of Tangjiashan Barrier Dam is about 105 m, and the reservoir storage capacity is 3.2×108 m3. When the dam broke the flood peak were estimated to be larger than 48000 m3/s, which might cause a enormous disaster to the downstream cities and residents. A discharge channel with 13 m deep and 8 m wide was drug, so that the water may flow out of the lake before the dam breaks. As a result, the drainage and risk mitigation project are successful. During the drainage process, the flood peak was about 6500 m3/s, and about 1.6×108 m3 of water was drained off and the residual reservoir capacity was only 8.97×107 m3. A new channel with average width 100 m was formed, which can bear floods of 200 years frequency. The successful experience and the collected data can be used to deal with the similar natural disasters in future. | LIU Ning1, ZHANG JianXin2, LIN Wei3, CHENG WuYI4 & CHEN ZuYu5 1 Ministry of Water Resources of the People’s Republic of China, Beijing 100053, China 2 Bureau of Hydrology of the Ministry of Water Resources of the People’s Republic of China, Beijing 100053, China 3 Sichuan Hydrographic and Water Resources Survey Bureau Chengdu 610031, China 4 HydroChina Chengdu Engineering Corporation, Chengdu 610072, China 5 China Institute of Water Resources and Hydropower Research, Beijing 100044, China | 2009 | Science China(Technological Sciences)2009，52，4： | 29 |
| 5 | Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells显示文摘Liver fibrosis is a consequence of chronic liver disease,causing morbidity and mortality.Interleukin-33(IL-33)is a critical mediator of inflammation,which may be involved in the development of liver fibrosis.Here,we investigated the role of IL-33 in human patients and experimental bile-duct ligation(BDL)-induced fibrosis in mice.We report increased hepatic IL-33 expression in the murine BDL model of fibrosis and in surgical samples obtained from patients with liver fibrosis.Liver injury,inflammatory cell infiltration and fibrosis were reduced in the absence of the IL-33/ST2 receptor,and the activation of hepatic stellate cells(HSCs)was decreased in ST2-deficient mice.Recombinant IL-33 activated HSCs isolated from C57BL/6 mice,leading to the expression of IL-6,TGF-β,α-SMA and collagen,which was abrogated in the absence of ST2 or by pharmacological inhibition of MAPK signaling.Finally,administration of recombinant IL-33 significantly increased hepatic inflammation in sham-operated BL6 mice but did not enhance BDL-induced hepatic inflammation and fibrosis.In conclusion,BDL-induced liver inflammation and fibrosis are dependent on ST2 signaling in HSCs,and therefore,the IL-33/ST2 pathway may be a potential therapeutic target in human patients with chronic hepatitis and liver fibrosis. | Zhongming Tan Qianghui Liu Runqiu Jiang Long Lv Siamak S Shoto Isabelle Maillet Valerie Quesniaux Junwei Tang Wenjie Zhang Beicheng Sun Bernhard Ryffel | 2018 | Cellular & Molecular Immunology2018，15，4： | 24 |
| 6 | Metabolic profiling analysis of a D-galactosamine/lipopolysaccharide- induced mouse model of fulminant hepatic failure显示文摘 | Feng, B Wu, SM Lv, S Liu, F Chen, HS Yan, XZ Li, Y Dong, FT Wei, L | 2007 | 中国生物学文摘2007，21，11： | 23 |
| 7 | 基于人工智能干预措施的临床试验方案指南:SPIRIT-AI扩展显示文摘《干预试验方案报告标准》(Standard Protocol Items:Recommendations for Interventional Trials,SPIRIT)2013通过为试验最小条目集的确定提供基于证据的建议,旨在改善临床试验方案报告的完整性。该指南有助于促进新干预措施的透明评估。近年来,人们越来越认识到,涉及人工智能(artificial interlligence,AI)的干预措施需要经过严格的前瞻性临床研究评估,以证明其对健康结局的影响。《人工智能干预试验方案报告标准(Standard Protocol Items:Recommendations for Interventional Trials-Artificial Intelligence,SPIRIT-AI)扩展》是一份新的评估AI干预措施的临床试验方案的报告指南。它与配套的《人工智能试验报告统一标准》(Consolidated Standards of Reporting Trials-Artificial Intelligence,CONSORT-AI)是同步编制的。这两项指南的编制通过分阶段的文献回顾和专家咨询等过程达成共识,产生26项候选条目。由国际多方利益相关小组在两阶段德尔菲调查(103个利益相关者)中对这些条目进行了咨询,并在共识会议上达成一致意见(31个利益相关者),通过34个试点参与进行了改进和优化。SPI RI T-AI扩展包括15项对AI干预的临床试验方案非常重要的新条目。除SPIRIT 2013的核心条目外,这些新条目也应定期报告。SPIRIT-AI建议研究人员提供关于AI干预的清晰描述,包括使用AI所需的说明和操作技能、AI干预集成环境的设置、输入和输出数据处理的注意事项、人-AI交互和错误案例分析。SPI RI T-AI将有助于提高AI干预临床试验方案的透明度和完整性,也有助于编辑、同行评审以及普通读者理解、解释和严格评估临床试验的设计和偏倚风险。 | 熊云云(译) 李子孝(译) 丁玲玲(译) 谷鸿秋(译) 王春娟(译) 王春雪(译) 赵性泉(译) 王拥军(译) CRUZ RIVERA S LIU X CHAN A | 2020 | 中国卒中杂志2020，15，11： | 20 |
| 8 | 人工智能干预性临床试验报告指南:CONSORT-AI扩展显示文摘《试验报告统一标准》(Consolidated Standards of Reporting Trials,CONSORT)2010声明提供了报告随机试验的最低准则。它的广泛使用有助于保证评估新的干预措施的透明性。最近,人们越来越认识到,涉及人工智能(artificial intelligence,AI)的干预需要经过严格的前瞻性评估,以明确其对健康的影响。《人工智能试验报告统一标准》(Consolidated Standards of Reporting Trials Artificial Intelligence,CONSORT-AI)是一个新的临床试验报告指南,用以评估具有AI成分的干预。它是与《人工智能干预试验方案报告标准》(Standard ProtocolItems:Recommendations forI nterventional Trials-Artificial Intelligence,SPIRIT-AI)同步编制的。这两项指南的编制通过分阶段的文献回顾和专家咨询等过程达成共识,产生29项候选条目。由国际多方利益相关者小组在两阶段德尔菲调查(103个利益相关者)中对这些条目进行了咨询,并在共识会议上达成一致意见(31个利益相关者),通过34个试点参与进行改进和优化。CONSORT-AI扩展包括14项新条目,这些新条目对于AI干预非常重要,除了2010年CONSORT声明的核心条目之外,试验报告还应常规包含这些内容。CONSORT-AI建议研究人员提供关于AI干预的清晰描述,包括使用AI所需的说明和技能、AI干预集成环境的设置、输入和输出数据处理的注意事项、人-AI交互和错误案例分析。CONSORT-AI将有助于提高AI干预临床试验方案的透明度和完整性,也有助于编辑、同行评审以及普通读者理解、解释和严格评估临床试验的设计和偏倚风险。 | 李子孝(译) 熊云云(译) 丁玲玲(译) 王春雪(译) 赵性泉(译) 王拥军(译) WANG Chun-Juan LIU X X CRUZ RIVERA S MOHER D | 2020 | 中国卒中杂志2020，15，12： | 19 |
| 9 | On coeffcient estimates for a class of holomorphic mappings显示文摘Let X be a complex Banach space with norm · , B be the unit ball in X, Dn be the unit polydisc in Cn. In this paper, we introduce a class of holomorphic mappings Mg on B or Dn. Let f(x) be a normalized locally biholomorphic mapping on B such that (Df(x))-1f(x) ∈ Mg and f(x) - x has a zero of order k + 1 at x = 0. We obtain coeffcient estimates for f(x). These results unify and generalize many known results. | XU QingHua1 & LIU TaiShun2 1 College of Mathematics and Information Science, Jiangxi Normal University, Nanchang 330027, China 2 Department of Mathematics, Huzhou Teacher’s College, Huzhou 313000, China | 2009 | Science China Mathematics2009，52，4： | 18 |
| 10 | Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosis显示文摘Background:Nonmotor symptoms are common among patients with Parkinson’s disease(PD)and some may precede disease diagnosis.Methods:We conducted a meta-analysis on the prevalence of selected nonmotor symptoms before and after PD diagnosis,using random-effect models.We searched PubMed(1965 through October/November 2012)for the following symptoms:hyposmia,constipation,rapid eye movement sleep behavior disorder,excessive daytime sleepiness,depression,and anxiety.Eligible studies were publications in English with original data on one or more of these symptoms.Results:The search generated 2,373 non-duplicated publications and 332 met the inclusion criteria,mostly(n=320)on symptoms after PD diagnosis.For all symptoms,the prevalence was substantially higher in PD cases than in controls,each affecting over a third of the patients.Hyposmia was the most prevalent(75.5%in cases vs.19.1%in controls),followed by constipation(50%vs.17.7%),anxiety(39.9%vs.19.1%),rapid eye movement sleep behavior disorder(37.0%vs.7.0%),depression(36.6%vs.14.9%),and excessive daytime sleepiness(33.9%vs.10.5%).We observed substantial heterogeneities across studies and meta-regression analyses suggested that several factors might have contributed to this.However,the prevalence estimates were fairly robust in several sensitivity analyses.Only 20 studies had data on any symptoms prior to PD diagnosis,but still the analyses revealed higher prevalence in future PD cases than in controls.Conclusion:These symptoms are common among PD patients both before and after diagnosis.Further studies are needed to understand the natural history of nonmotor symptoms in PD and their etiological and clinical implications. | Honglei Chen Edward J Zhao Wen Zhang Yi Lu Rui Liu Xuemei Huang Anna J Ciesielski-Jones Michele A Justice Deborah S Cousins Shyamal Peddada | 2015 | Translational Neurodegeneration2015，4，1： | 18 |
| 11 | Dehydration melting of solid amphibolite at 2.0 GPa: Effects of time and temperature显示文摘Two sets of dehydration-melting with a natural solid amphibolite, collected from North Himalayan structure zone, Tibet, have been carried out in multi-anvil apparatus at 2.0 GPa and 800―1000℃, for 12―200 h. One is keeping the pressure at 2.0 GPa and the annealing time of 12 h, changing the temperature (800―1000℃). The other is keeping the pressure at 2.0 GPa and temperature at 850℃, varying the annealing time (12―200 h). The products are inspected with microscope and electron probe. The results indicate that at 2.0 GPa, annealing time of 12 h, garnets, melts and clinopyroxenes occur in amphibolite gradually with increasing temperature and the chemical compositions of melt vary from tonalite to granodiorite, and then to tonalite. However, at 2.0 GPa and 850℃, with the annealing time increasing, the garnets, melts and cli-nopyroxenes also occur in amphibolite gradually and the chemical compositions of melt vary from tonalite to granodiorite. In both cases, melts interconnect with each other when the contents of melt are over the 5 vol.%. the viscosities of the melt produced in amphibolite at temperature higher than 850℃ are on a level with 104 Pa·s. The interconnected melt with such a viscosity may segregate from the source rock and form the magma over reasonable geological time. Therefore, it is believed that at the lower part of the overthickened crust, the tonlitic and grano-dioritic magma may be generated through the dehydration melting of amphibolite. | ZHOU Wenge1, XIE Hongsen1, LIU Yonggang1, ZHENG Xiaogang1, ZHAO Zhidan2 & ZHOU Hui3 1. Laboratory of Material in the Earth’s Interior, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China 2. Department of Geology, China University of Geosciences, Beijing 100083, China 3. Department of Geology, Peking University, Beijing 100871, China | 2005 | Science China Earth Sciences2005，48，8： | 17 |
| 12 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 13 | 贝伐珠单抗联合mFOLFOX6与单独使用mFOLFOX6作为一线治疗用于RAS突变型不可切除的结直肠癌局限性肝转移的随机对照试验显示文摘目的:评估贝伐珠单抗联合氟尿嘧啶、亚叶酸钙和奥沙利铂(mFOLFOX6)作为RAS突变型不可切除的结直肠癌肝转移一线治疗的疗效。方法:将2013年10月至2017年12月伴有RAS突变型不可切除的结直肠癌局限性肝转移患者随机分为mFOLFOX6+贝伐珠单抗治疗组(A组)和单独mFOLFOX6治疗组(B组)。肝转移灶的可切除性由本地的多学科讨论小组商讨决定。该研究的主要终点是肝转移灶经过治疗后转化为R0切除的比率。次要终点包括肿瘤反应、生存率和药物毒性。该研究采用区组随机法。 | 潘杰斌 TANG W T REN L LIU T S | 2020 | 结直肠肛门外科2020，26，5： | 17 |
| 14 | Multilineage differentiation of adipose-derived stromal cells from GFP transgenic mice显示文摘 | Lin Y Chen X Yan Z Liu L Tang W Zheng X Li Z Qiao J Li S Tian W | 2006 | 中国生物学文摘2006，20，5： | 16 |
| 15 | P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte- endothelial adhesion and promotes neurovascular injury during septic encephalopathy显示文摘 | Huan Wang Ling-Juan Hong Ji-Yun Huang Quan Jiang Rong-Rong Tao Chao Tan Nan-Nan Lu Cheng-Kun Wang Muhammad M Ahmed Ying-Mei Lu Zhi-Rong Liu Wei-Xing Shi En-Yin Lai Christopher S Wilcox Feng Han | 2015 | Cell Research2015，25，6： | 16 |
| 16 | Progress in research into the mechanism of Radix salviae miltiorrhizae in treatment of acute pancreatitis显示文摘BACKGROUND: Acute pancreatitis (AP) is a common acute abdomen with high mortality, multiple complications and complicated causes. There is no effective therapy for AP. Radix salviae miltiorrhizae (Danshen), a traditional herbal medicine, has a low price and a wide range of clinical applications. It is effective to promote blood flow, eliminate stagnancy, and relieve pain. It is also found to be effective in treating AP. We reviewed the progress in research into the mechanism of Radix salviae miltiorrhizae in treatment of AP. DATA SOURCES: An english-language literature search was conducted using MEDLINE (1988-2005) on Radix salviae miltiorrhizae (Danshen) and acute pancreatitis. RESULTS: The mechanisms of Danshen in the treatment of AP include improvement of microcirculatory disturbances; elimination of oxygen free radicals; modulation of the metabolism of lipid inflammatory mediator; and blocking of calcium inflow and prevention of calcium overload.CONCLUSION: Danshen can effectively reduce the mortality and complications of AP. | Xi-Ping Zhang, Zhi-Jun Li and Da-Ren Liu Department of General Surgery, Hangzhou First People’s Hospital, Hangzhou 310006, China , Zhejiang University of Traditional Chinese Medine, Hangzhou 310053, China Department of General Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，4： | 15 |
| 17 | 1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)显示文摘伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币. | 林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng Juanita A Haagsma Jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin Ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L James Theo Vos Christopher J L Murray | 2020 | 伤害医学(电子版)2020，9，2： | 15 |
| 18 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 19 | Proteome analysis of hepatocellular carcinoma by laser capture microdissection显示文摘 | Ai J Tan Y Ying W Hong Y Liu S Wu M Qian X Wang H | 2006 | 第二军医大学学报2006，27，5： | 14 |
| 20 | 中国社区健康素养与高血压治疗之间的关系:回顾性队列研究显示文摘健康素养较低与临床预后差相关。健康素养与血压之间的关系研究结果不一致。该研究调查了健康素养的决定因素和健康素养与高血压管理之间的潜在关系。方法:对360例高血压患者进行回顾性队列研究。基于标准方案进行测量、体检和实验室检查。 | 刘莉 叶鹏 Shi D Li J Wang Y Wang S Liu K Shi R Zhang Q Chen X | 2017 | 中华高血压杂志2017，25，5： | 14 |
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