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| 1 | Impact of sodium glucose cotransporter-2 inhibitors on liver steatosis/fibrosis/inflammation and redox balance in non-alcoholic fatty liver disease显示文摘BACKGROUND Sodium glucose cotransporter-2 inhibitors(SGLT2-I)are the most recently approved drugs for type 2 diabetes(T2D).Recent clinical trials of these compounds reported beneficial cardiovascular(CV)and renal outcomes.A major cause of vascular dysfunction and CV disease in diabetes is hyperglycemia associated with inflammation and oxidative stress.Pre-clinical studies demonstrated that SGLT2-I reduce glucotoxicity and promote anti-inflammatory effects by lowering oxidative stress.AIM To investigate the effects of SGLT2-I on markers of oxidative stress,inflammation,liver steatosis,and fibrosis in patients of T2D with non-alcoholic fatty liver disease(NAFLD).METHODS We referred fifty-two consecutive outpatients treated with metformin monotherapy and exhibiting poor glycemic control to our centre.We introduced the outpatients to an SGLT2-I(dapagliflozin,empagliflozin,or canagliflozin;n=26)or a different hypoglycemic drug[other glucose-lowering drugs(OTHER),n=26].We evaluated circulating interleukins and serum hydroxynonenal(HNE)-or malondialdehyde(MDA)-protein adducts,fatty liver index(FLI),NAFLD fibrosis score,aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio,AST-to-platelet-ratio index(APRI),and fibrosis-4 on the day before(T0)and following treatment for six months(T1).We also performed transient elastography at T0 and T1.RESULTS Add-on therapy resulted in improved glycemic control and reduced fasting blood glucose in both groups.Of note,following treatment for six months,a reduction of FLI and APRI,as well as of the FibroScan result,was reported in patients treated with SGLT2-I,but not in the OTHER group;furthermore,in the SGLT2-I group,we reported lower circulating levels of interleukin(IL)-1β,IL-6,tumor necrosis factor,vascular endothelial growth factor,and monocyte chemoattractant protein-1,and higher levels of IL-4 and IL-10.We did not observe any modification in circulating interleukins in the OTHER group.Finally,serum HNE-and MDA-protein adducts decreased significantly in SGLT2-I rather than OTHER patients and correlated with liver steatosis and fibrosis scores.CONCLUSION The present data indicate that treatment with SGLT2-I in patients with T2D and NAFLD is associated with improvement of liver steatosis and fibrosis markers and circulating pro-inflammatory and redox status,more than optimizing glycemic control. | Francesco Bellanti Aurelio Lo Buglio MichałDobrakowski Aleksandra Kasperczyk Sławomir Kasperczyk Palok Aich Shivaram P Singh Gaetano Serviddio Gianluigi Vendemiale | 2022 | World Journal of Gastroenterology2022，28，26： | 3 |
| 2 | Anti-canc-er effects of artesunate in a panel of chemoresistant neuro-blastoma cell lines显示文摘 | Michaelis M Kleinschmidt MC Barth S | 2010 | Biochem Pharmacol2010，79，： | 1 |
| 3 | Serum amyloid A enhances plasminogen activation: implication for a role in colon cancer 显示文摘 | Michaeli A Finci Yeheskel Z Dishon S | 2008 | Biochem Biophys Res Commun2008，368，2： | 1 |
| 4 | Study of HHV-8 DNA sequences in archival biopsies from lesional skin of Kaposi′s sarcoma,various mesenchymal tumors and related reactive conditions显示文摘 | Kazakov DV Prinz BM Michaelis S | 2002 | J Cutan Pathol2002，29，5： | 1 |
| 5 | Characterization and expression of the structural gene for pullulanase,a maltose-inducible secreted protein of Klebsiella pneumoniae显示文摘 | Michaelis S Chapon C d'Enfert C Pugsley A Schwartz M | | 0，，02： | 1 |
| 6 | Education in cancer pain manage-ment 显示文摘 | MichaelI Bennett Kate Flemming S Jos e Closs | 2011 | Curt Opin Support Palliat Care2011，5，： | 1 |
| 7 | Characterization and expression of the structural gene for pullulanase, a maltose- inducible secreted protein of Klebsiella pneumoniae 显示文摘 | Michaelis S Chapon C D' Enfert C | 1985 | J Bacteriol1985，164，2： | 1 |
| 8 | Additive electro- plating technology as a post CMOS process for the production of MEMS acceleration threshold switches for transportation applica- tions 显示文摘 | MICHAELIS S TIMME H J WYCISK M | 2000 | Journal of Mieromechanies and Microengineering2000，10，2： | 1 |
| 9 | Additive electroplating technology as a post-CMOS process for the production of MEMS accelerationthreshold switches for transportation applications显示文摘 | Michaelis S Timme H J Wycisk M el al | 2000 | Journal of Micromechanics and Microengineering2000，10，2： | 1 |
| 10 | Gene expression and activity of antioxidant enzymes in the blood cells of workers who were occupationally exposed to lead显示文摘 | Aleksandra Kasperczyk Grzegorz Machnik Micha? Dobrakowski Daniel Sypniewski Ewa Birkner S?awomir Kasperczyk | 2012 | Toxicology (-)2012，，1： | 1 |
| 11 | Preparation, characterisation and maintenance of drug efficacy of doxorubicin-loaded human serum albumin(HSA) nanoparticles 显示文摘 | DREIS S ROTHWEILER F MICHAELIS M | 2007 | Int J Pharm2007，341，12： | 1 |
| 12 | Additive Electroplating Technology As a Post-CMOS Process for the Production of MEMS Acceleration-threshold Switches for Transportation Applications 显示文摘 | Michaelis S Timme H J Wycisk M | 2000 | Journal of Micromechanics and Microengineering2000，10，2： | 1 |
| 13 | Safety aspects of chronic low-frequency transcranial magnetic stimulation based on localized proton magnetic resonance spectroscopy and histology of the rat brain显示文摘 | Liebetanz D Fauser S Michaelis T | 2003 | J Psychiatr Res2003，37，： | 1 |
| 14 | Determination and comparison of process-and quality-characteristics of injection-compression moulded polymer optics 显示文摘 | Hopmann Ch Michaeli W Hessner S Walach P | 2011 | Nanosystems2011，3，3： | 1 |
| 15 | Biofuels and biomass-to-liquid fuels in the biorefinery : Catalytic conversion of lignocellulosic biomass using porous materials 显示文摘 | MICHAE L S | 2008 | Angewandte C hemie International Edition2008，47，48： | 1 |
| 16 | Incidence, pathogens and resistance patterns of nosocomial infections at a rural hospital in Gabon显示文摘 | Micha S Katrin K Raymund EM | 2014 | BMC Infect Dis2014，11，14： | 1 |
| 17 | Highly specific HER2-mediated cellular uptake of antibody-modified nanoparticles in tumor cells显示文摘 | Wartlick H Michaelis K Balthasar S | 2004 | J Drug Target2004，12，7： | 1 |
| 18 | Serum amyloid A enhances plasminogen activation:implication for a role in colon cancer显示文摘 | Michaeli A Finci-Yeheskel Z Dishon S | | 0，，02： | 1 |
| 19 | Pressure-induced inactivation of selected food enzymes显示文摘 | Seyderhelm I Boguslawski S Michaelis G | 1996 | J Food Sci1996，61，： | 1 |
| 20 | Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines显示文摘 | Michaelis M Kleinschmidt MC Barth S | 2010 | Biochem Pharmacol2010，79，： | 1 |
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