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| 1 | Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives显示文摘Historically, natural products have represented a significant source of anticancer agents, with plant-derived drugs becoming increasingly explored. In particular, sanguinarine is a benzophenanthridine alkaloid obtained from the root of Sanguinaria canadensis, and from other poppy Fumaria species, with recognized anti-microbial, anti-oxidant and anti-inflammatory properties. Recently, increasing evidence that sanguinarine exibits anticancer potential through its capability of inducing apoptosis and/or antiproliferative effects on tumor cells, has been proved. Moreover, its antitumor seems to be due not only to its pro-apoptotic and inhibitory effects on tumor growth, but also to its antiangiogenic and anti-invasive properties. Although the precise mechanisms underlying the antitumor activity of this compound remain not fully understood, in this review we will focus on the most recent findings about the cellular and molecular pathways affected by sanguinarine, together with the rationale of its potential application in clinic. The complex of data currently available suggest the potential application of sanguinarine as an adjuvant in the therapy of cancer, but further pre-clinical studies are needed before such an antitumor strategy can be effectively translated in the clinical practice. | Roberta Gaziano Gabriella Moroni Cristina Buè Martino Tony Miele Paola Sinibaldi-Vallebona Francesca Pica | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 11 |
| 2 | Effects of full replacement of dietary fishmeal with insect meal from Tenebrio molitor on rainbow trout gut and skin microbiota显示文摘Background:Aquaculture must continue to reduce dependence on fishmeal(FM)and fishoil in feeds to ensure sustainable sector growth.Therefore,the use of novel aquaculture feed ingredients is growing.In this regard,insects can represent a new world of sustainable and protein-rich ingredients for farmed fish feeds.Accordingly,we investigated the effects of full replacement of FM with Tenebrio molitor(TM)larvae meal in the diet of rainbow trout(Oncorhynchus mykiss)on fish gut and skin microbiota.Methods:A feeding trial was conducted with 126 trout of about 80 g mean initial weight that were fed for 22 weeks with two isonitrogenous,isolipidic,and isoenergetic extruded experimental diets.Partially defatted TM meal was included in one of the diets to replace 100%(TM 100)of FM,whereas the other diet(TM 0)was without TM.To analyse the microbial communities,the Illumina MiSeq platform for sequencing of 16S rRNA gene and Qiime pipeline were used to identify bacteria in the gut and skin mucosa,and in the diets.Results:The data showed no major effects of full FM substitution with TM meal on bacterial species richness and diversity in both,gut mucosa-and skin mucus-associated microbiome.Skin microbiome was dominated by phylum Proteobacteria and especially by Gammaproteobacteria class that constituted approximately half of the bacterial taxa found.The two dietary fish groups did not display distinctive features,except for a decrease in the relative abundance of Deefgea genus(family Neisseriaceae)in trout fed with insect meal.The metagenomic analysis of the gut mucosa indicated that Tenericutes was the most abundant phylum,regardless of the diet.Specifically,within this phylum,the Mollicutes,mainly represented by Mycoplasmataceae family,were the dominant class.However,we observed only a weak dietary modulation of intestinal bacterial communities.The only changes due to full FM replacement with TM meal were a decreased number of Proteobacteria and a reduced number of taxa assigned to Ruminococcaceae and Neisseriaceae families.Conclusions:The data demonstrated that TM larvae meal is a valid alternative animal protein to replace FM in the aquafeeds.Only slight gut and skin microbiota changes occurred in rainbow trout after total FM replacement with insect meal.The mapping of the trout skin microbiota represents a novel contribution of the present study.Indeed,in contrast to the increasing knowledge on gut microbiota,the skin microbiota of major farmed fish species remains largely unmapped but it deserves thorough consideration. | Genciana Terova Elisabetta Gini Laura Gasco Federico Moroni Micaela Antonini Simona Rimoldi | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 6 |
| 3 | 3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration显示文摘Bone infections following open bone fracture or implant surgery remain a challenge in the orthopedics field.In order to avoid high doses of systemic drug administration,optimized local antibiotic release from scaffolds is required.3D additive manufactured(AM)scaffolds made with biodegradable polymers are ideal to support bone healing in non-union scenarios and can be given antimicrobial properties by the incorporation of antibiotics.In this study,ciprofloxacin and gentamicin intercalated in the interlamellar spaces of magnesium aluminum layered double hydroxides(MgAl)andα-zirconium phosphates(ZrP),respectively,are dispersed within a thermoplastic polymer by melt compounding and subsequently processed via high temperature melt extrusion AM(~190◦C)into 3D scaffolds.The inorganic fillers enable a sustained antibiotics release through the polymer matrix,controlled by antibiotics counterions exchange or pH conditions.Importantly,both antibiotics retain their functionality after the manufacturing process at high temperatures,as verified by their activity against both Gram+and Gram-bacterial strains.Moreover,scaffolds loaded with filler-antibiotic do not impair human mesenchymal stromal cells osteogenic differentiation,allowing matrix mineralization and the expression of relevant osteogenic markers.Overall,these results suggest the possibility of fabricating dual functionality 3D scaffolds via high temperature melt extrusion for bone regeneration and infection prevention. | María C´amara-Torres Stacy Duarte Ravi Sinha Ainhoa Egizabal Noelia´Alvarez Maria Bastianini Michele Sisani Paolo Scopece Marco Scatto Alessandro Bonetto Antonio Marcomini Alberto Sanchez Alessandro Patelli Carlos Mota Lorenzo Moroni | 2021 | Bioactive Materials2021，6，4： | 2 |
| 4 | Cast vs external fixation:a comparative study in elderly osteoporotic distal radial fracture patients 显示文摘 | Moroni A Vannini F Faldini C | 2004 | Scand J Surg2004，93，： | 1 |
| 5 | The life span determinant p66Shc localizes to mitochondria where it associates with mtHsp70 and regulates trans-membrane potential显示文摘 | MIGLIACCIO E MORONI M | 2004 | J Biol Chem2004，279，25： | 1 |
| 6 | Paraoxonase activity in high-density lipoproteins: a com- parison between healthy and obese females 显示文摘 | Ferretti G Bacchetti T Moroni C Savino S Linzzi A Balzola F | 2005 | J Clin Endocri- nol Metabol2005，90，3： | 1 |
| 7 | Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX-3 inhibits angiogenesis显示文摘 | Rusnati M Carmozzi M Moroni E | 2004 | {H}Blood2004，，01： | 1 |
| 8 | Identification of AFLP and microsatellite markers linked with an aluminium tolerance gene in barley (Hordeum vulgare L.)显示文摘 | H. Raman J. Moroni K. Sato B. Read B. Scott | 2002 | Theoretical and Applied Genetics (-)2002，，2： | 1 |
| 9 | Gene copy num- ber for epidermal growth factor receptor(EGFR)and clin- ical response to anti-EGFR treatment in colorectal cancer:a cohort study显示文摘 | Moroni M Veronese S Benvenuti S | 2005 | Lancet Oncol2005，6，5： | 1 |
| 10 | Inhibition of Poly(ADP-Ribose) glycohydrolase by gallotannin selectively up-regulates expression of proinflammatory genes显示文摘 | Rapizzi E Fossati S Moroni F | 2004 | Mol Pharmacol2004，66，4： | 1 |
| 11 | Pregnancy after lupus nephritis显示文摘 | Moroni G Ponticelli C | 2005 | Lupus2005，14，： | 1 |
| 12 | 显示文摘 | Carrino L Moroni G Pollni W | 2002 | J Mater Process Technol2002，121，： | 1 |
| 13 | Apoptosis in human aortic endothelial dells induced by hyper- glycemic condition involves mitochondrial depolariza- tion and is prevented by N acetyl-L-cysteine显示文摘 | Reechioni R Marcheselli F Moroni F | 2002 | Me- tabolism2002，51，11： | 1 |
| 14 | Bone morphogenic protein antagonist Dre/gremlin is a novel proangiogenic factor显示文摘 | Stabile H Mitola S Moroni E | 2007 | Blood2007，109，5： | 1 |
| 15 | Rapamycin passes the torch:a new generation of m TOR inhibitors显示文摘 | Benjamin D Colombi M Moroni C | 2011 | Nature review s Drug Discovery2011，10，11： | 1 |
| 16 | Pregnancy after lupus nephritis 显示文摘 | MORONI G PONTICELLI C | 2005 | Lupus2005，14，： | 1 |
| 17 | An unusual case of synovial cyst of the hip joint presenting as femoral vein compression and severe lower limb edema显示文摘 | Colasanti M Sapienza P Moroni E | 2006 | Eur J Vabc Endovasc Sury2006，32，4： | 1 |
| 18 | Dynamic characteristics of a long span seismic isolated bridge 显示文摘 | Boroschek Ruben L Moroni Mafia O Sarrazin Mauricio | 2003 | Engineering Structures2003，，25： | 1 |
| 19 | A study on the action of vitaminE supplementation on plasminogen activator inhibitor type I and platelet nitric oxide production in type 2 diabetic patients 显示文摘 | Vignini A Nanetti L Moroni C | 2008 | Nutr Metab Cardiovasc Dis2008，18，1： | 1 |
| 20 | 'Nephritic flares' are predictors of bad long-term renal outcome in lupus nephritis显示文摘 | Quaglini S Maccario M | 1996 | Kidney Int1996，50，6： | 1 |
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