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| 1 | Activation and dramatically increased cytolytic activity of tumor specific T lymphocytes after radio-frequency ablation in patients with hepatocellular carcinoma and colorectal liver metastases显示文摘瞄准:为了如果特定的细胞毒素的 T 房间回答能与恶意的肝在病人被导致,估计,肿瘤与无线电频率对待脱离(RFA ) 。方法:有颜色的肝转移的六个病人表面的癌症并且 6 与肝细胞,癌(HCC ) 经历了 RFA。血以前被取样,在 RFA 以后的 4 和 8 wk。测试抗原是活体检视从每个病人获得的自体同源的肝和肿瘤溶解产物。外部 T 房间激活被一个干扰素鲸鱼群妈(IFNgamma ) 估计分泌物试金和流动血细胞计数。T 房间是双 stained 让 CD4/CD8 和 IFNgamma 检测细胞毒素的 T 房间。积极的 IFNgamma 和 IFNgamma 否定 T 房间的比率作为刺激索引(SI ) 被决定。估计细胞溶解的活动, T 房间与人的 CaCo 颜色被共同孵化 cytosolic adenylate 激酶的表面的癌症和 HepG2 HCC 房间和版本被酶试金测量。结果:在 RFA SI 前是 0.021 (+/- 0.006 ) 为 CD4 (+) 并且 0.022 (+/- 0.004 ) 为对非恶意的肝织物的 CD8 (+) T 房间并且 0.018 (+/- 0.005 ) 为 CD4 (+) 并且 0.021 (+/- 0.004 ) 为对自体同源的肿瘤织物的 CD8 (+) 房间。在对肿瘤织物的 RFA SI 以后的四个星期增加了到 0.109 (+/- 0.005 )为 CD4 (+)并且 0.11 (+/- 0.012 )为对 HCC 的 CD8 (+) T 房间,并且到 0.115 (+/- 0.031 )为 CD4 (+)并且 0.15 (+/- 0.02 )为为颜色的 CD8 (+)房间表面的转移( P <
0.0001 )。没有增加的 SI 被观察与非,恶性瘤织物根本预定点。与 2.62 在对各自的癌症房间的 RFA 细胞溶解的的活动前是低的(+/- 0.37 ) 相对的光单位(RLU ) ,而是超过 100 合拢的玫瑰在 RFA 以后的 4 和 8 wk。自发的版本是 2% 最大值在所有实验释放的 <
。结论:病人与主要并且肝的继发性瘤在 RFA 以后与 CD8 (+) T 房间的一项戏剧性地增加的肿瘤 specific 细胞溶解的活动显示出重要肿瘤特定的细胞毒素的 T 房间刺激。 | Johannes Hansler Thaddaus Till Wissniowski Detlef Schuppan Astrid Witte Thomas Bernatik Eckhart Georg Hahn Deike Strobel | 2006 | World Journal of Gastroenterology2006，12，23： | 22 |
| 2 | Requirements for the transfer of lead-free piezoceramics into application显示文摘The recent review for the Restriction of Hazardous Substances Directive(RoHS)by the expert committee,appointed by the European Union,stated that the replacement of PZT“…may be scientifically and technologically practical to a certain degree…”,although replacement“…is scientifically and technically still impractical in the majority of applications.”Thus,two decades of sustained research and development may be approaching fruition,at first limited to a minority of applications.Therefore,it is of paramount importance to assess the viability of lead-free piezoceramics over a broad range of application-relevant properties.These are identified and discussed in turn:1.Cost,2.Reproducibility,3.Mechanical and Thermal Properties,4.Electrical Conductivity,and 5.Lifetime.It is suggested that the worldwide efforts into the development of lead-free piezoceramics now require a broader perspective to bring the work to the next stage of development by supporting implementation into real devices.Guidelines about pertinent research requirements into a wide range of secondary properties,measurement techniques,and salient literature are provided. | Jurij Koruza Andrew J.Bell Till Fromling Kyle G.Webber Ke Wang Jürgen Rodel | 2018 | Journal of Materiomics2018，4，1： | 14 |
| 3 | EGF基因多态性与结直肠癌的关系显示文摘 | 吴国洋 Michael Keese Till Hasenberg Jrg W.Sturm | 2005 | 中华普通外科杂志2005，20，11： | 9 |
| 4 | Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans. | Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier | 2018 | Bone Research2018，6，1： | 5 |
| 5 | 结直肠癌术后吻合口瘘与表皮生长因子、转化生长因子-β1、血管内皮生长因子基因多态性的关系显示文摘目的观察表皮生长因子(EGF)61*G/A、转化生长因子-β1(TGF-β1)-509*TIC、血管内皮生长因子(VEGF)936*T/C基因功能多态性对术后结肠吻合口瘘的影响。方法采用聚合酶链反应-限制性片段长度多态性(PCR—RFLP)方法检测伴有和不伴有术后结肠吻合口瘘结直肠癌患者的EGF 61*G/A,TGF-β1—509*T/C,VEGF 936*T/C基因型。结果伴有术后结肠吻合口瘘的结直肠癌患者TGF-β1-509*T/T基因型比例(0.0%)低于无术后吻合口瘘的患者(15.2%),两者差异有统计学意义(P〈0.05)。伴有术后结肠吻合口瘘的VEGF 936*C/C基因型和C等位基因比例(65.9%和80.6%)低于无术后吻合口瘘的患者(82.6%和90.5%),两者差异有统计学意义(基因型x^2=5.755,P〈0.05;等位基因x^2=5.275,P〈0.05)。伴有术后结肠吻合口瘘的结直肠癌患者EGF 61*G/G基因型比例(25.0%)低于无术后吻合口瘘的患者(55.5%),但两者差异无统计学意义(x^2=1.591,P〉0.05)。结论TGF-β1-509*T/T基因型,VEGF 936*C/C基因型或936*C等位基因有助于减少术后结肠吻合口瘘的发生。 | 吴国洋 王效民 Michael Keese Till Hasenberg Jǒrg W. Sturm | 2008 | 中华实验外科杂志2008，25，3： | 5 |
| 6 | 面向可持续的渔业补贴:共同渔业政策进入新一轮改革显示文摘本文为德国不来梅大学欧洲环境法规研究中心Till Markus发表在Marine Policy 2010年第34卷1117-1124页文章的中译文。2009年4月22日,欧洲委员会发布了'共同渔业政策改革绿皮书',指出该政策的一个矛盾,一方面对渔业领域的公共财政资助是重要的,另一方面这些资助常常与其他共同渔业政策(Common Fishery Policy,CFP)目标,特别是减少生产能力过剩的目标相冲突。文章提供了一种更好理解补贴影响的分析框架,以及对CFP下的基金计划总体评述,旨在解答欧洲委员会在绿皮书中提出的一些问题。问题的解答基于2种观点:海洋捕捞资源的开发最终依赖于可获得的鱼类种群水平,大量的补贴通过刺激投资动机使鱼类资源压力增大。忽视这种趋势的政策导致了无效和不可持续的捕捞以及公共基金的不公分配。虽然近年来CFP下的援助计划有所改观,但仍存在一些问题。未来对渔业的资助必需朝着可持续和有效利用的方向改革。文章对于了解欧盟的渔业补贴政策、增强渔业补贴经济学评价以及促进我国'强渔惠渔'政策的制定与实施等具有一定的参考意义。 | 林锡坤 Till Markus | 2010 | 中国渔业经济2010，，6： | 4 |
| 7 | 血管内皮生长因子936T/C基因多态性与结直肠癌及术后吻合口瘘的关系显示文摘目的通过研究血管内皮生长因子(VEGF)936T/C基因多态性了解该因子对结直肠癌生成及术后结肠吻合口瘘的影响。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测结直肠癌及正常对照的VEGF936T/C基因型。结果结直肠癌患者VEGF936T/C基因型或等位基因与对照组相比无差异。伴有术后结肠吻合口瘘的结直肠癌患者其VEGF936C/C基因型及C等位基因比例低于无术后结肠吻合口瘘的患者,两者差异有统计学意义(P<0·05)。结论VEGF936C/C基因型或936C等位基因与结直肠癌的发生无关,但提示术后结肠吻合口瘘的发生率降低。 | 吴国洋 王效民 Michael Keese Till Hasenberg Jrg W. Sturm | 2006 | 中华外科杂志2006，44，21： | 4 |
| 8 | 为有效防控新冠病毒肺炎争取时间——抗疫假期政策对疫情传播的影响显示文摘在新发突发传染病的早期阶段,快速应对对于疫情防控至关重要。用于控制疫情的公共假期能为大规模、迅速地进行社会隔离和其他举措提供关键的时间窗口期。本研究的目的是探讨抗疫假期的起始时间节点和持续时间对中国早期新冠病毒肺炎疫情传播的影响。我们开发了一个房室模型来模拟从2020年1月开始中国新冠病毒肺炎疫情的动态传播;预测并比较了春节期间在有抗疫假期和没有抗疫假期下的疫情传播;考虑了抗疫假期在不同持续时间、不同起始时间节点,以及在关于病毒传播率的不同假设下的多种情况;估计了在不同情况下达到某些感染阈值所需的天数延迟。结果表明,中国的抗疫假期使新冠病毒肺炎疫情的传播停滞了许多天。与不设抗疫假期的场景相比,基础场景的抗疫假期(湖北省为21 d,中国所有其他省为10 d)可使确诊感染100000例的时间延迟7.54 d。持续时间更长的抗疫假期会对疫情防控产生更大的影响。为期21 d的全国性抗疫假期可使确诊感染100000例的时间延迟近10 d。此外,研究发现,在新发突发传染病较早阶段实施抗疫假期比较晚阶段实施对遏制疫情蔓延更有效,抗疫假期期间采取额外的控制措施可以增强疫情控制效果。总之,抗疫假期能够通过有效地减少人群的社交接触频率及范围,从而减缓疫情的传播。抗疫假期使得新冠病毒肺炎传播暂时停滞,为疫情防控争取了时间,科学家可用争取的时间来发现传播途径并确定有效的公共卫生干预措施,政府可用争取的时间来完善基础设施、调配医疗用品、培训和部署专业人力资源,从而为长期防控做好准备。 | 陈思邈 陈秋实 杨维中 薛澜 刘远立 杨俊涛 王辰 Till Barnighausena | 2020 | Engineering2020，6，10： | 4 |
| 9 | Pyridine Nucleotide Cycling and Control of Intracellular Redox State in Relation to Poly (ADP-Ribose) Polymerase Activity and Nuclear Localization of Glutathione during Exponential Growth of Arabidopsis Cells in Culture显示文摘Pyridine 核苷酸, ascorbate 和谷胱甘肽是在植物房间的主要氧化还原作用代谢物,与在细胞的氧化还原作用动态平衡和房间周期的规定的特定的角色。然而,代谢物在指数的生长期间分享的这些的规定和他们在细胞周期的精确功能尚待被描绘。在在文化的 Arabidopsis 房间的指数的生长期间的许多 ascorbate,谷胱甘肽,和 pyridine 核苷酸的现在的分析为每这些氧化还原作用水池的微分规定提供证据。Ascorbate 早很充满生长周期,但是谷胱甘肽在这个点是低的。到 dehydroascorbate 的细胞的 ascorbate 和到谷胱甘肽二硫化物比率的减少的谷胱甘肽(GSH ) 高、不变,但是 pyridine 核苷酸分享大部分在指数的生长的时期上被氧化并且一旦生长停止了,仅仅变得更多减少。谷胱甘肽水池增加了与同时 poly (自动数据处理核糖) 聚合酶(PARP ) 活动并且一次由 transcriptome 信息是的高房间周期活动随许多 PARP1 和 PARP2 mRNAs 的增加显示了。在在细胞质和原子核之间的 GSH 的细胞内部的划分的显著变化被观察。由冲淡的指数的生长阶段的扩展或改变导致的媒介在谷胱甘肽和菸碱腺嘌 dinucleotide 增加,氧化形式( NAD ) -plus-nicotinamide 腺嘌 dinucleotide ,减少的形式( NADH )水池并且到更高的 NAD/NADH 比率但是菸碱腺嘌 dinucleotide 磷酸盐,氧化形式( NADP ) -plus-nicotinamide 腺嘌 dinucleotide 磷酸盐,减少的形式( NADPH )水池尺寸,和 NAPD/NADPH 比率是影响的少得多。在指数的生长阶段结束了以前, ascorbate,谷胱甘肽,和 pyridine 核苷酸水池和 PARP 活动减少了。我们断定在生长周期期间处于细胞内部的氧化还原作用状态有显著变化,但是氧化还原作用动态平衡被主要氧化还原作用 pyridine 核苷酸,谷胱甘肽,和 ascorbate 水池的相互影响维持。在 PARP 表示和活动和 GSH 累积并且发现那 GSH 能被招募到原子核之间的关联建议在氧化还原作用规定和原子酶活动之间的一种关系。 | Till K. Pellny Vittoria Locato Pedro Diaz Vivancos Jelena Markovic Laura De Gara Federico V. Pallardo Christine H. Foyer | 2009 | Molecular Plant2009，2，3： | 4 |
| 10 | Overweight and obesity in hip and knee arthroplasty:Evaluation of 6078 cases显示文摘AIM: To evaluate a possible association between thevarious levels of obesity and peri-operative characteristics of the procedure in patients who underwent endoprosthetic joint replacement in hip and knee joints. METHODS: We hypothesized that obese patients were treated for later stage of osteoarthritis, that more conservative implants were used, and the intraand perioperative complications increased for such patients. We evaluated all patients with body mass index(BMI) ≥ 25 who were treated in our institution from January 2011 to September 2013 for a primary total hip arthroplasty(THA) or total knee arthroplasty(TKA). Patients were split up by the levels of obesity according to the classification of the World Health Organization. Average age at the time of primary arthroplasty, preoperative Harris Hip Score(HHS), Hospital for Special Surgery score(HSS), gender, type of implanted prosthesis, and intra-and postoperative complications were evaluated.RESULTS: Six thousand and seventy-eight patients with a BMI ≥ 25 were treated with a primary THA or TKA. Age decreased significantly(P < 0.001) by increasing obesity in both the THA and TKA. HHS and HSS were at significantly lower levels at the time of treatment in the super-obese population(P < 0.001). Distribution patterns of the type of endoprostheses used changed with an increasing BMI. Peri- and postoperative complications were similar in form and quantity to those of the normal population. CONCLUSION: Higher BMI leads to endoprosthetic treatment in younger age, which is carried out at significantly lower levels of preoperative joint function. | Daniel Guenther Stefan Schmidl Till O Klatte Harald K Widhalm Mohamed Omar Christian Krettek Thorsten Gehrke Daniel Kendoff Carl Haasper | 2015 | World Journal of Orthopedics2015，6，1： | 4 |
| 11 | Strengthening population medicine to promote public health显示文摘As we enter.2022,we are facedwith the fact that coronavirus disease2019(CovID-19)has been devastating the world formore than 2full years.Since the original outbreak of COVID-19in December2019,the disease has proved to be a major threat to global health and,perhaps more importantly,one that is not likely to be resolved soon.Severe_acute respiratory syndrome coronavirus. | Chen Wang Simiao Chen Guangliang Shan Zhiwei Leng Till Bärnighausen Weizhong Yang | 2022 | Chinese Medical Journal2022，，10： | 3 |
| 12 | Association Between Diabetes and Stroke Subtype on Survival and Functional Outcome 3 Months After Stroke: Data From the European BIOMED Stroke Project显示文摘 | Salah-Eddine Megherbi Chantal Milan Dominique Minier Grégory Couvreur Guy-Victor Osseby Kate Tilling Antonio Di Carlo Domenico Inzitari Charles D.A. Wolfe Thibault Moreau Maurice Giroud | 2003 | Stroke: Journal of the American Heart Association2003，，3： | 3 |
| 13 | 磁共振对致心律失常性右室心肌病的诊断价值显示文摘 | 刘成伟 汪道文 夏黎明 邓又斌 陈新山 Till Barnighausen | 2002 | 中华内科杂志2002，41，3： | 3 |
| 14 | hsa-mir-183 is frequently methylated and related to poor survival in human hepatocellular carcinoma显示文摘AIM To screen clinically relevant micro RNAs (mi RNAs) silenced by DNA methylation in human hepatocellular carcinoma(HCC).METHODS Knockdown of DNA methyltransferases (DNMTs) using si RNAs and mi RNA profiling in HCC cell lines were performed to identify DNA hypermethylation-mediated mi RNA downregulation. Confirmation using individual quantitative real-time PCR (qR T-PCR) assays was thenperformed followed by DNA methylation quantification at the promoter of the mi RNA genes. Quantification of DNA methylation and mi RNA expression was then performed in primary HCC tumor samples and related with clinicopathological variables.RESULTS mi RNA profiling after DNMT knockdown in HCC cell lines revealed upregulation of mi R-23, mi R-25 and mi R-183. After q RT-PCR confirmation and Cp G island methylation quantification of these miR NAs in cell lines, further analysis in primary HCC specimens showed that hsa-mi R-183 is hypermethylated in 30% of HCC (n = 40). Expression of mature miR-183 showed an inverse correlation with DNA methylation levels. In HCC cells, DNMT knockdown and 5-aza-2'-deoxycytidine treatment reduced methylation and stimulated expression of mi R-183. In HCC patients, hypermethylation at hsami R-183 promoter significantly correlates with poor survival (log-rank test P = 0.03). DNA methylation analysis in healthy liver, benign liver tumors (hepatocellular adenoma and focal nodular hyperplasia) and their corresponding adjacent tissues showed absence of hypermethylation supporting the notion that aberrant methylation at hsa-miR-183 is specific for the malignant transformation of hepatocytes.CONCLUSION Our data indicate that hypermethylation of hsa-miR-183 is a frequent event in HCC and potentially useful as a novel surrogate diagnostic and prognostic marker. | Sumadi Lukman Anwar Till Krech Britta Hasemeier Elisa Schipper Nora Schweitzer Arndt Vogel Hans Kreipe Reena Buurman Britta Skawran Ulrich Lehmann | 2017 | World Journal of Gastroenterology2017，23，9： | 3 |
| 15 | NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis显示文摘 | Eran Elinav Till Strowig Andrew L. Kau Jorge Henao-Mejia Christoph A. Thaiss Carmen J. Booth David R. Peaper John Bertin Stephanie C. Eisenbarth Jeffrey I. Gordon Richard A. Flavell | 2011 | Cell2011，，5： | 3 |
| 16 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 17 | Radioembolization with yttrium‐90 glass microspheres in hepatocellular carcinoma: European experience on safety and long‐term survival显示文摘 | Philip Hilgard Monia Hamami Amr El Fouly André Scherag Stefan Müller Judith Ertle Till Heusner Vito R. Cicinnati Andreas Paul Andreas Bockisch Guido Gerken Gerald Antoch | 2010 | Hepatology2010，，： | 3 |
| 18 | The impact of early goal-directed fluid management on survival in an experimental model of severe acute pancreatitis显示文摘 | Constantin J. C. Trepte Kai A. Bachmann Jan H. Stork Till J. Friedheim Andrea Hinsch Matthias S. Goepfert Olliver Mann Jakob R. Izbicki Alwin E. Goetz Daniel A. Reuter | 2013 | Intensive Care Medicine2013，，4： | 2 |
| 19 | Endoscopic findings in patients with Schatzki rings:Evidence for an association with eosinophilic esophagitis显示文摘AIM:To investigate endoscopic findings in patients with Schatzki rings(SRs) with a focus on evidence for eosinophilic esophagitis(EoE).METHODS:We consecutively approached all adult patients scheduled for elective outpatient upper endoscopy for a variety of indications at the German Diagnostic Clinic,Wiesbaden,Germany between July 2007 and July 2010.All patients with endoscopically diagnosed SRs,defined as thin,symmetrical,mucosal structures located at the esophagogastric junction,were prospectively registered.Additional endoscopic findings,clinical information and histopathological findings with a focus on esophageal eosinophilia(≥ 20 eosinophils/high power field) were recorded.The criteria for active EoE were defined as:(1) eosinophilic tissue infiltration ≥ 20 eosinophils/hpf;(2) symptoms of esophageal dysfunction;and(3) exclusion of other causes of esophageal eosinophilia.Gastroesophageal reflux disease was excluded by proton pump inhibitor treatment prior to endoscopy.The presence of ≥ 20 eosinophils/hpf in esophageal biopsies in patients that did not fulfil the criteria of EoE was defined as esophageal hypereosinophilia.RESULTS:A SR was diagnosed in 171(3.3%;128 males,43 females,mean age 66 ± 12.9 years) of the 5163 patients that underwent upper gastrointestinalendoscopy.Twenty of the 116 patients(17%) from whom esophageal biopsies were obtained showed histological hypereosinophilia(≥ 20 eosinophils/hpf).Nine of these patients(8 males,1 female,mean age 49 ± 10 years) did not fulfill all diagnostic criteria of EoE,whereas in 11(9%) patients with ≥ 20 eosinophils/hpf,a definite diagnosis of EoE was made.Three of the 11 patients(27%) with definite EoE had no suspicious endoscopic features of EoE.In contrast,in the 25 patients in whom EoE was suspected by endoscopic features,EoE was only confirmed in 7(28%) patients.Patients with EoE were younger(mean age 41.5 ± 6.5 vs 50.5 ± 11.5 years,P = 0.012),were more likely to have a history of allergies(73% vs 29%,P = 0.007) and complained more often of dysphagia(91% vs 34%,P = 0.004) and food impaction(36% vs 6%,P = 0.007) than patients without EoE.Endoscopically,additional webs were found significantly more often in patients with EoE than in patients without EoE(36% vs 11%,P = 0.04).Furthermore,the SR had a tendency to be narrower in patients with EoE than in those without EoE(36% vs 18%,P = 0.22).The percentage of males(73% vs 72%,P = 1.0) and frequency of heartburn(27% vs 27%,P = 1.0) were not significantly different in both groups.The 9 patients with esophageal hypereosinophilia that did not fulfil the diagnostic criteria of EoE were younger(mean age 49 ± 10 years vs 58 ± 6 years,P = 0.0008) and were more likely to have a history of allergies(78% vs 24%,P = 0.003) than patients with < 20 eosinophils/hpf.Predictors of EoE were younger age,presence of dysphagia or food impaction and a history of allergies.CONCLUSION:A significant proportion of patients with SRs also have EoE,which may not always be suspected according to other endoscopic features. | Michaela Müller Alexander J Eckardt Annette Fisseler-Eckhoff Susanne Haas Ines Gockel Till Wehrmann | 2012 | World Journal of Gastroenterology2012，18，47： | 2 |
| 20 | Hepatitis B Virus Limits Response of Human Hepatocytes to Interferon-α in Chimeric Mice显示文摘 | Marc Lütgehetmann Till Bornscheuer Tassilo Volz Lena Allweiss Jan–Hendrick Bockmann Joerg M. Pollok Ansgar W. Lohse Joerg Petersen Maura Dandri | 2011 | Gastroenterology2011，，7： | 2 |
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