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| 1 | Stem cell mechanisms during left ventricular remodeling post-myocardial infarction:Repair and regeneration显示文摘Post-myocardial infarction(MI),the left ventricle(LV)undergoes a series of events collectively referred to as remodeling.As a result,damaged myocardium is replaced with fibrotic tissue consequently leading to contractile dysfunction and ultimately heart failure.LV remodeling post-MI includes inflammatory,fibrotic,and neovascularization responses that involve regulated cell recruitment and function.Stem cells(SCs)have been transplanted post-MI for treatment of LV remodeling and shown to improve LV function by reduction in scar tissue formation in humans and animal models of MI.The promising results obtained from the application of SCs post-MI have sparked a massive effort to identify the optimal SC for regeneration of cardiomyocytes and the paradigm for clinical applications.Although SC transplantations are generally associated with new tissue formation,SCs also secrete cytokines,chemokines and growth factors that robustly regulate cell behavior in a paracrine fashion during the remodeling process.In this review,the different types of SCs used for cardiomyogenesis,markers of differentiation,paracrine factor secretion,and strategies for cell recruitment and delivery are addressed. | Rogelio Zamilpa Mary M Navarro Iris Flores Sy Griffey | 2014 | World Journal of Cardiology2014，6，7： | 11 |
| 2 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 3 | A FINITE-ELEMENT ANALYSIS OF ELECTROMAGNETIC SHEET METAL-EXPANSION PROCESS显示文摘1INTRODUCTIONElectromagneticforming,esentialybeingakindofapplicationofimpulseintensivecurenttechniqueinmetalworking,dealswith... | Huang, SY Chang, ZH Wang, ZR Wang, LF Yang, M | 1998 | 中国有色金属学会会刊:英文版1998，8，3： | 4 |
| 4 | A modular clutter rejection technique for FLIR imagery using region-based principal component analysis显示文摘 | Syed A Rizvi Nasser M Nasrabadi | 2002 | Pattern Recognition2002，35，： | 2 |
| 5 | Left-sided Pancreatectomy: A Multicenter Comparison of Laparoscopic and Open Approaches显示文摘 | David A. Kooby Theresa Gillespie David Bentrem Attila Nakeeb Max c. Schmidt Nipun B. Merchant Alex A. Parikh Robert C. G. Martin Charles R. Scoggins Syed Ahmad Hong Jin Kim Jaemin Park Fabian Johnston Matthew J. Strouch Alex Menze Jennifer Rymer Rebecca M | 2008 | Annals of Surgery2008，，3： | 2 |
| 6 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 7 | Cyanidin-3-glucoside,a natural product derived from blackberry,exhibits chemopreventive and chemotherapeutic activity显示文摘 | Ding M Feng R Wang SY | 2006 | Journal of Biological Chemistry2006，，17： | 1 |
| 8 | Monoeyte transmigration induced by modification of low density lipoprotein in eocultures of human aortic wall cells is due to induction of monoeyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein显示文摘 | Imes SS Hama SY | 1991 | J Clin Invest1991，88，： | 1 |
| 9 | Recombinant E1~deleted adenovirus mediated gene therapy for cancer efficacy studies with p53 tumor suppressor gene and liver histology in tumor xenograft models显示文摘 | Nielsen LL Gurnani M Syed L | 1998 | Human gene therapy1998，9，： | 1 |
| 10 | Overexpression of multiple drug resistance genes in endothelial cells from patients withrefractory epilepsy显示文摘 | Dombrowski SM Desai SY Marroni M | 2001 | Epilepsia2001，42，12： | 1 |
| 11 | Compressor Capacity Modulation Scheme显示文摘 | SYED M ZUBAIR VIJAY BAHEL | 1989 | Heating Piping Air Conditioning1989，，1： | 1 |
| 12 | The Drosophila microRNA Mir- 14 suppresses cell death and is required for normal fat metabolism 显示文摘 | Xu P Vemooy SY Guo M | 2003 | Curr Biol2003，13，9： | 1 |
| 13 | Celiac artery aneurysm em- bolization by coil occlusion 显示文摘 | Syed M Shaikh A Neravetla S | 2005 | Ann Vase Surg2005，19，： | 1 |
| 14 | Statistical optimization of process va- riables for L-lysine production by Corynebacterium glutamicum 显示文摘 | Nelofer R Syed Q Nadeem M | 2008 | Ttirk Biyokimya Dergisi2008，33，2： | 1 |
| 15 | MRG15 is a novel PALB2-interaeting :ctor involved in homologous recombin:ion 显示文摘 | Sy S M Huen M S Chen J | 2009 | J Biol Chem2009，284，21： | 1 |
| 16 | Volumetric MRI study of the short and long insular cortices in schizophrenia spectrum disorders显示文摘 | Takahashi T Suzuki M Zhou SY | 2005 | Psychiatry Res2005，138，： | 1 |
| 17 | Immunomodulatory properties of Grifola frondosa in submerged culture显示文摘 | Wu M J Cheng TL Cheng SY | 2006 | Journal of Agricultural and Food Chemistry2006，54，8： | 1 |
| 18 | A phase Il study on continuous infusional paclitaxel and 5-Fu as first-line chemotherapy for patients with advanced esophageal cancer显示文摘 | Gu M Li SY Huang XE | 2013 | Asian Pac J Cancer Prev2013，13，： | 1 |
| 19 | Enhanced butanol production by mutant strains of Clostridium acetobutyli- cure in molasses medium 显示文摘 | Syed QUA Nadeem M Nelofer R | 2008 | Turk J Biochem2008，33，1： | 1 |
| 20 | Fragile X carrier screening in Korean women of reproductive age显示文摘 | Kim M J Kim SY Yang J H | 2013 | J Med Screen2013，20，1： | 1 |
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