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| 1 | 社区人群血压和颈动脉血流速度与脑容量和脑小血管病的关系显示文摘做脑磁共振成像(magnetic resonance imaging,MRI)经常发现脑小血管病(cerebral small vessel disease,CSVD)。研究已证明高血压和低颈动脉血流速度与脑血管病存在关联。但是,这种关联与脑容量和CSVD的相关性仍有待研究。本文纳入基于社区的I-Lan纵向衰老研究(I-Lan longitudinal aging study)中年龄≥50岁的成年人721例进行分析,采用多普勒超声测量颈总动脉和颈内动脉血流速度,包括收缩期峰值血流速度(peak systolic velocity,PSV)和舒张终末期血流速度(end-diastolic velocity,EDV)。 | 袁源(摘译) 郑武洪(审校) Chuang SY Wang PN Chen LK Chou KH Chung CP Chen CH Mitchell GF Pan WH Cheng HM | 2021 | 中华高血压杂志2021，29，9： | 4 |
| 2 | Design,synthesis and biological evaluation of amino organophosphorus imidazoles as a new type of potential antimicrobial agents显示文摘A series of amino organophosphorus imidazoles were designed and synthesized as a novel structural type of antimicrobial agents.Bioactive evaluation in vitro showed that compound 3f exhibited equipotent or superior anti-methicillin-resistant Staphylococcus aureus(anti-MRSA) and anti-S. cerevisiae efficiencies(minimal inhibitory concentration(MIC)=2 μg/mL) to clinical drugs,and the combinations with antibacterial or antifungal drugs enhanced the antimicrobial efficiency. Highly active molecule 3f showed low propensity for bacteria to develop resistance, and the preliminary action mechanism studies demonstrated that 3f was membrane-active, but had no significant intercalation towards MRSA DNA. The computational study on 3f reasonably explained its high antimicrobial activity. Experimental data revealed that ground-state 3f-HSA complexes were formed mainly through hydrophobic interactions and hydrogen bonds with a spontaneous process, and the non-radioactive energy transfer from HSA to 3f occurred beyond F鰎ster resonance energy transfer theory. The participation of metal ions in 3f-HSA supramolucular system could increase the concentration of free compound 3f, and shorten its storage time and half-life in the blood to improve the maximum antimicrobial efficacy. | Wei-Wei Gao Syed Rasheed VijaiKumarReddy Tangadanchu Yi Sun Xin-Mei Peng Yu Cheng Feng-Xiu Zhang Jian-Mei Lin Cheng-He Zhou | 2017 | Science China Chemistry2017，60，6： | 3 |
| 3 | EXPERIMENTAL INVESTIGATION AND COMPUTER SIMULATION ON DYNAMIC BUCKLING BEHAVIOR OF LIQUID-FILLED CYLINDRICAL SHELLS UNDER AXIAL IMPACT显示文摘This article reports an experimental investigation on the axial impact buckling of thin metalliccylindrical shells fully filled with water.Low velocity impact tests are carried out by DHR-9401 drop hammerrig.The whole process of dynamic buckling is simulated using LS-DYNA computer code.The consistencybetween experimental observation and numerical simulation is quite satisfactory.The investigation indieatesthat quite high internal hydrodynamic pressure occurs inside the shell during the impact process.Under thecombined action of the high internal pressure and axial compression plastic buckling occurs easily in the thin-walled shells and buckling modes take on regular and axisymmetric wrinkles. | Zhang, SY Lei, JP Zhao, LM Cheng, GQ Lu, GY | 2000 | Acta Mechanica Solida Sinica2000，13，2： | 2 |
| 4 | The Scorpion Venom Peptide Smp76 Inhibits Viral Infection by Regulating Type-Ⅰ Interferon Response显示文摘Dengue virus(DENV) and Zika virus(ZIKV) have spread throughout many countries in the developing world and infect millions of people every year, causing severe harm to human health and the economy. Unfortunately, there are few effective vaccines and therapies available against these viruses. Therefore, the discovery of new antiviral agents is critical.Herein, a scorpion venom peptide(Smp76) characterized from Scorpio maurus palmatus was successfully expressed and purified in Escherichia coli BL21(DE3). The recombinant Smp76(rSmp76) was found to effectively inhibit DENV and ZIKV infections in a dose-dependent manner in both cultured cell lines and primary mouse macrophages. Interestingly,rSmp76 did not inactivate the viral particles directly but suppressed the established viral infection, similar to the effect of interferon(IFN)-b. Mechanistically, rSmp76 was revealed to upregulate the expression of IFN-b by activating interferon regulatory transcription factor 3(IRF3) phosphorylation, enhancing the type-Ⅰ IFN response and inhibiting viral infection.This mechanism is significantly different from traditional virucidal antimicrobial peptides(AMPs). Overall, the scorpion venom peptide Smp76 is a potential new antiviral agent with a unique mechanism involving type-Ⅰ IFN responses,demonstrating that natural AMPs can enhance immunity by functioning as immunomodulators. | Zhenglin Ji Fangfang Li Zhiqiang Xia Xingchen Guo Minjun Gao Fang Sun Yuting Cheng Yingliang Wu Wenxin Li Syed Abid Ali Zhijian Cao | 2018 | Virologica Sinica2018，33，6： | 2 |
| 5 | Immunomodulatory properties of Grifola frondosa in submerged culture显示文摘 | Wu M J Cheng TL Cheng SY | 2006 | Journal of Agricultural and Food Chemistry2006，54，8： | 1 |
| 6 | Suseept I h ties to amphoteriein B and fluconazole of Candida species in TSARY 2002显示文摘 | Yang Y Li SY Cheng HH | 2005 | Diag Microbiol Infect Dis2005，13，3： | 1 |
| 7 | Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF121 and VEGF165 but not VEGF189显示文摘 | Cheng SY Nagane M Huang HS | 1997 | PNAS1997，94，12： | 1 |
| 8 | Effective ultrasonographic predictor for the diagnosis of acute lobar nephronia 显示文摘 | Cheng CH Tsau YK Hsu SY | 2004 | Pediatr Infect Dis J2004，23，1： | 1 |
| 9 | Ferulic acid provides neuroprotection against oxidative stress-related apoptosis after cerebral ischemialreperfusion injury by inhibiting ICAM-1 mRNA expression in rats显示文摘 | Cheng CY Su SY Tang NY | 2008 | Brain Res2008，1209，： | 1 |
| 10 | Prognostic features and treatment outcome in locoregionally advanced nasopharyngeal carcinoma following concurrent chemotherapy and radiotherapy 显示文摘 | Jian JJ Tsai Sy | 1998 | Int J Radiat Biol Phys1998，41，4： | 1 |
| 11 | Long-term survival of nasopharyngeal carcinoma following concomitant radiotherapy and chemotherapy显示文摘 | Jian J J Tsai SY | 2000 | Int J Radiat Oncol Biol Phys2000，48，5： | 1 |
| 12 | Paeonol attenuates H202-induced NF-KB-associated arnyloid precursor protein expression显示文摘 | Su sY Cheng CY Tsai TH | 2010 | Am J Chin Meal2010，38，6： | 1 |
| 13 | Special features of non-melanoma skin cancer in Hong Kong Chinese patients:10-year retrospective study显示文摘 | Cheng SY Luk NM Chong LY | 2001 | Hong Kong Med J2001，7，： | 1 |
| 14 | Guillain - Barre syndrome in Taiwan:a clinical study of 167 patients 显示文摘 | Lyu RK Tang LM Cheng SY | 1997 | J Neurol Neurosurg Psychiatry1997，63，： | 1 |
| 15 | Effects of psychological nursing intervention on personality characteristics and quality oflife of patients with esophageal cancer显示文摘 | Cheng QM Kong CQ Chang SY | 2013 | Clin Res Hepatol Gastroenterol2013，37，3： | 1 |
| 16 | Prevalence of dry eye among anelderly Chinese population in Taiwan:the Shihpai Eye Study显示文摘 | LIN PY TSAI SY CHENG CY | 2003 | Ophthalmol2003，110，6： | 1 |
| 17 | Prevalence of dry eye among an elderly Chinese population in Taiwan:the Shihpai Eye Study显示文摘 | Lin PY Tsai SY Cheng CY Liu JH Chou P Hsu WM | 2003 | Ophthalmology2003，110，6： | 1 |
| 18 | Good death study of elderly patients with terminal cancer in Taiwan显示文摘 | SY Cheng WY Hu WJ Liu | 2008 | Palliative Medicine2008，，22： | 1 |
| 19 | Expression of the Vascular vascular endothelial growth factor in human brain tumors显示文摘 | Nishikawa R Cheng SY Nagashima R | 1998 | Acta Neuropathol1998，96，： | 1 |
| 20 | Combined use of brachial-ankle pulse wave velocity and ankle-brachial index for fast assessment of arteriosclerosis and atherosclerosis in a community显示文摘 | Chuang SY Chen CH Cheng CM | 2005 | International Journal of Cardiology2005，98，： | 1 |
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