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| 1 | A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer显示文摘Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,respectively.Patients who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer. | Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg Naohiro Ishii Angela Toss Mona PTan Mathew A Cherian Erwei Song | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 2 | Baculovirus Host-Range显示文摘Baculoviruses are used as microbial insecticides, protein expression vectors, epitope display platforms, and most recently as vectors for gene therapy. Understanding the mechanisms that control baculovirus host-range and tissue tropisms are important for assessing their safety and for improving their properties for these biotechnology applications. In the past two decades some progress has been made and several baculovirus genes that influence host-range have been identified. Despite this progress, our understanding of the underlying mechanisms that restrict baculovirus host-range is still limited. Here we review what is currently known about baculovirus genes that influence virus host-range. | Suzanne M. Thien Xiao-Wen Cheng | 2009 | Virologica Sinica2009，24，5： | 2 |
| 3 | Assoc)ation of 77 Polymorphisms in 52 Candidate Genes with Blood Pressure Progression and Incident Hypertension: The Women's Genome Health Study显示文摘 | David Conen Suzanne Cheng Steiner | 2009 | J Hypertens2009，27，3： | 1 |
| 4 | Taylor Hypertension Genes Are Genetic Markers for Insulin Sensitivity and Resis- tance显示文摘 | Xiuqing Guo Suzanne Cheng Kent O et aI | 2005 | Hypertension2005，45，2： | 1 |
| 5 | Homozygosity for the Ala allele of the PPARΓ2 Pro12Ala polymorphism is associated with reduced risk of coronary artery disease显示文摘 | Andrea Galgani AnaMaria Valdes Henry A. Erlich Calvin Mano Suzanne Cheng Antonio Petrone Federica Sentinelli Andrea Berni Marco G. Baroni Raffaella Buzzetti | 2010 | Disease Markers2010，，： | 1 |
| 6 | HIV infection induces age-related changes to monocytes and innate immune activation in young men that persist despite combination antiretroviral therapy显示文摘 | Anna C. Hearps Anna Maisa Wan-Jung Cheng Thomas A. Angelovich Gregor F. Lichtfuss Clovis S. Palmer Alan L. Landay Anthony Jaworowski Suzanne M. Crowe | 2012 | AIDS2012，，7： | 1 |
| 7 | Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension:The Women's Genome Health Study显示文摘 | David Conen Suzanne Cheng Lori LSteiner | 2009 | J Hypertens2009，27，3： | 1 |
| 8 | Usefulness of Intra-Aortic Balloon Pump Counterpulsation in Patients With Cardiogenic Shock from Acute Myocardial Infarction显示文摘 | Jin M. Cheng Suzanne D.A. Valk Corstiaan A. den Uil Martin van der Ent Wim K. Lagrand Meike van de Sande Ron T. van Domburg Maarten L. Simoons | 2009 | The American Journal of Cardiology2009，，3： | 1 |
| 9 | Worsening renal function: What is a clinically meaningful change in creatinine during hospitalization with heart failure?显示文摘 | Grace L. Smith Viola Vaccarino Mikhail Kosiborod Judith H. Lichtman Susan Cheng Suzanne G. Watnick Harlan M. Krumholz | 2003 | Journal of Cardiac Failure2003，，： | 1 |
| 10 | A Meta-Analysis of Candidate Gene Polymorphisms and Ischemic Stroke in 6 Study Populations: Association of Lymphotoxin-Alpha in Nonhypertensive Patients显示文摘 | Xingyu Wang Suzanne Cheng Victoria H. Brophy Henry A. Erlich Christine Mannhalter Klaus Berger Wolfgang Lalouschek Warren S. Browner Yu Shi E Bernd Ringelstein Christof Kessler Jan Luedemann Klaus Lindpaintner Lisheng Liu Paul M. Ridker Robert Y.L. Zee Na | 2009 | Stroke2009，，3： | 1 |
| 11 | Effective amplification of long targets from cloned inserts and human genomic DNA显示文摘 | Suzanne Cheng Carita Fockler waylle M Barnes | 1994 | Proc Natl Acad Sci USA1994，91，： | 1 |
| 12 | Crowdsourcing in health and medical research:a systematic review显示文摘Background:Crowdsourcing is used increasingly in health and medical research.Crowdsourcing is the process of aggregating crowd wisdom to solve a problem.The purpose of this systematic review is to summarize quantitative evidence on crowdsourcing to improve health.Methods:We followed Cochrane systematic review guidance and systematically searched seven databases up to September 4th 2019.Studies were included if they reported on crowdsourcing and related to health or medicine.Studies were excluded if recruitment was the only use of crowdsourcing.We determined the level of evidence associated with review findings using the GRADE approach.Results:We screened 3508 citations,accessed 362 articles,and included 188 studies.Ninety-six studies examined effectiveness,127 examined feasibility,and 37 examined cost.The most common purposes were to evaluate surgical skills(17 studies),to create sexual health messages(seven studies),and to provide layperson cardiopulmonary resuscitation(CPR)out-of-hospital(six studies).Seventeen observational studies used crowdsourcing to evaluate surgical skills,finding that crowdsourcing evaluation was as effective as expert evaluation(low quality).Four studies used a challenge contest to solicit human immunodeficiency virus(HIV)testing promotion materials and increase HIV testing rates(moderate quality),and two of the four studies found this approach saved money.Three studies suggested that an interactive technology system increased rates of layperson initiated CPR out-ofhospital(moderate quality).However,studies analyzing crowdsourcing to evaluate surgical skills and laypersoninitiated CPR were only from high-income countries.Five studies examined crowdsourcing to inform artificial intelligence projects,most often related to annotation of medical data.Crowdsourcing was evaluated using different outcomes,limiting the extent to which studies could be pooled.Conclusions:Crowdsourcing has been used to improve health in many settings.Although crowdsourcing is effective at improving behavioral outcomes,more research is needed to understand effects on clinical outcomes and costs.More research is needed on crowdsourcing as a tool to develop artificial intelligence systems in medicine. | Cheng Wang Larry Han Gabriella Stein Suzanne Day Cedric Bien-Gund Allison Mathews Jason JOng Pei-Zhen Zhao Shu-Fang Wei Jennifer Walker Roger Chou Amy Lee Angela Chen Barry Bayus Joseph D.Tucker | 2020 | Infectious Diseases of Poverty2020，9，1： | 0 |
| 13 | Ultrasound mechanotransduction on osteoblastic mineralization and mitigating bone loss显示文摘Introduction Mechanotransduction has demonstrated potentials for tissue adaptation in vivo and in vitro. It is well documented that ultrasound,as a mechanical signal,can produce a wide variety of biological effects in vitro and in vivo [1]. As an example, | Sardar Uddin Suzanne Ferreri Jacky Cheng | 2010 | 医用生物力学2010，25，S1： | 0 |
| 14 | 四联与三联抗逆转录病毒疗法作为HIV感染者一线治疗效果比较:一项随机对照试验的系统综述和meta分析显示文摘目的比较四药联用(四联)和三药联用(三联)的抗逆转录病毒疗法作为HIV感染者一线治疗的疗效和安全性,并探讨现有的临床试验对临床实践及未来研究的启示。研究设计随机对照试验的系统综述和meta分析。数据来源系统检索了PubMed、EMBASE、CENTRAL、Web of Science及Allied Health Literature数据库2001年3月至2016年12月期间发表的研究(其中PubMed和EMBASE的检索更新至2018年6月),以及合格研究和相关综述的参考文献。入选标准比较四联与三联抗逆转录病毒疗法作为HIV感染者一线治疗的作用,并评价了至少一种疗效或安全性结局的随机对照试验。分析方法对检测不到的HIV-1 RNA、CD4 T细胞计数、病毒学失败、新发艾滋病事件、死亡和严重不良反应等结局的资料采用随机效应模型进行meta分析。结果共找到12项合格研究,包括4251例HIV感染者。四联和三联抗逆转录病毒疗法对各个疗效和安全性结局的影响均类似,且没有一个总体效应估计值的点值落在支持四联疗法的一侧。与三联疗法相比,四联疗法组出现不同结局的相对危险度及其95%可信区间如下:检测不到的HIV-1 RNA,0.99(0.93~1.05);病毒学失败,1.00(0.90~1.11);新发艾滋病事件,1.17(0.84~1.63);死亡,1.23(0.74~2.05);严重不良反应,1.09(0.89~1.33)。两组CD4 T细胞计数增加的平均差值为-19.55个细胞/μl(-43.02~3.92)。无论联合抗逆转录病毒疗法的具体方案如何,上述2组比较的结果大体不变,且在所有亚组和敏感性分析中均变化不大。结论在HIV感染者的一线治疗中,四联抗逆转录病毒疗法的效果并不优于三联疗法。这一发现为当前推荐三联疗法作为一线治疗的指南提供了支持。除非对现有证据的系统综述显示确有必要,否则不应该再开展新的临床试验去比较四联与三联疗法。当然,本系统综述并不排除当有新的抗逆转录病毒药物种类出现时包含该类药物的四联疗法比三联疗法更好的可能性。 | 冯倚(译) 周傲霜 邹华春 Suzanne M Ingle Margaret T May 蔡卫平 Chien-Yu Cheng 杨祖耀 唐金陵 冯琦(译) 唐金陵(译) | 2020 | 英国医学杂志中文版2020，23，1： | 0 |
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